Reverse Vaccinology

The aim for the ReVAMP project was to develop vaccines against, and diagnostics to detect, two important infectious diseases of cattle, Johne’s disease and bovine tuberculosis.

Infections are a leading cause of sickness and death in cattle, causing direct economic losses to producers and even more serious losses associated with international trade restrictions (as seen with mad cow disease) and decreased public confidence in food quality. Infectious diseases also pose a risk to human health if they are transferred to people. The most effective way to prevent infectious disease in animals such as cattle is vaccination. Lack of effective vaccines for some diseases contributes to the overuse of antibiotics and to a strategy of slaughtering infected animals, which has come under increasing public scrutiny.

The project value was $7.4 million funded from Genome Canada, VIDO-InterVac, Genome Prairie and Genome British Columbia.