All Peer-reviewed Publications
Displaying 733 Publications
735
Angiogenesis-associated pathways play critical roles in neonatal sepsis outcomes
Fidanza M, Hibbert J, Acton E, Harbeson D, Schoeman E, Skut P, Woodman T, Eynaud A, Hartnell L, Brook B, Cai B, Lo M, Falsafi R, Hancock REW, Chiume-Kayuni M, Lufesi N, Popescu CR, Lavoie PM, Strunk T, Currie AJ, Kollmann TR, Amenyogbe N, Lee AH.
(2024) Sci Rep
14:
10.1038/s41598-024-62195-9
734
Supervised Multi-Omics Integration Identifies Differential Biomarkers of COVID Versus Non-COVID Acute Respiratory Distress Syndrome
J. Tai, E. Acton, E. Churcher, C.M. Vaswani, G. Tan, J. Tsoporis, R.E.W. Hancock, A. An, A.H.Y. Lee, A. Formosa, and C.C. Dos Santos.
(2024) AM J Respir Crit Care Med
209:
A2840
733
Biodistribution of Native and Nanoformulated Innate Defense Regulator Peptide 1002
Tullio V. F. Esposito, Colin Blackadar, Lan Wu, Cristina Rodríguez-Rodríguez, Evan F. Haney, Daniel Pletzer, Katayoun Saatchi, Robert E. W. Hancock, and Urs O. Häfeli
(2024) Mol. Pharmaceutics
10.1021/acs.molpharmaceut.3c01169
731
Gene Expression Profiling in Pediatric Appendicitis
Dhillon, Bhavjinder K; Kortbeek, Simone; Baghela, Arjun; Brindle, Mary; Martin, Dori-Ann; Jenne, Craig N; Vogel, Hans J; Lee, Amy H Y; Thompson, Graham C; Hancock, Robert E W
(2024) JAMA Pediatrics
DOI10.1001/jamapediatrics.2023.6721
730
Antibiofilm peptides enhance the corrosion resistance of titanium in the presence of Streptococcus mutans
Wang D, Yue Y, Liu H, Zhang T, Haney EF, Hancock REW, Yu J, Shen Y.
(2024) Front Bioeng Biotechnol
11:
10.3389/fbioe.2023.1339912
729
Implementation and impact of the global access principles at the University of British Columbia: current successes and future challenges
Gallini N, Hancock REW, Lester R, Sharp B, Wasan KM.
(2023) Front Pharmacol.
14:
1271618
728
Influence of a D-enantiomeric peptide on the anticorrosion ability of titanium with different surface roughness against Streptococcus mutans biofilms
Wang D, Yu J, Liu H, Zhang T, Haney EF, Hancock REW, Peng L, Shen Y.
(2023) J Dent
139:
104777
727
Antibiotic failure: Beyond antimicrobial resistance
Fuente-Nunez, Cesar de la; Angela Cesaro; Robert E.W. Hancock
(2023) Drug Resist. Updates
71:
10.1016/j.drup.2023.101012
726
Persistence is Key: Unresolved Immune Dysfunction is Lethal in Both COVID-19 and non-COVID-19 Sepsis
Ay An, A Baghela, PGY Zhang, R Falsafi, AH Lee, U Trahtemberg, A Baker, CC Dos Santos, R.E.W. Hancock
(2023) Front. Immunol.
14:
725
Dynamic killing effectiveness of mouthrinses and a d-enantiomeric peptide on oral multispecies biofilms grown on dental restorative material surfaces
Hu J, Yu J, Liu H, Wang Z, Haapasalo M, Haney EF, Hancock REW, Deng S, Shen Y.
(2023) J Dent
134:
104552
724
Impacts of PEGylation and Glycosylation on the Biological Properties of Host Defense Peptide IDR1018
Etayash H, Yip F, Hancock REW
(2023) Pharmaceutics
15(5):
1391
723
Efficient in planta production of amidated antimicrobial peptides that are active against drug-resistant ESKAPE pathogens
Chaudhary S, Ali Z, Tehseen M, Haney EF, Pantoja-Angles A, Alshehri S, Wang T, Clancy GJ, Ayach M, Hauser C, Hong PY, Hamdan SM, Hancock REW, Mahfouz M.
(2023) Nat Commun
14(1):
1464
722
Predicting severity in COVID-19 disease using sepsis blood gene expression signatures
Baghela A, An A, Zhang P, Acton E, Gauthier J, Brunet-Ratnasingham E, Blimkie T, Freue GC, Kaufmann D, Lee AHY, Levesque RC, Hancock REW.
(2023) Sci Rep
13(1):
1247
721
HLA-DPB1 is associated with ANCA-associated vasculitis in children
Gibson KM, Drögemöller BI, Foell D, Benseler SM, Graham J, Hancock REW, Luqmani RA, Cabral DA, Brown KL, Ross CJ; PedVas Investigator's Network.
(2022) Arthritis Rheumatol.
Epub :
ahead of print
720
Novel Alligator Cathelicidin As-CATH8 Demonstrates Anti-Infective Activity against Clinically Relevant and Crocodylian Bacterial Pathogens
Santana FL, Estrada K, Alford MA, Wu BC, Dostert M, Pedraz L, Akhoundsadegh N, Kalsi P, Haney EF, Straus SK, Corzo G, Hancock REW
(2022) Antibiotics (Basel)
11(11):
1603
PDF
719
718
Biodistribution and Toxicity of Innate Defense Regulator 1018 (IDR-1018)
V F Esposito T, Rodríguez-Rodríguez C, Blackadar C, Haney EF, Pletzer D, REW Hancock, Saatchi K, Häfeli UO.
(2022) Eur J Pharm Biopharm
online:
ahead of print
717
SPECT/CT Imaging of 111Ag for the Preclinical Evaluation of Silver-Based Antimicrobial Nanomedicines
Colin Blackadar, Ka-Yee Grace Choi, Mary F. Embree, Heather M. Hennkens, Cristina Rodríguez-Rodríguez, Robert E. W. Hancock, Katayoun Saatchi, and Urs O. Häfeli
(2022) ACS Appl. Mater. Interfaces
14 (23):
26382-26393
716
Assessing the Activity of Antimicrobial Peptides Against Common Marine Bacteria Located in Rotifer (Brachionus plicatilis) Cultures.
Woods, C., Woolley, L., Partridge, G, Chen, M, Haney EF, Hancock REW, Buller N, Currie A
(2022) Probiotics & Antimicro. Prot.
10.1007/s12602-022-09928-2
715
Competition between Pseudomonas aeruginosa and Staphylococcus aureus is dependent on intercellular signaling and regulated by the NtrBC two-component system.
Alford, M.A., Mann, S., Akhoundsadegh, N. and REW Hancock
(2022) Sci Rep
12:
9027
714
Antimicrobial properties of spray-dried cellulose nanocrystals and metal oxide-based nanoparticles-in-microspheres
Alberto Baldelli, Hashem Etayash, Hale Oguzlu, Ronit Mandal, Feng Jiang, Robert E.W. Hancock, Anubhav Pratap-Singh,
(2022) Chemical Engineering Journal Advances
10:
10.1016/j.ceja.2022.100273
713
Assessing the In Vivo Effectiveness of Cationic Lipid Nanoparticles with a Triple Adjuvant for Intranasal Vaccination against the Respiratory Pathogen Bordetella pertussis
Aibani N, Patel P, Buchanan R, Strom S, Wasan KM, Hancock REW, Gerdts V, Wasan EK
(2022) Mol. Pharmaceutics
10.1021/acs.molpharmaceut.1c00852
712
Gene Expression Profiling: Identification of Novel Pathways and Potential Biomarkers in Severe Acute Pancreatitis
Nesvaderani, Maryam; Dhillon, Bhavjinder K; Chew, Tracy; Tang, Benjamin F; Baghela, Arjun; Hancock, Robert EW; Eslick, Guy F; Cox, Michael
(2022) Journal of the American College of Surgeons
10.1097/XCS.0000000000000115
711
Antibiofilm and immunomodulatory resorbable nanofibrous filing for dental pulp regenerative procedures
Mauricio Gonçalves da Costa Sousa, Gabriela Conceição de Almeida, Danilo César Martins Mota, Rosiane Andrade da Costa, Simoni Campos Dias, Samuel Nunes Limberger, Frank Ko, Li Ting Lin, Evan F. Haney, Hashem Etayash, Beverlie Baquir, Michael J. Trimble, Ya Shen, Zheng Su, Markus Haapasalo, Daniel Pletzer, Letícia Chaves de Souza, Gláucia Schuindt Teixeira, Renato M. Silva, Robert E.W. Hancock, Octavio Luiz Franco, Taia Maria Berto Rezende,
(2022) Bioactive Materials
16:
173-186
710
Self-Assembly of Antimicrobial Peptoids Impacts Their Biological Effects on ESKAPE Bacterial Pathogens
Nielsen JE, Alford MA, Yung DBY, Molchanova N, Fortkort JA, Lin JS, Diamond G, Hancock REW, Jenssen H, Pletzer D, Lund R, Barron AE.
(2022) ACS Infect. Dis.
10.1021/acsinfecdis.1c00536
709
Predicting sepsis severity at first clinical presentation: The role of endotypes and mechanistic signatures
Arjun Baghela, Olga M. Pena, Amy H. Lee, Beverlie Baquir, Reza Falsafi,
Andy An, Susan W. Farmer, Andrew Hurlburt, Alvaro Mondragon-Cardona, Juan Diego Rivera, Andrew Baker, Uriel Trahtemberg, Maryam Shojaei, Carlos Eduardo Jimenez-Canizales, Claudia C. dos Santos, Benjamin Tang, Hjalmar R. Bouma, Gabriela V. Cohen Freue, and Robert E.W. Hancock (2022) eBiomedicine 75: 103776
Andy An, Susan W. Farmer, Andrew Hurlburt, Alvaro Mondragon-Cardona, Juan Diego Rivera, Andrew Baker, Uriel Trahtemberg, Maryam Shojaei, Carlos Eduardo Jimenez-Canizales, Claudia C. dos Santos, Benjamin Tang, Hjalmar R. Bouma, Gabriela V. Cohen Freue, and Robert E.W. Hancock (2022) eBiomedicine 75: 103776
708
Gut microbes shape microglia and cognitive function during malnutrition
Bauer KC, York EM, Cirstea MS, Radisavljevic N, Petersen C, Huus KE, Brown EM, Bozorgmehr T, Berdún R, Bernier LP, Lee AHY, Woodward SE, Krekhno Z, Han J, Hancock REW, Ayala V, MacVicar BA, Finlay BB.
(2022) Glia
Epub :
ahead of print
707
Systems Biology Methods Applied to Blood and Tissue for a Comprehensive Analysis of Immune Response to Hepatitis B Vaccine in Adults
Ben-Othman R, B Cai, AC Liu, N Varankovich, D He, TM Blimkie, AH Lee, EE Gill, M Novotny, B Aevermann, S Drissler, CP Shannon, S McCann, K Marty, G Bjornson, RD Edgar, D Tse S Lin, N Gladish, J Maclsaac, N Amenyogbe, Q Chan, A Llibre, J Collin, E Landais, K Le, SM Reiss, WC Koff, C Havenar-Daughton, M Heran, B Sangha, D Walt, M Krajden, S Crotty, D Sok, B Briney, DR Burton, D Duffy, LJ Foster, WW Mohn, MS Kobor, SJ Tebbutt, RR Brinkman, RH Scheuermann, R.E.W. Hancock , TR Kollmann, M Sadarangani
(2020) Front. Immunol.
11:
580373
PDF
706
Multifunctional Antibiotic-Host Defense Peptide Conjugate Kills Bacteria, Eradicates Biofilms, and Modulates the Innate Immune Response
Etayash E, M Alford, N Akhoundsadegh, M Drayton, SK Straus, R.E.W. Hancock
(2021) J. Med. Chem.
64(22):
16854-16863
705
Host Defense Peptide-Mimicking Polymers and Polymeric-Brush-Tethered Host Defense Peptides: Recent Developments, Limitations, and Potential Success
Etayash H, REW Hancock
(2021) Pharmaceutics
13:
1820
704
Enzymatically releasable polyethylene glycol - host defense peptide conjugates with improved activity and biocompatibility
Drayton M, Alford MA, Pletzer D, Haney EF, Machado Y, Luo HD, Overall CM, Kizhakkedathu JN, Hancock REW, Straus SK.
(2021) J Control Release
339:
220-231
703
Machine learning-based single cell and integrative analysis reveals that baseline mDC predisposition predicts protective Hepatitis B vaccine response.
Aevermann B.D., CP. Shannon, M. Novotny, R. Ben-Othman, B. Cai, Y. Zhang, J.C. Ye, M.S. Kobor, A. Lee, N. Gladish, T.M. Blimkie, R.E.W. Hancock, A. Llibre, D. Duffy, W.C. Koff, M. Sadarangani, S.J. Tebbutt, T.R. Kollmann, and R.H. Scheuermann.
(2021) Front. Immunol.
12:
10.1101/2021.02.22.21251864
PDF
702
The Pseudomonas aeruginosa whole genome sequence - a 20th anniversary celebration.
Brinkman, F.S.L., G. Winsor, R.E. Done, A. Filloux, V.I. Francis, J.B. Goldberg, E.P. Greenberg, K. Han, R.E.W. Hancock, C.H. Haney, S. Häußler, J. Klockgether, I. Lamont, R.C. Levesque, S. Lory, P.I. Nikel, S.L. Porter, M.W. Scurlock, H.P. Schweizer, B. Tümmler, M. Wang, and M. Welch.
(2021) Micorbiology
79:
25-88
701
PaIntDB: Network-based omics integration and visualization using protein-protein interactions in Pseudomonas aeruginosa
Castillo-Arnemann JJ, Solodova O, Dhillon BK, Hancock, R.E.W.
(2021) Bioinformatics
btab363:
10.1093/bioinformatics/btab36
700
Antibiofilm activity of host defence peptides: complexity provides opportunities.
Hancock, R.E.W., Alford, M.A. & Haney, E.F
(2021) Nature Rev. Microbiol.
10.1038/s41579-021-00585-w
699
Genomic insights into diversity, virulence and resistance of Klebsiella pneumoniae extensively drug resistant clinical isolates.
Lee, A.H.Y., W.F. Porto, C. de Faria-Jr, S.C. Dias, S.A. Alencar, D.J. Pickard, R.E.W. Hancock, and O.L. Franco.
(2021) Microb Genom.
7:
10.1099/mgen.0.000613
PDF
698
RNase III and RNase E Influence Posttranscriptional Regulatory Networks Involved in Virulence Factor Production, Metabolism, and Regulatory RNA Processing in Bordetella pertussis
Ifill G, Blimkie T, Lee AH, Mackie GA, Chen Q, Stibitz S, Hancock REW, Fernandez RC.
(2021) mSphere
6(4):
10.1128/mSphere.00650-21
PDF
697
Contribution of swarming motility to dissemination in a Pseudomonas aeruginosa murine skin abscess infection model
Coleman SR, D Pletzer, R.E.W. Hancock
(2020) J. Infect. Diseases
224:
726–733
696
Testing physiologically relevant conditions in minimal inhibitory concentration assays
Belanger C and R.E.W. Hancock
(2021) Nat Protoc
16:
3761-3774
695
Rapid Assembly of Infection-Resistant Coatings: Screening and Identification of Antimicrobial Peptides Works in Cooperation with an Antifouling Background
Yu K, Alzahrani A, Khoddami S, Cheng JTJ, Mei Y, Gill A, Luo HD, Haney EF, Hilpert K, Hancock REW, Lange D, Kizhakkedathu JN.
(2021) ACS Appl. Mater. Interfaces
13:
36784-36799
694
NtrBC selectively regulates host-pathogen interactions, virulence and ciprofloxacin susceptibility of Pseudomonas aeruginosa.
Alford, M.A., B. Baquir, A. An, K.-Y.G. Choi, and R.E.W. Hancock
(2021) Front Cell Infect Microbiol .
44:
553
PDF
693
The use of host defense peptides in root canal therapy in rats
Lima SMF, Freire MS, Cantuária APC, Martins DCM, Amorim IA, Dantas EMGL, Farias JO, Castro MB, Silva JS, Barriviera FA, Barriviera M, Almeida JA, Uehara IA, Silva MJB, Oliveira APL, Silva ON, Hancock REW, Franco OL, Rezende TMB.
(2020) Clin Oral Investig.
25:
3623-3632
691
Microtitre plate assays to assess antibiofilm activity against bacteria.
Haney, E.F., M.J. Trimble, and R.E.W. Hancock.
(2021) Nature Protocols
16:
2615–2632
690
Peptide 1018 inhibits swarming and influences Anr-regulated gene expression downstream of the stringent stress response in Pseudomonas aeruginosa
Wilkinson LV, Alford MA, Coleman SR,Wu BC, Lee AHY, Blimkie TM, Bains M, Falsafi R, Pletzer D, Hancock, R.E.W.
(2021) PLoS One
16:
e0250977
PDF
689
Identification of a crocodylian β-defensin variant from Alligator mississippiensis with antimicrobial and antibiofilm activity
Santana FL, Arenas I, Haney EF, Estrada K, Hancock, R.E.W., Corzo G
(2021) Peptides
141:
170549
688
Immunomodulatory streptococci that inhibit CXCL8 secretion and NFκB activation are common members of the oral microbiota.
Myers, S., T. Do. J.L. Meade, A. Tugnait, J.J. Vernon, J. Pistolic, R.E.W. Hancock, P.D. Marsh, H.M. Trivedi, D. Chen and D.A. Devine.
(2021) J. Med. Microbiol.
70:
001329
PDF
687
Assessing biofilm inhibition and immunomodulatory activity of small amounts of synthetic host defense peptides synthesized using SPOT-array technology.
Etayash, H., Haney, E.F. & Hancock, R.E.W.
(2021) Nature Protocols
16:
1850–1870
686
685
Self-Limiting Mussel Inspired Thin Antifouling Coating with Broad-Spectrum Resistance to Biofilm Formation to Prevent Catheter-Associated Infection in Mouse and Porcine Models
Yu K, Alzahrani A, Khoddami S, Ferreira D, Scotland KB, Cheng JTJ, Yazdani-Ahmadabadi H, Mei Y, Gill A, Takeuchi LE, Yeung E, Grecov D, Hancock REW, Chew BH, Lange D, Kizhakkedathu JN.
(2021) Adv Healthc Mater.
e2001573:
684
Recovery of oral in vitro biofilms after exposure to peptides and chlorhexidine.
Zhang, T., L.Xia, Z. Wang, R.E.W. Hancock, and M. Haapasalo.
(2021) J Endod
47:
466-471
683
Different disease endotypes in phenotypically similar vasculitides affecting small-to-medium sized blood vessels.
Gill, E.E., M. Smith, K.M. Gibson, K.A. Morishita, A.H. Lee, R. Falsafi, J. Graham, D. Foell, S. Benseler, Colin Ross, R. Luqmani, D. Cabral, R.E.W. Hancock, and K.L. Brown.
(2021) Front. Immunol.
12:
638571
PDF
682
Murine models of sinusitis infection for screening antimicrobial and immunomodulatory therapies.
Alford, M.A., K.-Y.G. Choi, M.J. Trimble, H. Masoudi, P. Kalsi, D. Pletzer, R.E.W. Hancock.
(2021) Front Cell Infect Microbiol .
11:
621081
PDF
681
Rapid microwave-based method for the preparation of antimicrobial lignin-capped silver nanoparticles active against multidrug-resistant bacteria
Pletzer D, Asnis J, Slavin YN, Hancock REW, Bach H, Saatchi K, Häfeli UO.
(2021) Int J Pharm.
596:120299:
10.1016/j.ijpharm.2021.120299
680
Ivacaftor or lumacaftor/ivacaftor treatment does not alter the core CF airway epithelial gene response to rhinovirus
De Jong, Emma; Luke W. Garratt, Kevin Looi, Amy H.Y. Lee, Kak-Ming Ling, Maren L. Smith, Reza Falsafi, Erika N. Sutanto, Jessica Hillas, Thomas Iosifidis, Kelly M. Martinovich, Nicole C. Shaw, Samuel T. Montgomery, Elizabeth Kicic-Starcevich, Francis J. Lannigan, Shyan Vijayasekaran, Robert E.W. Hancock, Stephen M. Stick, Anthony Kicic, CF AREST,
(2020) J Cyst Fibros
19(4):
10.1016/j.jcf.2020.07.004
679
Human organoid biofilm model for assessing antibiofilm activity of novel agents.
Bing (Catherine) Wu, Evan F. Haney, Noushin Akhoundsadegh, Daniel Pletzer, Michael J. Trimble, Alwin E. Adriaans, Peter H. Nibbering & Robert E. W. Hancock
(2021) npj Biofilms Microbiomes
7:
https://doi.org/10.1038/s41522-020-00182-4
PDF
678
The small RNAs PA2952.1 and PrrH as regulators of virulence, motility and iron metabolism in Pseudomonas aeruginosa
Coleman SR, Manjeet Bains, Maren L. Smith, Victor Spicer, Ying Lao, Patrick K. Taylor, Neeloffer Mookherjee, Robert E.W. Hancock
(2020) Appl. Environ. Microbiol
87:
doi: 10.1128/AEM.02182-20
PDF
677
676
Identification of novel targets of azithromycin activity against Pseudomonas aeruginosa grown in physiologically relevant media
Belanger CR, AHY Lee, D Pletzer, BK Dhillon, R Falsafi, R.E.W. Hancock
(2020) PNAS
117:
33519-33529
675
Multi-omic data integration allows baseline immune signatures to predict hepatitis B vaccine response in a small cohort.
Shannon, C.P., T.M. Blimkie, R.B. Othman, N. Gladish, N.A. Amenyogbe, S. Drissler, R.D. Edgar, Q. Chan, M. Krajden, L.J. Foster, M.S. Kobor, B. Mohn, R.R. Brinkman, K.-A. Le Cao, R.H. Scheuermann, S.J. Tebbutt, R.E.W. Hancock, W. Koff, T. Kollmann, M. Sadarangani, and A.H. Lee.
(2020) Front. Immunol.
11:
578801
PDF
674
A bovine enteric Mycobacterium infection model to analyze parenteral vaccine-induced mucosal immunity and accelerate vaccine discovery.
Facciuolo, A., A.H. Lee, M.J. Trimble, N. Rawlyk, H.G.G. Townsend, M. Bains, N. Arsic, L.M. Mutharia, A. Potter, V. Gerdts, S. Napper, R.E.W. Hancock, and P.J. Griebel.
(2020) Front. Immunol.
11:
PDF
673
Unique inducible filamentous motility identified in pathogenic Bacillus cereus group species
Liu MM, S Coleman, L Wilkinson, ML Smith, T Hoang, N Niyah, M Mukherjee, S Huynh, CT Parker, J Kovac, R.E.W. Hancock, EC Gaynor
(2020) ISME J.
14:
2997–3010
PDF
672
Molecular dynamics simulations informed by membrane lipidomics reveal the structure–interaction relationship of polymyxins with the lipid A-based outer membrane of Acinetobacter baumannii
Jiang, X., K. Yang, B. Yuan, M. Han, Y. Zhu, K.D. Roberts, N. Patil, J. Li, B. Gong, R.E.W. Hancock, T. Velkov, F. Schreiber, L. Wang, and J. Li.
(2020) J. Antimicrob. Chemother.
75(12):
3534-3543
PDF
671
Host Defense Peptide-Mimicking Amphiphilic β-Peptide Polymer (Bu:DM) Exhibiting Anti-Biofilm, Immunomodulatory, and in Vivo Anti-Infective Activity
Etayash H, Qian Y, Pletzer D, Zhang Q, Xie J, Cui R, Dai C, Ma P, Qi F, Liu R, Hancock REW.
(2020) J. Med. Chem.
63:
12921-12928
670
Systems biology methods applied to blood and tissue for a comprehensive analysis of immune response to hepatitis B vaccine in adults.
Ben-Othman, R., B Cai, A. Liu, N. Varankovich, D. He, T.M Blimkie, A.H. Lee, E.E. Gill, M. Novotny, B. Aevermann, S. Drissler, C.P. Shannon, S. McCann, K. Marty, G. Bjornson, R.D. Edgar, N. Gladish, D.T.S. Lin, J. MacIsaac, N.A. Amenyogbe, Q. Chan, A. Llibre, C. Joyce, E. Landais, K. Le, S.M. Reiss, C. Havenar-Daughton, M. Heran, B. Sangha, D. Walt, M. Krajden, S. Crotty, D. Sok, B. Briney, D. Burton, D. Duffy, L.J. Foster, W.W. Mohn, M.S. Kobor, S.J. Tebbutt, R.R. Brinkman, R.H. Scheuermann, R.E.W. Hancock, T.R. Kollmann, and M. Sadarangani.
(2020) Front. Immunol.
11:
580373
PDF
669
Preparing for life: Plasma proteome changes and immune system development during the first week of human life.
Bennike, T.B., B. Fatou, A. Angelidou, J.D. Arce, R. Falsafi, R. Ford, E.E. Gill, S.D. Van Haren, O.T. Idoko, A.H. Lee, R. Ben Othman, W.S. Pomat, C.P. Shannon, K.K. Smolen, S.J. Tebbutt, A. Ozonoff, P.C. Richmond, A.H.J. Van Den Biggelaar, R.E.W. Hancock, B. Kampmann, T.R. Kollmann, O. Levy, H. Steen.
(2020) Front. Immunol.
11:
578505
668
Exploring the pathophysiology of post-sepsis syndrome to identify therapeutic opportunities
van der Slikkea, EC; A.Y. An, R.E.W. Hancock, H.R. Bouma
(2020) eBiomedicine
61:
10.1016/j.ebiom.2020.103044
PDF
667
Cyclic Derivative of Host-Defense Peptide IDR-1018 Improves Proteolytic Stability, Suppresses Inflammation, and Enhances In Vivo Activity
Etayash H, D Pletzer, P Kumar, SK. Straus, and R.E.W. Hancock
(2020) J. Med. Chem.
63:
9228–9236
666
Mechanistic understanding enables the rational design of salicylanilide combination therapies for Gram-negative infections.
Copp, J.C., D. Pletzer, A.S. Brown, J. Van der Heijden, C.M. Miton, R.J. Edgar, M.H. Rich, R.F. Little, E. Williams, R.E.W. Hancock, N. Tokuriki, and D.F. Ackerley.
(2020) mBio
11:
e02068-20.
PDF
665
Characterization of immune responses and the lung transcriptome in a murine model of IL-33 challenge.
Piyadasa, H., D. Lloyd, A.H.Y. Lee, A. Altieri, M. Hemshekhar, N. Osawa, S. Basu, T. Blimkie, R. Falsafi, A. Halayko, R.E.W. Hancock and N. Mookherjee.
(2020) Biochim. Biophys. Acta.
1866(12):
165950
664
In Vivo anti-inflammatory activity of lipidated peptidomimetics Pam-(Lys-βNspe)6-NH2 and Lau-(Lys-βNspe)6-NH2 against PMA-induced acute inflammation.
Wu, B.C., S.L. Skovbakke, H. Masoud, R.E.W. Hancock, and H. Franzyk.
(2020) Front. Immunol.
11:
2102
PDF
663
Cathelicidin host defense peptides and inflammatory signaling: striking a balance.
Alford, M.A., B. Baquir, F. Santana, E.F. Haney, R.E.W. Hancock
(2020) Front. Microbiol.
11:
1902
PDF
662
MDA-MB-231 Breast Cancer Cells Resistant to Pleurocidin-Family Lytic Peptides Are Chemosensitive and Exhibit Reduced Tumor-Forming Capacity.
Hilchie, AL; EE Gill, MR Power Coombs, R Falsafi, R.E.W. Hancock, David W Hoskin
(2020) Biomolecules
10(9):
E1220
PDF
661
A novel mouse model of chronic suppurative otitis media and its use in preclinical antibiotic evaluation
Khomtchouk KM, A Kouhi, A Xia, LA Bekale, S.M. Massa, JM. Sweere, D Pletzer, R.E.W Hancock, PL. Bollyky, PL. Santa Maria
(2020) Science Advances
6:
DOI: 10.1126/sciadv.abc1828
PDF
660
The value of antimicrobial peptides in the age of resistance
Magana, Maria; Muthuirulan Pushpanathan, Ana L Santos, Leon Leanse, Michael Fernandez, Anastasios Ioannidis, Marc A Giulianotti, Yiorgos Apidianakis, Steven Bradfute, Andrew L Ferguson, Artem Cherkasov, Mohamed N Seleem, Clemencia Pinilla, Cesar de la Fuente-Nunez, Themis Lazaridis, Tianhong Dai, Richard A Houghten, Robert E W Hancock, George P Tegos
(2020) Lancet Infect. Dis.
9:
659
658
The stringent stress response controls proteases and global regulators under optimal growth conditions in Pseudomonas aeruginosa.
Pletzer, D., T. Blimkie, H. Wolfmeier, Y. Li, A. Baghela, A Lee, R. Falsafi, and R.E.W. Hancock
(2020) mSystems
5:
e00495-20.
PDF
657
Rhinovirus Infection Drives Complex Host Airway Molecular Responses in Children With Cystic Fibrosis
Ling KM, Garratt LW, Gill EE, Lee AHY, Agudelo-Romero P, Sutanto EN, Iosifidis T, Rosenow T, Turvey SE, Lassmann T, Hancock REW, Kicic A, Stick SM.
(2020) Front. Immunol.
11:
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PDF
656
Bacterial aggregation triggered by fibril forming tryptophan rich sequences: effects of peptide side chain and membrane phospholipids
Bagheri M, H Nikolenko, S Arasteh, N Rezaei, M Behzadi, M.E.A. Dathe, and R.E.W. Hancock
(2020) ACS Appl. Mater. Interfaces
https://doi.org/10.1021/acsami.0c04336
655
Whole Blood Transcriptional Responses of Very Preterm Infants During Late-Onset Sepsis
Ng, Sherrianne; Tobias Strunk, Amy H Lee, Erin E Gill, Reza Falsafi, Tabitha Woodman, Julie Hibbert, R.E.W. Hancock Andrew Currie
(2020) PLoS One
15(6):
10.1371/journal.pone.0233841
PDF
654
Regional Dichotomy in Enteric Mucosal Immune Responses to a Persistent Mycobacterium avium Ssp. paratuberculosis Infection
Facciuolo, Antonio; Amy H. Lee, Patricia Gonzalez Cano, Hugh G. G. Townsend, Reza Falsafi, Volker Gerdts, Andrew Potter, Scott Napper, R.E.W. Hancock Lucy M. Mutharia, Philip J. Griebel
(2020) Front. Immunol.
10.3389/fimmu.2020.01020
PDF
653
In vitro and in vivo antibiotic capacity of two host defence peptides
Arenas I, MA Ibarra, FL Santana, E Villegas, R.E.W. Hancock, G Corzo
(2020) Mechanisms of Action: Physiological Effects
64:
DOI: 10.1128/AAC.00145-20
PDF
652
The importance of reporting house dust mite endotoxin abundance: impact on the lung transcriptome.
Pascoe CD, Jha A, Basu S, Mahood TH, Lee A, Hinshaw S, Falsafi R, Hancock REW, Mookherjee N, Halayko AJ.
(2020) Am J Physiol Lung Cell Mol Physiol.
10.1152/ajplung.00103.2020
651
EcDBS1R6: A Novel Cationic Antimicrobial Peptide Derived From a Signal Peptide Sequence
Porto WF, LN Irazazabal, V Humblot, EF Haney, SM Ribeiro, R.E.W. Hancock, A Ladram, OL Franco
(2020) Biochim. Biophys. Acta.
1864:
DOI: 10.1016/j.bbagen.2020.129633
650
Utilizing Organoid and Air-Liquid Interface Models as a Screening Method in the Development of New Host Defense Peptides
Choi, Ka-Yee Grace; Bing Catherine Wu, Amy Huei-Yi Lee, Beverlie Baquir, R.E.W. Hancock
(2020) Front Cell Infect Microbiol .
10:
10.3389/fcimb.2020.00228.
PDF
649
NtrBC Regulates Invasiveness and Virulence of Pseudomonas aeruginosa During High-Density Infection
Alford, Morgan A; Arjun Baghela, Amy T Y Yeung, Daniel Pletzer, R.E.W. Hancock
(2020) Front. Microbiol. 11:773: 10.3389/fmicb.2020.00773 PDF
(2020) Front. Microbiol. 11:773: 10.3389/fmicb.2020.00773 PDF
648
Overexpression of the Small RNA PA0805.1 in Pseudomonas Aeruginosa Modulates the Expression of a Large Set of Genes and Proteins, Resulting in Altered Motility, Cytotoxicity, and Tobramycin Resistance
Coleman SR, M L Smith, V Spicer, Y Lao, N Mookherjee, R.E.W. Hancock
(2020) mSystems
5:
doi: 10.1128/mSystems.00204-20.
PDF
647
Clinical Protocol for a Longitudinal Cohort Study Employing Systems Biology to Identify Markers of Vaccine Immunogenicity in Newborn Infants in The Gambia and Papua New Guinea
Idoko, Olubukola T; Kinga K Smolen, Oghenebrume Wariri, Abdulazeez Imam, Casey P Shannon, Tida Dibassey, Joann Diray-Arce, Alansana Darboe, Julia Strandmark, Rym Ben-Othman, Oludare A Odumade, Kerry McEnaney, Nelly Amenyogbe, William S Pomat, Simon van Haren, Guzmán Sanchez-Schmitz, Ryan R Brinkman, Hanno Steen, R.E.W. Hancock , Scott J Tebbutt, Peter C Richmond, Anita H J van den Biggelaar, Tobias R Kollmann, Ofer Levy, Al Ozonoff, Beate Kampmann
(2020) Front. Pediatr.
8:197:
10.3389/fped.2020.00197
PDF
646
Defective cell migration as a mechanism of dysregulated asthmatic airway epithelial repair
Iosifidis T, Sutanto EN, Buckley A, Coleman LA, Gill EE, Lee AH, Ling KM, Hillas J, Looi K, Garratt LW, Martinovich KM, Shaw NC, Montgomery ST, Kicic-Starcevich E, Karpievitch YV, Le Souef P, Laing IA, Vijayasekaran S, Lannigan FJ, Rigby PJ, Hancock REW, Knight D, Stick SM, Kicic A, Waerp OBO, AusREC OBO.
(2020) JCI Insight
pii: 133125.:
doi: 10.1172/jci.insight.133125
PDF
645
Selective anticancer activity of synthetic peptides derived from the host defence peptide tritrpticin
Arias, Mauricio; Evan F. Haney, Ashley L. Hilchie, Jennifer A. Corcoran, M. Eric Hyndman, Robert E.W. Hancock, Hans J. Vogel
(2020) Biochim. Biophys. Acta.
https://doi.org/10.1016/j.bbamem.2020.183228
644
MetaBridge: An Integrative Multi-Omics Tool for Metabolite-Enzyme Mapping
Blimkie, Travis; Amy Huei‐Yi Lee, R.E.W. Hancock
(2020) Curr Protoc Bioinformatics .
70(01):
10.1002/cpbi.98.
643
Insights into the mechanism of action of two analogues of aurein 2.2.
Raheem N, Kumar P, Lee E, Cheng JTJ, Hancock REW, Straus SK
(2020) Biochim. Biophys. Acta.
1862:
183262
642
Surfing motility is a complex adaptation dependent on the stringent stress response in Pseudomonas aeruginosa LESB58.
Pletzer D, Sun E, Ritchie C, Wilkinson L, Liu LT, Trimble MJ, Wolfmeier H, Blimkie TM, Hancock REW.
(2020) PLos Pathogens
16(3):
e1008444
PDF
641
AB569, a nontoxic chemical tandem that kills major human pathogenic bacteria
McDaniel, CT; Warunya Panmanee, Geoffrey L. Winsor, Erin Gill, Claire Bertelli, Michael J. Schurr, Prateek Dongare, Andrew T. Paul, Seung-Hyun B. Ko, Gee W. Lau, Nupur Dasgupta, Amy L. Bogue, William E. Miller, Joel E. Mortensen, David B. Haslam, Phillip Dexheimer, Daniel A. Muruve, Bruce J. Aronow, Malcolm D. E. Forbes, Marek Danilczuk, Fiona S. L. Brinkman, Robert E. W. Hancock, Thomas J. Meyer, and Daniel J. Hassett
(2020) PNAS
117(9):
4921-4930
640
Multidrug adaptive resistance of Pseudomonas aeruginosa swarming cells.
Coleman SR, Blimkie T, Falsafi R, Hancock, R.E.W.
(2019)
10.1128/AAC.01999-19.
639
Effect of Long-term Exposure to Peptides on Mono- and Multispecies Biofilms in Dentinal Tubules
Huang, Xiangya; Markus Haapasalo, Zhejun Wang, Robert E.W. Hancock, Xi Wei, Ya Shen
(2019) J. Endodontics
45(12):
1522-1528
PDF
638
Metabolomics study of the synergistic killing of polymyxin B in combination with amikacin against polymyxin-susceptible and -resistant Pseudomonas aeruginosa
Hussein Maytham ; Mei-Ling Han; Yan Zhu; Qi (Tony) Zhou; Yu-Wei Lin; Robert. E.W. Hancock; Daniel Hoyer; Darren J Creek; Jian Li; Tony Velkov
(2019) J. Antimicrob. Chemother.
10.1128/AAC.01587-19
PDF
637
Influence of Non-natural Cationic Amino Acids on the Biological Activity Profile of Innate Defense Regulator Peptides
Haney, Evan F. Simone C. Barbosa; Beverlie Baquir; R.E.W. Hancock
(2019) J. Med. Chem.
10.1021/acs.jmedchem.9b01344
636
A Genome-Wide Knockout Screen in Human Macrophages Identified Host Factors Modulating Salmonella Infection.
Yeung ATY, Choi YH, Lee AHY, Hale C, Ponstingl H, Pickard D, Goulding D, Thomas M, Gill E, Kim JK, Bradley A, Hancock REW, Dougan G.
(2019) mBio
10(5):
e02169-19
PDF
635
Outer membrane interaction kinetics of new polymyxin B analogs in Gram-negative bacilli.
Akhoundsadegh N, Belanger CR, Hancock REW
(2019) Antimicrob. Agents Chemother.
63(10):
10.1128/AAC.00935-19
PDF
634
Controlling biofilm formation with nitroxide functional surfaces
Woehlk, Hendrik; Michael J. Trimble, Sarah C. Mansour, Daniel Pletzer, Vanessa Trouillet, Alexander Welle, Leonie Barner, Robert E. W. Hancock, Christopher Barner-Kowollik and Kathryn E. Fairfull-Smith
(2019) Polym. Chem.
10:
4252-4258
PDF
633
Identification of Novel Adenosine Deaminase 2 Gene Variants and Varied Clinical Phenotype in Pediatric Vasculitis.
Gibson KM, Morishita KA, Dancey P, Moorehead P, Drögemöller B, Han X, Graham J, Hancock REW, Foell D, Benseler S, Luqmani R, Yeung RSM, Shenoi S, Bohm M, Rosenberg AM, Ross CJ, Cabral DA, Brown KL; PedVas Investigators Network.
(2019) Arthritis Rheumatol.
71(10):
1747-1755
PDF
632
NetworkAnalyst 3.0: a visual analytics platform for comprehensive gene expression profiling and meta-analysis
Zhou G, O Soufan, J Ewald, REW Hancock, N Basu, J Xia
(2019) Nucleic Acids Research
1:
10.1093/nar/gkz240
631
Short Cationic Peptide Derived from Archaea with Dual Antibacterial Properties and Anti-Infective Potential.
Cândido ES, Cardoso MH, Chan LY, Torres MDT, Oshiro KGN, Porto WF, Ribeiro SM, Haney EF, Hancock REW, Lu TK, de la Fuente-Nunez C, Craik DJ, Franco OL.
(2019) ACS Infect. Dis.
10.1021/acsinfecdis.9b00073
PDF
630
Improving in vivo safety of the anti-biofilm peptide DJK-5 by using hyaluronic acid-based nanogels.
Kłodzińska SN, Pletzer D, Rahanjam N, Rades T, Hancock REW, Nielsen HM.
(2019) Nanomedicine
10.1016/j.nano.2019.102022
PDF
629
Dismantling the bacterial virulence program
Alford MA , D Pletzer, REW Hancock
(2019) Microbial Biotechnology
doi.org/10.1111/1751-7915.13388
PDF
628
Aurein-Derived Antimicrobial Peptides Formulated with Pegylated Phospholipid Micelles to Target Methicillin-Resistant Staphylococcus aureus Skin Infections
Kumar, Prashant; Daniel Pletzer, Evan F. Haney, Negin Rahanjam, John T. J. Cheng, Marty Yue, Waleed Aljehani, Robert E. W. Hancock, Jayachandran N. Kizhakkedathu, and Suzana K. Straus
(2018) ACS Infect. Dis.
10.1021/acsinfecdis.8b00319
PDF
627
Dynamic molecular changes during the first week of human life follow a robust developmental trajectory
Lee, A. H., Shannon, C. P., Amenyogbe, N., Bennike, T. B., Diray-Arce, J., Idoko, O. T., Gill EE, Ben-Othman R, Pomat WS, van Haren SD, Le Cao KA, Cox M, Darboe A, Falsafi R, Ferrari D, Harbenson DJ, He D, Bing C, Hinshaw SJ, Ndure J, Nije-Jobe J, Pettengill MA, Richmond PC, Ford R, Saleu G, Masiria G, Matlam JP, Kirarock W, Roberts E, Malek M, Sanchez-Smitz G, Sing A, Angelidou A, Smolen KK, The EPIC Consortium, Brinkman RR, Ozonoff A, Hancock REW, van der Biggelaar AHJ, Steen H, Tebbutt SJ, Krampmann B, Levy O, Kollmann, T. R.
(2019) Nature
10:
1092
PDF
626
A lipidic delivery system of a triple vaccine adjuvant enhances mucosal immunity following nasal administration in mice
Wasan E K, J Sueda, S Strom, J Cawthray, R.E.W. Hancock, K.M. Wasan, V Gerdts
(2019) Vaccine
37:
1503-1515
PDF
625
624
Identification of an IDR peptide formulation candidate that prevents peptide aggregation and retains immunomodulatory activity
Haney EF, KC. Wuerth, N Rahanjam, NS Nikouei, A Ghassemi MA Noghani A Boey, R.E.W. Hancock
(2018) J. Peptide Sci.
e24077
623
Characterization of host responses during Pseudomonas aeruginosa acute lung infection in the lungs and blood and after treatment with the synthetic immunomodulatory peptide IDR-1002
Wuerth K, Lee AHY, Falsafi R, Gill EE, Hancock REW.
(2018) Infect. Immun.
87(1):
10.1128/IAI.00661-18
PDF
622
Bone Environment Influences Irreversible Adhesion of a Methicillin-Susceptible Staphylococcus aureus Strain.
Reffuveille F, Josse J, Velard F, Lamret F, Varin-Simon J, Dubus M, Haney EF, Hancock REW, Mongaret C and Gangloff SC
(2018) Front. Microbiol.
https://doi.org/10.3389/fmicb.2018.02865
PDF
621
S100A12 serum levels and PMN counts are elevated in childhood systemic vasculitides especially involving proteinase 3 specific anti-neutrophil cytoplasmic antibodies
KL. Brown, JM Lubieniecka, G Armaroli, K Kessel, K Gibson, J Graham, D Liu, R.E.W. Hancock, C Ross, S Benseler, RA. Luqmani, DA. Cabral, D Foell and C Kessel
(2018) Frontiers in Pediatrics
10.3389/fped.2018.00341
PDF
620
619
Interleukin-22 promotes phagolysosomal fusion to induce protection against Salmonella enterica Typhimurium in human epithelial cells
Forbester JL, Lees EA, Goulding D, Forrest S, Yeung A, Speak A, Clare S, Coomber EL, Mukhopadhyay S, Kraiczy J, Schreiber F, Lawley TD, Hancock, R.E.W., Uhlig HH, Zilbauer M, Powrie F, Dougan G.
(2018) Proc. Natl. Acad. Sci. USA.
115(40):
10118-10123
PDF
618
617
616
615
Broad-Spectrum Adaptive Antibiotic Resistance Associated with Pseudomonas aeruginosa Mucin-Dependent Surfing Motility.
Sun, E., E.E. Gill, R. Falsafi, A. Yeung, S. Liu, and R.E.W. Hancock
(2018) Antimicrob. Agents Chemother.
62(9):
10.1128/AAC.00848-18.
PDF
614
Liposomal Therapy Attenuates Dermonecrosis Induced by Community-Associated Methicillin-Resistant Staphylococcus aureus by Targeting α-Type Phenol-Soluble Modulins and α-Hemolysin
Wolfmeier H., SC. Mansour, LT. Liu, D Pletzer, A Draeger, E.B. Babiychuk, R.E.W. Hancock
(2018) eBiomedicine
PDF
613
Biofilm formation by Helicobacter pylori is differentially affected by common culture conditions and protein plays a central role in the biofilm matrix
Windham IH, Servetas SL, Whitmire JM, Pletzer D, Hancock, R.E.W., Merrell DS.
(2018) Appl. Environ. Microbiol
84(14):
10.1128/AEM.00391-1
612
Retinoic acid elicits a coordinated expression of gut homing markers on T lymphocytes of Zambian men receiving oral Vivotif, but not Rotarix, Dukoral or OPVERO vaccines
Mwanza-Lisulo M, Chomba MS, Chama M, Besa EC, Funjika E, Zyambo K, Banda R, Imikendu M, Sianongo S, Hancock, R.E.W., Lee A, Chilengi R, Stagg AJ, Namangala B, Kelly PM.
(2018) Vaccine
36(28):
4134-4141
PDF
611
Development of Molecularly Imprinted Polymers To Block Quorum Sensing and Inhibit Bacterial Biofilm Formation.
Ma L, Feng S, Fuente-Núñez C, Hancock, R.E.W., Lu X.
(2018) ACS Appl. Mater. Interfaces
10(22):
18450-18457
610
609
608
In silico optimization of a guava antimicrobial peptide enables combinatorial exploration for peptide design.
Porto WF, Irazazabal L, Alves ESF, Ribeiro SM, Matos CO Pires ÁS, Fensterseifer ICM, Miranda VJ, Haney EF, Humblot V, Torres MDT, Hancock REW, Liao LM, Ladram A, Lu TK, de la Fuente-Nunez C, Franco OL.
(2018) Nat Commun
9(1):
1490
PDF
607
High-throughput detection of RNA processing in bacteria.
Gill, E.E., L.S. Chan, G.L. Winsor, N. Dobson, R. Lo, S.J. Ho Sui, B.K. Dhillon, P.K. Taylor, R. Shrestha, C. Spencer, R.E.W. Hancock, P.J. Unrau, F.S.L. Brinkman.
(2018) BMC Genomics
19(1):
223
PDF
606
Induction by innate defence regulator peptide 1018 of pro-angiogenic molecules and endothelial cell migration in a high glucose environment.
Marin-Luevano P, Trujillo V, Rodriguez-Carlos A, González-Curiel I, Enciso-Moreno JA, Hancock, R.E.W., Rivas-Santiago B.
(2018) Peptides
101:
135-144
PDF
605
Novel roles for two-component regulatory systems in cytotoxicity and virulence-related properties in Pseudomonas aeruginosa
Gellatly S., M. Bains, E.B.M. Breidenstein, J. Strehmel, F. Reffuveille, P.K. Taylor, A.T.Y. Yeung, J.Overhage, R.E.W. Hancock
(2018) AIMS Microbiology
4(1):
173-191
PDF
604
Computer-aided Discovery of Peptides that Specifically Attack Bacterial Biofilms.
Haney EF, Brito-Sánchez Y, Trimble MJ, Mansour SC, Cherkasov A, Hancock REW.
(2018) Scientific Reports
8:
1871
PDF
603
602
601
Sensing Mg2+ contributes to the resistance of Pseudomonas aeruginosa to complement-mediated opsonophagocytosis
Qadi, M., S. Izquierdo-Rabassa, M. Mateu Borrás, A. Doménech-Sánchez, C. Juan, J.B. Goldberg, R.E.W. Hancock, and S. Albertí.
(2017) Environ Microbiol
19(10):
4278-4286
PDF
600
599
Antibiofilm Effect of D-enantiomeric Peptide Alone and Combined with EDTA In Vitro
Wang D, Ya Shen, Jingzhi Ma, R.E.W.Hancock, Markus Haapasalo
(2017) J. Endodontics
43 :
1862-1867
PDF
598
597
Aggregation and Its Influence on the Immunomodulatory Activity of Synthetic Innate Defense Regulator Peptides.
Haney EF, Wu BC, Lee K, Hilchie AL, Hancock REW
(2017) Cell Chem Biol
10.1016/j.chembiol.2017.07.010
PDF
596
595
An immunomodulatory peptide that confers protection in an experimental candidemia murine model
Freitas CG, Lima SMF, Freire MS, Cantuária APC, Júnior NGO, Santos TS, Folha JS, Ribeiro SM, Dias SC, Rezende TMB, Albuquerque P, Nicola AM, de la Fuente-Núñez C, Hancock REW, Franco OL, Felipe MSS.
(2017) Antimicrob. Agents Chemother.
61(8):
10.1128/AAC.02518-16
594
Ciprofloxacin-nitroxide hybrids with potential for biofilm control
Anthony D Verderosa, César de la Fuente-Núñez, Sarah C Mansour, Jicong Cao, Timothy K Lu, REW Hancock, Kathryn E Fairfull-Smith
(2017) Eur. J. Med. Chem.
138:
590-601
593
Alternative strategies for the study and treatment of clinical bacterial biofilms
Belanger CR, SC Mansour, D Pletzer, R.E.W. Hancock
(2017) Emerging Topics in Life Sciences
1(1):
41-53
592
Exploiting induced pluripotent stem cell-derived macrophages to unravel host factors influencing Chlamydia trachomatis pathogenesis.
Yeung, A.T.Y., C. Hale, A.H. Lee, E. E. Gill, W. Bushell, D. Parry-Smith, D. Goulding, D. Pickard, T. Roumeliotis, J. Choudhary, N. Thomson, W.C. Skarnes, G. Dougan and R.E.W. Hancock.
(2017) Nat Commun
8:15013:
10.1038/ncomms15013
PDF
591
New Mouse Model for Chronic Infections by Gram-Negative Bacteria Enabling the Study of Anti-Infective Efficacy and Host-Microbe Interactions
Pletzer D, Mansour SC, Wuerth K, Rahanjam N, Hancock REW
(2017) mBio
8(1):
10.1128/mBio.00140-17
PDF
590
Antimicrobial efficacy against Pseudomonas aeruginosa biofilm formation in a three-dimensional lung epithelial model and the influence of fetal bovine serum
Crabbé A, Liu Y, Matthijs N, Rigole P, De La Fuente-Nùñez C, Davis R, Ledesma MA, Sarker S, Van Houdt R, Hancock REW, Coenye T, Nickerson CA
(2017) Scientific Reports
7:
43321
PDF
589
Two isoforms of Clp peptidase in Pseudomonas aeruginosa control distinct aspects of cellular physiology.
Hall B.M., E.B.M. Breidenstein, C. de la Fuente-Núñez, F. Reffuveille, G.D. Mawla, R.E.W. Hancock, T.A. Baker.
(2016) J. Bacteriol.
199(3):
10.1128/JB.00568-16
588
Anticancer activities of bovine and human lactoferricin-derived peptides.
Arias M., A. Hilchie, E.F. Haney, J.G.M. Bolscher, M.E. Hyndman, R.E.W. Hancock, H.J. Vogel.
(2016) Biochemistry and Cell Biology
95(1):
91-98
587
586
585
Anti-adhesive antimicrobial peptide coating prevents catheter associated infection in a mouse urinary infection model.
Yu K., J.C.Y. Lo, M. Yan, X. Yang, D.E. Brooks, R.E.W. Hancock, D. Lange, J.N. Kizhakkedathu.
(2017) Biomaterials
116:
69-81
584
Low doses of innate defence regulator peptide, IDR-1018, enhances HDL-medicated cholesterol efflux from smooth muscle cells and macrophages.
Afacan, N.J., T. Chan T, J. Pistolic, J. Kong, G.A. Francis, and R.E.W. Hancock.
(2016) J. Nutritional Biol.
2:
1
PDF
583
Peptide IDR-1002 Inhibits NF-kB Nuclear Translocation by Inhibition of IkBalpha Degradation, and Activates p38/ERK1/2-MSK1 Dependent CREB Phosphorylation in Macrophages Stimulated With Lipopolysaccharide.
Huante-Mendoza A., O. Silva-García, J, Oviedo-Boyso, R.E.W. Hancock, V. Baizabal-Aguirre.
(2016) Front. Immunol.
7:
533
582
2-Deoxyglucose modulates innate defence regulator peptide activity.
Afacan N.J., A. Hilchie, E.E. Gill, R. Falsafi, R.E.W. Hancock.
(2016) Cellular Immunology and Immunotherapeutics.
2(1):
1-8
581
Treatment of Oral Biofilms by a D-Enantiomeric Peptide.
Zhang T., Z. Wang, R.E.W. Hancock, C. de la Fuente-Núñez, M. Haapasalo.
(2016) PLoS One
11(11):
e0166997
PDF
580
An anti-infective synthetic peptide with dual antimicrobial and immunomodulatory activities.
Silva O.N., C. de la Fuente-Núñez, E.F. Haney, I.C.M. Fensterseifer, S.M. Ribeiro, W.F. Porto, P .Brown, C. Faria-Junior, T.M.B Rezende, S.E. Moreno, T.K. Lu, R.E.W. Hancock, O.L. Franco.
(2016) Scientific Reports
6:
35465
PDF
579
Mastoparan is a membranolytic anti-cancer peptide that works synergistically with gemcitabine in a mouse model of mammary carcinoma.
Hilchie A.L., A.J. Sharon, E.F. Haney, D.W. Hoskin, M.B. Bally, O.L. Franco, J.A. Corcoran, R.E.W. Hancock.
(2016) Biochim. Biophys. Acta.
1858:
3195-3204
PDF
578
Bacterial abscess formation is controlled by the stringent stress response and can be targeted therapeutically.
Mansour S.C., D. Pletzer, C. de la Fuente-Núñez, P. Kim, G.Y.C. Cheung, H. Joo, M. Otto, R.E.W. Hancock.
(2016) eBiomedicine
12:
219-226
PDF
577
Endosomal pH modulation by peptide-gold nanoparticle hybrids enables potent anti-inflammatory activity in phagocytic immune cells.
Yang H., L. Kozicky, A. Saferali, S. Fung, N. Afacan, B. Cai, R. Falsafi, E. Gill, M. Liu, T.R. Kollmann, R.E.W. Hancock, L.M. Sly, S.E. Turvey.
(2016) Biomaterials
111:
90-102
576
Synthesis and evaluation of ciprofloxacin-nitroxide conjugates as anti-biofilm agents.
Verderosa A.D., S.C. Mansour, C. de la Fuente-Núñez, R.E.W. Hancock, K.E. Fairfull-Smith.
(2016) Molecules
21(7):
841
PDF
575
574
Experimental and theoretical investigation of multispecies oral biofilm resistance to chlorhexidine treatment.
Shen, Y., J. Zhao, C. de la Fuente-Núñez, Z. Wang, R.E.W. Hancock, C.R. Roberts, J. Ma, Q. Wang, and M. Haapasalo.
(2016) Scientific Reports
6:
27537
PDF
573
572
A new cationic antimicrobial peptide (AMP) from human ApoE with activities against multidrug-resistant bacteria and immunomodulatory effects on human cells.
Pane, K., V. Sgambati., A. Zanfardino, G. Smaldone, V. Cafaroa, T. Angrisano, E. Pedone, S. Di Gaetano, C. Domenica, E.F. Haney, V. Izzo, M. Varcamonti, E. Notomista, R.E.W. Hancock, A. Di Donato, and E. Pizzo.
(2016) FEBS J.
283(11):
2115-31
PDF
571
Structural Studies of a Lipid-Binding Peptide from Tunicate Hemocytes with Anti-Biofilm Activity
Silva ON, ES Alves, C de la Fuente-Nunez, SM Ribeiro, SM Mandal, D Gaspar, AS Veiga, MA Castanho, CA Andrade, JM Nascimento, IC Fensterseifer, WF Porto, JR Correa, REW Hancock, S Korpole, AL Oliveira, LM Liao, OL Franco
(2016) Scientific Reports
6:
27128
PDF
570
Interconnection of post-transcriptional regulation: The RNA-binding protein Hfq is a novel target of the Lon protease in Pseudomonas aeruginosa.
Fernández, L., E.B.M. Breidenstein, P.K. Taylor, M. Bains, C. de la Fuente-Núñez, Y. Fang, L.J. Foster, and R.E.W. Hancock.
(2016) Scientific Reports
6:
26811
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569
The immunology of host defence peptides: Beyond antimicrobial activity.
Hancock, R.E.W., E.F. Haney and E.E. Gill. 2016.
(2016) Nature Rev. Immunol.
16:
321-334
568
Tryptic stability of synthetic bactenecin derivatives is determined by the side chain length of cationic residues and the peptide conformation.
Bagheri, M., S. Arasteh, E. Haney, and R.E.W. Hancock.
(2016) J. Med. Chem.
59(7):
3079-86
567
Identification of synthetic- and natural host defense peptides with leishmanicidal activity.
Marr, A.K., S. Cen, R.E.W. Hancock, and W.R. McMaster.
(2016) Antimicrob. Agents Chemother.
60(4):
2484-91
PDF
566
Synthetic antibiofilm peptides.
de la Fuente-Núñez, C., M.H. Cardoso, E. de Souza Cândido, O.L. Franco, and R.E.W. Hancock.
(2016) Biochim. Biophys. Acta.
1858:
1061-1069
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565
A polyalanine peptide derived from polar fish with anti-infectious activities.
Cardoso, M.H., S.M. Ribeiro, D.O. Nolasco, C. de la Fuente-Núñez, M.R. Felício, S. Gonçalves, C.O. Matos, L.M. Liao, N.C. Santos, R.E.W. Hancock, O.L. Franco and L. Migliolo.
(2016) Scientific Reports
6:
21385
PDF
564
In vivo, in vitro, and in silico characterization of peptoids as antimicrobial agents.
Czyzewski A.M., H. Jenssen, C.D. Fjell, M. Waldbrook, N.P. Chongsiriwatana, E. Yuen, R.E.W. Hancock, and A.E. Barron.
(2016) PLoS One
11:
e0135961. doi:10.1371/journal.pone.0135961
PDF
563
Alternatives to antibiotics - a pipeline portfolio review.
Czaplewski, L., R. Bax, M. Clokie, M. Dawson, H. Fairhead, V.A. Fischetti, S. Foster, B.F. Gilmore, R.E.W. Hancock, D. Harper, I.R. Henderson, K. Hilpert, B.V Jones, A. Kadioglu, D. Knowles, S. Ólafsdóttir, D. Payne, S. Projan, S. Shaunak, J. Silverman, C.M. Thomas, T.J. Trust, P. Warn, J.H. Rex.
(2016) Lancet Infect. Dis.
16:
239-251 (Selected from thousands of recently published articles to be awarded the Elsevier Atlas Award)
562
The Structure of a Type 3 Secretion System (T3SS) Ruler Protein Suggests a Molecular Mechanism for Needle Length Sensing.
Bergeron J.R.C., L. Fernández, G.A. Wasney, M. Vuckovic, F. Reffuveille, R.E.W. Hancock, N.C.J. Strynadka.
(2016) J. Biol. Chem.
291(4):
1678-1691
PDF
561
Identification of novel cyclic lipopeptides from a positional scanning combinatorial library with enhanced antibacterial and antibiofilm activities.
Bionda N., R.M. Fleeman, C. de la Fuente-Núñez, M.C. Rodriguez, F. Reffuveille, L.N. Shaw, I. Pastar, S.C. Davis, R.E.W. Hancock, and P. Cudic.
(2016) Eur. J. Med. Chem.
108:
354-363
PDF
560
Towards infection resistant surfaces: Achieving high antimicrobial peptide potency by modulating the functionality of polymer brush and peptide.
Yu, K., J. Lo, Y. Mei, E. Haney, E. Siren, M. Kalathottukaren, R.E.W. Hancock, D. Lange, and J. Kizhakkedathu.
(2015) ACS Appl. Mater. Interfaces
7:
28591-28605
PDF
559
LL-37 immunomodulatory activity during Mycobacterium tuberculosis infection in macrophages.
Torres-Juarez, F., A. Cardenas-Vargas, A. Montoya-Rosales, I. González-Curiel, M.H. Garcia-Hernandez, J.A. Enciso-Moreno, R.E.W. Hancock, and B. Rivas-Santiago.
(2015) Infect. Immun.
83:
4495-4503
PDF
558
Enhanced killing of breast cancer cells by a D-amino acid analog of the winter flounder-derived pleurocidin NRC-03.
Hilchie, A.L., E. Haney, D.M. Pinto, R.E.W. Hancock, and D.W. Hoskin.
(2015) Experimental Molec. Pathol.
99:
426-434
PDF
557
Clinical exploitation of genomics data produced by the international Pseudomonas aeruginosa consortium.
Freschi L., J. Jeukens, I. Kukavica-Ibrulj, B. Boyle, M.-J. Dupont, J. Laroche, S. Larose, H. Maaroufi, J.L. Fothergill, M. Moore, G.L. Winsor, S.D. Aaron, J. Barbeau, S.C. Bell, J.L. Burns, M.Camara, A. Cantin, S.J. Charette, K. Dewar, E. Déziel, K. Grimwood, R.E.W. Hancock, J.J. Harrison, S. Heeb, L. Jelsbak, D.T. Kenna, T.J. Kidd, J. Klockgether, J.S. Lam, I.L. Lamont, S. Lewenza, N. Loman, F. Malouin, A.G. McArthur, J. McKeown, J. Milot, H. Naghra, D. Nguyen, S.K. Pereira, G.G. Perron, P.B. Rainey, S. Rousseau, P.M. Santos, A. Stephenson, V. Taylor, J.F. Turton, N. Waglechner, P. Williams, S. Wingaard, G.D. Wright, F.S.L. Brinkman, N.P. Tucker, B. Tümmler, C. Winstanley, R.C. Leveque.
(2015) Front. Microbiol.
6:
1036
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556
High throughput screening methods for assessing antibiofilm and immunomodulatory activities of synthetic peptides.
Haney, E.F., S. Mansour, A.L. Hilchie, C. de la Fuente-Núñez and R.E.W. Hancock.
(2015) Peptides
71:
276-285
PDF
555
Potentiation of ciprofloxacin action against Gram-negative bacterial biofilms by a nitroxide.
Reffuveille, F., C. de la Fuente-Núñez, K. Fairfull-Smith, and R.E.W. Hancock.
(2015) Pathogens and Disease
73(5):
pii ftv016
PDF
554
553
552
Treatment of oral multispecies biofilms by an anti-biofilm peptide.
Wang, Z., C. de la Fuente-Núñez, Y. Shen, M. Haapasalo, R.E.W. Hancock.
(2015) PLoS One
10(7):
e0132512
PDF
551
Anti-biofilm peptides increase the susceptibility of carbapenemase-producing Klebsiella pneumoniae clinical isolates to β-lactam antibiotics
Ribeiro, S., C. de la Fuente-Núñez, B. Baquir, C. Faria-Junior, O. Franco, and R.E.W. Hancock.
(2015) Antimicrob. Agents Chemother.
59:
3906-3912
PDF
550
In-situ Raman spectroscopic-based microfluidic “lab-on-a-chip” platform for non-destructive and continuous characterization of Pseudomonas aeruginosa biofilms.
Feng, J., C. de la Fuente-Núñez, M.J. Trimble, H. Zeng, J. Xu, R.E.W. Hancock, X. Lu.
(2015) ChemComm.
51:
8966-8969
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549
548
547
Peptides KT2 and RT2 are taken up into bacterial cells and kill planktonic and biofilm bacteria. Biochim
Anunthawan, T., C. de la Fuente-Núñez, R.E.W. Hancock and S. Thammasirirak. 2015
(2015) Biochim. Biophys. Acta.
1848:
1352-1358
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546
Conditional-ready mouse embryonic stem cell derived macrophages enable the study of essential genes in macrophage function.
Yeung, A.T.Y., C. Hale, J. Xia, P.H. Tate, D. Goulding, J.A. Keane, S. Mukhopadhyay, L. Forrester, O. Billker, W.C. Skarnes, R.E.W. Hancock, and G. Dougan.
(2015) Scientific Reports
5:
8908
PDF
545
D-enantiomeric peptides that eradicate wild-type and multi-drug resistant bacterial biofilms and protect against lethal Pseudomonas aeruginosa infections.
de la Fuente-Núñez, C., F. Reffuveille, S.C. Mansour, S.L. Reckseidler-Zenteno, D. Hernández, G. Brackman, T. Coenye and R.E.W. Hancock.
(2015) Chem. Biol.
22:
196-205
PDF
544
Tuning the affinity of anion binding sites in porin channels with negatively charged residues: Molecular details for OprP
Modi, N., I. Barcena-Uribarri, M. Bains, R. Benz, R.E.W. Hancock, and U. Kleinekathoefer
(2015) ACS Chemical Biol.
10:
441-451
PDF
543
542
Anti-biofilm and immunomodulatory activities of peptides that inhibit biofilms formed by pathogens isolated from cystic fibrosis patients.
de la Fuente-Núñez, C., S.C. Mansour, Z. Wang, L. Jiang, E.B.M. Breidenstein, M. Elliott, F. Reffuveille, D.P. Speert, S.L. Reckseidler-Zenteno, Y. Shen, M. Haapasalo and R.E.W. Hancock.
(2014) Antibiotics
3:
509-526
PDF
541
An endotoxin tolerance signature predicts sepsis and organ dysfunction at initial clinical presentation.
Pena, O.M., D.G. Hancock, N.H. Lyle, A. Linder, J.A. Russell, J. Xia, C.D. Fjell, J.H. Boyd, and R.E.W. Hancock.
(2014) eBiomedicine
1:
64-71
PDF
540
Antimicrobial peptide delivery from trabecular bone grafts.
Mehdi Kazemzadeh-Narbat, M., Q. Wang, R.E.W. Hancock, R. Wang.
(2014) J. Biomaterials Tissue Engineer
4:
967-972
539
538
537
536
A broad-spectrum anti-biofilm peptide enhances antibiotic action against bacterial biofilms.
Reffuveille, F., C. de la Fuente-Núñez, S. Mansour and R.E.W. Hancock.
(2014) Antimicrob. Agents Chemother.
58:
5363-5371
PDF
535
534
Pseudomonas aeruginosa elastase disrupts the cortisol-binding activity of corticosteroid-binding globulin.
Simard, M., L.A. Hill, C.M. Underhill, B.O. Keller, I. Villanueva, R.E.W. Hancock, and G.L. Hammond.
(2014) Endocrinol.
155:
2900-2908
PDF
533
532
Identification of a novel inhibition site in translocase MraY based upon the site of interaction with lysis protein E from bacteriophage ϕX174.
Rodolis, M.T., A. Mihalyi, A. O'Reilly, J. Slikas, D.I. Roper, R.E.W. Hancock, and T.D. Bugg.
(2014) Chembiochem.
15:
1300-1308
PDF
531
Increased IL-8 production in human bronchial epithelial cells after exposure to azithromycin pre-treated Pseudomonas aeruginosa in vitro.
Fan, L., Q.Wang, C. de la Fuente-Núñez, F. Sun, J. Xia, P. Xia, and R.E.W. Hancock.
(2014) FEMS Microbiol. Lett.
355:
43-50
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530
A systems biology approach to the analysis of subset-specific responses to lipopolysaccharide in dendritic cells.
Hancock, D.G., E. Shklovskaya, T.V. Guy, R. Falsafi, C.D. Fjell, W. Ritchie, R.E.W. Hancock, and B. Fazekas de St Groth.
(2013) PLoS One
9(6):
e100613
PDF
529
Innate defence regulator peptide 1018 protects against perinatal brain injury.
Bolouri, H., K. Sävman,W. Wang, A. Thomas, N. Maurer, E. Dullaghan, C.D. Fjell, H. Hagberg, R.E.W. Hancock, K.L. Brown, and C. Mallard. 2014
(2014) Ann. Neurol.
75:
395-410
PDF
528
Skin electroporation of a plasmid encoding hCAP-18/LL-37 host defense peptide promotes wound healing.
Steinstraesser, L., M.C. Lam, F. Jacobsen, P.E. Porporato, K.K. Chereddy, M. Becerikli, I. Stricker, R.E.W. Hancock, M. Lehnhardt, P. Sonveaux, V. Préat, and G. Vandermeulen.
(2014) Mol. Ther.
22:
734-742
PDF
527
Broad-spectrum anti-biofilm peptide that targets a cellular stress response.
Fuente-Núñez, C., F. Reffuveille, E.F. Haney, S.K. Straus and R.E.W. Hancock.
(2014) PLos Pathogens
10(5):
e1004152
PDF
526
Requirement of the Pseudomonas aeruginosa CbrA sensor kinase for full virulence in a murine acute lung infection model.
Yeung, A.T., L.Janot, O.M.Pena, A.Neidig, I.Kukavica-Ibrulj, A.Hilchie, R.C.Levesque, J. Overhage, and R.E.W. Hancock.
(2014) Infect. Immun.
82:
1256-1267
PDF
525
Antimicrobial host defence peptide, LL-37, as a potential vaginal contraceptive.
Srakaew, N., C.D. Young, A. Sae-wu, H. Xu, K.L. Quesnel1, R. di Brisco, K. Kongmanas, D. Fongmoon, G. Hommalai, W. Weerachatyanukul, S.H. Hall, Y.-L. Zhang, L. Panza, L. Franchini, F. Compostella, T.W. Pearson, R.E.W. Hancock, R.J. Oko, L.S. Hermo and N. Tanphaichitr.
(2014) Human Reprod.
29:
683-696
PDF
524
523
Consensus Statement: Understanding Health and Malnutrition through a Systems Approach: The ENOUGH Program for Early Life.
Kaput, J., B. van Ommen, B. Kremer, C. Priami, J.P. Monteiro. M. Morine, F. Pepping, Z. Diaz, M. Fenech, Y. He, R. Albers, C.A. Drevon, C. T. Evelo, R.E.W. Hancock, C. Ijsselmuiden, L.H. Lumey, A.-M. Minihane, M. Muller, C. Murgia, M. Radonjic, B. Sobral, and K.P. West, for the Participants of the Essential Nutrients Workshop.
(2014) Genes and Nutrition
9:
378
PDF
522
INVEX – a web-based tool for integrative visualization of expression data.
Xia, J., M.L. Mayer, N.H. Lyle, OM. Pena, and R.E.W. Hancock.
(2013) Bioinformatics
29:
3232-3234
PDF
521
520
The extra-cytoplasmic function sigma factor SigX modulates biofilm formation and virulence-related properties in Pseudomonas aeruginosa.
Gicquel, G., E. Bouffartigues, M. Bains, V. Oxaran, T. Rosay, O. Lesouhaitier, N. Connil, A. Bazire, O. Maillot, M. Bénard, P. Cornelis, R.E.W. Hancock, A. Dufour, M.G.J. Feuilloley, N. Orange, E. Déziel and S. Chevalier.
(2013) PLoS One
8:
e80407
PDF
519
518
Bacterial biofilm development as a multicellular adaptation: Antibiotic resistance and new therapeutic strategies.
Fuente-Núñez, C., F. Reffuveille, L. Fernández and R.E.W. Hancock.
(2013) Curr. Opin. Microbiol.
16:
580-589
PDF
517
Synthetic analogues of bovine bactenecin dodecapeptide reduce Herpes Simplex Virus type 2 infectivity in mice.
Shestakova, A., H. Jenssen, R.E.W. Hancock, I. Nordströma, and K. Eriksson.
(2013) Antiviral Res.
100:
455-459
PDF
516
515
514
The effect of nitroxides on swarming motility and biofilms, multicellular behaviors in Pseudomonas aeruginosa.
Fuente-Núñez, C., F. Reffuveille, K.E. Fairfull-Smith and R.E.W. Hancock.
(2013) Antimicrob. Agents Chemother.
57:
4877-4881
PDF
513
The role of the central arginine towards the ion selectivity of the phosphate specific channel OprP: effects of charge and solvation.
Modi, N., I. Bárcena-Uribarri, M. Bains, R. Benz, R.E.W. Hancock, and U. Kleinekathöfer.
(2013) Biochemistry
52:
5522-5532
PDF
512
The innate defense regulator peptides IDR-HH2, IDR-1002 and IDR-1018 modulate human neutrophil functions.
Niyonsaba, F., L. Madera, K. Okumura, H. Ogawa, and R.E.W. Hancock.
(2013) J. Leukocyte Biol.
94:
159-170
PDF
511
Novel vaccine formulations against pertussis offer earlier onset of immunity and provide protection in the presence of maternal antibodies.
Polewicz, M., A. Gracia, S. Garlapati, J. van Kessel, S. Strom, S.A. Halperin, R.E.W. Hancock, A.A. Potter, L.A. Babiuk, and V. Gerdts.
(2013) Vaccine
31:
3148-3155
PDF
510
INMEX – a web-based tool for integrative meta-analysis of expression data.
Xia, J., C.D. Fjell, M.L. Mayer, O.M. Pena, D.S. Wishart and R.E.W. Hancock.
(2013) Nucl. Acids Res.
41:
W63-W70
PDF
509
Multilayered coating on titanium for controlled release of antimicrobial peptides for the prevention of implant-associated infections.
Kazemzadeh-Narbat, M., J. Kindrachuk, K. Duan, H. Jenssen, R.E.W. Hancock, and R. Wang.
(2013) Biomaterials
34:
5969-5977
PDF
508
Manipulation of innate immunity by a bacterial secreted peptide; the lantibiotic nisin Z is selectively immunomodulatory.
Kindrachuk, J., H. Jenssen, M. Elliot, A. Nijnik, L. Magrangeas-Janot, M. Pasupuleti, L. Thorson, S. Ma, D.M. Easton, M. Bains, B. Finlay, E.J. Breukink, H. Georg-Sahl, and R.E.W. Hancock.
(2013) Innate Immunity
19:
315-327
PDF
507
Functional genetic variation in NFKBIA and susceptibility to childhood asthma, bronchiolitis, and bronchopulmonary dysplasia.
Ali, S., A.F. Hirschfeld, M.L. Mayer, E.S. Fortuno, N. Corbett, M. Kaplan, S. Wang, J. Schneiderman, C.D. Fjell, J. Yan, L. Akhabir, F. Aminuddin, N. Marr, T. Lacaze-Masmonteil, R.G. Hegele, A. Becker, M. Chan-Yeung, R.E.W. Hancock, T.R. Kollmann, D. Daley, A.J. Sandford, P.M. Lavoie and S.E. Turvey.
(2013) J. Immunol.
190:
3949-3958
PDF
506
505
Ability of innate defence regulator peptides IDR-1002, IDR-HH2 and IDR-1018 to protect against Mycobacterium tuberculosis infections in animal models.
Rivas-Santiago, B., J.E. Castañeda-Delgado, C.E.Rivas Santiago, M. Waldbrook, I. González-Curiel, J. C. León–Contreras, A. Enciso-Moreno, V. del Villar, J. Méndez-Ramos, R.E.W. Hancock, R. Hernandez-Pando.
(2013) PLoS One
8:
e59119
PDF
504
503
Rescue of dysfunctional autophagy by IDR-1018 attenuates hyperinflammatory responses from cystic fibrosis cells.
Mayer, M.L., C.J. Blohmke, R. Falsafi, C.D. Fjell, L. Madera, S.E. Turvey, and R.E.W. Hancock.
(2013) J. Immunol.
190:
1227-1238
PDF
502
501
The Liver X receptor agonist GW3965 improves recovery from mild repetitive traumatic brain injury in mice partly through apolipoprotein E.
Namjoshi, D.R., G. Martin, J. Donkin, A. Wilkinson, S. Stukas, J. Fan, M. Carr, S. Tabarestani, K. Wuerth, R.E.W. Hancock, and C.L. Wellington.
(2013) PLoS One
8:
e53529
PDF
500
Activity of LL-37, CRAMP and antimicrobial peptide-derived compounds E2, E6, and CP26 against Mycobacterium tuberculosis.
Rivas-Santiago B., C.E. Rivas-Santiago, J.E. Castañeda-Delgado, J. C. León-Contreras, R.E.W. Hancock, and R. Hernandez-Pando.
(2013) Intl. J. Antimicrob. Agents
41:
143-148
PDF
499
Synthetic cationic peptide IDR-1018 modulates human macrophage differentiation.
Pena O.M., N. Afacan, J. Pistolic, C. Chen, L. Madera, R. Falsafi, C.D. Fjell, and R.E.W. Hancock.
(2013) PLoS One
8:
e52449
PDF
498
InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation.
Breuer, K., A. Foroushani, M. Laird, C. Chen, A. Sribnaia, R. Lo, G. Winsor, R.E.W. Hancock, F.S.L. Brinkman, and D.J. Lynn.
(2013) Nucl. Acids Res.
41(D1):
D1228-33
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497
Characterization of the polymyxin B resistome of Pseudomonas aeruginosa.
Fernández, L., C. Álvarez-Ortega, I. Wiegand, J. Olivares, D. Kocíncová, J.S. Lam, J.L. Martínez, and R.E.W. Hancock.
(2013) Antimicrob. Agents Chemother.
57:
110-119
PDF
496
Impaired pulmonary defense against Pseudomonas aeruginosa in VEGF gene inactivated mouse lung.
Breen, E.C., J.L. Malloy, K. Tang, F. Xia, Z. Fu, R.E.W. Hancock, J. Overhage, P.D. Wagner, R.G. Spragg.
(2013) J. Cell. Physiol.
228:
371-379
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495
Modeling the ion selectivity of the phosphate specific channel OprP. J
Niraj Modi, N., R. Benz, R.E.W. Hancock, and U. Kleinekathöfer
(2013) J. Phys. Chem. Letters
3:
3639-3645
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494
Atypical activation of the unfolded protein response in cystic fibrosis airway cells contributes to p38 MAPK-mediated innate immune responses.
Blohmke, C.J., M. Mayer, C.D. Fjell, A.C Tang, M.Sze, A.F. Hirschfeld, R. Falsafi, M.A. Chilvers, J.C. Hogg, R.E.W. Hancock, and S.E. Turvey.
(2012) J. Immunol.
189:
5467-5475
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493
The two-component system CprRS senses cationic peptides and triggers adaptive resistance in Pseudomonas aeruginosa independently of ParRS.
Fernández, L., H. Jenssen, M. Bains, I. Wiegand, W.J. Gooderham, and R.E.W. Hancock.
(2012) Antimicrob. Agents Chemother.
56:
6212-6222
PDF
492
The Lon protease is essential for full virulence in Pseudomonas aeruginosa.
Breidenstein, E.B.M., L. Janot, J. Strehmel, L. Fernández, P.K. Taylor,I. Kukavica-Ibrulj, S.L. Gellatly, R.C. Levesque, J. Overhage, and R.E.W. Hancock.
(2012) PLoS One
7:
e49123
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491
Specific association of lectin LecB with the surface of Pseudomonas aeruginosa: Role of outer membrane protein OprF.
Funken, H., K.Bartels, S. Wilhelm, M. Brocker, M. Bott, M. Bains, R.E.W. Hancock, F. Rosenau, and K.-E. Jaeger.
(2012) PLoS One
7:
e46857
PDF
490
LpxC inhibition protects mice from resistant Acinetobacter baumannii by modulating inflammation and enhancing phagocytosis.
Lin, L., B. Tan, P. Pantapalangkoor, T. Ho, B. Baquir, A. Tomaras, J.I. Montgomery, U. Reilly, E.G. Barbacci, K. Hujer, R.A. Bonomo, L. Fernández, R.E.W. Hancock, M.D. Adams, S.W. French, V.S. Buslon, and B. Spellberg.
(2012) mBio
3(5):
e00312-12
PDF
489
488
487
486
The Pseudomonas aeruginosa PhoP-PhoQ two-component regulatory system is induced upon interaction with epithelial cells and controls cytotoxicity and inflammation
Gellatly, S.L., B. Needham, L. Madera, M. S. Trent, and R.E.W. Hancock.
(2012) Infect. Immun.
80:
3122-3131
PDF
485
Innate defense regulator peptide 1018 in wound healing and wound infection.
Steinstraesser, L., T. Hirsch, M. Schulte, M. Kueckelhaus, F. Jacobsen, E.A. Mersch, I. Stricker, N. Afacan, H. Jenssen, R.E.W. Hancock and J. Kindrachuk.
(2012) PLoS One
7(8):
10.1371/journal.pone.0039373
PDF
484
Transcription of the OprF porin of Pseudomonas aeruginosa is dependent mainly on the SigX sigma factor and is sucrose-induced.
Bouffartigues, E., G. Gicquel, A. Bazire, M. Bains, O. Maillot, J. Vieillard, M.G.F. Feuilloley, N. Orange, R.E.W. Hancock, A. Dufour, and S. Chevalier.
(2012) J. Bacteriol.
194:
4301-4311
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The bacterial surface layer provides protection against antimicrobial peptides.
Fuente-Núñez, C., J. Mertens, J. Smit, and R.E.W. Hancock.
(2012) Appl. Environ. Microbiol
10:
442
PDF
482
Enhanced immune responses and protection by vaccination with respiratory syncytial virus fusion protein formulated with CpG oligodeoxynucleotide and synthetic innate defense regulator peptide in polyphosphazene microparticles.
Garlapati, S., R. Garg, R. Brownlie, L. Latimer, E. Simko, R.E.W. Hancock, L. Babiuk, V. Gerdts, A. Potter, and S. van den Hurk.
(2012) Vaccine
30:
5206-5214
PDF
481
The role of sphingosine-1-phosphate transporter Spns2 in immune system function.
Nijnik, A., S. Clare, C. Hale, J. Chen, C. Raisen, L. Mottram, M. Lucas, J. Estabel, E. Ryder, H. Adissu, Sanger Mouse Genetics Project, N.C. Adams, R. Ramirez-Solis, J.K. White, K.P. Steel, G. Dougan, and R.E.W. Hancock.
(2012) J. Immunol.
189:
102-111
PDF
480
479
Effective adjunctive therapy by an innate defense regulatory peptide in a pre-clinical model of severe malaria.
Achtman, A.H., S. Pilat, C.W. Law, D.J. Lynn, L. Janot, M. Mayer, S. Ma, J. Kindrachuk, B.B. Finlay, F.S.L. Brinkman, G.K. Smyth, R.E.W. Hancock and L. Schofield.
(2012) Science Transl. Med
4:
135ra64
PDF
478
Drug release and bone growth studies of antimicrobial peptide-loaded calcium phosphate coating on titanium.
Kazemzadeh-Narbat, M., S. Noordin, B.A. Masri, D.S. Garbuz, C.P. Duncan, R.E.W. Hancock, and R. Wang.
(2012) J. Biomed. Mater. Res.B. - Appl. Biomater.
100:
1344-1352
PDF
477
Involvement of the Lon protease in the SOS response triggered by ciprofloxacin in Pseudomonas aeruginosa PAO1.
Breidenstein, E.B.M., M. Bains, and R.E.W. Hancock
(2012) Antimicrob. Agents Chemother.
56:
2879-2887
PDF
476
475
Inhibition of bacterial biofilm formation and swarming motility by a small synthetic cationic peptide.
Fuente-Núñez, C., V. Korolik, M. Bains, U. Nguyen, E.B.M. Breidenstein, S. Horsman, S. Lewenza, L. Burrows and R.E.W. Hancock.
(2012) Antimicrob. Agents Chemother.
56:
2696-2704
PDF
474
Local delivery of antimicrobial peptides using self-organized TiO2 nanotube arrays for peri-implant infections.
Ma, M., M. Kazemzadeh-Narbat, Y. Hui, S. Lu, C. Ding, D.D.Y. Chen, R.E.W. Hancock and R. Wang.
(2012) J. Biomed. Materials Res. Part A
100A:
278-285
PDF
473
The role of the Src family kinase Lyn in the immunomodulatory activities of cathelicidin peptide LL-37 on monocytic cells.
Nijnik, A., J. Pistolic, P. Cho, N.C.J. Filewod, R. Falsafi, A. Ramin, K.W. Harder, and R.E.W. Hancock.
(2012) J. Leukocyte Biol.
91:
599-607
PDF
472
Protein Interaction Data Curation - The International Molecular Exchange Consortium (IMEx).
Orchard, S., S.Kerrien, S.Abbani, B.Aranda, J.Bhate, S.Bidwell, A.Bridge, L.Briganti, F.Brinkman, G.Cesareni, A.Chatr-aryamontri, E.Chautard, C.Chen, M.Dumousseau, D.Eisenberg, J.Goll, R.E.W. Hancock, L.Hannick, I.Jurisica, J.Khadake, D.J.Lynn, U.Mahadevan, L.Perfetto, A.Raghunath, S.Ricard-Blum, B.Roechert, L.Salwinski, V.Stümpflen, M.Tyers, P.Uetz, I.Xenarios, and H.Hermjakob.
(2012) Nature Methods
9:
345-350
PDF
471
470
Biomembrane interactions reveal the mechanism of action of surface-immobilized host defense IDR-1010 peptide.
Gao, G., J.T.J. Cheng, J. Kindrachuk, R.E.W. Hancock, S.K. Straus, and J.N. Kizhakkedathu.
(2012) Chem. Biol.
19:
199-209
PDF
469
Therapeutic potential of host defense peptides in antibiotic-resistant infections.
Afacan, N.J., A.T.Y. Yeung, O.M. Pena and R.E.W. Hancock.
(2012) Curr. Pharm. Design
18:
807-819
PDF
468
The critical role of histone H2A-deubiquitinase Mysm1 in haematopoiesis and lymphocyte differentiation.
Nijnik, A., S. Clare, C. Hale, C. Raisen, R.E. McIntyre, K. Yusa, A.R. Everitt, L. Mottram, C. Podrini, M. Lucas, J. Estabel, D. Goulding, N. Adams, R. Ramirez-Solis, J.K. White, D.J. Adams, R.E.W. Hancock, and G. Dougan.
(2012) Blood
119:
1370-1379
PDF
467
Role of intracellular proteases in the antibiotic resistance, motility, and biofilm formation of Pseudomonas aeruginosa.
Fernández, L., E.B.M. Breidenstein, D. Song, and R.E.W. Hancock.
(2012) Antimicrob. Agents Chemother.
56:
1128-1132
PDF
466
Structure, dynamics, antimicrobial and immune modulatory activities of human LL-23 and its single residue variants mutated on the basis of homologous primate cathelicidins.
Wang, G., M. Elliott, A.L. Cogen, E.L. Ezell, R.L. Gallo, and R.E.W. Hancock.
(2012) Biochemistry
51:
653-664
PDF
465
Complete genome sequences of three Pseudomonas aeruginosa isolates with phenotypes of polymyxin B adaptation and inducible resistance
Boyle B., L. Fernández, J. Laroche, I. Kukavica-Ibrulj, C.M.F. Mendes, R.E.W. Hancock and R.C. Levesque.
(2012) J. Bacteriol.
194:
529-530
PDF
464
463
Comparison of immune responses and protective efficacy of intranasal prime-boost immunization regimens using adenovirus-based and CpG/HH2 adjuvanted-subunit vaccines against genital Chlamydia muridarum infection.
Brown, T.H.T., J. David, E. Acosta-Ramirez, J.M. Moore, S. Lee, G. Zhong, R.E.W. Hancock, Z. Xing, S.A. Halperin and J. Wang.
(2012) Vaccine
30:
350-360
PDF
462
Designing antimicrobial peptides: Form follows function.
Fjell, C.D., J. A. Hiss, R.E.W. Hancock and G. Schneider.
(2012) Nature Rev. Drug Discov.
11:
37-51
PDF
461
Antibacterial surfaces based on polymer brushes: Investigation on the influence of brush properties on antimicrobial peptide immobilization and antimicrobial activity.
Gao, G., K. Yu, J. Kindrachuk, D.E. Brooks, R.E.W. Hancock, and J.N. Kizhakkedathu. 2011
(2011) Biomacromolecules
12:
3715-3727
PDF
460
459
The human transcriptome during non-typhoid Salmonella and HIV co-infection reveals attenuated NFkB-mediated inflammation and persistent cell-cycle disruption
Schreiber, F., D.J. Lynn, A. Houston, J. Peters, G. Mwafulirwa, B.B Finlay, F. Brinkman, R.E.W. Hancock, R.S. Heyderman, G. Dougan and M.A. Gordon.
(2011) J. Infect. Dis.
204:
1237-1245
PDF
458
457
Modulation of IL-1β-induced inflammatory responses by a synthetic cationic innate defence regulator peptide, IDR-1002, in synovial fibroblasts.
Turner-Brannen, E., K.-Y. Choi, D.N.D. Lippert, J.P. Cortens, R.E.W. Hancock, H. El-Gabalawy and N. Mookherjee.
(2011) Arthritis Res. Ther.
13:
R129
PDF
456
Immunization with PCEP microparticles containing pertussis toxoid, CpG ODN and a synthetic innate defense regulator peptide induces protective immunity against pertussis.
Garlapati, S., N.F. Eng, T. Kiros, J. Kindrachuk, G.K. Mutwiri, R.E.W. Hancock, S.A. Halperin, A.A. Potter, L.A. Babiuk and V. Gerdts.
(2011) Vaccine
29:
6540-6548
PDF
455
The olsA gene mediates the synthesis of an ornithine lipid in Pseudomonas aeruginosa during growth in phosphate limiting conditions but not antimicrobial peptide susceptibility.
Lewenza, S., R. Falsafi, M. Bains, P. Rohs, J. Stupak, G.D. Sprott, and R.E.W. Hancock.
(2011) FEMS Microbiol. Lett.
320:
35-102
PDF
454
Pseudomonas aeruginosa: all roads lead to resistance.
Breidenstein, E.B.M., C. de la Fuente-Núñez, and R.E.W. Hancock.
(2011) Trends Microbiol.
19:
419-426
PDF
453
The pmrCAB operon mediates polymyxin resistance in Acinetobacter baumannii ATCC 17978 and clinical isolates through phosphoethanolamine modification of Lipid A.
Arroyo, L.A., C.M. Herrera, L. Fernández, J.V. Hankins, M.S. Trent and R.E.W. Hancock.
(2011) Antimicrob. Agents Chemother.
55:
3743-3751
PDF
452
Antimicrobial properties of MX-2401, a second generation lipopeptide active in presence of lung surfactant.
Dugourd, D., H. Yang, M. Elliott, R. Siu, J.J. Clement, S.K. Straus, R.E.W. Hancock, and E. Rubinchik.
(2011) Antimicrob. Agents Chemother.
55:
3720-3728
PDF
451
PSICQUIC and PSISCORE - Accessing and scoring molecular interaction data.
Aranda, B., H. Blankenburg, S. Kerrien, F.S.L. Brinkmann, A. Ceol, E. Chautard, J. De La Rivas, E. Galeota, A. Gaulton, J. Goll, R.E.W. Hancock, R. Isserlin, R. Jimenez, D.J. Lynn, M. Michaut, G. O’Kelly, K. Ono, S. Orchard, C. Prieto, S. Razick, O. Rigina, L. Salwinski, M. Simonovic, A. Winter, G. Wu, G. Bader, G. Cesareni, I.M. Donaldson, D. Eisenberg, J. Overington, S. Ricard-Blum, M. Tyers, M. Albrecht, H. Hermjakob.
(2011) Nature Methods
8:
528-529
PDF
450
Lipopolysaccharide renders transgenic mice expressing human Serum amyloid P component sensitive to Shiga toxin 2.
Griener T.P., J.G. Strecker, R.M. Humphries, G.L. Mulvey, C. Fuentealba, R.E.W. Hancock and G.D. Armstrong.
(2011) PLoS One
6(6):
10.1371/journal.pone.0021457
PDF
449
Effect of BMAP-28 antimicrobial peptides on Leishmania major promastigote and amastigote growth: role of leishmanolysin in parasite survival.
Lynn, M.A., J. Kindrachuk, H. Jenssen, N. Panté, M.R. Elliott, S. Napper, R.E.W. Hancock, W.R. McMaster.
(2011) PLoS Neglected Trop. Dis.
5:
e1141
PDF
448
447
446
Mechanism of action and limited cross resistance of a new lipopeptide MX-2401.
Rubinchik, E., T. Schneider, M. Elliott, W.R.P. Scott, J. Pan, C. Anklin, H. Yang, D. Dugourd, A. Müller, K. Gries, S. K. Straus, H.G. Sahl and R.E.W. Hancock.
(2011) Antimicrob. Agents Chemother.
55:
2743-2754
PDF
445
Host defence peptide LL-37 selectively reduces pro-inflammatory macrophage responses.
Brown, K.L., G.F.T. Poon, D. Birkenhead, O.M. Pena, R. Falsafi, C. Dahlgren, A. Karlsson, J. Bylund, R.E.W. Hancock and P. Johnson.
(2011) J. Immunol.
186:
5497-5505
PDF
444
The intrinsic resistome of Pseudomonas aeruginosa to β-lactams.
Alvarez-Ortega, C., I. Wiegand, J. Olivares, R.E.W. Hancock, and J.L. Martínez. 2011
(2011) Virulence
2:
144-146
PDF
443
In vitro susceptibility of Burkholderia vietnamiensis to aminoglycosides
Jassem, A.N., J.E.A. Zlosnik, D.A. Henry, R.E.W. Hancock, R.K. Ernst, and D.P. Speert.
(2011) Antimicrob. Agents Chemother.
55:
2256-2264
PDF
442
Involvement of an ATP-dependent protease (PA0779/AsrA) in inducing heat shock in response to tobramycin in Pseudomonas aeruginosa.
Kindrachuk, K.N., L. Fernández, M. Bains, and R.E.W. Hancock.
(2011) Antimicrob. Agents Chemother.
55:
1874-1882
PDF
441
The biocompatibility and biofilm resistance of implant coatings based on hydrophilic polymer brushes conjugated with antimicrobial peptides
Gao, G., D. Lange, K. Hilpert, J. Kindrachuk, Y. Zou, J.T.J. Cheng, M. Kazemzadeh, Kai Yu, R. Wang, S.K. Straus, D.E. Brooks, B.H. Chew, R.E.W. Hancock, J.N. Kizhakkedathu.
(2011) Biomaterials
32:
3899-3909
PDF
440
Deciphering the mode of action of a synthetic antimicrobial peptide (Bac8c).
Spindler, E.C., J.D. Hale, T.H. Giddings Jr, R.E.W. Hancock, and R.T. Gill
(2011) Antimicrob. Agents Chemother.
55:
1706-1716
PDF
439
438
437
Antibody responses in adult and neonatal BALB/c mice to immunization with novel Bordetella pertussis vaccine formulations.
Gracia, A., M. Polewicz, S.A. Halperin, R.E.W. Hancock, A.A. Potter, L.A. Babiuk, and V. Gerdts.
(2011) Vaccine
29:
1595-1604
PDF
436
435
The Pseudomonas aeruginosa autoinducer 3O-C12 homoserine lactone provokes hyperinflammatory responses from cystic fibrosis airway epithelial cells in a calcium-dependent manner.
Mayer, M.L., J.A. Sheridan, C.J. Blohmke, S.E. Turvey, and R.E.W. Hancock
(2011) PLoS One
6:
e16249
PDF
434
The human cathelicidin, LL-37, induces granzyme-mediated apoptosis in cytotoxic T lymphocytes.
Mader, J.S., M. Marcet-Palacios, R.E.W. Hancock, and C. Bleackley.
(2011) Exptl. Cell Res.
317:
531-538
PDF
433
Pseudomonas Genome Database: Improved comparative analysis and population genomics capability for Pseudomonas genomes.
Winsor, G.L., D.K.W. Lam, L. Fleming, R. Lo, M.D. Whiteside, N.Y. Yu, R.E.W. Hancock and F.S.L. Brinkman.
(2011) Nucl. Acids Res.
39:
D596-600
PDF
432
Optimization of antibacterial peptides by genetic algorithms and cheminformatics.
Fjell, C.D., H. Jenssen, W.A. Cheung, R.E.W. Hancock and A. Cherkasov
(2011) Chem. Biol. Drug Des.
77:
48-56
PDF
431
The importance of bacterial membrane composition in the structure and function of aurein 2.2 and selected variants.
Cheng, J.T., J.D. Hale, M. Elliott, R.E.W. Hancock, and S.K. Straus.
(2011) Biochim. Biophys. Acta.
1808:
622-633
PDF
430
The human cathelicidin LL-37 preferentially promotes apoptosis of infected airway epithelium.
Barlow, P.G., P.E. Beaumont, C. Cosseau, A. Mackellar, T.S. Wilkinson, R.E.W. Hancock, C. Haslett, J.R.W. Govan, A.J.N Simpson, and D.J. Davidson.
(2010) Amer. J. Respir. Cell Mol. Biol.
43:
692-702
PDF
429
428
Permeabilization of fungal hyphae by the plant defensin NaD1 occurs through a cell wall dependent process.
Van der Weerden, N.L., R.E.W. Hancock, and M.A. Anderson.
(2010) J. Biol. Chem.
285:
37513-37520
PDF
427
Importance of residue 13 and the C-terminus for the structure and activity of the antimicrobial Peptide aurein 2.2.
Cheng J.T., J.D. Hale, J. Kindrachuk, H. Jessen, M. Elliott, R.E.W.Hancock and S.K. Straus.
(2010) Biophys. J.
99:
2926-2935
PDF
426
Systems-level comparison of host responses induced by pandemic and seasonal influenza A H1N1 viruses in primary human type I-like alveolar epithelial cells in vitro.
Lee, S.M.Y., R.W.Y. Chan, J.L. Gardy, C.K. Lo, A.D.L. Sihoe, S.S.R. Kang, T.K.W. Cheung, Y. Guan, M.C.W. Chan, R.E.W. Hancock, and J.S.M. Peiris.
(2010) Respir. Res.
11:
147
PDF
425
Antimicrobial peptides on calcium phosphate-coated titanium for the prevention of implant-associated infections.
Kazemzadeh-Narbat, M., J. Kindrachuk, K. Duan, H. Jenssen, R.E.W Hancock, and R. Wang.
(2010) Biomaterials
31:
9519-9526
PDF
424
Cost-effective expression and purification of antimicrobial and host defense peptides in Escherichia coli.
Bommarius, B., H. Jenssen, M. Elliott, J. Kindrachuk, H. Gieren, K.-E. Jaeger, R.E.W. Hancock and D. Kalman.
(2010) Peptides
31:
1957-1965
PDF
423
Structural studies of a peptide with immune modulating and direct antimicrobial activity.
Wieczorek, M., H. Jenssen, J. Kindrachuk, W.R.P. Scott, M. Elliot, K. Hilpert, J.T.J. Cheng, R.E.W. Hancock and S.K. Straus.
(2010) Chem. Biol.
17:
970-980
PDF
422
Genetic determinants involved in the susceptibility of Pseudomonas aeruginosa to β-lactam antibiotics.
Alvarez-Ortega, C., I. Wiegend, J. Olivares, R.E.W. Hancock, and J. Luis Martínez
(2010) Antimicrob. Agents Chemother.
421:
4159-4167
PDF
421
Short cationic antimicrobial peptides interact with ATP.
Hilpert, K., B. McLeod, J. Yu, M.R. Elliott, M. Rautenbach, S. Ruden, J. Bürck, C. Muhle-Goll, A.S. Ulrich, S. Keller and R.E.W. Hancock.
(2010) Antimicrob. Agents Chemother.
54:
4480-4483
PDF
420
Curating the innate immunity interactome.
Lynn, D.J., C. Chan, M. Naseer, M. Yau, R. Lo, A. Sribnaia, G. Ring, J. Que, K. Wee, G.L. Winsor, M.R. Laird, K. Breuer, A.K. Foroushani, F.S.L. Brinkman, and R.E.W. Hancock.
(2010) BMC Systems Biology
4:
117
PDF
419
Adaptive resistance to the “last hope” antibiotics polymyxin B and colistin in Pseudomonas aeruginosa is mediated by the novel two-component regulatory system ParR-ParS.
Fernández, L., W.J. Gooderham, M. Bains, J.B. McPhee, I. Wiegand, and R.E.W. Hancock.
(2010) Antimicrob. Agents Chemother.
54:
3372-3382
PDF
418
Transcriptional differences between a virulent and an attenuated strain of Mycobacterium tuberculosis infecting murine bone-marrow derived macrophages.
Li, A.H., S.J. Waddell, J. Hinds, C.A. Malloff, M. Bains, R.E.W. Hancock, W.L. Lam, P.D. Butcher, and R.W. Stokes.
(2010) PLoS One
5:
e11066
PDF
417
416
415
Robust TLR4-induced gene expression patterns are not an accurate indicator of human immunity.
Brown, K.L., R. Falsafi, W. Kum, P. Hamill, J.L. Gardy, D.J. Davidson, S. Turvey, B.B. Finlay, D.P. Speert and R.E.W. Hancock.
(2010) J. Translational Med.
8:
10.1186/1479-5876-8-6
PDF
414
Synthetic cationic peptide IDR-1002 provides protection against bacterial infections through chemokine induction and enhanced leukocyte recruitment.
Nijnik A., L. Madera, S. Ma, M. Waldbrook, M. Elliott, S.C. Mullaly, J. Kindrachuk, H. Jenssen, R.E.W. Hancock.
(2010) J. Immunol.
184:
2539-2550
PDF
413
Strategies for the identification and advancement of novel cationic antimicrobial peptides.
Hadley, E.B., and R.E.W. Hancock
(2010) Curr. Topics Medicinal Chem.
8:
1872-1881
412
G-protein-coupled receptor independent, immunomodulatory properties of chemokine CXCL9
Gong, J.-H. E.F. Nicholls, M.R. Elliott, K.L. Brown, K. Hokamp, F.M. Roche, C.Y Cheung, R. Falsafi, F.S. Brinkman, D.M.E. Bowdish, and R.E.W. Hancock.
(2010) Cellular Immunol.
261:
105-113
411
410
Manual annotation and analysis of the defensin gene cluster in the C57BL/6J mouse reference genome.
Amid, C., L.M. Rehaume, K.L. Brown, J.G.R. Gilbert, G. Dougan, R.E.W. Hancock, and J.L. Harrow.
(2009) BMC Genomics
10:
10.1186/1471-2164-10-606
PDF
409
Systems-Level Comparison of Host-Responses Elicited by Avian H5N1 and Seasonal H1N1 Influenza Viruses in Primary Human Macrophages.
Lee, S.M.Y., J.L. Gardy, C.Y. Cheung, T.K.W. Cheung, K.P.Y. Hui1, W.W. Gai1, N.Y. Ip, Y. Guan, R.E.W. Hancock, and J.S.M. Peiris
(2009) PLoS One
4(12):
10.1371/journal.pone.0008072
PDF
408
Sequestosome-1/p62 is the key intracellular target of innate defense regulator peptide.
Yu, H.B., A. Kielczewska, A. Rozek, S. Takenaka, Y. Li, L. Thorson, R.E.W. Hancock, M.M. Guarna, J.R. North, L.J. Foster, O. Donini and B.B. Finlay.
(2009) J. Biol. Chem.
284:
36007-36011
PDF
407
Human cathelicidin peptide LL-37 modulates the effects of IFN-gamma on APCs.
Nijnik, A., J. Pistolic, A. Wyatt, S. Tam, and R.E.W. Hancock.
(2009) J. Immunol.
183:
5788-5798
PDF
406
Synthesis of peptide arrays using SPOT-technology and the CelluSpots-method.
Winkler, D.F.H., K. Hilpert, O. Brandt and R.E.W. Hancock.
(2009) Meth. Molec. Biol.
570:
157-174
PDF
405
Swarming of Pseudomonas aeruginosa is controlled by a broad spectrum of transcriptional regulators including MetR.
Yeung, A.T.Y., E.C.W. Torfs, F. Jamshidi, M. Bains, I. Wiegand, R.E.W. Hancock, and J. Overhage.
(2009) J. Bacteriol.
191:
5591-5602
PDF
404
Involvement of pmrAB and phoPQ in polymyxin B adaptation and inducible resistance in non-cystic fibrosis clinical isolates of Pseudomonas aeruginosa.
Schurek, K.N., J.L.M. Sampaio, C.R.V. Kiffer, S. Sinto, C.M.F. Mendes, and R.E.W. Hancock.
(2009) Antimicrob. Agents Chemother.
53:
4345-4351
PDF
403
Intracellular receptor for human host defence peptide LL-37 in monocytes.
Mookherjee, N., D.N.D. Lippert, P. Hamill, R. Falsafi, A. Nijnik, J. Kindrachuk, J. Pistolic, J. Gardy, P. Miri, M. Naseer, L.J. Foster, and R.E.W. Hancock.
(2009) J. Immunol.
183:
2688-2696
PDF
402
Potential of immunomodulatory host defense peptides as novel anti-infectives.
Easton, D.M., A. Nijnik, M.L. Mayer, and R.E.W. Hancock.
(2009) Trends in Biotechnol.
27:
582-590
PDF
401
A novel vaccine adjuvant comprised of a synthetic innate defence regulator peptide and CpG oligonucleotide links innate and adaptive immunity.
Kindrachuk, J., H. Jenssen, M. Elliott, R. Townsend, A. Nijnik, S.F. Lee, V. Gerdts, L.A. Babiuk, S.A. Halperin and R.E.W. Hancock.
(2009) Vaccine
27:
4662-4671
PDF
400
Low concentrations of LL-37 alter IL-8 production by keratinocytes and bronchial epithelial cells in response to pro-inflammatory stimuli.
Filewod, N., J. Pistolic, R.E.W. Hancock. 2009
(2009) FEMS Immunol. Medical Microbiol
53:
223-240
PDF
398
The major outer membrane protein OprG of Pseudomonas aeruginosa contributes to cytotoxicity and forms an anaerobically-regulated, cation-selective channel.
McPhee, J.B., S. Tamber, M. Bains, E. Maier, S. Gellatly, A. Lo, R. Benz, and R.E.W. Hancock.
(2009) FEMS Microbiol. Lett.
296:
241-247
PDF
397
An iron-starvation inducible LysR-type regulator regulates the polymyxin resistance pmrF operon and controls virulence in Yersinia pseudotuberculosis.
Arafah, S., M.-L. Rosso, L. Rehaume, R.E.W. Hancock, M. Simonet, and M. Marceau.
(2009) Microbiology
155:
2168-2181
396
395
The novel adjuvant combination of CpG ODN, indolicidin and polyphosphazene induces potent antibody and cell-mediated immune responses in mice.
Kovacs-Nolan, J., L. Latimer, A. Landi, H. Jenssen, R.E.W. Hancock, L.A. Babiuk, and S. van Drunen Littel-van den Hurk.
(2009) Vaccine
27:
2055-2064
PDF
394
Systems biology evaluation of immune responses induced by human host defence peptide LL-37 in mononuclear cells.
Mookherjee, N., P. Hamill, J. Gardy, D. Blimkie, R. Falsafi, A. Chikatamarla, D.J. Arenillas, S. Doria, T.R. Kollmann, R.E.W. Hancock.
(2009) Molec. BioSystems
5(5):
483-496
PDF
393
Identification of Novel Antibacterial Peptides by Chemoinformatics and Machine Learning.
Fjell, C.D., H. Jenssen, K. Hilpert, W.A. Cheung, N. Panté, R.E.W. Hancock and A. Cherkasov.
(2009) J. Med. Chem.
52:
2006-2015
PDF
392
The human host defense peptide LL-37 induces apoptosis in a calpain- and apoptosis-inducing factor-dependent manner involving Bax activity
Mader J.S., N. Mookherjee, R.E.W. Hancock, and R.C. Bleackley.
(2009) Mol Cancer Res.
7:
689-702
PDF
391
Killing of Trypanosomatid parasites by a modified bovine host defense peptide, BMAP-18.
Haines, L.R., J.M. Thomas, A.M. Jackson, B.A. Eyford, M. Razavi, C.N. Watson, B. Gowen, R.E.W. Hancock, and T.W. Pearson.
(2009) PLoS Neglected Trop. Dis.
3(2):
e373
PDF
390
The sensor kinase PhoQ mediates virulence in Pseudomonas aeruginosa.
Gooderham, W.J., S. Gellatly, F. Sanschagrin, J.B. McPhee, M. Bains, Celine Cosseau, R.C. Levesque, and R.E.W. Hancock.
(2009) Microbiology
155:
699-711
PDF
389
Strategies to link innate and adaptive immunity when designing vaccine adjuvants.
Garlapati, S., M. Facci, M. Polewicz, S. Strom, L.A. Babiuk, G. Mutwiri, R.E.W. Hancock, M.R. Elliott, and V. Gerdts.
(2009) Vet. Immunol. Immunopathol.
128:
184-191
PDF
388
387
Host defense peptide LL-37 induces IL-6 expression in human bronchial epithelial cells by activation of the NF-κB signaling pathway.
Pistolic, J., C. Cosseau, Y. Li, J.Yu, N.Filewod, S. Gellatly, L. Rehaume, D.M. Bowdish, and R.E.W. Hancock.
(2009) J. Innate Immun.
1:
254-267
PDF
386
Screening and characterization of surface-tethered cationic peptides for antimicrobial activity.
Hilpert, K., M. Elliott, H. Jenssen, J. Kindrachuk, CD. Fjell, J. Körner, D.F.H. Winkler, L.L. Weaver, P. Henklein, A.S. Ulrich, S.H.Y. Chiang, S.W. Farmer, N. Pante, R. Volkmer, and R.E.W. Hancock.
(2009) Chem. Biol.
16:
58-69
PDF
385
Use of artificial intelligence in the design of small peptide antibiotics effective against a broad spectrum of highly antibiotic resistant Superbugs.
Cherkasov, A., K. Hilpert, H. Jenssen, C.D. Fjell, M. Waldbrook, S.C. Mullaly, R. Volkmer and R.E.W. Hancock.
(2009) ACS Chemical Biol.
4:
65-74
PDF
384
Pseudomonas Genome Database: Facilitating user-friendly, comprehensive comparisons of microbial genomes.
Winsor, G.L., T. Van Rossum, R. Lo, B. Khaira, MD. Whiteside, R.E.W. Hancock and F.S.L. Brinkman.
(2009) Nucl. Acids Res.
378:
D483-488
PDF
383
The effect of membrane composition on the antimicrobial peptides Aurein 2.2 and 2.3 from Australian southern bell frogs.
Cheng, J.T.J., J.D. Hale, M. Elliot, R.E.W. Hancock, and S.K. Straus.
(2009) Biophys. J.
96:
552-565
PDF
382
381
Bovine lactoferrin and lactoferricin interfere with intracellular trafficking of herpes simplex virus-1.
Marr, A. K., H. Jenssen, M. R. Moniri, R.E.W. Hancock and N. Panté.
(2009) Biochimie.
91:
160-164
PDF
380
Newly introduced genomic prophage islands are critical determinants of in vivo competitiveness in the Liverpool Epidemic Strain of Pseudomonas aeruginosa.
Winstanley, C., M.G.I. Langille, J.L. Fothergill, I. Kukavica-Ibrulj, C. Paradis-Bleau, F. Sanschagrin, N.R. Thomson, G.L. Winsor, M.A. Quail, N. Lennard, A. Bignell, L. Clarke, K. Seeger, D. Saunders, D. Harris, J. Parkhill, R.E.W. Hancock, F.S.L. Brinkman, and R.C. Levesque.
(2009) Genome Research
19:
12-23
PDF
379
378
377
376
The global access initiative at the University of British Columbia (UBC): Availability of UBC discoveries and technologies to the developing world (Invited Commentary)
Wasan K.M., S.J. Thornton, Ian Bell, R.E. Goulding, M. Gretes, A.P. Gray, R.E.W. Hancock and B. Campbell.
(2009) J. Pharmaceut. Sci.
89:
791-794
PDF
375
Effects of Hydrophobicity on the Antifungal Activity of α-Helical Antimicrobial Peptides.
Jiang Z., B.J. Kullberg, H. van der Lee, A.I. Vasil, J.D. Hale, C.T. Mant, R.E.W. Hancock, M.L. Vasil, M.G. Netea and R.S. Hodges.
(2008) Chem. Biology Drug Design
72:
483-495
PDF
374
Novel genetic determinants of low-level aminoglycoside resistance in Pseudomonas aeruginosa.
Schurek, K.N., A.K. Marr, P.K. Taylor, I. Wiegand, L. Semenec, B. K. Khaira, and R.E.W. Hancock.
(2008) Antimicrob. Agents Chemother.
52:
4213-4219
PDF
373
A complex ciprofloxacin resistome revealed by screening of a library of Pseudomonas aeruginosa mutants for altered susceptibility.
Breidenstein, E.B.M., B.K. Khaira, I. Wiegand and R.E.W. Hancock.
(2008) Antimicrob. Agents Chemother.
52:
4486-4491
PDF
372
Neutrophil elastase is required for innate host defense against Pseudomonas aeruginosa.
Hirche, T.O., R. Benabid, G. Deslee, S. Gangloff, S. Achilefu, M. Guenounou, F. Lebargy, R.E.W. Hancock, and A. Belaaouaj.
(2008) J. Immunol.
181:
4945-4954
PDF
371
Mutator genes giving rise to decreased antibiotic susceptibility in Pseudomonas aeruginosa.
Wiegand, I., A.K. Marr, E.B.M. Breidenstein, K.N. Schurek, P. Taylor, and R.E.W. Hancock.
(2008) Antimicrob. Agents Chemother.
52:
3810-3813
PDF
370
The human host defence peptide LL-37 prevents bacterial biofilm formation.
Overhage, J., A. Campisano, M. Bains, E.C.W. Torfs, B.H.A. Rehm, and R.E.W. Hancock.
(2008) Infect. Immun.
76:
4176-4182
PDF
369
Facilitating systems level analyses of the mammalian innate immune response.
Lynn, D.J., G.L. Winsor, C. Chan, N. Richard, M.R. Laird, A. Barsky, J.L. Gardy, F.M. Roche, T.H.W. Chan, N. Shah, R. Lo, M. Naseer, J. Que, M. Yau, M. Acab, D. Tulpan, M. Whiteside, A. Chikatamarla, B. Mah, T.M. Munzner, K. Hokamp, R.E.W. Hancock, and F.S.L. Brinkman.
(2008) Molec. Systems Biol.
4:
218 Epub
PDF
368
The commensal Streptococcus salivarius K12 down-regulates the innate immune responses of human epithelial cells and promotes host-microbe homeostasis.
Cosseau, C., D.A. Devine, E. Dullaghan, J.L. Gardy, A. Chikatamarla, S. Gellatly, L.L. Yu, J. Pistolic, R. Falsafi, J. Tagg, and R.E.W. Hancock.
(2008) Infect. Immun.
76:
4163-4175
PDF
367
X-ray spectromicroscopy study of competitive adsorption of protein and peptide onto polystyrene-poly (methyl methacrylate).
Leung B.O., A.P. Hitchcock, J.L. Brash, A. Scholl, A. Doran, P. Henklein, J. Overhage, K. Hilpert, J.D. Hale, R.E.W. Hancock.
(2008) Biointerphases
3:
FB27-FB35
PDF
366
Induction by cationic antimicrobial peptides and involvement in intrinsic polymyxin and antimicrobial peptide resistance, biofilm formation and swarming motility of PsrA in Pseudomonas aeruginosa.
Gooderham W.J., M. Bains, J.B. McPhee, I. Wiegand, R.E.W. Hancock.
(2008) J. Bacteriol.
190:
5624-5634
PDF
365
ROS-deficient monocytes have aberrant gene expression that correlate with inflammatory disorders of chronic granulomatous disease.
Brown, K.L., J. Bylund, K.L. MacDonald, G.X. Song-Zhao, M.R. Elliott, R. Falsafi, R.E.W. Hancock and D.P. Speert.
(2008) Clin. Immunol.
129:
90-102
PDF
364
Neutrophil-derived defensins as modulators of innate immune function.
Rehaume, L., and R.E.W. Hancock.
(2008) Crit. Rev. Immunol.
28:
185-200
363
362
Inhibition of HSV cell-to-cell spread by lactoferrin and lactoferricin.
Jenssen, H., K. Sandvik, J.H. Andersen, R.E.W. Hancock, and T.J. Gutteberg.
(2008) Antiviral Res.
79:
192-198
PDF
361
Innate immunity mediated by TLR5 as a novel anti-inflammatory target for cystic fibrosis lung disease.
Blohmke, C.J., A.F. Hirschfeld, I. Elias, R.E. Victor, D.G. Hancock, A.G.F. Davidson, P.G. Wilcox, K.D. Smith, J. Overhage, R.E.W. Hancock, and S.E. Turvey.
(2008) J. Immunol.
180:
7764-7773
PDF
360
Identification of novel host defense peptides and the absence of alpha-defensins in the bovine genome.
Fjell, C.D., H. Jennsen, P. Fries, P. Aich, P. Griebel, K. Hilpert, R.E.W. Hancock, and A. Cherkasov.
(2008) Proteins
73:
420-430
PDF
359
Metabolic changes associated with adaptive diversification in Escherichia coli.
Le Gac, M., M.D. Brazas, M. Bertrand, J.G. Tyerman, C.C. Spencer, R.E.W. Hancock, and M. Doebeli.
(2008) Genetics
178:
1049-1060
PDF
358
Effects of net charge and the number of positively charged residues on the biological activity of amphipathic alpha-helical cationic antimicrobial peptides.
Jiang, Z., A.I. Vasil, J. Hale, R.E.W. Hancock, M.L. Vasil and R.S. Hodges
(2008) Biopolymers
90:
369-383
PDF
357
356
Pseudomonas.
Goldberg, J.G., R.E.W. Hancock, R.E. Parales, J. Loper, and P. Cornelis.
(2008) J. Bacteriol.
190:
2649-2662
PDF
355
354
353
Expression of a polyphemusin variant in transgenic tobacco confers resistance against plant pathogenic bacteria, fungi and a virus.
Bhargava, A., M. Osusky, B.S. Forward, R.E.W. Hancock, W.M. Kay, and S. Misra.
(2007) Plant Cell Tiss. Organ Cult.
88:
301-312
PDF
352
Antiviral indolicidin variant peptides: Evaluation for broad-spectrum disease resistance in transgenic Nicotiana tabacum.
Bhargava, A., M. Osusky, R.E.W. Hancock, B.S. Forward, W.M. Kay, and S. Misra.
(2007) Plant Sci.
172:
515-523
PDF
351
NMR structural studies of the antibiotic lipopeptide daptomycin in DHPC micelles.
Scott W.R., S.B. Baek, D. Jung, R.E.W. Hancock and S.K. Straus.
(2007) Biochim. Biophys. Acta.
1768:
3116-3126
PDF
350
349
Effect of divalent cations on the structure of the antibiotic daptomycin.
Ho, S.W., D. Jung, J.R. Calhoun, J.D. Lear, M. Okon, W.R.P. Scott, R.E.W. Hancock, and S.K. Straus.
(2007) Europ. J. Biophys.
37:
421-433
PDF
348
Host defence peptide LL-37, in synergy with inflammatory mediator IL-1β, augments immune responses by multiple pathways.
Yu, J., N. Mookherjee, K. Wee, D.M.E. Bowdish, J. Pistolic, Y. Li, L. Rehaume, and R.E.W. Hancock.
(2007) J. Immunol.
179:
7684-7691
PDF
347
346
Role of Lon protease in resistance of Pseudomonas aeruginosa to ciprofloxacin.
Brazas, M.D., E.B.M. Breidenstein, J. Overhage and R.E.W.Hancock.
(2007) Antimicrob. Agents Chemother.
51:
4276-4283
PDF
345
Evaluating different descriptors for model design of antimicrobial 12-mer peptides with enhanced activity towards Pseudomonas aeruginosa.
Jenssen H., T. Lejon, K. Hilpert, C. Fjell, A.Cherkasov and R.E.W.Hancock.
(2007) Chem. Biol. Drug Des.
70:
134-142
PDF
344
343
Using intrinsic X-ray absorption spectral differences to identify and map peptides and proteins.
Stewart-Ornstein, J., A.P. Hitchcock, D. Hernàndez-Cruz, P. Henklein, J. Overhage, K. Hilpert, J.D. Hale and R.E.W. Hancock.
(2007) J. Phys. Chem.
111:
7691-7699
PDF
342
341
Cellulose-bound peptide arrays: Preparation and applications.
Hilpert, K., D. Winkler, and R.E.W. Hancock.
(2007) Biotechnol. Genet. Engineer. Rev.
24:
31-106
PDF
340
339
Secondary acylation of Klebsiella pneumoniae lipopolysaccharide contributes to sensitivity to antibacterial peptides.
Clements, A., D. Tull, A.W. Jenney, J.L. Farn, S.-H Kim, Bishop, R.E., J.B. McPhee, R.E.W Hancock, E.L. Hartland, M.J. Pearse, O.L.C. Wijburg, D.C. Jackson, M.J. McConville and R. A. Strugnell.
(2007) J. Biol. Chem.
282:
15569-15577
PDF
338
337
336
An anti-infective peptide that selectively modulates the innate immune response.
Scott, M.G., E. Dullaghan, N. Mookherjee, N. Glavas, M. Waldbrook, A. Thompson, A. Wang, K. Lee, S. Doria, P. Hamill, J. Yu, Y. Li, O. Donini, M.M. Guarna, B.B. Finlay, J.R. North, and R.E.W. Hancock.
(2007) Nature Biotechnology
25:
465-472
PDF
335
334
333
Enhanced inflammatory responses of chronic granulomatous disease leukocytes involve reactive oxygen species-independent activation of NF-κB.
Bylund, J., K.L. MacDonald, K.L. Brown, P. Mydel, L.V. Collins, R.E.W. Hancock and D.P. Speert.
(2007) J. Immunol.
37:
1087-1096
PDF
332
Characterization of the structure and membrane interaction of the antimicrobial peptides Aurein 2.2 and 2.3 from Australian Southern Bell Frog.
Pan, Y.-L., J.T.J. Cheng, J. Hale, J. Pan, R.E.W. Hancock, and S.K. Straus.
(2007) Biophys. J.
92:
2854-2864
PDF
331
330
An arginine ladder mediates phosphate specific transfer across membranes.
Moraes, T.F., M. Bains, R.E.W. Hancock, and N.C. Strynadka.
(2007) Nature Struct. Molec. Biol.
14:
85-87
PDF
329
328
Antimicrobial, Host Defence Peptides and Proteins.
Brown, K.L, N. Mookherjee, and R.E.W. Hancock
(2007) eLS
327
326
325
Bovine and human cathelicidin cationic host defence peptides similarly suppress global transcriptional responses to bacterial lipopolysaccharide.
Mookherjee, N., H.L. Wilson, S. Doria, Y. Popowych, R. Falsafi, J. Yu, Y. Li, S. Veatch, F.M. Roche, K.L. Brown, F.S.L. Brinkman, K. Hokamp, A. Potter, L. A. Babiuk, P.J. Griebel and R.E.W. Hancock.
(2007) J. Leukocyte Biol.
80:
1563-1574
PDF
324
323
IRAK-4 mutation (Q293X): rapid detection, and characterisation of defective posttranscriptional TLR/IL-1R responses in human myeloid and non-myeloid cells.
Davidson, D.J., A.J. Currie, DM.E. Bowdish, K.L. Brown, C.M. Rosenberger, RC. Ma, J. Bylund, P.A. Campsall, A. Puel, C. Picard, J.-L. Casanova, S.E. Turvey, R.E.W. Hancock, R.S. Devon, and D.P. Speert.
(2006) J. Immunol.
177:
8202-8211
PDF
322
321
Sequence requirements and a novel optimization strategy for short antimicrobial peptides.
Hilpert, K., M.R. Elliott, R. Volkmer-Engert, P. Henklein, O. Donini, Q. Zhou, D.F.H. Winkler and R.E.W. Hancock.
(2006) Chem. Biol.
13:
1101-1107
PDF
320
319
318
The human cationic host defense peptide LL-37 mediates contrasting effects on apoptotic pathways in different primary cells of the innate immune system.
Barlow, P.G., Y. Li, T.S.Wilkinson, D.M.E. Bowdish, Y.E. Lau, C. Cosseau, C. Haslett, A.J. Simpson, R.E.W. Hancock, and D.J. Davidson.
(2006) J. Leukocyte Biol.
80:
509-520
PDF
317
The antimicrobial peptide polyphemusin localizes to the cytoplasm of Escherichia coli following treatment.
Powers, J.P., M.M. Martin, D.L. Goosney and R.E.W. Hancock.
(2005) Antimicrob. Agents Chemother.
50:
1522-1524
PDF
316
315
Contribution of the PhoP-PhoQ and PmrA-PmrB two-component regulatory systems to Mg2+-induced gene regulation in Pseudomonas aeruginosa.
McPhee, J.B., M. Bains, G. Winsor, S. Lewenza, A. Kwasnicka, M.D. Brazas, F.S.L. Brinkman and R.E.W. Hancock.
(2006) J. Bacteriol.
188:
3995-4006
PDF
314
313
Apoptosis of airway epithelial cells: human serum sensitive induction by the cathelicidin LL-37.
Lau, Y.E., D.M.E. Bowdish, C. Cosseau, R.E.W. Hancock and D.J. Davidson.
(2005) J. Resp. Cell and Molec. Biol.
34:
399-409
PDF
312
Comparison of biophysical and biologic properties of alpha-helical enantiomeric antimicrobial peptides.
Chen Y., A.I. Vasil, L. Rehaume, C.T. Mant, J.L. Burns, M.L. Vasil, R.E.W. Hancock, and R.S. Hodges.
(2005) Chem. Biol. Drug Des.
67:
162-173
PDF
311
Modulation of the Toll-like receptor-mediated inflammatory response by the endogenous human host defence peptide LL-37.
Mookherjee, N., K.L. Brown, D.M.E. Bowdish, S. Doria, R. Falsafi, K. Hokamp, F.M. Roche, R. Mu, G.H. Doho, J. Pistolic, J. Powers, J. Bryan, F.S.L. Brinkman and R.E.W. Hancock.
(2005) J. Immunol.
176:
2455-2464
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310
309
308
307
306
305
Recognition of host immune activation by Pseudomonas aeruginosa.
Wu, L., O. Estrada, O. Zaborina, M. Bains, L. Shen, J.E. Kohler, N. Patel, M.W. Musch, E.B. Chang, Y. Fu, M.V. Olson, M.A. Jacobs, M.I. Nishimura, R.E.W. Hancock, J.R. Turner, and J.C. Alverdy.
(2005) Science
309:
774-777
PDF
304
Use of polymyxin as an endotoxin blocker in the prevention of diffuse lamellar keratitis in an animal model.
Morck, D.W., S.P. Holland, H. Ceri, RE.W.. Hancock, M. Scott-Gough, V. Nguyen, E.J. Keith, and T.L. Lee.
(2005) J. Refect. Surg.
21:
152-157
PDF
303
Pathogen-induced expression of a cecropin A-melittin antimicrobial peptide gene confers antifungal resistance in transgenic tobacco
Yevtushenko D.P, R. Romero, B.S. Forward, R.EW. Hancock, W.W. Kay, and S. Misra
(2005) J. Exptl. Botany
56:
1685-1695
PDF
302
High-throughput generation of small antibacterial peptides with improved activity.
Hilpert, K., R.Volkmer-Engert, T. Walter, and R.E.W. Hancock.
(2005) Nature Biotechnology
23:
1008-1012
PDF
301
300
299
298
Antimicrobial peptide therapeutics for cystic fibrosis.
Zhang, L., J. Parente, S.M. Harris, D.E. Woods, R.E.W. Hancock, and T.J. Falla.
(2005) Antimicrob. Agents Chemother.
49:
2921-2927
PDF
297
Rational design of α-helical antimicrobial peptides with enhanced activities and specificity/therapeutic index
Chen Y., C.T. Mant, S.W. Farmer, R.E.W. Hancock, M.L. Vasil, and R.S. Hodges.
(2005) J. Biol. Chem.
280:
12316-12329
PDF
296
295
Construction of a mini-Tn5-luxCDABE mutant library in Pseudomonas aeruginosa PAO1: a tool for identifying differentially regulated genes.
Lewenza S., R.K. Falsafi, G. Winsor, W.J. Gooderham, J.B. McPhee, F.S.L. Brinkman and R.E.W. Hancock.
(2005) Genome Research
15:
583-589
PDF
294
Immunomodulatory activities of small host defense peptides.
Bowdish, D.M.E., D.J. Davidson, M.G. Scott, and R.E.W. Hancock.
(2005) Antimicrob. Agents Chemother.
49:
1727-1732
PDF
293
292
291
Impact of LL-37 on anti-infective immunity.
Bowdish, D.M.E., D.J. Davidson, Y.E. Lau, K. Lee, M.G. Scott, and R.E.W. Hancock.
(2005) J. Leukocyte Biol.
77:
451-459
PDF
290
Pseudomonas aeruginosa Genome Database and PseudoCAP: Facilitating community-based, continually updated, genome annotation.
Winsor, G., R. Lo, S.J. Ho Sui, K.S.E. Ung, S. Huang, D. Cheng, W.-K. Ho
Ching, R.E.W. Hancock, and F.S.L. Brinkman. (2005) Nucl. Acids Res. 33: D338-343 PDF
Ching, R.E.W. Hancock, and F.S.L. Brinkman. (2005) Nucl. Acids Res. 33: D338-343 PDF
289
Interaction and cellular localization of the human host defence peptide, LL-37, with lung epithelial cells
Lau, Y.E., A. Rozek, M.G. Scott, D.L. Goosney, D.J. Davidson and R.E.W. Hancock.
(2005) Infect. Immun.
73:
583-591
PDF
288
Design of host defence peptides for antimicrobial and immunity enhancing activities.
McPhee, J.B. M.G. Scott, and R.E.W. Hancock.
(2005) Combinat. Chem. High Throughput Screening
8:
257-272
PDF
287
286
Differential expression of porins OmpP2A and OmpP2B of Haemophilus ducreyi.
Prather, D.T., M.Bains, R.E.W. Hancock, M.J. Filiatrault, and A.A. Campagnari
(2004) Infect. Immun.
72:
6271-6278
PDF
285
Transgenic potatoes expressing a novel cationic peptide are resistant to late blight and pink rot.
Osusky, M. L. Osuska, R. E.W Hancock, W. Kay, and S. Misra.
(2004) Transgenic Research
13:
181-190
PDF
284
283
ProbeLynx: A tool for updating the association of microarray probes to genes.
Roche, F.M. K. Hokamp, M. Acab, L.A. Babiuk, R.E.W. Hancock, and F.S.L. Brinkman.
(2004) Nucl. Acids Res.
32:
W457-459
PDF
282
Structure and association of human lactoferrin peptides with Escherichia coli lipopolysaccharide.
Chapple D.S., R. Hussain, C.L. Joannou, R.E.W. Hancock, E. Odell, R.W. Evans, and G.Siligardi.
(2004) Antimicrob. Agents Chemother.
48:
2190-2198
PDF
281
280
Effects of single D-amino acid substitutions on disruption of β-sheet structure and hydrophobicity in cyclic 14-residue antimicrobial peptide analogs related to gramicidin S. J.
Lee, D.L., J.P.S. Powers, K. Pflegerl, M.L. Vasil, R.E.W. Hancock, and R.S. Hodges.
(2004) J.Peptide Res.
63:
69-84
PDF
279
The human cationic peptide LL-37 induces activation of the extracellular signal regulated kinase and p38 kinase pathways in primary human monocytes.
Bowdish D.M.E., D.J. Davidson, D.P. Speert, and R.E.W. Hancock.
(2004) J. Immunol.
172:
3758-3765
PDF
278
ArrayPipe: a flexible processing pipeline for microarray data.
Hokamp K., F.M. Roche, M. Acab, M.E. Rousseau, B. Kuo, D. Goode, D. Aeschliman, J. Bryan, L. Babiuk, R.E.W. Hancock, and F.S.L. Brinkman.
(2004) Nucl. Acids Res.
32:
W471-474
PDF
277
276
The cationic antimicrobial peptide LL-37 modulates dendritic cell development and DC-induced T cell polarisation.
Davidson, D.J., A.J. Currie, G. Reid, D.M.E. Bowdish, K. MacDonald, R. Ma, R.E.W. Hancock, and D.P. Speert.
(2004) J. Immunol.
172:
1146-1156
PDF
275
274
273
272
Membrane binding and permeation by indolicidin analogs studied by a biomimetic lipid/polydiacetylene vesicle assay.
Halevy, R., A. Rozek, S. Kolusheva, R.E.W. Hancock, and R. Jelinek.
(2003) Peptides
24:
1753-1761
PDF
271
270
269
Cationic antimicrobial peptide killing of African trypanosomes and Sodalis glossinidius, a bacterial symbiont of the insect vector of sleeping sickness.
Haines, L.R., ,b>R.E.W. Hancock and T.W. Pearson.
(2003) Vector Borne and Zoonotic Dis.
3:
175-186
268
267
Role of Pseudomonas putida tol-oprL gene products in uptake of solutes through the cytoplasmic membrane.
Llamas, M.A., J.J. Rodriguez-Herva, R.E.W. Hancock, W. Bitter, J. Tommassen, and J.L. Ramos.
(2003) J. Bacteriol.
185:
4707-4716
PDF
266
Broad-spectrum peptide inhibitors of aminoglycoside resistance enzymes.
Boehr, D.D., K. Draker, K. Koteva, M. Bains, R.E.W. Hancock, and G.D. Wright
(2003) Chem. Biol.
10:
189-196
PDF
265
On the mechanism of solute transport in Pseudomonas.
Tamber, S., and R.E.W. Hancock.
(2003) Frontiers in Bioscience
8:
S472-S483
264
Aminoglycoside efflux in Pseudomonas aeruginosa: involvement of novel outer membrane proteins.
Jo, J.T.H., F.S.L.Brinkman, and R.E.W.Hancock
(2003) Antimicrob. Agents Chemother.
47:
1101-1111
PDF
263
262
261
Pseudomonas aeruginosa anaerobic respiration in biofilms: Relationships to cystic fibrosis pathogenesis.
Yoon, S.S., R.F. Hennigan, G.M. Hilliard, U.A.Ochsner, K.Parvatiyar, M.C.Kamani, H.L.Allen, T.R.DeKievit, P.R. Gardner, U.Schwab, J.J.Rowe, B.H.Iglewski, T.R.McDermott, R.P.Mason, D.J.Wozniak, R.E.W. Hancock, M.R.Parsek, T.L.Noah, R.C.Boucher, and D.J.Hassett.
(2002) Developmental Cell.
3:
593-603
PDF
260
The human antimicrobial peptide, LL-37, is a multifunctional modulator of innate immune responses.
Scott, M.G., D.J. Davidson, M.R. Gold, D. Bowdish, and R.E.W. Hancock.
(2001) J. Immunol.
169:
3883-3891
PDF
259
Evidence that plant-like genes in Chlamydia species reflect an ancestral relationship between Chlamydiaceae, cyanobacteria and the chloroplast.
Brinkman, F.S.L., J.L. Blanchard, A. Cherkasov, H. Greberg, Y. Av-Gay, R.C. Brunham, R.C. Fernandez, B.B. Finlay, S.P. Otto, B.F.F. Ouellette, P.J. Keeling, A.M. Rose, R.E.W. Hancock and S.J.M. Jones
(2002) Genome Research
12:
1159-1167
PDF
258
Exploring relationships between mimic configuration, peptide conformation and biological activity in indolizidin-2-one amino acid analogs of gramicidin S.
Roy, S., H.G. Lombart, W.D. Lubell, R.E.W. Hancock, and S.W. Farmer.
(2002) J. Pept. Res.
60:
197-213
PDF
257
Multidrug efflux systems play an important role in the invasiveness of Pseudomonas aeruginosa.
Hirakata, Y., R. Srikumar, K. Poole, N. Gotoh, T. Suematsu, S. Kohno, S. Kamihira, R.E.W. Hancock, and D.P. Speert.
(2002) J. Exp. Med.
196:
109-118
PDF
256
255
254
253
Optimization of microbial specificity in cyclic peptides by modulation of hydrophobicity within a defined structural framework.
Kondejewski, L.H., D.L. Lee, M. Jelokhani-Niaraki, S.W. Farmer, R.E.W. Hancock, and Robert S. Hodges.
(2002) J. Biol. Chem.
277:
67-74
PDF
252
Sub-lethal concentrations of pleurocidin-derived antimicrobial peptides inhibit macromolecular synthesis in Escherichia coli.
Patrzykat, A., C.L. Friedrich, L.Zhang, V. Mendoza, and R.E.W.Hancock.
(2002) Antimicrob. Agents Chemother.
46:
605-614
PDF
251
250
249
248
247
246
245
Morphology of fast-tumbling bicelles: a small angle neutron scattering and NMR study.
Luchette, P.A., T.N. Vetman, R.S. Prosser, R.E.W.Hancock, M.P. Nieh, C.J. Glinka, S. Krueger, and J. Katsaras.
(2001) Biochim. Biophys. Acta.
1513:
83-94
PDF
244
243
Evolutionary relationships amongst virulence associated histidine kinases.
Brinkman, F.S.L., E.L.A. MacFarlane, P. Warrener, and R.E.W. Hancock.
(2001) Infect. Immun.
69:
5207-5211
PDF
242
241
In vitro aerosol delivery and regional airway surface liquid concentration of a liposomal cationic peptide.
Lange, C.F., R.E.W. Hancock, J. Samuel, and W.H. Finlay.
(2001) J. Pharmaceut. Sci.
90:
1647-1657
PDF
240
Structure and mechanism of action of an indolicidin peptide derivative with improved activity against Gram-positive bacteria.
Friedrich, C.L., A.Rozek, A. Patrzykat, and R.E.W.Hancock.
(2001) J. Biol. Chem.
276:
24015-24022
PDF
239
238
Synergy of histone-derived peptides of Coho salmon with lysozyme and the flounder peptide pleurocidin.
Patrzykat, A., L. Zhang, V. Mendoza, G.K. Iwama, and R.E.W.Hancock.
(2001) Antimicrob. Agents Chemother.
45:
1337-1342
PDF
237
PhyloBLAST: A tool facilitating phylogenetic analysis of BLAST results.
Brinkman, F.S.L., I. Wan, R.E.W. Hancock, A.M. Rose, and S.J. Jones.
(2001) Bioinformatics
17:
385-387
PDF
236
235
Determination of membrane immersion depth with O2: A high pressure 19F NMR study.
Prosser, R.S., P.A. Luchette, P.W. Westermann, A. Rozek, and R.E.W. Hancock.
(2000) Biophys. J.
80:
1406-1430
PDF
234
233
Interaction of polyphemusin I and structural analogs with bacterial membranes, lipopolysaccharide and lipid monolayers.
Zhang, L., M.G. Scott, H. Yan, L.D. Mayer, and R.E.W.Hancock.
(2000) Biochemistry
39:
14504-14514
PDF
232
Interactions of bacterial cationic peptide antibiotics with outer and cytoplasmic membranes of Pseudomonas aeruginosa.
Zhang, L., P. Dhillon, H. Yan, S. Farmer, and R.E.W. Hancock.
(2000) Antimicrob. Agents Chemother.
44:
3317-3321
PDF
231
Cationic antimicrobial peptides and their multifunctional role in the immune system.
Scott, M.G., and R.E.W. Hancock.
(2000) Crit. Rev. Immunol.
20:
407-431
230
Diastereoisomeric analogues of gramicidin S: structure, biological activity and interaction with bilayers.
Jelokhani-Niaraki, M., L.H. Kondajewski, S.W.Farmer, R.E.W.Hancock, C.M.Kay, and R.S.Hodges.
(2000) J. Biochem.
349:
747-755
PDF
229
An α-helical cationic antimicrobial peptide selectively modulates macrophage responses to LPS and directly alters macrophage gene expression
Scott, M.G., C.M. Rosenberger, M.R. Gold, B.B. Finlay, and R.E.W. Hancock.
(2000) J. Immunol.
165:
3358-3365
PDF
228
Transgenic plants expressing cationic peptide chimeras exhibit broad-spectrum resistance to phytopathogens.
Osusky, M., G. Zhou, L.Osuska, R.E.W. Hancock, W.W. Kay and S. Misra.
(2000) Nature Biotechnology
18:
1162-1166
PDF
227
226
225
224
Complete genome sequence of Pseudomonas aeruginosa: an opportunistic pathogen
Stover, K.C., X.Q. Pham, A.L. Erwin, S.D. Mizoguchi, P. Warrener, M.J. Hickey, F.S.L. Brinkman, W. O. Hufnagle, D.J. Kowalik, M. Lagrou, R.L. Garber, L. Goltry, E. Tolentino, S. Westbrock-Wadman, Y. Yuan, L.L. Brody, S.N. Coulter, K.R. Folger, A. Kas, R. Lim, K. Smith, D. Spencer, G.K.-S. Wong, Z. Wu, I. Paulsen, J. Reizer, M.H. Saier, R.E.W. Hancock, S. Lory, and M.V. Olson.
(2000) Nature
406:
959-964
PDF
223
222
221
220
Comparative genomics of Helicobacter pylori: Analysis of the outer membrane protein families.
Alm, R., J. Bina, B.M. Andrews, P. Doig, R.E.W. Hancock and T.J. Trust.
(2000) Infect. Immun.
68:
4155-4168
PDF
219
218
Antibacterial action of structurally diverse cationic peptides on Gram-positive bacteria.
Friedrich, C.L., D. Moyles, T.J.Beveridge, and R.E.W. Hancock.
(2000) Antimicrob. Agents Chemother.
44:
2086-2092
PDF
217
Salmonella typhimurium and lipopolysaccharide induce similar changes in macrophage gene expression.
Rosenberger, C.M., M.G. Scott, M.R. Gold, R.E.W. Hancock, and B.B. Finlay
(2000) J. Immunol.
164:
5594-5904
PDF
216
In vitro characterization of the anticancer activity of membrane-active cationic peptides. I. Peptide-mediated cytotoxicity and peptide-enhanced cytotoxic activity of doxyrubicin against wild-type and P-glycoprotein over-expressing tumor cell lines.
Johnstone, S.A., K. Gelmon, L.D. Mayer, R.E.W. Hancock, and M.B. Bally
(2000) Anti-Cancer Drug Design
15:
151-160
215
214
213
212
Antimicrobial peptides protect Coho salmon from Vibrio anguillarum infections.
Jia, X., A. Patrzykat, R. Devlin, P.A. Ackerman, G.K. Iwama, and R.E.W. Hancock.
(2000) Appl. Environ. Microbiol
66:
1928-1932
PDF
211
210
Cutting Edge: Cationic antimicrobial peptides block the binding of lipopolysaccharide (LPS) to LPS binding protein.
Scott, M.G., A.C.E. Vreugdenhil, W.A. Buurman, R.E.W. Hancock, and M.R. Gold.
(2000) J. Immunol.
164:
549-553
PDF
209
Helicobacter pylori uptake and efflux: Basis for intrinsic susceptibility to antibiotics in vitro.
Bina, J., R. A. Alm, M. Uria-Nuickelsen, S.R.Thomas, T.J.Trust, and R.E.W. Hancock.
(2000) Antimicrob. Agents Chemother.
44:
248-254
PDF
208
207
PhoP-PhoQ homologues in Pseudomonas aeruginosa regulate expression of the outer-membrane protein OprH and Polymyxin B resistance.
Macfarlane, E.L.A., A.Kwasnicka, M.M.Ochs, and R.E.W.Hancock.
(1999) Molec. Microbiol.
34:
305-316
PDF
206
205
204
Dissociation of antimicrobial and hemolytic activities in cyclic peptide diastereomers by systematic alterations in amphipathicity.
Kondejewski, L.H., M.Jelokhani-Niaraki, S.W.Farmer, B. Lix, C.M.Kay, B.D.Sykes, R.E.W.Hancock, and R.S.Hodges.
(1999) J. Biol. Chem.
274:
13181-13192
PDF
203
Negative regulation of the Pseudomonas aeruginosa outer membrane porin OprD selective for imipenem and basic amino acids
Ochs, M.M., M.P.McCusker, M.Bains and R.E.W.Hancock.
(1999) Antimicrob. Agents Chemother.
43:
1085-1090
PDF
202
201
200
Salt-resistant alpha-helical cationic antimicrobial peptides.
Friedrich, C., M.G. Scott, N.Karunaratne, H.Yan, and R.E.W.Hancock.
(1999) Antimicrob. Agents Chemother.
43:
1542-1548
PDF
199
198
197
Identification of oprG, a gene encoding a major outer membrane protein of Pseudomonas aeruginosa.
Gensberg, K., A.W.Smith, F.S.L.Brinkman, and R.E.W.Hancock.
(1999) J. Antimicrob. Chemother.
43:
607-608
PDF
196
195
194
Structural variations in nisin associated with different membrane mimicking and pH environments.
Dykes, G.A., R.E.W.Hancock, and J.W.Hastings.
(1998) Biochem. Biophys. Res. Commun.
247:
723-727
PDF
193
Determinants of recombinant production of antimicrobial cationic peptides and creation of peptide variants in bacteria
Zhang, L., T.Falla, M.Wu, S.Fidai, J.Burian, W.Kay, and R.E.W.Hancock.
(1998) Biochem. Biophys. Res. Commun.
247:
674-680
PDF
192
191
Influence of preformed α-helix and α-helix induction on the activity of cationic antimicrobial peptides.
Houston,M.E., L.H.Kondejewski, D.N.Karunaratne, M.Gough, S.Fidai, R.S.Hodges, and R.E.W.Hancock.
(1998) J.Peptide Res.
52:
81-88
PDF
190
189
188
187
186
Cloning and characterization of the major outer membrane protein gene (OmpH) of Pasteurella multocida X-73.
Luo, Y., J.R. Glisson, M.W. Jackwood, R.E.W. Hancock, M. Bains, I.N. Cheng, and C. Wang.
(1997) J. Bacteriol.
179:
7856-7864
PDF
185
Antimycobacterial polyynes of Devil’sClub (Oplopanax horridus), a north american native medicinal plant.
Kobaisy, M., Z.Abramowski, L.Lerner, G.Saxena, R.E.W.Hancock, G.H.N.Towers, D.Doxsee, and R.W.Stokes
(1997) J. Natural Prod.
60:
1210-1213
184
183
Influence of OprM expression on multiple antibiotic resistance in Pseudomonas aeruginosa.
Wong, K.K.Y., K.Poole, N.Gotoh, and R.E.W.Hancock.
(1997) Antimicrob. Agents Chemother.
41:
2009-2012
PDF
182
Sequence analysis and recombinant expression of a 28-kilodalton Treponema pallidum subsp. pallidum rare outer membrane protein (Tromp2).
Champion, C.I., D.R. Blanco, M.M. Exner, H. Erdjument-Bromage, R.E.W. Hancock, P. Tempst, J.N. Miller and M.A. Lovett.
(1997) J. Bacteriol.
179:
1230-1238
PDF
181
180
179
178
177
176
175
Anti-mycobacterial screening of British Columbian Medicinal Plants.
McCutcheon, A.R., R.W. Stokes, L.M. Thorson, S.M. Ellis, R.E.W. Hancock, and G.H.N. Towers.
(1997) Intl. Journ. Pharmacog.
35:
77-83
PDF
174
173
Purification and partial characterization of the OmpA family of proteins of Pasteurella haemolytica.
Mahasreshti, P.J., G.L. Murphy, J.H. Wyckoff, S. Farmer, R.E.W. Hancock and A.W. Confer.
(1997) Infect. Immun.
65:
211-218
PDF
172
Recombinant Treponema pallidum rare outer membrane protein 1 (Tromp1) expressed in Escherichia coli has porin activity and surface antigenic exposure.
Blanco, D.R., C.I. Champion, M.M. Exner, E.S. Shang, J.T. Skare, R.E.W. Hancock, J.N. Miller and M.A. Lovett.
(1996) J. Bacteriol.
178:
6685-6692
PDF
171
Effect of ring size of gramicidin S analogs on structure, antibacterial and hemolytic activity.
Kondejewski, L.H., S.W. Farmer, D.S. Wishart, C.M. Kay, R.E.W. Hancock, and R.S. Hodges.
(1996) J. Biol. Chem.
271:
25261-25268
PDF
170
Anti-endotoxin potential of cationic peptide antimicrobials.
169
Role of gyrA mutation and loss of OprF in the multiple antibiotic resistance (MAR) phenotype of Pseudomonas aeruginosa G49.
Pumbwe, L., M.J. Everett, R.E.W. Hancock, and L.J.V. Piddock.
(1996) FEMS Microbiol. Lett.
143:
25-28
PDF
168
167
166
165
164
163
Antibacterial and antifungal polyine compounds from Glehnia littoralis ssp Leiocarpa.
Matsuura, H., G. Saxena, S.W. Farmer, R.E.W. Hancock, and G.H.N. Towers.
(1996) Planta Medica
62:
256-259
PDF
162
161
Gramicidin S is active against both gram-positive and gram-negative bacteria.
Kondejewski, L.H., S.W. Farmer, D.S. Wishart, R.E.W. Hancock and R.S. Hodges.
(1996) Int. J. Pept. Prot. Res.
47:
460-466
PDF
160
Antibacterial in vitro activity of fourth generation cephalosporins.
Hancock, R.E.W. and F. Bellido.
(1996) J. Chemotherapy
8 Supp 2:
31-36
159
158
Physical mapping of 32 genetic markers on the Pseudomonas aeruginosa PAO1 chromosome.
Liao, X., I. Charlebois, C. Ouellet, M.-J. Morency, K. Dewar, J. Lightfoot, J. Foster, R. Siehnel, H. Schweizer, J. Lam, R.E.W. Hancock and R.C. Levesque.
(1996) Microbiology
142:
79-86
PDF
157
An antibacterial thiophene from Balsamorhiza sagittata.
Matsuura, H., G. Saxena, S.W. Farmer, R.E.W. Hancock and G.H.N. Towers.
(1996) Planta Medica
62:
65-66
PDF
156
155
154
Functional and regulatory analysis of the OmpF-like porin, OpnP, of the symbiotic bacterium Xenorhabdus nematophilus.
Forst, S., J. Waukau, G. Leisman, M. Exner and R.E.W. Hancock.
(1995) Molec. Microbiol.
18:
779-789
PDF
153
152
Antibacterial and antifungal compounds from Empetrum nigrum.
Matsuura, H., G. Saxena, S.W. Farmer, R.E.W. Hancock and G.H.N. Towers.
(1995) Planta Medica
61:
580
PDF
151
150
149
Antiviral screening of British Columbian medicinal plants.
McCutcheon, A.R., T.E. Roberts, E. Gibbons, S.M. Ellis, L.A. Babiuk, R.E.W. Hancock, and G.H.N. Towers.
(1995) J. Ethnopharmacol.
49:
101-110
PDF
148
Porin activity and sequence analysis of a 31-kilodalton Treponema pallidum subsp. pallidum rare outer membrane protein (Tromp1).
Blanco, D.R., C.I. Champion, M.E. Exner, H. Erdjument-Bromage, R.E.W. Hancock, P. Tempst, J.N. Miller, and M.A. Lovett.
(1995) J. Bacteriol.
177:
3556-3562
PDF
147
The rare outer membrane protein, OmpL1, of pathogenic Leptospira species is a heat-modifiable porin.
Shang, E.S., M.M. Exner, T.A. Summers, C. Martinich, C.I. Champion, R.E.W. Hancock, and D.A. Haake.
(1995) Infect. Immun.
63:
3174-3181
PDF
146
145
144
Development of multiple-antibiotic-resistant (MAR) mutants of Pseudomonas aeruginosa after serial exposure to fluoroquinolones.
Zhanel, G.G., J.A. Karlowsky, M.H. Saunders, R.J. Davidson, D.J. Hoban, R.E.W. Hancock, I. McLean, and L.E. Nicolle.
(1995) Antimicrob. Agents Chemother.
39:
489-495
PDF
143
142
Use of specific dyes in the detection of antimicrobial compounds from crude plant extracts using a thin layer chromatography agar overlay technique.
Saxena, G., S. Farmer, G.H.N. Towers, and R.E.W. Hancock
(1995) Phytochem. Anal
6:
125-129
141
Antimicrobial compounds from Alnus rubra
Saxena, G., S. Farmer, R.E.W. Hancock, and G.H.N. Towers
(1995) Intl. J. Pharmacognosy
33:
33-36
PDF
140
Antimicrobial constituents of Rhus glabra.
Saxena, G., A.R. McCutcheon, S. Farmer, G.H.N. Towers and R.E.W. Hancock.
(1994) J. Ethnopharmacol.
42:
95-99
140
Cationic bactericidal peptides.
Hancock, R.E.W., T. Falla and M.H. Brown,
(1995) Adv. Microb. Physiol
37:
135-175
139
Isolation of the outer membranes from Treponema pallidum and Treponema vincentii.
Blanco, D.R., K. Reimann, J. Skare, C.I. Champion, D. Foley, M.M. Exner, R.E.W. Hancock, J.N. Miller, and M.A. Lovett.
(1994) J. Bacteriol.
176:
6088-6099
PDF
138
Antifungal screening of medicinal plants of British Columbian native peoples
McCutcheon, A.R., S.M. Ellis, R.E.W. Hancock and G.H.N. Towers.
(1994) J. Ethnopharmacol.
44:
157-169
137
136
135
134
133
Conservation of surface epitopes in Pseudomonas aeruginosa outer membrane porin protein OprF.
Martin, N.M. E. G. Rawling, R. Wong, M. Rosok, and R.E.W. Hancock
(1993) FEMS Microbiol. Lett.
113:
261-266
PDF
132
131
130
129
Pore-forming properties of the major 53-kilodalton surface antigen from the outer sheath of Treponema denticola.
Egli, C., W.K. Leung, K.H. Müller, R.E.W. Hancock, and B.C. McBride
(1993) Infect. Immun.
61:
1694-1699
PDF
128
127
126
Analysis of two gene regions involved in the expression of the imipenem-specific, outer membrane porin protein OprD of Pseudomonas aeruginosa.
Huang, H., R.J. Siehnel, F. Bellido, E. Rawling, and R.E.W. Hancock
(1992) FEMS Microbiol. Lett.
97:
267-274
PDF
125
Role of Pseudomonas aeruginosa outer membrane protein OprH in polymyxin and gentamicin resistance: Isolation of an OprH-deficient mutant by gene replacement techniques.
Young, M.L., M. Bains, A. Bell and R.E.W. Hancock.
(1992) Antimicrob. Agents Chemother.
36:
2566-2568
PDF
124
123
122
Antibiotic screening of medicinal plants of the British Columbian native peoples.
McCutcheon, A.R., S.M. Ellis, R.E.W. Hancock and G.H.N. Towers.
(1992) J. Ethnopharmacol.
37:
213-223
121
Analysis of the Pseudomonas aeruginosa major outer membrane protein OprF by use of truncated OprF derivatives and monoclonal antibodies.
Finnen, R.L., N.L. Martin, R.J. Siehnel, W.A. Woodruff, M. Rosok, and R.E.W. Hancock.
(1992) J. Bacteriol.
174:
4977-4985.
PDF
120
Reevaluation, using intact cells, of the exclusion limit and role of porin OprF in Pseudomonas aeruginosa outer membrane permeability.
Bellido, F., N.L. Martin, R.J. Siehnel, and R.E.W. Hancock.
(1992) J. Bacteriol.
174:
5196-5203.
PDF
119
Characterization of lipid A from Pseudomonas aeruginosa O-antigenic B-band lipopolysaccharide by 1D and 2D NMR and mass spectral analysis.
Karunaratne, D.N., J.C. Richards and R.E.W. Hancock.
(1992) Arch. Biochem. Biophys.
299:
368-376.
PDF
118
Extracellular lipase from Pseudomonas aeruginosa is an amphiphilic protein.
Jaeger, K.E., F.-J. Adrian, H.E. Meyer, R.E.W. Hancock, and U.K. Winkler.
(1992) Biochim. Biophys. Acta.
1120:
315-321.
PDF
117
116
115
A pleiotropic, post-therapy, enoxacin-resistant mutant of Pseudomonas aeruginosa.
Piddock, L.J.V., M.C. Hall, F. Bellido, M. Bains, and R.E.W. Hancock
(1992) Antimicrob. Agents Chemother.
36:
1057-1061.
PDF
114
113
112
111
110
109
108
107
106
Interaction of aminoglycosides with the outer membranes and purified lipopolysaccharide and OmpF porin of Escherichia coli.
Hancock, R.E.W., S.W. Farmer, Z. Li, and K. Poole.
(1991) Antimicrob. Agents Chemother.
35:
1309-1314.
PDF
105
Conservation of the gene for outer membrane protein OprF in the family Pseudomonadaceae: Sequence of the Pseudomonas syringae OprF gene.
Ullstrom, C.A., R. Siehnel, W. Woodruff, S. Steinbach, and R.E.W. Hancock.
(1991) J. Bacteriol.
173:
768-775.
PDF
104
103
102
Comparison of the outer membrane protein and lipopolysaccharide profiles of mucoid and nonmucoid Pseudomonas aeruginosa.
Kelly, N.M., M.H. MacDonald, N. Martin, T.I. Nicas, and R.E.W. Hancock.
(1990) J. Clin. Microbiol.
28:
2017-2021.
PDF
101
Pseudomonas aeruginosa pili as ligands for nonopsonic phagocytosis by fibronectin-stimulated macrophages.
Kelly, N.M., J.L. Kluftinger, B.L. Pasloske, W. Paranchych, and R.E.W. Hancock.
(1989) Infect. Immun.
57:
3841-3845.
PDF
100
Fibronectin as an enhancer of nonopsonic phagocytosis of Pseudomonas aeruginosa by macrophages.
Kluftinger, J.L., N.M. Kelly, B.H. Jost and R.E.W. Hancock.
(1989) Infect. Immun.
57:
2782-2785.
PDF
99
Determinants of the efficacy of tobramycin therapy against isogenic nonmucoid and mucoid derivatives of Pseudomonas aeruginosa PA01 growing in peritoneal chambers in mice.
Kelly, N.M., E.G. Rawling and R.E.W. Hancock.
(1989) Antimicrob. Agents Chemother.
33:
1207-1211.
PDF
98
97
96
95
94
93
92
91
90
89
Monoclonal antibodies provide protection against ocular Pseudomonas aeruginosa infection.
Moon, M.M., L.D. Hazlett, R.E.W. Hancock, R.S. Berk and R. Barrett.
(1988) Invest. Opthamol. Vis. Sci.
29:
1277-1284.
PDF
88
Enhanced binding of polycationic antibiotics to lipopolysaccharide from an aminoglycoside-supersusceptible, tolA mutant strain of Pseudomonas aeruginosa.
Rivera, M., R.E.W. Hancock, J.G. Sawyer, A. Haug and E.J. McGroarty.
(1988) Antimicrob. Agents Chemother.
32:
649-655.
PDF
87
86
85
84
Large-scale purification and biochemical characterization of crystallization-grade porin protein P from Pseudomonas aeruginosa.
Worobec, B., N.L. Martin, W. McCubbin, C. Kay, G. Brayer and R.E.W. Hancock.
(1988) Biochim. Biophys. Acta.
939:
366-374.
PDF
83
Gene cloning and expression of the Pseudomonas aeruginosa periplasmic phosphate-binding protein.
Worobec, B., R. Siehnel, P. Gladman and R.E.W. Hancock.
(1988) FEMS Microbiol. Lett.
52:
235-238.
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Colonial dissociation and susceptibility to phagocytosis of Pseudomonas aeruginosa grown in a chamber implant model in mice.
Kelly, N.M., J.P. Arbuthnott, J. Battershill, S. Kuo, and R.E.W. Hancock.
(1987) Infect. Immun.
55:
2841-2843.
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An immunohistological evaluation of Pseudomonas aeruginosa pulmonary infection in two patients with cystic fibrosis.
Speert, D.P., J.E. Dimmick, G.B. Pier, J.M. Saunders, R.E.W. Hancock and N.M. Kelly.
(1987) Pediatr. Res.
22:
743-747.
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Role of β-lactamase in in vivo development of ceftazidime resistance in experimental Pseudomonas aeruginosa endocarditis.
Bayer, A.S., J. Peters, T.R. Parr, L. Chan and R.E.W. Hancock.
(1987) Antimicrob. Agents Chemother.
31:
253-258.
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73
Role of porins in intrinsic antibiotic resistance of Pseudomonas cepacia.
Parr, T.R., R.A. Moore, L.V. Moore and R.E.W. Hancock.
(1987) Antimicrob. Agents Chemother.
31:
121-123.
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Isolation of the outer membrane and characterization of the major outer membrane protein of Spirocheata aurantia.
Kropinski, A.M., T.R. Parr, B. Angus, R.E.W. Hancock, W.C. Ghiorse, and E.P. Greenberg.
(1987) J. Bacteriol.
169:
172-179
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Role of lysines in ion selectivity of bacterial outer membrane porins.
Hancock, R.E.W., A. Schmidt, K. Bauer, and R. Benz.
(1986) Biochim. Biophys. Acta.
860:
263-267.
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65
Expression in Escherichia coli and function of Pseudomonas aeruginosa outer membrane porin protein F.
Woodruff, W.A., T.R. Parr, R.E.W. Hancock, L. Hanne, T.I. Nicas, and B. Iglewski.
(1986) J. Bacteriol.
167:
473-479.
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Monoclonal antibodies specific for Escherichia coli J-5 lipopolysaccharide: Cross-reaction with other gram-negative bacterial species.
Mutharia, L.M., G. Crockford, W.C. Bogard, and R.E.W. Hancock.
(1984) Infect. Immun.
45:
631-636.
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Photodynamic action on Escherichia coli of natural acetylenic thiophenes, particularly 5-(buten-l-ynyl)-2,2'-bithienyl.
40
Immunogenicity of Pseudomonas aeruginosa outer membrane antigens examined by crossed immunoelectrophoresis.
Lam, J.S., L.M. Mutharia, R.E.W. Hancock, N. Hoiby, K. Lam, L. Baek, and J.W. Costerton.
(1983) Infect. Immun.
42:
88-98.
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39
Effects of growth temperature, 47-megadalton plasmid, and calcium deficiency on the outer membrane protein porin and lipopolysaccharide composition of Yersina pestis EV76.
Darveau, R.P., W.T. Charnetzky, R.E. Hurlbert, and R.E.W. Hancock.
(1983) Infect. Immun.
42:
1092-1101.
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38
Purification and reconstitution in lipid bilayer membranes of an outer membrane pore-forming protein of Aeromonas salmonicida.
Darveau, R.P., S. MacIntyre, J.T. Buckley, and R.E.W. Hancock.
(1983) J. Bacteriol.
156:
1006-1011.
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37
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Pseudomonas aeruginosa isolates from patients with cystic fibrosis: a class of serum-sensitive, nontypable strains deficient in lipopolysaccharide 0 side-chains.
Hancock, R.E.W., L.M. Mutharia, L. Chan, R.P. Darveau, D.P. Speert, and G.B. Pier
(1983) Infect. Immun.
42:
170-177.
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Monoclonal antibodies against Pseudomonas aeruginosa outer membrane antigens: Isolation and characterization.
Hancock, R.E.W., A.A. Wieczorek, L.M. Mutharia, and K. Poole.
(1982) Infect. Immun.
37:
166-171.
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23
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Chemical and chromatographic analysis of lipopolysaccharide from an antibiotic-supersusceptible mutant of Pseudomonas aeruginosa.
Kropinski, A.M.B., J. Kuzio, B.L. Angus, and R.E.W. Hancock.
(1982) Antimicrob. Agents Chemother.
21:
310-319.
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21
Outer membrane permeability in Pseudomonas aeruginosa: Comparison of a wild-type with an antibiotic-supersusceptible mutant.
Angus, B.L., A.M. Carey, D.A. Caron, A.M.B. Kropinski, and R.E.W. Hancock.
(1982) Antimicrob. Agents Chemother.
21:
299-309.
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