All Peer-reviewed Publications

Displaying 730 Publications

731

Gene Expression Profiling in Pediatric Appendicitis

Dhillon, Bhavjinder K; Kortbeek, Simone; Baghela, Arjun; Brindle, Mary; Martin, Dori-Ann; Jenne, Craig N; Vogel, Hans J; Lee, Amy H Y; Thompson, Graham C; Hancock, Robert E W (2024) JAMA Pediatrics DOI10.1001/jamapediatrics.2023.6721

730

Antibiofilm peptides enhance the corrosion resistance of titanium in the presence of Streptococcus mutans

Wang D, Yue Y, Liu H, Zhang T, Haney EF, Hancock REW, Yu J, Shen Y. (2024) Front Bioeng Biotechnol 11: 10.3389/fbioe.2023.1339912

729

Implementation and impact of the global access principles at the University of British Columbia: current successes and future challenges

Gallini N, Hancock REW, Lester R, Sharp B, Wasan KM. (2023) Front Pharmacol. 14: 1271618

728

Influence of a D-enantiomeric peptide on the anticorrosion ability of titanium with different surface roughness against Streptococcus mutans biofilms

Wang D, Yu J, Liu H, Zhang T, Haney EF, Hancock REW, Peng L, Shen Y. (2023) J Dent 139: 104777

727

Antibiotic failure: Beyond antimicrobial resistance

Fuente-Nunez, Cesar de la; Angela Cesaro; Robert E.W. Hancock (2023) Drug Resist. Updates In Press.

726

Persistence is Key: Unresolved Immune Dysfunction is Lethal in Both COVID-19 and non-COVID-19 Sepsis

Ay An, A Baghela, PGY Zhang, R Falsafi, AH Lee, U Trahtemberg, A Baker, CC Dos Santos, R.E.W. Hancock (2023) Front. Immunol. In Press.

725

Dynamic killing effectiveness of mouthrinses and a d-enantiomeric peptide on oral multispecies biofilms grown on dental restorative material surfaces

Hu J, Yu J, Liu H, Wang Z, Haapasalo M, Haney EF, Hancock REW, Deng S, Shen Y. (2023) J Dent 134: 104552

724

Impacts of PEGylation and Glycosylation on the Biological Properties of Host Defense Peptide IDR1018

Etayash H, Yip F, Hancock REW (2023) Pharmaceutics 15(5): 1391

723

Efficient in planta production of amidated antimicrobial peptides that are active against drug-resistant ESKAPE pathogens

Chaudhary S, Ali Z, Tehseen M, Haney EF, Pantoja-Angles A, Alshehri S, Wang T, Clancy GJ, Ayach M, Hauser C, Hong PY, Hamdan SM, Hancock REW, Mahfouz M. (2023) Nat Commun 14(1): 1464

722

Predicting severity in COVID-19 disease using sepsis blood gene expression signatures

Baghela A, An A, Zhang P, Acton E, Gauthier J, Brunet-Ratnasingham E, Blimkie T, Freue GC, Kaufmann D, Lee AHY, Levesque RC, Hancock REW. (2023) Sci Rep 13(1): 1247

721

HLA-DPB1 is associated with ANCA-associated vasculitis in children

Gibson KM, Drögemöller BI, Foell D, Benseler SM, Graham J, Hancock REW, Luqmani RA, Cabral DA, Brown KL, Ross CJ; PedVas Investigator's Network. (2022) Arthritis Rheumatol. Epub : ahead of print

720

Novel Alligator Cathelicidin As-CATH8 Demonstrates Anti-Infective Activity against Clinically Relevant and Crocodylian Bacterial Pathogens

Santana FL, Estrada K, Alford MA, Wu BC, Dostert M, Pedraz L, Akhoundsadegh N, Kalsi P, Haney EF, Straus SK, Corzo G, Hancock REW (2022) Antibiotics (Basel) 11(11): 1603 PDF

719

A transcriptomic analysis of the effects of macrophage polarization and endotoxin tolerance on the response to Salmonella

Sedivy-Haley K, Blimkie T, Falsafi R, Lee AH, Hancock REW (2021) PLoS One 19(10): e0276010 PDF

718

Biodistribution and Toxicity of Innate Defense Regulator 1018 (IDR-1018)

V F Esposito T, Rodríguez-Rodríguez C, Blackadar C, Haney EF, Pletzer D, REW Hancock, Saatchi K, Häfeli UO. (2022) Eur J Pharm Biopharm online: ahead of print

717

SPECT/CT Imaging of 111Ag for the Preclinical Evaluation of Silver-Based Antimicrobial Nanomedicines

Colin Blackadar, Ka-Yee Grace Choi, Mary F. Embree, Heather M. Hennkens, Cristina Rodríguez-Rodríguez, Robert E. W. Hancock, Katayoun Saatchi, and Urs O. Häfeli (2022) ACS Appl. Mater. Interfaces 14 (23): 26382-26393

716

Assessing the Activity of Antimicrobial Peptides Against Common Marine Bacteria Located in Rotifer (Brachionus plicatilis) Cultures.

Woods, C., Woolley, L., Partridge, G, Chen, M, Haney EF, Hancock REW, Buller N, Currie A (2022) Probiotics & Antimicro. Prot. 10.1007/s12602-022-09928-2

715

Competition between Pseudomonas aeruginosa and Staphylococcus aureus is dependent on intercellular signaling and regulated by the NtrBC two-component system.

Alford, M.A., Mann, S., Akhoundsadegh, N. and REW Hancock (2022) Sci Rep 12: 9027

714

Antimicrobial properties of spray-dried cellulose nanocrystals and metal oxide-based nanoparticles-in-microspheres

Alberto Baldelli, Hashem Etayash, Hale Oguzlu, Ronit Mandal, Feng Jiang, Robert E.W. Hancock, Anubhav Pratap-Singh, (2022) Chemical Engineering Journal Advances 10: 10.1016/j.ceja.2022.100273

713

Assessing the In Vivo Effectiveness of Cationic Lipid Nanoparticles with a Triple Adjuvant for Intranasal Vaccination against the Respiratory Pathogen Bordetella pertussis

Aibani N, Patel P, Buchanan R, Strom S, Wasan KM, Hancock REW, Gerdts V, Wasan EK (2022) Mol. Pharmaceutics 10.1021/acs.molpharmaceut.1c00852

712

Gene Expression Profiling: Identification of Novel Pathways and Potential Biomarkers in Severe Acute Pancreatitis

Nesvaderani, Maryam; Dhillon, Bhavjinder K; Chew, Tracy; Tang, Benjamin F; Baghela, Arjun; Hancock, Robert EW; Eslick, Guy F; Cox, Michael (2022) Journal of the American College of Surgeons 10.1097/XCS.0000000000000115

711

Antibiofilm and immunomodulatory resorbable nanofibrous filing for dental pulp regenerative procedures

Mauricio Gonçalves da Costa Sousa, Gabriela Conceição de Almeida, Danilo César Martins Mota, Rosiane Andrade da Costa, Simoni Campos Dias, Samuel Nunes Limberger, Frank Ko, Li Ting Lin, Evan F. Haney, Hashem Etayash, Beverlie Baquir, Michael J. Trimble, Ya Shen, Zheng Su, Markus Haapasalo, Daniel Pletzer, Letícia Chaves de Souza, Gláucia Schuindt Teixeira, Renato M. Silva, Robert E.W. Hancock, Octavio Luiz Franco, Taia Maria Berto Rezende, (2022) Bioactive Materials 16: 173-186

710

Self-Assembly of Antimicrobial Peptoids Impacts Their Biological Effects on ESKAPE Bacterial Pathogens

Nielsen JE, Alford MA, Yung DBY, Molchanova N, Fortkort JA, Lin JS, Diamond G, Hancock REW, Jenssen H, Pletzer D, Lund R, Barron AE. (2022) ACS Infect. Dis. 10.1021/acsinfecdis.1c00536

709

Predicting sepsis severity at first clinical presentation: The role of endotypes and mechanistic signatures

Arjun Baghela, Olga M. Pena, Amy H. Lee, Beverlie Baquir, Reza Falsafi,
Andy An, Susan W. Farmer, Andrew Hurlburt, Alvaro Mondragon-Cardona, Juan Diego Rivera, Andrew Baker, Uriel Trahtemberg, Maryam Shojaei, Carlos Eduardo Jimenez-Canizales, Claudia C. dos Santos, Benjamin Tang, Hjalmar R. Bouma, Gabriela V. Cohen Freue, and Robert E.W. Hancock (2022) eBiomedicine 75: 103776

708

Gut microbes shape microglia and cognitive function during malnutrition

Bauer KC, York EM, Cirstea MS, Radisavljevic N, Petersen C, Huus KE, Brown EM, Bozorgmehr T, Berdún R, Bernier LP, Lee AHY, Woodward SE, Krekhno Z, Han J, Hancock REW, Ayala V, MacVicar BA, Finlay BB. (2022) Glia Epub : ahead of print

707

Systems Biology Methods Applied to Blood and Tissue for a Comprehensive Analysis of Immune Response to Hepatitis B Vaccine in Adults

Ben-Othman R, B Cai, AC Liu, N Varankovich, D He, TM Blimkie, AH Lee, EE Gill, M Novotny, B Aevermann, S Drissler, CP Shannon, S McCann, K Marty, G Bjornson, RD Edgar, D Tse S Lin, N Gladish, J Maclsaac, N Amenyogbe, Q Chan, A Llibre, J Collin, E Landais, K Le, SM Reiss, WC Koff, C Havenar-Daughton, M Heran, B Sangha, D Walt, M Krajden, S Crotty, D Sok, B Briney, DR Burton, D Duffy, LJ Foster, WW Mohn, MS Kobor, SJ Tebbutt, RR Brinkman, RH Scheuermann, R.E.W. Hancock , TR Kollmann, M Sadarangani (2020) Front. Immunol. 11: 580373 PDF

706

Multifunctional Antibiotic-Host Defense Peptide Conjugate Kills Bacteria, Eradicates Biofilms, and Modulates the Innate Immune Response

Etayash E, M Alford, N Akhoundsadegh, M Drayton, SK Straus, R.E.W. Hancock (2021) J. Med. Chem. 64(22): 16854-16863

705

Host Defense Peptide-Mimicking Polymers and Polymeric-Brush-Tethered Host Defense Peptides: Recent Developments, Limitations, and Potential Success

Etayash H, REW Hancock (2021) Pharmaceutics 13: 1820

704

Enzymatically releasable polyethylene glycol - host defense peptide conjugates with improved activity and biocompatibility

Drayton M, Alford MA, Pletzer D, Haney EF, Machado Y, Luo HD, Overall CM, Kizhakkedathu JN, Hancock REW, Straus SK. (2021) J Control Release 339: 220-231

703

Machine learning-based single cell and integrative analysis reveals that baseline mDC predisposition predicts protective Hepatitis B vaccine response.

Aevermann B.D., CP. Shannon, M. Novotny, R. Ben-Othman, B. Cai, Y. Zhang, J.C. Ye, M.S. Kobor, A. Lee, N. Gladish, T.M. Blimkie, R.E.W. Hancock, A. Llibre, D. Duffy, W.C. Koff, M. Sadarangani, S.J. Tebbutt, T.R. Kollmann, and R.H. Scheuermann. (2021) Front. Immunol. 12: 10.1101/2021.02.22.21251864 PDF

702

The Pseudomonas aeruginosa whole genome sequence - a 20th anniversary celebration.

Brinkman, F.S.L., G. Winsor, R.E. Done, A. Filloux, V.I. Francis, J.B. Goldberg, E.P. Greenberg, K. Han, R.E.W. Hancock, C.H. Haney, S. Häußler, J. Klockgether, I. Lamont, R.C. Levesque, S. Lory, P.I. Nikel, S.L. Porter, M.W. Scurlock, H.P. Schweizer, B. Tümmler, M. Wang, and M. Welch. (2021) Micorbiology 79: 25-88

701

PaIntDB: Network-based omics integration and visualization using protein-protein interactions in Pseudomonas aeruginosa

Castillo-Arnemann JJ, Solodova O, Dhillon BK, Hancock, R.E.W. (2021) Bioinformatics btab363: 10.1093/bioinformatics/btab36

700

Antibiofilm activity of host defence peptides: complexity provides opportunities.

Hancock, R.E.W., Alford, M.A. & Haney, E.F (2021) Nature Rev. Microbiol. 10.1038/s41579-021-00585-w

699

Genomic insights into diversity, virulence and resistance of Klebsiella pneumoniae extensively drug resistant clinical isolates.

Lee, A.H.Y., W.F. Porto, C. de Faria-Jr, S.C. Dias, S.A. Alencar, D.J. Pickard, R.E.W. Hancock, and O.L. Franco. (2021) Microb Genom. 7: 10.1099/mgen.0.000613 PDF

698

RNase III and RNase E Influence Posttranscriptional Regulatory Networks Involved in Virulence Factor Production, Metabolism, and Regulatory RNA Processing in Bordetella pertussis

Ifill G, Blimkie T, Lee AH, Mackie GA, Chen Q, Stibitz S, Hancock REW, Fernandez RC. (2021) mSphere 6(4): 10.1128/mSphere.00650-21 PDF

697

Contribution of swarming motility to dissemination in a Pseudomonas aeruginosa murine skin abscess infection model

Coleman SR, D Pletzer, R.E.W. Hancock (2020) J. Infect. Diseases 224: 726–733

696

Testing physiologically relevant conditions in minimal inhibitory concentration assays

Belanger C and R.E.W. Hancock (2021) Nat Protoc 16: 3761-3774

695

Rapid Assembly of Infection-Resistant Coatings: Screening and Identification of Antimicrobial Peptides Works in Cooperation with an Antifouling Background

Yu K, Alzahrani A, Khoddami S, Cheng JTJ, Mei Y, Gill A, Luo HD, Haney EF, Hilpert K, Hancock REW, Lange D, Kizhakkedathu JN. (2021) ACS Appl. Mater. Interfaces 13: 36784-36799

694

NtrBC selectively regulates host-pathogen interactions, virulence and ciprofloxacin susceptibility of Pseudomonas aeruginosa.

Alford, M.A., B. Baquir, A. An, K.-Y.G. Choi, and R.E.W. Hancock (2021) Front Cell Infect Microbiol . 44: 553 PDF

693

The use of host defense peptides in root canal therapy in rats

Lima SMF, Freire MS, Cantuária APC, Martins DCM, Amorim IA, Dantas EMGL, Farias JO, Castro MB, Silva JS, Barriviera FA, Barriviera M, Almeida JA, Uehara IA, Silva MJB, Oliveira APL, Silva ON, Hancock REW, Franco OL, Rezende TMB. (2020) Clin Oral Investig. 25: 3623-3632

691

Microtitre plate assays to assess antibiofilm activity against bacteria.

Haney, E.F., M.J. Trimble, and R.E.W. Hancock. (2021) Nature Protocols 16: 2615–2632

690

Peptide 1018 inhibits swarming and influences Anr-regulated gene expression downstream of the stringent stress response in Pseudomonas aeruginosa

Wilkinson LV, Alford MA, Coleman SR,Wu BC, Lee AHY, Blimkie TM, Bains M, Falsafi R, Pletzer D, Hancock, R.E.W. (2021) PLoS One 16: e0250977 PDF

689

Identification of a crocodylian β-defensin variant from Alligator mississippiensis with antimicrobial and antibiofilm activity

Santana FL, Arenas I, Haney EF, Estrada K, Hancock, R.E.W., Corzo G (2021) Peptides 141: 170549

688

Immunomodulatory streptococci that inhibit CXCL8 secretion and NFκB activation are common members of the oral microbiota.

Myers, S., T. Do. J.L. Meade, A. Tugnait, J.J. Vernon, J. Pistolic, R.E.W. Hancock, P.D. Marsh, H.M. Trivedi, D. Chen and D.A. Devine. (2021) J. Med. Microbiol. 70: 001329 PDF

687

Assessing biofilm inhibition and immunomodulatory activity of small amounts of synthetic host defense peptides synthesized using SPOT-array technology.

Etayash, H., Haney, E.F. & Hancock, R.E.W. (2021) Nature Protocols 16: 1850–1870

686

An Overview of Biological and Computational Methods for Designing Mechanism-Informed Anti-biofilm Agents

An Ay, Choi KYG, Baghela AS, Hancock, R.E.W. (2021) Front. Microbiol. 12: 640787 PDF

685

Self-Limiting Mussel Inspired Thin Antifouling Coating with Broad-Spectrum Resistance to Biofilm Formation to Prevent Catheter-Associated Infection in Mouse and Porcine Models

Yu K, Alzahrani A, Khoddami S, Ferreira D, Scotland KB, Cheng JTJ, Yazdani-Ahmadabadi H, Mei Y, Gill A, Takeuchi LE, Yeung E, Grecov D, Hancock REW, Chew BH, Lange D, Kizhakkedathu JN. (2021) Adv Healthc Mater. e2001573:

684

Recovery of oral in vitro biofilms after exposure to peptides and chlorhexidine.

Zhang, T., L.Xia, Z. Wang, R.E.W. Hancock, and M. Haapasalo. (2021) J Endod 47: 466-471

683

Different disease endotypes in phenotypically similar vasculitides affecting small-to-medium sized blood vessels.

Gill, E.E., M. Smith, K.M. Gibson, K.A. Morishita, A.H. Lee, R. Falsafi, J. Graham, D. Foell, S. Benseler, Colin Ross, R. Luqmani, D. Cabral, R.E.W. Hancock, and K.L. Brown. (2021) Front. Immunol. 12: 638571 PDF

682

Murine models of sinusitis infection for screening antimicrobial and immunomodulatory therapies.

Alford, M.A., K.-Y.G. Choi, M.J. Trimble, H. Masoudi, P. Kalsi, D. Pletzer, R.E.W. Hancock. (2021) Front Cell Infect Microbiol . 11: 621081 PDF

681

Rapid microwave-based method for the preparation of antimicrobial lignin-capped silver nanoparticles active against multidrug-resistant bacteria

Pletzer D, Asnis J, Slavin YN, Hancock REW, Bach H, Saatchi K, Häfeli UO. (2021) Int J Pharm. 596:120299: 10.1016/j.ijpharm.2021.120299

680

Ivacaftor or lumacaftor/ivacaftor treatment does not alter the core CF airway epithelial gene response to rhinovirus

De Jong, Emma; Luke W. Garratt, Kevin Looi, Amy H.Y. Lee, Kak-Ming Ling, Maren L. Smith, Reza Falsafi, Erika N. Sutanto, Jessica Hillas, Thomas Iosifidis, Kelly M. Martinovich, Nicole C. Shaw, Samuel T. Montgomery, Elizabeth Kicic-Starcevich, Francis J. Lannigan, Shyan Vijayasekaran, Robert E.W. Hancock, Stephen M. Stick, Anthony Kicic, CF AREST, (2020) J Cyst Fibros 19(4): 10.1016/j.jcf.2020.07.004

679

Human organoid biofilm model for assessing antibiofilm activity of novel agents.

Bing (Catherine) Wu, Evan F. Haney, Noushin Akhoundsadegh, Daniel Pletzer, Michael J. Trimble, Alwin E. Adriaans, Peter H. Nibbering & Robert E. W. Hancock (2021) npj Biofilms Microbiomes 7: https://doi.org/10.1038/s41522-020-00182-4 PDF

678

The small RNAs PA2952.1 and PrrH as regulators of virulence, motility and iron metabolism in Pseudomonas aeruginosa

Coleman SR, Manjeet Bains, Maren L. Smith, Victor Spicer, Ying Lao, Patrick K. Taylor, Neeloffer Mookherjee, Robert E.W. Hancock (2020) Appl. Environ. Microbiol 87: doi: 10.1128/AEM.02182-20 PDF

677

Antibiofilm peptides: overcoming biofilm-related treatment failure.

Dostert, M., M.J. Trimble, and R.E.W. Hancock. (2021) RSC Advances 11: 2718-2728 PDF

676

Identification of novel targets of azithromycin activity against Pseudomonas aeruginosa grown in physiologically relevant media

Belanger CR, AHY Lee, D Pletzer, BK Dhillon, R Falsafi, R.E.W. Hancock (2020) PNAS 117: 33519-33529

675

Multi-omic data integration allows baseline immune signatures to predict hepatitis B vaccine response in a small cohort.

Shannon, C.P., T.M. Blimkie, R.B. Othman, N. Gladish, N.A. Amenyogbe, S. Drissler, R.D. Edgar, Q. Chan, M. Krajden, L.J. Foster, M.S. Kobor, B. Mohn, R.R. Brinkman, K.-A. Le Cao, R.H. Scheuermann, S.J. Tebbutt, R.E.W. Hancock, W. Koff, T. Kollmann, M. Sadarangani, and A.H. Lee. (2020) Front. Immunol. 11: 578801 PDF

674

A bovine enteric Mycobacterium infection model to analyze parenteral vaccine-induced mucosal immunity and accelerate vaccine discovery.

Facciuolo, A., A.H. Lee, M.J. Trimble, N. Rawlyk, H.G.G. Townsend, M. Bains, N. Arsic, L.M. Mutharia, A. Potter, V. Gerdts, S. Napper, R.E.W. Hancock, and P.J. Griebel. (2020) Front. Immunol. 11: PDF

673

Unique inducible filamentous motility identified in pathogenic Bacillus cereus group species

Liu MM, S Coleman, L Wilkinson, ML Smith, T Hoang, N Niyah, M Mukherjee, S Huynh, CT Parker, J Kovac, R.E.W. Hancock, EC Gaynor (2020) ISME J. 14: 2997–3010 PDF

672

Molecular dynamics simulations informed by membrane lipidomics reveal the structure–interaction relationship of polymyxins with the lipid A-based outer membrane of Acinetobacter baumannii

Jiang, X., K. Yang, B. Yuan, M. Han, Y. Zhu, K.D. Roberts, N. Patil, J. Li, B. Gong, R.E.W. Hancock, T. Velkov, F. Schreiber, L. Wang, and J. Li. (2020) J. Antimicrob. Chemother. 75(12): 3534-3543 PDF

671

Host Defense Peptide-Mimicking Amphiphilic β-Peptide Polymer (Bu:DM) Exhibiting Anti-Biofilm, Immunomodulatory, and in Vivo Anti-Infective Activity

Etayash H, Qian Y, Pletzer D, Zhang Q, Xie J, Cui R, Dai C, Ma P, Qi F, Liu R, Hancock REW. (2020) J. Med. Chem. 63: 12921-12928

670

Systems biology methods applied to blood and tissue for a comprehensive analysis of immune response to hepatitis B vaccine in adults.

Ben-Othman, R., B Cai, A. Liu, N. Varankovich, D. He, T.M Blimkie, A.H. Lee, E.E. Gill, M. Novotny, B. Aevermann, S. Drissler, C.P. Shannon, S. McCann, K. Marty, G. Bjornson, R.D. Edgar, N. Gladish, D.T.S. Lin, J. MacIsaac, N.A. Amenyogbe, Q. Chan, A. Llibre, C. Joyce, E. Landais, K. Le, S.M. Reiss, C. Havenar-Daughton, M. Heran, B. Sangha, D. Walt, M. Krajden, S. Crotty, D. Sok, B. Briney, D. Burton, D. Duffy, L.J. Foster, W.W. Mohn, M.S. Kobor, S.J. Tebbutt, R.R. Brinkman, R.H. Scheuermann, R.E.W. Hancock, T.R. Kollmann, and M. Sadarangani. (2020) Front. Immunol. 11: 580373 PDF

669

Preparing for life: Plasma proteome changes and immune system development during the first week of human life.

Bennike, T.B., B. Fatou, A. Angelidou, J.D. Arce, R. Falsafi, R. Ford, E.E. Gill, S.D. Van Haren, O.T. Idoko, A.H. Lee, R. Ben Othman, W.S. Pomat, C.P. Shannon, K.K. Smolen, S.J. Tebbutt, A. Ozonoff, P.C. Richmond, A.H.J. Van Den Biggelaar, R.E.W. Hancock, B. Kampmann, T.R. Kollmann, O. Levy, H. Steen. (2020) Front. Immunol. 11: 578505

668

Exploring the pathophysiology of post-sepsis syndrome to identify therapeutic opportunities

van der Slikkea, EC; A.Y. An, R.E.W. Hancock, H.R. Bouma (2020) eBiomedicine 61: 10.1016/j.ebiom.2020.103044 PDF

667

Cyclic Derivative of Host-Defense Peptide IDR-1018 Improves Proteolytic Stability, Suppresses Inflammation, and Enhances In Vivo Activity

Etayash H, D Pletzer, P Kumar, SK. Straus, and R.E.W. Hancock (2020) J. Med. Chem. 63: 9228–9236

666

Mechanistic understanding enables the rational design of salicylanilide combination therapies for Gram-negative infections.

Copp, J.C., D. Pletzer, A.S. Brown, J. Van der Heijden, C.M. Miton, R.J. Edgar, M.H. Rich, R.F. Little, E. Williams, R.E.W. Hancock, N. Tokuriki, and D.F. Ackerley. (2020) mBio 11: e02068-20. PDF

665

Characterization of immune responses and the lung transcriptome in a murine model of IL-33 challenge.

Piyadasa, H., D. Lloyd, A.H.Y. Lee, A. Altieri, M. Hemshekhar, N. Osawa, S. Basu, T. Blimkie, R. Falsafi, A. Halayko, R.E.W. Hancock and N. Mookherjee. (2020) Biochim. Biophys. Acta. 1866(12): 165950

664

In Vivo anti-inflammatory activity of lipidated peptidomimetics Pam-(Lys-βNspe)6-NH2 and Lau-(Lys-βNspe)6-NH2 against PMA-induced acute inflammation.

Wu, B.C., S.L. Skovbakke, H. Masoud, R.E.W. Hancock, and H. Franzyk. (2020) Front. Immunol. 11: 2102 PDF

663

Cathelicidin host defense peptides and inflammatory signaling: striking a balance.

Alford, M.A., B. Baquir, F. Santana, E.F. Haney, R.E.W. Hancock (2020) Front. Microbiol. 11: 1902 PDF

662

MDA-MB-231 Breast Cancer Cells Resistant to Pleurocidin-Family Lytic Peptides Are Chemosensitive and Exhibit Reduced Tumor-Forming Capacity.

Hilchie, AL; EE Gill, MR Power Coombs, R Falsafi, R.E.W. Hancock, David W Hoskin (2020) Biomolecules 10(9): E1220 PDF

661

A novel mouse model of chronic suppurative otitis media and its use in preclinical antibiotic evaluation

Khomtchouk KM, A Kouhi, A Xia, LA Bekale, S.M. Massa, JM. Sweere, D Pletzer, R.E.W Hancock, PL. Bollyky, PL. Santa Maria (2020) Science Advances 6: DOI: 10.1126/sciadv.abc1828 PDF

660

The value of antimicrobial peptides in the age of resistance

Magana, Maria; Muthuirulan Pushpanathan, Ana L Santos, Leon Leanse, Michael Fernandez, Anastasios Ioannidis, Marc A Giulianotti, Yiorgos Apidianakis, Steven Bradfute, Andrew L Ferguson, Artem Cherkasov, Mohamed N Seleem, Clemencia Pinilla, Cesar de la Fuente-Nunez, Themis Lazaridis, Tianhong Dai, Richard A Houghten, Robert E W Hancock, George P Tegos (2020) Lancet Infect. Dis. 9:

659

Systems Biology Approaches to Understanding the Human Immune System

Dhillon BK, M Smith, A Baghela, AHY Lee, R.E.W. Hancock (2020) Front. Immunol. 11: 1683 PDF

658

The stringent stress response controls proteases and global regulators under optimal growth conditions in Pseudomonas aeruginosa.

Pletzer, D., T. Blimkie, H. Wolfmeier, Y. Li, A. Baghela, A Lee, R. Falsafi, and R.E.W. Hancock (2020) mSystems 5: e00495-20. PDF

657

Rhinovirus Infection Drives Complex Host Airway Molecular Responses in Children With Cystic Fibrosis

Ling KM, Garratt LW, Gill EE, Lee AHY, Agudelo-Romero P, Sutanto EN, Iosifidis T, Rosenow T, Turvey SE, Lassmann T, Hancock REW, Kicic A, Stick SM. (2020) Front. Immunol. 11: 1327 PDF

656

Bacterial aggregation triggered by fibril forming tryptophan rich sequences: effects of peptide side chain and membrane phospholipids

Bagheri M, H Nikolenko, S Arasteh, N Rezaei, M Behzadi, M.E.A. Dathe, and R.E.W. Hancock (2020) ACS Appl. Mater. Interfaces https://doi.org/10.1021/acsami.0c04336

655

Whole Blood Transcriptional Responses of Very Preterm Infants During Late-Onset Sepsis

Ng, Sherrianne; Tobias Strunk, Amy H Lee, Erin E Gill, Reza Falsafi, Tabitha Woodman, Julie Hibbert, R.E.W. Hancock Andrew Currie (2020) PLoS One 15(6): 10.1371/journal.pone.0233841 PDF

654

Regional Dichotomy in Enteric Mucosal Immune Responses to a Persistent Mycobacterium avium Ssp. paratuberculosis Infection

Facciuolo, Antonio; Amy H. Lee, Patricia Gonzalez Cano, Hugh G. G. Townsend, Reza Falsafi, Volker Gerdts, Andrew Potter, Scott Napper, R.E.W. Hancock Lucy M. Mutharia, Philip J. Griebel (2020) Front. Immunol. 10.3389/fimmu.2020.01020 PDF

653

In vitro and in vivo antibiotic capacity of two host defence peptides

Arenas I, MA Ibarra, FL Santana, E Villegas, R.E.W. Hancock, G Corzo (2020) Mechanisms of Action: Physiological Effects 64: DOI: 10.1128/AAC.00145-20 PDF

652

The importance of reporting house dust mite endotoxin abundance: impact on the lung transcriptome.

Pascoe CD, Jha A, Basu S, Mahood TH, Lee A, Hinshaw S, Falsafi R, Hancock REW, Mookherjee N, Halayko AJ. (2020) Am J Physiol Lung Cell Mol Physiol. 10.1152/ajplung.00103.2020

651

EcDBS1R6: A Novel Cationic Antimicrobial Peptide Derived From a Signal Peptide Sequence

Porto WF, LN Irazazabal, V Humblot, EF Haney, SM Ribeiro, R.E.W. Hancock, A Ladram, OL Franco (2020) Biochim. Biophys. Acta. 1864: DOI: 10.1016/j.bbagen.2020.129633

650

Utilizing Organoid and Air-Liquid Interface Models as a Screening Method in the Development of New Host Defense Peptides

Choi, Ka-Yee Grace; Bing Catherine Wu, Amy Huei-Yi Lee, Beverlie Baquir, R.E.W. Hancock (2020) Front Cell Infect Microbiol . 10: 10.3389/fcimb.2020.00228. PDF

649

NtrBC Regulates Invasiveness and Virulence of Pseudomonas aeruginosa During High-Density Infection

Alford, Morgan A; Arjun Baghela, Amy T Y Yeung, Daniel Pletzer, R.E.W. Hancock
(2020) Front. Microbiol. 11:773: 10.3389/fmicb.2020.00773 PDF

648

Overexpression of the Small RNA PA0805.1 in Pseudomonas Aeruginosa Modulates the Expression of a Large Set of Genes and Proteins, Resulting in Altered Motility, Cytotoxicity, and Tobramycin Resistance

Coleman SR, M L Smith, V Spicer, Y Lao, N Mookherjee, R.E.W. Hancock (2020) mSystems 5: doi: 10.1128/mSystems.00204-20. PDF

647

Clinical Protocol for a Longitudinal Cohort Study Employing Systems Biology to Identify Markers of Vaccine Immunogenicity in Newborn Infants in The Gambia and Papua New Guinea

Idoko, Olubukola T; Kinga K Smolen, Oghenebrume Wariri, Abdulazeez Imam, Casey P Shannon, Tida Dibassey, Joann Diray-Arce, Alansana Darboe, Julia Strandmark, Rym Ben-Othman, Oludare A Odumade, Kerry McEnaney, Nelly Amenyogbe, William S Pomat, Simon van Haren, Guzmán Sanchez-Schmitz, Ryan R Brinkman, Hanno Steen, R.E.W. Hancock , Scott J Tebbutt, Peter C Richmond, Anita H J van den Biggelaar, Tobias R Kollmann, Ofer Levy, Al Ozonoff, Beate Kampmann (2020) Front. Pediatr. 8:197: 10.3389/fped.2020.00197 PDF

646

Defective cell migration as a mechanism of dysregulated asthmatic airway epithelial repair

Iosifidis T, Sutanto EN, Buckley A, Coleman LA, Gill EE, Lee AH, Ling KM, Hillas J, Looi K, Garratt LW, Martinovich KM, Shaw NC, Montgomery ST, Kicic-Starcevich E, Karpievitch YV, Le Souef P, Laing IA, Vijayasekaran S, Lannigan FJ, Rigby PJ, Hancock REW, Knight D, Stick SM, Kicic A, Waerp OBO, AusREC OBO. (2020) JCI Insight pii: 133125.: doi: 10.1172/jci.insight.133125 PDF

645

Selective anticancer activity of synthetic peptides derived from the host defence peptide tritrpticin

Arias, Mauricio; Evan F. Haney, Ashley L. Hilchie, Jennifer A. Corcoran, M. Eric Hyndman, Robert E.W. Hancock, Hans J. Vogel (2020) Biochim. Biophys. Acta. https://doi.org/10.1016/j.bbamem.2020.183228

644

MetaBridge: An Integrative Multi-Omics Tool for Metabolite-Enzyme Mapping

Blimkie, Travis; Amy Huei‐Yi Lee, R.E.W. Hancock (2020) Curr Protoc Bioinformatics . 70(01): 10.1002/cpbi.98.

643

Insights into the mechanism of action of two analogues of aurein 2.2.

Raheem N, Kumar P, Lee E, Cheng JTJ, Hancock REW, Straus SK (2020) Biochim. Biophys. Acta. 1862: 183262

642

Surfing motility is a complex adaptation dependent on the stringent stress response in Pseudomonas aeruginosa LESB58.

Pletzer D, Sun E, Ritchie C, Wilkinson L, Liu LT, Trimble MJ, Wolfmeier H, Blimkie TM, Hancock REW. (2020) PLos Pathogens 16(3): e1008444 PDF

641

AB569, a nontoxic chemical tandem that kills major human pathogenic bacteria

McDaniel, CT; Warunya Panmanee, Geoffrey L. Winsor, Erin Gill, Claire Bertelli, Michael J. Schurr, Prateek Dongare, Andrew T. Paul, Seung-Hyun B. Ko, Gee W. Lau, Nupur Dasgupta, Amy L. Bogue, William E. Miller, Joel E. Mortensen, David B. Haslam, Phillip Dexheimer, Daniel A. Muruve, Bruce J. Aronow, Malcolm D. E. Forbes, Marek Danilczuk, Fiona S. L. Brinkman, Robert E. W. Hancock, Thomas J. Meyer, and Daniel J. Hassett (2020) PNAS 117(9): 4921-4930

640

Multidrug adaptive resistance of Pseudomonas aeruginosa swarming cells.

Coleman SR, Blimkie T, Falsafi R, Hancock, R.E.W. (2019) 10.1128/AAC.01999-19.

639

Effect of Long-term Exposure to Peptides on Mono- and Multispecies Biofilms in Dentinal Tubules

Huang, Xiangya; Markus Haapasalo, Zhejun Wang, Robert E.W. Hancock, Xi Wei, Ya Shen (2019) J. Endodontics 45(12): 1522-1528 PDF

638

Metabolomics study of the synergistic killing of polymyxin B in combination with amikacin against polymyxin-susceptible and -resistant Pseudomonas aeruginosa

Hussein Maytham ; Mei-Ling Han; Yan Zhu; Qi (Tony) Zhou; Yu-Wei Lin; Robert. E.W. Hancock; Daniel Hoyer; Darren J Creek; Jian Li; Tony Velkov (2019) J. Antimicrob. Chemother. 10.1128/AAC.01587-19 PDF

637

Influence of Non-natural Cationic Amino Acids on the Biological Activity Profile of Innate Defense Regulator Peptides

Haney, Evan F. Simone C. Barbosa; Beverlie Baquir; R.E.W. Hancock (2019) J. Med. Chem. 10.1021/acs.jmedchem.9b01344

636

A Genome-Wide Knockout Screen in Human Macrophages Identified Host Factors Modulating Salmonella Infection.

Yeung ATY, Choi YH, Lee AHY, Hale C, Ponstingl H, Pickard D, Goulding D, Thomas M, Gill E, Kim JK, Bradley A, Hancock REW, Dougan G. (2019) mBio 10(5): e02169-19 PDF

635

Outer membrane interaction kinetics of new polymyxin B analogs in Gram-negative bacilli.

Akhoundsadegh N, Belanger CR, Hancock REW (2019) Antimicrob. Agents Chemother. 63(10): 10.1128/AAC.00935-19 PDF

634

Controlling biofilm formation with nitroxide functional surfaces

Woehlk, Hendrik; Michael J. Trimble, Sarah C. Mansour, Daniel Pletzer, Vanessa Trouillet, Alexander Welle, Leonie Barner, Robert E. W. Hancock, Christopher Barner-Kowollik and Kathryn E. Fairfull-Smith (2019) Polym. Chem. 10: 4252-4258 PDF

633

Identification of Novel Adenosine Deaminase 2 Gene Variants and Varied Clinical Phenotype in Pediatric Vasculitis.

Gibson KM, Morishita KA, Dancey P, Moorehead P, Drögemöller B, Han X, Graham J, Hancock REW, Foell D, Benseler S, Luqmani R, Yeung RSM, Shenoi S, Bohm M, Rosenberg AM, Ross CJ, Cabral DA, Brown KL; PedVas Investigators Network. (2019) Arthritis Rheumatol. 71(10): 1747-1755 PDF

632

NetworkAnalyst 3.0: a visual analytics platform for comprehensive gene expression profiling and meta-analysis

Zhou G, O Soufan, J Ewald, REW Hancock, N Basu, J Xia (2019) Nucleic Acids Research 1: 10.1093/nar/gkz240

631

Short Cationic Peptide Derived from Archaea with Dual Antibacterial Properties and Anti-Infective Potential.

Cândido ES, Cardoso MH, Chan LY, Torres MDT, Oshiro KGN, Porto WF, Ribeiro SM, Haney EF, Hancock REW, Lu TK, de la Fuente-Nunez C, Craik DJ, Franco OL. (2019) ACS Infect. Dis. 10.1021/acsinfecdis.9b00073 PDF

630

Improving in vivo safety of the anti-biofilm peptide DJK-5 by using hyaluronic acid-based nanogels.

Kłodzińska SN, Pletzer D, Rahanjam N, Rades T, Hancock REW, Nielsen HM. (2019) Nanomedicine 10.1016/j.nano.2019.102022 PDF

629

Dismantling the bacterial virulence program

Alford MA , D Pletzer, REW Hancock (2019) Microbial Biotechnology doi.org/10.1111/1751-7915.13388 PDF

628

Aurein-Derived Antimicrobial Peptides Formulated with Pegylated Phospholipid Micelles to Target Methicillin-Resistant Staphylococcus aureus Skin Infections

Kumar, Prashant; Daniel Pletzer, Evan F. Haney, Negin Rahanjam, John T. J. Cheng, Marty Yue, Waleed Aljehani, Robert E. W. Hancock, Jayachandran N. Kizhakkedathu, and Suzana K. Straus (2018) ACS Infect. Dis. 10.1021/acsinfecdis.8b00319 PDF

627

Dynamic molecular changes during the first week of human life follow a robust developmental trajectory

Lee, A. H., Shannon, C. P., Amenyogbe, N., Bennike, T. B., Diray-Arce, J., Idoko, O. T., Gill EE, Ben-Othman R, Pomat WS, van Haren SD, Le Cao KA, Cox M, Darboe A, Falsafi R, Ferrari D, Harbenson DJ, He D, Bing C, Hinshaw SJ, Ndure J, Nije-Jobe J, Pettengill MA, Richmond PC, Ford R, Saleu G, Masiria G, Matlam JP, Kirarock W, Roberts E, Malek M, Sanchez-Smitz G, Sing A, Angelidou A, Smolen KK, The EPIC Consortium, Brinkman RR, Ozonoff A, Hancock REW, van der Biggelaar AHJ, Steen H, Tebbutt SJ, Krampmann B, Levy O, Kollmann, T. R. (2019) Nature 10: 1092 PDF

626

A lipidic delivery system of a triple vaccine adjuvant enhances mucosal immunity following nasal administration in mice

Wasan E K, J Sueda, S Strom, J Cawthray, R.E.W. Hancock, K.M. Wasan, V Gerdts (2019) Vaccine 37: 1503-1515 PDF

625

Reassessing the Host Defence Peptide Landscape

Haney EF, SK Straus, R.E.W. Hancock (2019) Front. Chem. 7: 43 PDF

624

Identification of an IDR peptide formulation candidate that prevents peptide aggregation and retains immunomodulatory activity

Haney EF, KC. Wuerth, N Rahanjam, NS Nikouei, A Ghassemi MA Noghani A Boey, R.E.W. Hancock (2018) J. Peptide Sci. e24077

623

Characterization of host responses during Pseudomonas aeruginosa acute lung infection in the lungs and blood and after treatment with the synthetic immunomodulatory peptide IDR-1002

Wuerth K, Lee AHY, Falsafi R, Gill EE, Hancock REW. (2018) Infect. Immun. 87(1): 10.1128/IAI.00661-18 PDF

622

Bone Environment Influences Irreversible Adhesion of a Methicillin-Susceptible Staphylococcus aureus Strain.

Reffuveille F, Josse J, Velard F, Lamret F, Varin-Simon J, Dubus M, Haney EF, Hancock REW, Mongaret C and Gangloff SC (2018) Front. Microbiol. https://doi.org/10.3389/fmicb.2018.02865 PDF

621

S100A12 serum levels and PMN counts are elevated in childhood systemic vasculitides especially involving proteinase 3 specific anti-neutrophil cytoplasmic antibodies

KL. Brown, JM Lubieniecka, G Armaroli, K Kessel, K Gibson, J Graham, D Liu, R.E.W. Hancock, C Ross, S Benseler, RA. Luqmani, DA. Cabral, D Foell and C Kessel (2018) Frontiers in Pediatrics 10.3389/fped.2018.00341 PDF

620

Antimicrobial Effect of Peptide DJK-5 Used Alone or Mixed with EDTA on Mono- and Multispecies Biofilms in Dentin Canals

Wang D, Shen Y, Hancock REW, Ma J, Haapasalo M. (2018) J Endod 44(11): 1709-1713 PDF

619

Interleukin-22 promotes phagolysosomal fusion to induce protection against Salmonella enterica Typhimurium in human epithelial cells

Forbester JL, Lees EA, Goulding D, Forrest S, Yeung A, Speak A, Clare S, Coomber EL, Mukhopadhyay S, Kraiczy J, Schreiber F, Lawley TD, Hancock, R.E.W., Uhlig HH, Zilbauer M, Powrie F, Dougan G. (2018) Proc. Natl. Acad. Sci. USA. 115(40): 10118-10123 PDF

618

Surfing Motility: A Conserved yet Diverse Adaptation among Motile Bacteria

Sun E, Liu S, Hancock REW. (2018) J. Bacteriol. 200(23): 10.1128/JB.00394-18 PDF

617

MetaBridge: Enabling Network-Based Integrative Analysis via Direct Protein Interactors of Metabolites

Hinshaw SJ, AHY Lee, EE Gill, R.E.W. Hancock (2018) Bioinformatics 34(18): 3225–3227 PDF

616

Design and Assessment of Anti-Biofilm Peptides: Steps Toward Clinical Application.

Dostert M, Belanger CR, Hancock REW. (2018) J. Innate Immun. 11(3): 193-204 PDF

615

Broad-Spectrum Adaptive Antibiotic Resistance Associated with Pseudomonas aeruginosa Mucin-Dependent Surfing Motility.

Sun, E., E.E. Gill, R. Falsafi, A. Yeung, S. Liu, and R.E.W. Hancock (2018) Antimicrob. Agents Chemother. 62(9): 10.1128/AAC.00848-18. PDF

614

Liposomal Therapy Attenuates Dermonecrosis Induced by Community-Associated Methicillin-Resistant Staphylococcus aureus by Targeting α-Type Phenol-Soluble Modulins and α-Hemolysin

Wolfmeier H., SC. Mansour, LT. Liu, D Pletzer, A Draeger, E.B. Babiychuk, R.E.W. Hancock (2018) eBiomedicine PDF

613

Biofilm formation by Helicobacter pylori is differentially affected by common culture conditions and protein plays a central role in the biofilm matrix

Windham IH, Servetas SL, Whitmire JM, Pletzer D, Hancock, R.E.W., Merrell DS. (2018) Appl. Environ. Microbiol 84(14): 10.1128/AEM.00391-1

612

Retinoic acid elicits a coordinated expression of gut homing markers on T lymphocytes of Zambian men receiving oral Vivotif, but not Rotarix, Dukoral or OPVERO vaccines

Mwanza-Lisulo M, Chomba MS, Chama M, Besa EC, Funjika E, Zyambo K, Banda R, Imikendu M, Sianongo S, Hancock, R.E.W., Lee A, Chilengi R, Stagg AJ, Namangala B, Kelly PM. (2018) Vaccine 36(28): 4134-4141 PDF

611

Development of Molecularly Imprinted Polymers To Block Quorum Sensing and Inhibit Bacterial Biofilm Formation.

Ma L, Feng S, Fuente-Núñez C, Hancock, R.E.W., Lu X. (2018) ACS Appl. Mater. Interfaces 10(22): 18450-18457

610

Synergy between conventional antibiotics and anti-biofilm peptides in a murine, sub-cutaneous abscess model caused by recalcitrant ESKAPE pathogens

Pletzer D, Mansour S.C., Hancock, R.E.W. (2018) PLos Pathogens 14(6): e1007084 PDF

609

Critical Assessment of Methods to Quantify Biofilm Growth and Evaluate Antibiofilm Activity of Host Defence Peptides

Haney E, MJ. Trimble, JT. Cheng, Q Vallé, R.E.W. Hancock (2018) Biomolecules 8(2): 29 PDF

608

In silico optimization of a guava antimicrobial peptide enables combinatorial exploration for peptide design.

Porto WF, Irazazabal L, Alves ESF, Ribeiro SM, Matos CO Pires ÁS, Fensterseifer ICM, Miranda VJ, Haney EF, Humblot V, Torres MDT, Hancock REW, Liao LM, Ladram A, Lu TK, de la Fuente-Nunez C, Franco OL. (2018) Nat Commun 9(1): 1490 PDF

607

High-throughput detection of RNA processing in bacteria.

Gill, E.E., L.S. Chan, G.L. Winsor, N. Dobson, R. Lo, S.J. Ho Sui, B.K. Dhillon, P.K. Taylor, R. Shrestha, C. Spencer, R.E.W. Hancock, P.J. Unrau, F.S.L. Brinkman. (2018) BMC Genomics 19(1): 223 PDF

606

Induction by innate defence regulator peptide 1018 of pro-angiogenic molecules and endothelial cell migration in a high glucose environment.

Marin-Luevano P, Trujillo V, Rodriguez-Carlos A, González-Curiel I, Enciso-Moreno JA, Hancock, R.E.W., Rivas-Santiago B. (2018) Peptides 101: 135-144 PDF

605

Novel roles for two-component regulatory systems in cytotoxicity and virulence-related properties in Pseudomonas aeruginosa

Gellatly S., M. Bains, E.B.M. Breidenstein, J. Strehmel, F. Reffuveille, P.K. Taylor, A.T.Y. Yeung, J.Overhage, R.E.W. Hancock (2018) AIMS Microbiology 4(1): 173-191 PDF

604

Computer-aided Discovery of Peptides that Specifically Attack Bacterial Biofilms.

Haney EF, Brito-Sánchez Y, Trimble MJ, Mansour SC, Cherkasov A, Hancock REW. (2018) Scientific Reports 8: 1871 PDF

603

New Perspectives in Biofilm Eradication

Wolfmeier H, Pletzer D, Mansour SC, Hancock, R.E.W. (2017) ACS Infect. Dis. PDF

602

Mechanisms of the Innate Defense Regulator Peptide-1002 Anti-Inflammatory Activity in a Sterile Inflammation Mouse Model

Wu BC, Lee AH, Hancock REW. (2017) J. Immunol. 188(10): 3592-3603 PDF

601

Sensing Mg2+ contributes to the resistance of Pseudomonas aeruginosa to complement-mediated opsonophagocytosis

Qadi, M., S. Izquierdo-Rabassa, M. Mateu Borrás, A. Doménech-Sánchez, C. Juan, J.B. Goldberg, R.E.W. Hancock, and S. Albertí. (2017) Environ Microbiol 19(10): 4278-4286 PDF

600

Synthetic host defense peptide IDR-1002 reduces inflammation in Pseudomonas aeruginosa lung infection

Wuerth K, R Falsafi, R.E.W. Hancock (2017) PLoS One 12(11): e0187565 PDF

599

Antibiofilm Effect of D-enantiomeric Peptide Alone and Combined with EDTA In Vitro

Wang D, Ya Shen, Jingzhi Ma, R.E.W.Hancock, Markus Haapasalo (2017) J. Endodontics 43 : 1862-1867 PDF

598

Synthetic Peptides to Target Stringent Response-Controlled Virulence in a Pseudomonas aeruginosa Murine Cutaneous Infection Model.

Pletzer D, Wolfmeier H, Bains M, Hancock REW. (2017) Front. Microbiol. 10.3389/fmicb.2017.01867 PDF

597

Aggregation and Its Influence on the Immunomodulatory Activity of Synthetic Innate Defense Regulator Peptides.

Haney EF, Wu BC, Lee K, Hilchie AL, Hancock REW (2017) Cell Chem Biol 10.1016/j.chembiol.2017.07.010 PDF

596

A novel small RNA is important for biofilm formation and pathogenicity in Pseudomonas aeruginosa

Taylor PK, Van Kessel ATM, Colavita A, Hancock REW, Mah T-F (2017) PLoS One 12(8): e0182582 PDF

595

An immunomodulatory peptide that confers protection in an experimental candidemia murine model

Freitas CG, Lima SMF, Freire MS, Cantuária APC, Júnior NGO, Santos TS, Folha JS, Ribeiro SM, Dias SC, Rezende TMB, Albuquerque P, Nicola AM, de la Fuente-Núñez C, Hancock REW, Franco OL, Felipe MSS. (2017) Antimicrob. Agents Chemother. 61(8): 10.1128/AAC.02518-16

594

Ciprofloxacin-nitroxide hybrids with potential for biofilm control

Anthony D Verderosa, César de la Fuente-Núñez, Sarah C Mansour, Jicong Cao, Timothy K Lu, REW Hancock, Kathryn E Fairfull-Smith (2017) Eur. J. Med. Chem. 138: 590-601

593

Alternative strategies for the study and treatment of clinical bacterial biofilms

Belanger CR, SC Mansour, D Pletzer, R.E.W. Hancock (2017) Emerging Topics in Life Sciences 1(1): 41-53

592

Exploiting induced pluripotent stem cell-derived macrophages to unravel host factors influencing Chlamydia trachomatis pathogenesis.

Yeung, A.T.Y., C. Hale, A.H. Lee, E. E. Gill, W. Bushell, D. Parry-Smith, D. Goulding, D. Pickard, T. Roumeliotis, J. Choudhary, N. Thomson, W.C. Skarnes, G. Dougan and R.E.W. Hancock. (2017) Nat Commun 8:15013: 10.1038/ncomms15013 PDF

591

New Mouse Model for Chronic Infections by Gram-Negative Bacteria Enabling the Study of Anti-Infective Efficacy and Host-Microbe Interactions

Pletzer D, Mansour SC, Wuerth K, Rahanjam N, Hancock REW (2017) mBio 8(1): 10.1128/mBio.00140-17 PDF

590

Antimicrobial efficacy against Pseudomonas aeruginosa biofilm formation in a three-dimensional lung epithelial model and the influence of fetal bovine serum

Crabbé A, Liu Y, Matthijs N, Rigole P, De La Fuente-Nùñez C, Davis R, Ledesma MA, Sarker S, Van Houdt R, Hancock REW, Coenye T, Nickerson CA (2017) Scientific Reports 7: 43321 PDF

589

Two isoforms of Clp peptidase in Pseudomonas aeruginosa control distinct aspects of cellular physiology.

Hall B.M., E.B.M. Breidenstein, C. de la Fuente-Núñez, F. Reffuveille, G.D. Mawla, R.E.W. Hancock, T.A. Baker. (2016) J. Bacteriol. 199(3): 10.1128/JB.00568-16

588

Anticancer activities of bovine and human lactoferricin-derived peptides.

Arias M., A. Hilchie, E.F. Haney, J.G.M. Bolscher, M.E. Hyndman, R.E.W. Hancock, H.J. Vogel. (2016) Biochemistry and Cell Biology 95(1): 91-98

587

High-Performance Liquid Chromatography and Mass Spectrometry-Based Design of Proteolytically Stable Antimicrobial Peptides.

Bagheri, M., Hancock, REW. (2017) Methods Mol Biol 1548: 61-71 PDF

586

Antimicrobial Peptides: An Introduction.

Haney, E., Mansour S., Hancock REW. (2017) Methods in Molecular Biology 1548: 3-22 PDF

585

Anti-adhesive antimicrobial peptide coating prevents catheter associated infection in a mouse urinary infection model.

Yu K., J.C.Y. Lo, M. Yan, X. Yang, D.E. Brooks, R.E.W. Hancock, D. Lange, J.N. Kizhakkedathu. (2017) Biomaterials 116: 69-81

584

Low doses of innate defence regulator peptide, IDR-1018, enhances HDL-medicated cholesterol efflux from smooth muscle cells and macrophages.

Afacan, N.J., T. Chan T, J. Pistolic, J. Kong, G.A. Francis, and R.E.W. Hancock. (2016) J. Nutritional Biol. 2: 1 PDF

583

Peptide IDR-1002 Inhibits NF-kB Nuclear Translocation by Inhibition of IkBalpha Degradation, and Activates p38/ERK1/2-MSK1 Dependent CREB Phosphorylation in Macrophages Stimulated With Lipopolysaccharide.

Huante-Mendoza A., O. Silva-García, J, Oviedo-Boyso, R.E.W. Hancock, V. Baizabal-Aguirre. (2016) Front. Immunol. 7: 533

582

2-Deoxyglucose modulates innate defence regulator peptide activity.

Afacan N.J., A. Hilchie, E.E. Gill, R. Falsafi, R.E.W. Hancock. (2016) Cellular Immunology and Immunotherapeutics. 2(1): 1-8

581

Treatment of Oral Biofilms by a D-Enantiomeric Peptide.

Zhang T., Z. Wang, R.E.W. Hancock, C. de la Fuente-Núñez, M. Haapasalo. (2016) PLoS One 11(11): e0166997 PDF

580

An anti-infective synthetic peptide with dual antimicrobial and immunomodulatory activities.

Silva O.N., C. de la Fuente-Núñez, E.F. Haney, I.C.M. Fensterseifer, S.M. Ribeiro, W.F. Porto, P .Brown, C. Faria-Junior, T.M.B Rezende, S.E. Moreno, T.K. Lu, R.E.W. Hancock, O.L. Franco. (2016) Scientific Reports 6: 35465 PDF

579

Mastoparan is a membranolytic anti-cancer peptide that works synergistically with gemcitabine in a mouse model of mammary carcinoma.

Hilchie A.L., A.J. Sharon, E.F. Haney, D.W. Hoskin, M.B. Bally, O.L. Franco, J.A. Corcoran, R.E.W. Hancock. (2016) Biochim. Biophys. Acta. 1858: 3195-3204 PDF

578

Bacterial abscess formation is controlled by the stringent stress response and can be targeted therapeutically.

Mansour S.C., D. Pletzer, C. de la Fuente-Núñez, P. Kim, G.Y.C. Cheung, H. Joo, M. Otto, R.E.W. Hancock. (2016) eBiomedicine 12: 219-226 PDF

577

Endosomal pH modulation by peptide-gold nanoparticle hybrids enables potent anti-inflammatory activity in phagocytic immune cells.

Yang H., L. Kozicky, A. Saferali, S. Fung, N. Afacan, B. Cai, R. Falsafi, E. Gill, M. Liu, T.R. Kollmann, R.E.W. Hancock, L.M. Sly, S.E. Turvey. (2016) Biomaterials 111: 90-102

576

Synthesis and evaluation of ciprofloxacin-nitroxide conjugates as anti-biofilm agents.

Verderosa A.D., S.C. Mansour, C. de la Fuente-Núñez, R.E.W. Hancock, K.E. Fairfull-Smith. (2016) Molecules 21(7): 841 PDF

575

Anti-biofilm peptides: Potential as broad-spectrum agents.

Pletzer, D., and R.E.W. Hancock. (2016) J. Bacteriol. 198: 2572-2578 PDF

574

Experimental and theoretical investigation of multispecies oral biofilm resistance to chlorhexidine treatment.

Shen, Y., J. Zhao, C. de la Fuente-Núñez, Z. Wang, R.E.W. Hancock, C.R. Roberts, J. Ma, Q. Wang, and M. Haapasalo. (2016) Scientific Reports 6: 27537 PDF

573

Anti-biofilm peptides as a new weapon in antimicrobial warfare.

Pletzer, D., S.R. Coleman, and R.E.W. Hancock. (2016) Curr. Opin. Microbiol. 33: 35-40 PDF

572

A new cationic antimicrobial peptide (AMP) from human ApoE with activities against multidrug-resistant bacteria and immunomodulatory effects on human cells.

Pane, K., V. Sgambati., A. Zanfardino, G. Smaldone, V. Cafaroa, T. Angrisano, E. Pedone, S. Di Gaetano, C. Domenica, E.F. Haney, V. Izzo, M. Varcamonti, E. Notomista, R.E.W. Hancock, A. Di Donato, and E. Pizzo. (2016) FEBS J. 283(11): 2115-31 PDF

571

Structural Studies of a Lipid-Binding Peptide from Tunicate Hemocytes with Anti-Biofilm Activity

Silva ON, ES Alves, C de la Fuente-Nunez, SM Ribeiro, SM Mandal, D Gaspar, AS Veiga, MA Castanho, CA Andrade, JM Nascimento, IC Fensterseifer, WF Porto, JR Correa, REW Hancock, S Korpole, AL Oliveira, LM Liao, OL Franco (2016) Scientific Reports 6: 27128 PDF

570

Interconnection of post-transcriptional regulation: The RNA-binding protein Hfq is a novel target of the Lon protease in Pseudomonas aeruginosa.

Fernández, L., E.B.M. Breidenstein, P.K. Taylor, M. Bains, C. de la Fuente-Núñez, Y. Fang, L.J. Foster, and R.E.W. Hancock. (2016) Scientific Reports 6: 26811 PDF

569

The immunology of host defence peptides: Beyond antimicrobial activity.

Hancock, R.E.W., E.F. Haney and E.E. Gill. 2016. (2016) Nature Rev. Immunol. 16: 321-334

568

Tryptic stability of synthetic bactenecin derivatives is determined by the side chain length of cationic residues and the peptide conformation.

Bagheri, M., S. Arasteh, E. Haney, and R.E.W. Hancock. (2016) J. Med. Chem. 59(7): 3079-86

567

Identification of synthetic- and natural host defense peptides with leishmanicidal activity.

Marr, A.K., S. Cen, R.E.W. Hancock, and W.R. McMaster. (2016) Antimicrob. Agents Chemother. 60(4): 2484-91 PDF

566

Synthetic antibiofilm peptides.

de la Fuente-Núñez, C., M.H. Cardoso, E. de Souza Cândido, O.L. Franco, and R.E.W. Hancock. (2016) Biochim. Biophys. Acta. 1858: 1061-1069 PDF

565

A polyalanine peptide derived from polar fish with anti-infectious activities.

Cardoso, M.H., S.M. Ribeiro, D.O. Nolasco, C. de la Fuente-Núñez, M.R. Felício, S. Gonçalves, C.O. Matos, L.M. Liao, N.C. Santos, R.E.W. Hancock, O.L. Franco and L. Migliolo. (2016) Scientific Reports 6: 21385 PDF

564

In vivo, in vitro, and in silico characterization of peptoids as antimicrobial agents.

Czyzewski A.M., H. Jenssen, C.D. Fjell, M. Waldbrook, N.P. Chongsiriwatana, E. Yuen, R.E.W. Hancock, and A.E. Barron. (2016) PLoS One 11: e0135961. doi:10.1371/journal.pone.0135961 PDF

563

Alternatives to antibiotics - a pipeline portfolio review.

Czaplewski, L., R. Bax, M. Clokie, M. Dawson, H. Fairhead, V.A. Fischetti, S. Foster, B.F. Gilmore, R.E.W. Hancock, D. Harper, I.R. Henderson, K. Hilpert, B.V Jones, A. Kadioglu, D. Knowles, S. Ólafsdóttir, D. Payne, S. Projan, S. Shaunak, J. Silverman, C.M. Thomas, T.J. Trust, P. Warn, J.H. Rex. (2016) Lancet Infect. Dis. 16: 239-251 (Selected from thousands of recently published articles to be awarded the Elsevier Atlas Award)

562

The Structure of a Type 3 Secretion System (T3SS) Ruler Protein Suggests a Molecular Mechanism for Needle Length Sensing.

Bergeron J.R.C., L. Fernández, G.A. Wasney, M. Vuckovic, F. Reffuveille, R.E.W. Hancock, N.C.J. Strynadka. (2016) J. Biol. Chem. 291(4): 1678-1691 PDF

561

Identification of novel cyclic lipopeptides from a positional scanning combinatorial library with enhanced antibacterial and antibiofilm activities.

Bionda N., R.M. Fleeman, C. de la Fuente-Núñez, M.C. Rodriguez, F. Reffuveille, L.N. Shaw, I. Pastar, S.C. Davis, R.E.W. Hancock, and P. Cudic. (2016) Eur. J. Med. Chem. 108: 354-363 PDF

560

Towards infection resistant surfaces: Achieving high antimicrobial peptide potency by modulating the functionality of polymer brush and peptide.

Yu, K., J. Lo, Y. Mei, E. Haney, E. Siren, M. Kalathottukaren, R.E.W. Hancock, D. Lange, and J. Kizhakkedathu. (2015) ACS Appl. Mater. Interfaces 7: 28591-28605 PDF

559

LL-37 immunomodulatory activity during Mycobacterium tuberculosis infection in macrophages.

Torres-Juarez, F., A. Cardenas-Vargas, A. Montoya-Rosales, I. González-Curiel, M.H. Garcia-Hernandez, J.A. Enciso-Moreno, R.E.W. Hancock, and B. Rivas-Santiago. (2015) Infect. Immun. 83: 4495-4503 PDF

558

Enhanced killing of breast cancer cells by a D-amino acid analog of the winter flounder-derived pleurocidin NRC-03.

Hilchie, A.L., E. Haney, D.M. Pinto, R.E.W. Hancock, and D.W. Hoskin. (2015) Experimental Molec. Pathol. 99: 426-434 PDF

557

Clinical exploitation of genomics data produced by the international Pseudomonas aeruginosa consortium.

Freschi L., J. Jeukens, I. Kukavica-Ibrulj, B. Boyle, M.-J. Dupont, J. Laroche, S. Larose, H. Maaroufi, J.L. Fothergill, M. Moore, G.L. Winsor, S.D. Aaron, J. Barbeau, S.C. Bell, J.L. Burns, M.Camara, A. Cantin, S.J. Charette, K. Dewar, E. Déziel, K. Grimwood, R.E.W. Hancock, J.J. Harrison, S. Heeb, L. Jelsbak, D.T. Kenna, T.J. Kidd, J. Klockgether, J.S. Lam, I.L. Lamont, S. Lewenza, N. Loman, F. Malouin, A.G. McArthur, J. McKeown, J. Milot, H. Naghra, D. Nguyen, S.K. Pereira, G.G. Perron, P.B. Rainey, S. Rousseau, P.M. Santos, A. Stephenson, V. Taylor, J.F. Turton, N. Waglechner, P. Williams, S. Wingaard, G.D. Wright, F.S.L. Brinkman, N.P. Tucker, B. Tümmler, C. Winstanley, R.C. Leveque. (2015) Front. Microbiol. 6: 1036 PDF

556

High throughput screening methods for assessing antibiofilm and immunomodulatory activities of synthetic peptides.

Haney, E.F., S. Mansour, A.L. Hilchie, C. de la Fuente-Núñez and R.E.W. Hancock. (2015) Peptides 71: 276-285 PDF

555

Potentiation of ciprofloxacin action against Gram-negative bacterial biofilms by a nitroxide.

Reffuveille, F., C. de la Fuente-Núñez, K. Fairfull-Smith, and R.E.W. Hancock. (2015) Pathogens and Disease 73(5): pii ftv016 PDF

554

Rethinking the antibiotic discovery paradigm (commentary).

Hancock, R.E.W. (2015) eBiomedicine 2: 627-628 PDF

553

Anti-infective peptide IDR-1002 augments monocyte chemotaxis towards CCR5 chemokines.

Madera, L. and R.E.W. Hancock. (2015) Biochem. Biophys. Res. Commun. 464: 800-806 PDF

552

Treatment of oral multispecies biofilms by an anti-biofilm peptide.

Wang, Z., C. de la Fuente-Núñez, Y. Shen, M. Haapasalo, R.E.W. Hancock. (2015) PLoS One 10(7): e0132512 PDF

551

Anti-biofilm peptides increase the susceptibility of carbapenemase-producing Klebsiella pneumoniae clinical isolates to β-lactam antibiotics

Ribeiro, S., C. de la Fuente-Núñez, B. Baquir, C. Faria-Junior, O. Franco, and R.E.W. Hancock. (2015) Antimicrob. Agents Chemother. 59: 3906-3912 PDF

550

In-situ Raman spectroscopic-based microfluidic “lab-on-a-chip” platform for non-destructive and continuous characterization of Pseudomonas aeruginosa biofilms.

Feng, J., C. de la Fuente-Núñez, M.J. Trimble, H. Zeng, J. Xu, R.E.W. Hancock, X. Lu. (2015) ChemComm. 51: 8966-8969 PDF

549

NetworkAnalyst for statistical, visual and network-based meta-analysis of gene expression data.

Xia J, E Gill and REW Hancock. (2015) Nature Protocols 10: 823-844 PDF

548

Peptide IDR-1018: modulating the immune system and targeting bacterial biofilms to treat antibiotic-resistant bacterial infections.

Mansour, S., C. de la Fuente-Núñez and R.E.W. Hancock. (2015) J. Pept. Res. 21: 323-329 PDF

547

Peptides KT2 and RT2 are taken up into bacterial cells and kill planktonic and biofilm bacteria. Biochim

Anunthawan, T., C. de la Fuente-Núñez, R.E.W. Hancock and S. Thammasirirak. 2015 (2015) Biochim. Biophys. Acta. 1848: 1352-1358 PDF

546

Conditional-ready mouse embryonic stem cell derived macrophages enable the study of essential genes in macrophage function.

Yeung, A.T.Y., C. Hale, J. Xia, P.H. Tate, D. Goulding, J.A. Keane, S. Mukhopadhyay, L. Forrester, O. Billker, W.C. Skarnes, R.E.W. Hancock, and G. Dougan. (2015) Scientific Reports 5: 8908 PDF

545

D-enantiomeric peptides that eradicate wild-type and multi-drug resistant bacterial biofilms and protect against lethal Pseudomonas aeruginosa infections.

de la Fuente-Núñez, C., F. Reffuveille, S.C. Mansour, S.L. Reckseidler-Zenteno, D. Hernández, G. Brackman, T. Coenye and R.E.W. Hancock. (2015) Chem. Biol. 22: 196-205 PDF

544

Tuning the affinity of anion binding sites in porin channels with negatively charged residues: Molecular details for OprP

Modi, N., I. Barcena-Uribarri, M. Bains, R. Benz, R.E.W. Hancock, and U. Kleinekathoefer (2015) ACS Chemical Biol. 10: 441-451 PDF

543

Antibiotic adjuvants: Diverse strategies for controlling drug-resistant pathogens.

Gill, E.E., O.L. Franco and R.E.W. Hancock. (2015) Chem. Biol. Drug Des. 85: 56-78 PDF

542

Anti-biofilm and immunomodulatory activities of peptides that inhibit biofilms formed by pathogens isolated from cystic fibrosis patients.

de la Fuente-Núñez, C., S.C. Mansour, Z. Wang, L. Jiang, E.B.M. Breidenstein, M. Elliott, F. Reffuveille, D.P. Speert, S.L. Reckseidler-Zenteno, Y. Shen, M. Haapasalo and R.E.W. Hancock. (2014) Antibiotics 3: 509-526 PDF

541

An endotoxin tolerance signature predicts sepsis and organ dysfunction at initial clinical presentation.

Pena, O.M., D.G. Hancock, N.H. Lyle, A. Linder, J.A. Russell, J. Xia, C.D. Fjell, J.H. Boyd, and R.E.W. Hancock. (2014) eBiomedicine 1: 64-71 PDF

540

Antimicrobial peptide delivery from trabecular bone grafts.

Mehdi Kazemzadeh-Narbat, M., Q. Wang, R.E.W. Hancock, R. Wang. (2014) J. Biomaterials Tissue Engineer 4: 967-972

539

Antibiotic resistance in Pseudomonas aeruginosa biofilms: towards the development of novel anti-biofilm therapies.

Taylor, P.K., A.T.Y. Yeung, and R.E.W. Hancock. (2014) J. Biotechnol. 191: 121-130 PDF

538

Barriers to the effective treatment of sepsis: antimicrobial agents, sepsis definitions and host directed therapies.

Lyle, N.H., O.M. Pena, J.H. Boyd, and R.E.W. Hancock. (2014) Ann. NY Acad. Sci. 1323: 101-114 PDF

537

Host defense peptides: front-line immunomodulators.

Mansour, S.C., O.M. Pena, and R.E.W. Hancock. (2014) Trends Immunol. 35: 443-450 PDF

536

A broad-spectrum anti-biofilm peptide enhances antibiotic action against bacterial biofilms.

Reffuveille, F., C. de la Fuente-Núñez, S. Mansour and R.E.W. Hancock. (2014) Antimicrob. Agents Chemother. 58: 5363-5371 PDF

535

Bordetella pertussis Lipid A glucosamine modification confers resistance to cationic antimicrobial peptides and increases resistance to outer membrane perturbation.

Shah, N., R.E.W. Hancock, and R. Fernández. (2014) Antimicrob. Agents Chemother. 58: 2931-4934 PDF

534

Pseudomonas aeruginosa elastase disrupts the cortisol-binding activity of corticosteroid-binding globulin.

Simard, M., L.A. Hill, C.M. Underhill, B.O. Keller, I. Villanueva, R.E.W. Hancock, and G.L. Hammond. (2014) Endocrinol. 155: 2900-2908 PDF

533

NetworkAnalyst – integrative approaches for protein-protein interaction network analysis and visual exploration.

Xia, J., M. Benner, and R.E.W. Hancock. 42: W167-4 PDF

532

Identification of a novel inhibition site in translocase MraY based upon the site of interaction with lysis protein E from bacteriophage ϕX174.

Rodolis, M.T., A. Mihalyi, A. O'Reilly, J. Slikas, D.I. Roper, R.E.W. Hancock, and T.D. Bugg. (2014) Chembiochem. 15: 1300-1308 PDF

531

Increased IL-8 production in human bronchial epithelial cells after exposure to azithromycin pre-treated Pseudomonas aeruginosa in vitro.

Fan, L., Q.Wang, C. de la Fuente-Núñez, F. Sun, J. Xia, P. Xia, and R.E.W. Hancock. (2014) FEMS Microbiol. Lett. 355: 43-50 PDF

530

A systems biology approach to the analysis of subset-specific responses to lipopolysaccharide in dendritic cells.

Hancock, D.G., E. Shklovskaya, T.V. Guy, R. Falsafi, C.D. Fjell, W. Ritchie, R.E.W. Hancock, and B. Fazekas de St Groth. (2013) PLoS One 9(6): e100613 PDF

529

Innate defence regulator peptide 1018 protects against perinatal brain injury.

Bolouri, H., K. Sävman,W. Wang, A. Thomas, N. Maurer, E. Dullaghan, C.D. Fjell, H. Hagberg, R.E.W. Hancock, K.L. Brown, and C. Mallard. 2014 (2014) Ann. Neurol. 75: 395-410 PDF

528

Skin electroporation of a plasmid encoding hCAP-18/LL-37 host defense peptide promotes wound healing.

Steinstraesser, L., M.C. Lam, F. Jacobsen, P.E. Porporato, K.K. Chereddy, M. Becerikli, I. Stricker, R.E.W. Hancock, M. Lehnhardt, P. Sonveaux, V. Préat, and G. Vandermeulen. (2014) Mol. Ther. 22: 734-742 PDF

527

Broad-spectrum anti-biofilm peptide that targets a cellular stress response.

Fuente-Núñez, C., F. Reffuveille, E.F. Haney, S.K. Straus and R.E.W. Hancock. (2014) PLos Pathogens 10(5): e1004152 PDF

526

Requirement of the Pseudomonas aeruginosa CbrA sensor kinase for full virulence in a murine acute lung infection model.

Yeung, A.T., L.Janot, O.M.Pena, A.Neidig, I.Kukavica-Ibrulj, A.Hilchie, R.C.Levesque, J. Overhage, and R.E.W. Hancock. (2014) Infect. Immun. 82: 1256-1267 PDF

525

Antimicrobial host defence peptide, LL-37, as a potential vaginal contraceptive.

Srakaew, N., C.D. Young, A. Sae-wu, H. Xu, K.L. Quesnel1, R. di Brisco, K. Kongmanas, D. Fongmoon, G. Hommalai, W. Weerachatyanukul, S.H. Hall, Y.-L. Zhang, L. Panza, L. Franchini, F. Compostella, T.W. Pearson, R.E.W. Hancock, R.J. Oko, L.S. Hermo and N. Tanphaichitr. (2014) Human Reprod. 29: 683-696 PDF

524

Collateral Damage (New and Views).

Hancock, R.E.W. (2014) Nature Biotechnology 32: 66-68 PDF

523

Consensus Statement: Understanding Health and Malnutrition through a Systems Approach: The ENOUGH Program for Early Life.

Kaput, J., B. van Ommen, B. Kremer, C. Priami, J.P. Monteiro. M. Morine, F. Pepping, Z. Diaz, M. Fenech, Y. He, R. Albers, C.A. Drevon, C. T. Evelo, R.E.W. Hancock, C. Ijsselmuiden, L.H. Lumey, A.-M. Minihane, M. Muller, C. Murgia, M. Radonjic, B. Sobral, and K.P. West, for the Participants of the Essential Nutrients Workshop. (2014) Genes and Nutrition 9: 378 PDF

522

INVEX – a web-based tool for integrative visualization of expression data.

Xia, J., M.L. Mayer, N.H. Lyle, OM. Pena, and R.E.W. Hancock. (2013) Bioinformatics 29: 3232-3234 PDF

521

Peptide design for antimicrobial and immunomodulatory applications.

Haney, E.F. and R.E.W. Hancock. (2013) Biopolymers 100: 572-583 PDF

520

The extra-cytoplasmic function sigma factor SigX modulates biofilm formation and virulence-related properties in Pseudomonas aeruginosa.

Gicquel, G., E. Bouffartigues, M. Bains, V. Oxaran, T. Rosay, O. Lesouhaitier, N. Connil, A. Bazire, O. Maillot, M. Bénard, P. Cornelis, R.E.W. Hancock, A. Dufour, M.G.J. Feuilloley, N. Orange, E. Déziel and S. Chevalier. (2013) PLoS One 8: e80407 PDF

519

Immune modulation by multifaceted cationic host defence (antimicrobial) peptides.

Hilchie, A.L., K. Wuerth, and R.E.W. Hancock (2013) Nature Chem. Biol. 9: 761-768 PDF

518

Bacterial biofilm development as a multicellular adaptation: Antibiotic resistance and new therapeutic strategies.

Fuente-Núñez, C., F. Reffuveille, L. Fernández and R.E.W. Hancock. (2013) Curr. Opin. Microbiol. 16: 580-589 PDF

517

Synthetic analogues of bovine bactenecin dodecapeptide reduce Herpes Simplex Virus type 2 infectivity in mice.

Shestakova, A., H. Jenssen, R.E.W. Hancock, I. Nordströma, and K. Eriksson. (2013) Antiviral Res. 100: 455-459 PDF

516

Expression of an engineered heterologous antimicrobial peptide in potato alters plant development and mitigates normal abiotic and biotic responses.

Goyal, R.K., R.E.W. Hancock, A.K. Mattoo, and S. Misra. (2013) PLoS One 8: e77505 PDF

515

Characterization of a proteolytically stable multifunctional host defense peptidomimetic.

Jahnsen, R.D., E.F. Haney, H. Franzyk, R.E.W. Hancock. (2013) Chem. Biol. 20: 1202-1203 PDF

514

The effect of nitroxides on swarming motility and biofilms, multicellular behaviors in Pseudomonas aeruginosa.

Fuente-Núñez, C., F. Reffuveille, K.E. Fairfull-Smith and R.E.W. Hancock. (2013) Antimicrob. Agents Chemother. 57: 4877-4881 PDF

513

The role of the central arginine towards the ion selectivity of the phosphate specific channel OprP: effects of charge and solvation.

Modi, N., I. Bárcena-Uribarri, M. Bains, R. Benz, R.E.W. Hancock, and U. Kleinekathöfer. (2013) Biochemistry 52: 5522-5532 PDF

512

The innate defense regulator peptides IDR-HH2, IDR-1002 and IDR-1018 modulate human neutrophil functions.

Niyonsaba, F., L. Madera, K. Okumura, H. Ogawa, and R.E.W. Hancock. (2013) J. Leukocyte Biol. 94: 159-170 PDF

511

Novel vaccine formulations against pertussis offer earlier onset of immunity and provide protection in the presence of maternal antibodies.

Polewicz, M., A. Gracia, S. Garlapati, J. van Kessel, S. Strom, S.A. Halperin, R.E.W. Hancock, A.A. Potter, L.A. Babiuk, and V. Gerdts. (2013) Vaccine 31: 3148-3155 PDF

510

INMEX – a web-based tool for integrative meta-analysis of expression data.

Xia, J., C.D. Fjell, M.L. Mayer, O.M. Pena, D.S. Wishart and R.E.W. Hancock. (2013) Nucl. Acids Res. 41: W63-W70 PDF

509

Multilayered coating on titanium for controlled release of antimicrobial peptides for the prevention of implant-associated infections.

Kazemzadeh-Narbat, M., J. Kindrachuk, K. Duan, H. Jenssen, R.E.W. Hancock, and R. Wang. (2013) Biomaterials 34: 5969-5977 PDF

508

Manipulation of innate immunity by a bacterial secreted peptide; the lantibiotic nisin Z is selectively immunomodulatory.

Kindrachuk, J., H. Jenssen, M. Elliot, A. Nijnik, L. Magrangeas-Janot, M. Pasupuleti, L. Thorson, S. Ma, D.M. Easton, M. Bains, B. Finlay, E.J. Breukink, H. Georg-Sahl, and R.E.W. Hancock. (2013) Innate Immunity 19: 315-327 PDF

507

Functional genetic variation in NFKBIA and susceptibility to childhood asthma, bronchiolitis, and bronchopulmonary dysplasia.

Ali, S., A.F. Hirschfeld, M.L. Mayer, E.S. Fortuno, N. Corbett, M. Kaplan, S. Wang, J. Schneiderman, C.D. Fjell, J. Yan, L. Akhabir, F. Aminuddin, N. Marr, T. Lacaze-Masmonteil, R.G. Hegele, A. Becker, M. Chan-Yeung, R.E.W. Hancock, T.R. Kollmann, D. Daley, A.J. Sandford, P.M. Lavoie and S.E. Turvey. (2013) J. Immunol. 190: 3949-3958 PDF

506

Pseudomonas aeruginosa: New insights into pathogenesis and host defenses.

Gellatly, S. and R.E.W. Hancock. (2013) Pathogens and Disease 67: 159-173 PDF

505

Ability of innate defence regulator peptides IDR-1002, IDR-HH2 and IDR-1018 to protect against Mycobacterium tuberculosis infections in animal models.

Rivas-Santiago, B., J.E. Castañeda-Delgado, C.E.Rivas Santiago, M. Waldbrook, I. González-Curiel, J. C. León–Contreras, A. Enciso-Moreno, V. del Villar, J. Méndez-Ramos, R.E.W. Hancock, R. Hernandez-Pando. (2013) PLoS One 8: e59119 PDF

504

Genome-wide identification of genes conferring energy related resistance to a synthetic antimicrobial peptide (Bac8c).

Spindler, E.C., N.R. Boyle, R.E.W. Hancock, and R. T Gill. (2013) PLoS One 8: e55052 PDF

503

Rescue of dysfunctional autophagy by IDR-1018 attenuates hyperinflammatory responses from cystic fibrosis cells.

Mayer, M.L., C.J. Blohmke, R. Falsafi, C.D. Fjell, L. Madera, S.E. Turvey, and R.E.W. Hancock. (2013) J. Immunol. 190: 1227-1238 PDF

502

Armand-Frappier Outstanding Student Award - Role of ATP-dependent proteases in antibiotic resistance and virulence.

Breidenstein, E.B.M., and R.E.W. Hancock. (2013) Can. J. Microbiol. 59: 1-8 PDF

501

The Liver X receptor agonist GW3965 improves recovery from mild repetitive traumatic brain injury in mice partly through apolipoprotein E.

Namjoshi, D.R., G. Martin, J. Donkin, A. Wilkinson, S. Stukas, J. Fan, M. Carr, S. Tabarestani, K. Wuerth, R.E.W. Hancock, and C.L. Wellington. (2013) PLoS One 8: e53529 PDF

500

Activity of LL-37, CRAMP and antimicrobial peptide-derived compounds E2, E6, and CP26 against Mycobacterium tuberculosis.

Rivas-Santiago B., C.E. Rivas-Santiago, J.E. Castañeda-Delgado, J. C. León-Contreras, R.E.W. Hancock, and R. Hernandez-Pando. (2013) Intl. J. Antimicrob. Agents 41: 143-148 PDF

499

Synthetic cationic peptide IDR-1018 modulates human macrophage differentiation.

Pena O.M., N. Afacan, J. Pistolic, C. Chen, L. Madera, R. Falsafi, C.D. Fjell, and R.E.W. Hancock. (2013) PLoS One 8: e52449 PDF

498

InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation.

Breuer, K., A. Foroushani, M. Laird, C. Chen, A. Sribnaia, R. Lo, G. Winsor, R.E.W. Hancock, F.S.L. Brinkman, and D.J. Lynn. (2013) Nucl. Acids Res. 41(D1): D1228-33 PDF

497

Characterization of the polymyxin B resistome of Pseudomonas aeruginosa.

Fernández, L., C. Álvarez-Ortega, I. Wiegand, J. Olivares, D. Kocíncová, J.S. Lam, J.L. Martínez, and R.E.W. Hancock. (2013) Antimicrob. Agents Chemother. 57: 110-119 PDF

496

Impaired pulmonary defense against Pseudomonas aeruginosa in VEGF gene inactivated mouse lung.

Breen, E.C., J.L. Malloy, K. Tang, F. Xia, Z. Fu, R.E.W. Hancock, J. Overhage, P.D. Wagner, R.G. Spragg. (2013) J. Cell. Physiol. 228: 371-379 PDF

495

Modeling the ion selectivity of the phosphate specific channel OprP. J

Niraj Modi, N., R. Benz, R.E.W. Hancock, and U. Kleinekathöfer (2013) J. Phys. Chem. Letters 3: 3639-3645 PDF

494

Atypical activation of the unfolded protein response in cystic fibrosis airway cells contributes to p38 MAPK-mediated innate immune responses.

Blohmke, C.J., M. Mayer, C.D. Fjell, A.C Tang, M.Sze, A.F. Hirschfeld, R. Falsafi, M.A. Chilvers, J.C. Hogg, R.E.W. Hancock, and S.E. Turvey. (2012) J. Immunol. 189: 5467-5475 PDF

493

The two-component system CprRS senses cationic peptides and triggers adaptive resistance in Pseudomonas aeruginosa independently of ParRS.

Fernández, L., H. Jenssen, M. Bains, I. Wiegand, W.J. Gooderham, and R.E.W. Hancock. (2012) Antimicrob. Agents Chemother. 56: 6212-6222 PDF

492

The Lon protease is essential for full virulence in Pseudomonas aeruginosa.

Breidenstein, E.B.M., L. Janot, J. Strehmel, L. Fernández, P.K. Taylor,I. Kukavica-Ibrulj, S.L. Gellatly, R.C. Levesque, J. Overhage, and R.E.W. Hancock. (2012) PLoS One 7: e49123 PDF

491

Specific association of lectin LecB with the surface of Pseudomonas aeruginosa: Role of outer membrane protein OprF.

Funken, H., K.Bartels, S. Wilhelm, M. Brocker, M. Bott, M. Bains, R.E.W. Hancock, F. Rosenau, and K.-E. Jaeger. (2012) PLoS One 7: e46857 PDF

490

LpxC inhibition protects mice from resistant Acinetobacter baumannii by modulating inflammation and enhancing phagocytosis.

Lin, L., B. Tan, P. Pantapalangkoor, T. Ho, B. Baquir, A. Tomaras, J.I. Montgomery, U. Reilly, E.G. Barbacci, K. Hujer, R.A. Bonomo, L. Fernández, R.E.W. Hancock, M.D. Adams, S.W. French, V.S. Buslon, and B. Spellberg. (2012) mBio 3(5): e00312-12 PDF

489

Adaptive and mutational resistance: Role of porins and efflux pumps in drug resistance.

Fernández, L., and R.E.W. Hancock. (2012) Clin. Microbiol. Rev. 25: 661-681 PDF

488

Synthetic immunomodulatory peptide IDR-1002 enhances monocyte migration and adhesion on fibronectin.

Madera, L., and R.E.W. Hancock. (2012) J. Innate Immun. 4: 553-568 PDF

487

Phosphate starvation promotes swarming motility and cytotoxicity in Pseudomonas aeruginosa.

Bains, M., L. Fernández and R.E.W. Hancock. (2012) Appl. Environ. Microbiol 78: 6762-6768 PDF

486

The Pseudomonas aeruginosa PhoP-PhoQ two-component regulatory system is induced upon interaction with epithelial cells and controls cytotoxicity and inflammation

Gellatly, S.L., B. Needham, L. Madera, M. S. Trent, and R.E.W. Hancock. (2012) Infect. Immun. 80: 3122-3131 PDF

485

Innate defense regulator peptide 1018 in wound healing and wound infection.

Steinstraesser, L., T. Hirsch, M. Schulte, M. Kueckelhaus, F. Jacobsen, E.A. Mersch, I. Stricker, N. Afacan, H. Jenssen, R.E.W. Hancock and J. Kindrachuk. (2012) PLoS One 7(8): 10.1371/journal.pone.0039373 PDF

484

Transcription of the OprF porin of Pseudomonas aeruginosa is dependent mainly on the SigX sigma factor and is sucrose-induced.

Bouffartigues, E., G. Gicquel, A. Bazire, M. Bains, O. Maillot, J. Vieillard, M.G.F. Feuilloley, N. Orange, R.E.W. Hancock, A. Dufour, and S. Chevalier. (2012) J. Bacteriol. 194: 4301-4311 PDF

483

The bacterial surface layer provides protection against antimicrobial peptides.

Fuente-Núñez, C., J. Mertens, J. Smit, and R.E.W. Hancock. (2012) Appl. Environ. Microbiol 10: 442 PDF

482

Enhanced immune responses and protection by vaccination with respiratory syncytial virus fusion protein formulated with CpG oligodeoxynucleotide and synthetic innate defense regulator peptide in polyphosphazene microparticles.

Garlapati, S., R. Garg, R. Brownlie, L. Latimer, E. Simko, R.E.W. Hancock, L. Babiuk, V. Gerdts, A. Potter, and S. van den Hurk. (2012) Vaccine 30: 5206-5214 PDF

481

The role of sphingosine-1-phosphate transporter Spns2 in immune system function.

Nijnik, A., S. Clare, C. Hale, J. Chen, C. Raisen, L. Mottram, M. Lucas, J. Estabel, E. Ryder, H. Adissu, Sanger Mouse Genetics Project, N.C. Adams, R. Ramirez-Solis, J.K. White, K.P. Steel, G. Dougan, and R.E.W. Hancock. (2012) J. Immunol. 189: 102-111 PDF

480

Signalling pathways mediating chemokine induction in keratinocytes by cathelicidin LL-37 and flagellin.

Nijnik, A., J. Pistolic, N.C.J. Filewod, and R.E.W. Hancock. (2012) J. Innate Immun. 4: 377-386 PDF

479

Effective adjunctive therapy by an innate defense regulatory peptide in a pre-clinical model of severe malaria.

Achtman, A.H., S. Pilat, C.W. Law, D.J. Lynn, L. Janot, M. Mayer, S. Ma, J. Kindrachuk, B.B. Finlay, F.S.L. Brinkman, G.K. Smyth, R.E.W. Hancock and L. Schofield. (2012) Science Transl. Med 4: 135ra64 PDF

478

Drug release and bone growth studies of antimicrobial peptide-loaded calcium phosphate coating on titanium.

Kazemzadeh-Narbat, M., S. Noordin, B.A. Masri, D.S. Garbuz, C.P. Duncan, R.E.W. Hancock, and R. Wang. (2012) J. Biomed. Mater. Res.B. - Appl. Biomater. 100: 1344-1352 PDF

477

Involvement of the Lon protease in the SOS response triggered by ciprofloxacin in Pseudomonas aeruginosa PAO1.

Breidenstein, E.B.M., M. Bains, and R.E.W. Hancock (2012) Antimicrob. Agents Chemother. 56: 2879-2887 PDF

476

Mucin promotes rapid surface motility in Pseudomonas aeruginosa.

Yeung, A.T.Y., A. Parayno, and R.E.W. Hancock. (2012) mBio 3: e00073-12 PDF

475

Inhibition of bacterial biofilm formation and swarming motility by a small synthetic cationic peptide.

Fuente-Núñez, C., V. Korolik, M. Bains, U. Nguyen, E.B.M. Breidenstein, S. Horsman, S. Lewenza, L. Burrows and R.E.W. Hancock. (2012) Antimicrob. Agents Chemother. 56: 2696-2704 PDF

474

Local delivery of antimicrobial peptides using self-organized TiO2 nanotube arrays for peri-implant infections.

Ma, M., M. Kazemzadeh-Narbat, Y. Hui, S. Lu, C. Ding, D.D.Y. Chen, R.E.W. Hancock and R. Wang. (2012) J. Biomed. Materials Res. Part A 100A: 278-285 PDF

473

The role of the Src family kinase Lyn in the immunomodulatory activities of cathelicidin peptide LL-37 on monocytic cells.

Nijnik, A., J. Pistolic, P. Cho, N.C.J. Filewod, R. Falsafi, A. Ramin, K.W. Harder, and R.E.W. Hancock. (2012) J. Leukocyte Biol. 91: 599-607 PDF

472

Protein Interaction Data Curation - The International Molecular Exchange Consortium (IMEx).

Orchard, S., S.Kerrien, S.Abbani, B.Aranda, J.Bhate, S.Bidwell, A.Bridge, L.Briganti, F.Brinkman, G.Cesareni, A.Chatr-aryamontri, E.Chautard, C.Chen, M.Dumousseau, D.Eisenberg, J.Goll, R.E.W. Hancock, L.Hannick, I.Jurisica, J.Khadake, D.J.Lynn, U.Mahadevan, L.Perfetto, A.Raghunath, S.Ricard-Blum, B.Roechert, L.Salwinski, V.Stümpflen, M.Tyers, P.Uetz, I.Xenarios, and H.Hermjakob. (2012) Nature Methods 9: 345-350 PDF

471

Modulating immunity as a therapy for bacterial infections.

Hancock, R.E.W., A. Nijnik and D.J. Philpott. (2012) Nature Rev. Microbiol. 10: 243-254 PDF

470

Biomembrane interactions reveal the mechanism of action of surface-immobilized host defense IDR-1010 peptide.

Gao, G., J.T.J. Cheng, J. Kindrachuk, R.E.W. Hancock, S.K. Straus, and J.N. Kizhakkedathu. (2012) Chem. Biol. 19: 199-209 PDF

469

Therapeutic potential of host defense peptides in antibiotic-resistant infections.

Afacan, N.J., A.T.Y. Yeung, O.M. Pena and R.E.W. Hancock. (2012) Curr. Pharm. Design 18: 807-819 PDF

468

The critical role of histone H2A-deubiquitinase Mysm1 in haematopoiesis and lymphocyte differentiation.

Nijnik, A., S. Clare, C. Hale, C. Raisen, R.E. McIntyre, K. Yusa, A.R. Everitt, L. Mottram, C. Podrini, M. Lucas, J. Estabel, D. Goulding, N. Adams, R. Ramirez-Solis, J.K. White, D.J. Adams, R.E.W. Hancock, and G. Dougan. (2012) Blood 119: 1370-1379 PDF

467

Role of intracellular proteases in the antibiotic resistance, motility, and biofilm formation of Pseudomonas aeruginosa.

Fernández, L., E.B.M. Breidenstein, D. Song, and R.E.W. Hancock. (2012) Antimicrob. Agents Chemother. 56: 1128-1132 PDF

466

Structure, dynamics, antimicrobial and immune modulatory activities of human LL-23 and its single residue variants mutated on the basis of homologous primate cathelicidins.

Wang, G., M. Elliott, A.L. Cogen, E.L. Ezell, R.L. Gallo, and R.E.W. Hancock. (2012) Biochemistry 51: 653-664 PDF

465

Complete genome sequences of three Pseudomonas aeruginosa isolates with phenotypes of polymyxin B adaptation and inducible resistance

Boyle B., L. Fernández, J. Laroche, I. Kukavica-Ibrulj, C.M.F. Mendes, R.E.W. Hancock and R.C. Levesque. (2012) J. Bacteriol. 194: 529-530 PDF

464

A systems biology approach to nutritional immunology-focus on innate immunity. Molec

Afacan, N.J., C.D. Fjell and R.E.W. Hancock. (2012) Molec. Aspects Medicine 33: 14-25 PDF

463

Comparison of immune responses and protective efficacy of intranasal prime-boost immunization regimens using adenovirus-based and CpG/HH2 adjuvanted-subunit vaccines against genital Chlamydia muridarum infection.

Brown, T.H.T., J. David, E. Acosta-Ramirez, J.M. Moore, S. Lee, G. Zhong, R.E.W. Hancock, Z. Xing, S.A. Halperin and J. Wang. (2012) Vaccine 30: 350-360 PDF

462

Designing antimicrobial peptides: Form follows function.

Fjell, C.D., J. A. Hiss, R.E.W. Hancock and G. Schneider. (2012) Nature Rev. Drug Discov. 11: 37-51 PDF

461

Antibacterial surfaces based on polymer brushes: Investigation on the influence of brush properties on antimicrobial peptide immobilization and antimicrobial activity.

Gao, G., K. Yu, J. Kindrachuk, D.E. Brooks, R.E.W. Hancock, and J.N. Kizhakkedathu. 2011 (2011) Biomacromolecules 12: 3715-3727 PDF

460

New insights into cathelicidin modulation of adaptive immunity.

Wuerth, K., and R.E.W. Hancock. (2011) Eruop. J. Immunol. 41: 2817-2819 PDF

459

The human transcriptome during non-typhoid Salmonella and HIV co-infection reveals attenuated NFkB-mediated inflammation and persistent cell-cycle disruption

Schreiber, F., D.J. Lynn, A. Houston, J. Peters, G. Mwafulirwa, B.B Finlay, F. Brinkman, R.E.W. Hancock, R.S. Heyderman, G. Dougan and M.A. Gordon. (2011) J. Infect. Dis. 204: 1237-1245 PDF

458

Cathelicidin peptide LL-37 modulates TREM-1 expression and inflammatory responses to microbial compounds.

Amatngalim, G.D., A. Nijnik, P.S. Hiemstra, and R.E.W. Hancock. (2011) Inflammation 34: 412-425 PDF

457

Modulation of IL-1β-induced inflammatory responses by a synthetic cationic innate defence regulator peptide, IDR-1002, in synovial fibroblasts.

Turner-Brannen, E., K.-Y. Choi, D.N.D. Lippert, J.P. Cortens, R.E.W. Hancock, H. El-Gabalawy and N. Mookherjee. (2011) Arthritis Res. Ther. 13: R129 PDF

456

Immunization with PCEP microparticles containing pertussis toxoid, CpG ODN and a synthetic innate defense regulator peptide induces protective immunity against pertussis.

Garlapati, S., N.F. Eng, T. Kiros, J. Kindrachuk, G.K. Mutwiri, R.E.W. Hancock, S.A. Halperin, A.A. Potter, L.A. Babiuk and V. Gerdts. (2011) Vaccine 29: 6540-6548 PDF

455

The olsA gene mediates the synthesis of an ornithine lipid in Pseudomonas aeruginosa during growth in phosphate limiting conditions but not antimicrobial peptide susceptibility.

Lewenza, S., R. Falsafi, M. Bains, P. Rohs, J. Stupak, G.D. Sprott, and R.E.W. Hancock. (2011) FEMS Microbiol. Lett. 320: 35-102 PDF

454

Pseudomonas aeruginosa: all roads lead to resistance.

Breidenstein, E.B.M., C. de la Fuente-Núñez, and R.E.W. Hancock. (2011) Trends Microbiol. 19: 419-426 PDF

453

The pmrCAB operon mediates polymyxin resistance in Acinetobacter baumannii ATCC 17978 and clinical isolates through phosphoethanolamine modification of Lipid A.

Arroyo, L.A., C.M. Herrera, L. Fernández, J.V. Hankins, M.S. Trent and R.E.W. Hancock. (2011) Antimicrob. Agents Chemother. 55: 3743-3751 PDF

452

Antimicrobial properties of MX-2401, a second generation lipopeptide active in presence of lung surfactant.

Dugourd, D., H. Yang, M. Elliott, R. Siu, J.J. Clement, S.K. Straus, R.E.W. Hancock, and E. Rubinchik. (2011) Antimicrob. Agents Chemother. 55: 3720-3728 PDF

451

PSICQUIC and PSISCORE - Accessing and scoring molecular interaction data.

Aranda, B., H. Blankenburg, S. Kerrien, F.S.L. Brinkmann, A. Ceol, E. Chautard, J. De La Rivas, E. Galeota, A. Gaulton, J. Goll, R.E.W. Hancock, R. Isserlin, R. Jimenez, D.J. Lynn, M. Michaut, G. O’Kelly, K. Ono, S. Orchard, C. Prieto, S. Razick, O. Rigina, L. Salwinski, M. Simonovic, A. Winter, G. Wu, G. Bader, G. Cesareni, I.M. Donaldson, D. Eisenberg, J. Overington, S. Ricard-Blum, M. Tyers, M. Albrecht, H. Hermjakob. (2011) Nature Methods 8: 528-529 PDF

450

Lipopolysaccharide renders transgenic mice expressing human Serum amyloid P component sensitive to Shiga toxin 2.

Griener T.P., J.G. Strecker, R.M. Humphries, G.L. Mulvey, C. Fuentealba, R.E.W. Hancock and G.D. Armstrong. (2011) PLoS One 6(6): 10.1371/journal.pone.0021457 PDF

449

Effect of BMAP-28 antimicrobial peptides on Leishmania major promastigote and amastigote growth: role of leishmanolysin in parasite survival.

Lynn, M.A., J. Kindrachuk, H. Jenssen, N. Panté, M.R. Elliott, S. Napper, R.E.W. Hancock, W.R. McMaster. (2011) PLoS Neglected Trop. Dis. 5: e1141 PDF

448

Multifunctional cationic host-defence peptides and clinical applications.

Yeung, A.T.Y., S.L. Gellatly, and R.E.W. Hancock. (2011) Cell. Molec. Life Sci. 68: 2161-2176 PDF

447

Endotoxin tolerance represents a distinctive state of alternative polarization (M2) in human mononuclear cells.

Pena, O.M., J. Pistolic, D. Raj, C.D. Fjell, R.E.W. Hancock. (2011) J. Immunol. 186: 7243-7254 PDF

446

Mechanism of action and limited cross resistance of a new lipopeptide MX-2401.

Rubinchik, E., T. Schneider, M. Elliott, W.R.P. Scott, J. Pan, C. Anklin, H. Yang, D. Dugourd, A. Müller, K. Gries, S. K. Straus, H.G. Sahl and R.E.W. Hancock. (2011) Antimicrob. Agents Chemother. 55: 2743-2754 PDF

445

Host defence peptide LL-37 selectively reduces pro-inflammatory macrophage responses.

Brown, K.L., G.F.T. Poon, D. Birkenhead, O.M. Pena, R. Falsafi, C. Dahlgren, A. Karlsson, J. Bylund, R.E.W. Hancock and P. Johnson. (2011) J. Immunol. 186: 5497-5505 PDF

444

The intrinsic resistome of Pseudomonas aeruginosa to β-lactams.

Alvarez-Ortega, C., I. Wiegand, J. Olivares, R.E.W. Hancock, and J.L. Martínez. 2011 (2011) Virulence 2: 144-146 PDF

443

In vitro susceptibility of Burkholderia vietnamiensis to aminoglycosides

Jassem, A.N., J.E.A. Zlosnik, D.A. Henry, R.E.W. Hancock, R.K. Ernst, and D.P. Speert. (2011) Antimicrob. Agents Chemother. 55: 2256-2264 PDF

442

Involvement of an ATP-dependent protease (PA0779/AsrA) in inducing heat shock in response to tobramycin in Pseudomonas aeruginosa.

Kindrachuk, K.N., L. Fernández, M. Bains, and R.E.W. Hancock. (2011) Antimicrob. Agents Chemother. 55: 1874-1882 PDF

441

The biocompatibility and biofilm resistance of implant coatings based on hydrophilic polymer brushes conjugated with antimicrobial peptides

Gao, G., D. Lange, K. Hilpert, J. Kindrachuk, Y. Zou, J.T.J. Cheng, M. Kazemzadeh, Kai Yu, R. Wang, S.K. Straus, D.E. Brooks, B.H. Chew, R.E.W. Hancock, J.N. Kizhakkedathu. (2011) Biomaterials 32: 3899-3909 PDF

440

Deciphering the mode of action of a synthetic antimicrobial peptide (Bac8c).

Spindler, E.C., J.D. Hale, T.H. Giddings Jr, R.E.W. Hancock, and R.T. Gill (2011) Antimicrob. Agents Chemother. 55: 1706-1716 PDF

439

The human cathelicidin, LL-37, induces granzyme-mediated apoptosis in regulatory T cells.

Mader, J.S., C. Ewen, R.E.W. Hancock, and C. Bleackley. (2011) J. Immunother. 34: 229-235 PDF

438

Creeping baselines and adaptive resistance to antibiotics.

Fernández, L., E.B.M. Breidenstein, and R.E.W. Hancock (2011) Drug Resist. Updates 14: 1-21 PDF

437

Antibody responses in adult and neonatal BALB/c mice to immunization with novel Bordetella pertussis vaccine formulations.

Gracia, A., M. Polewicz, S.A. Halperin, R.E.W. Hancock, A.A. Potter, L.A. Babiuk, and V. Gerdts. (2011) Vaccine 29: 1595-1604 PDF

436

The sensor kinase CbrA is a global regulator that modulates metabolism, virulence and antibiotic resistance in Pseudomonas aeruginosa.

Yeung A.T.Y., M. Bains, and R.E.W. Hancock. (2011) J. Bacteriol. 193: 918-931 PDF

435

The Pseudomonas aeruginosa autoinducer 3O-C12 homoserine lactone provokes hyperinflammatory responses from cystic fibrosis airway epithelial cells in a calcium-dependent manner.

Mayer, M.L., J.A. Sheridan, C.J. Blohmke, S.E. Turvey, and R.E.W. Hancock (2011) PLoS One 6: e16249 PDF

434

The human cathelicidin, LL-37, induces granzyme-mediated apoptosis in cytotoxic T lymphocytes.

Mader, J.S., M. Marcet-Palacios, R.E.W. Hancock, and C. Bleackley. (2011) Exptl. Cell Res. 317: 531-538 PDF

433

Pseudomonas Genome Database: Improved comparative analysis and population genomics capability for Pseudomonas genomes.

Winsor, G.L., D.K.W. Lam, L. Fleming, R. Lo, M.D. Whiteside, N.Y. Yu, R.E.W. Hancock and F.S.L. Brinkman. (2011) Nucl. Acids Res. 39: D596-600 PDF

432

Optimization of antibacterial peptides by genetic algorithms and cheminformatics.

Fjell, C.D., H. Jenssen, W.A. Cheung, R.E.W. Hancock and A. Cherkasov (2011) Chem. Biol. Drug Des. 77: 48-56 PDF

431

The importance of bacterial membrane composition in the structure and function of aurein 2.2 and selected variants.

Cheng, J.T., J.D. Hale, M. Elliott, R.E.W. Hancock, and S.K. Straus. (2011) Biochim. Biophys. Acta. 1808: 622-633 PDF

430

The human cathelicidin LL-37 preferentially promotes apoptosis of infected airway epithelium.

Barlow, P.G., P.E. Beaumont, C. Cosseau, A. Mackellar, T.S. Wilkinson, R.E.W. Hancock, C. Haslett, J.R.W. Govan, A.J.N Simpson, and D.J. Davidson. (2010) Amer. J. Respir. Cell Mol. Biol. 43: 692-702 PDF

429

Immunomodulators as adjuvants for vaccines and antimicrobial therapy.

Nicholls, E.F., L. Madera and R.E.W. Hancock. (2010) Ann. NY Acad. Sci. 1213: 46-61 PDF

428

Permeabilization of fungal hyphae by the plant defensin NaD1 occurs through a cell wall dependent process.

Van der Weerden, N.L., R.E.W. Hancock, and M.A. Anderson. (2010) J. Biol. Chem. 285: 37513-37520 PDF

427

Importance of residue 13 and the C-terminus for the structure and activity of the antimicrobial Peptide aurein 2.2.

Cheng J.T., J.D. Hale, J. Kindrachuk, H. Jessen, M. Elliott, R.E.W.Hancock and S.K. Straus. (2010) Biophys. J. 99: 2926-2935 PDF

426

Systems-level comparison of host responses induced by pandemic and seasonal influenza A H1N1 viruses in primary human type I-like alveolar epithelial cells in vitro.

Lee, S.M.Y., R.W.Y. Chan, J.L. Gardy, C.K. Lo, A.D.L. Sihoe, S.S.R. Kang, T.K.W. Cheung, Y. Guan, M.C.W. Chan, R.E.W. Hancock, and J.S.M. Peiris. (2010) Respir. Res. 11: 147 PDF

425

Antimicrobial peptides on calcium phosphate-coated titanium for the prevention of implant-associated infections.

Kazemzadeh-Narbat, M., J. Kindrachuk, K. Duan, H. Jenssen, R.E.W Hancock, and R. Wang. (2010) Biomaterials 31: 9519-9526 PDF

424

Cost-effective expression and purification of antimicrobial and host defense peptides in Escherichia coli.

Bommarius, B., H. Jenssen, M. Elliott, J. Kindrachuk, H. Gieren, K.-E. Jaeger, R.E.W. Hancock and D. Kalman. (2010) Peptides 31: 1957-1965 PDF

423

Structural studies of a peptide with immune modulating and direct antimicrobial activity.

Wieczorek, M., H. Jenssen, J. Kindrachuk, W.R.P. Scott, M. Elliot, K. Hilpert, J.T.J. Cheng, R.E.W. Hancock and S.K. Straus. (2010) Chem. Biol. 17: 970-980 PDF

422

Genetic determinants involved in the susceptibility of Pseudomonas aeruginosa to β-lactam antibiotics.

Alvarez-Ortega, C., I. Wiegend, J. Olivares, R.E.W. Hancock, and J. Luis Martínez (2010) Antimicrob. Agents Chemother. 421: 4159-4167 PDF

421

Short cationic antimicrobial peptides interact with ATP.

Hilpert, K., B. McLeod, J. Yu, M.R. Elliott, M. Rautenbach, S. Ruden, J. Bürck, C. Muhle-Goll, A.S. Ulrich, S. Keller and R.E.W. Hancock. (2010) Antimicrob. Agents Chemother. 54: 4480-4483 PDF

420

Curating the innate immunity interactome.

Lynn, D.J., C. Chan, M. Naseer, M. Yau, R. Lo, A. Sribnaia, G. Ring, J. Que, K. Wee, G.L. Winsor, M.R. Laird, K. Breuer, A.K. Foroushani, F.S.L. Brinkman, and R.E.W. Hancock. (2010) BMC Systems Biology 4: 117 PDF

419

Adaptive resistance to the “last hope” antibiotics polymyxin B and colistin in Pseudomonas aeruginosa is mediated by the novel two-component regulatory system ParR-ParS.

Fernández, L., W.J. Gooderham, M. Bains, J.B. McPhee, I. Wiegand, and R.E.W. Hancock. (2010) Antimicrob. Agents Chemother. 54: 3372-3382 PDF

418

Transcriptional differences between a virulent and an attenuated strain of Mycobacterium tuberculosis infecting murine bone-marrow derived macrophages.

Li, A.H., S.J. Waddell, J. Hinds, C.A. Malloff, M. Bains, R.E.W. Hancock, W.L. Lam, P.D. Butcher, and R.W. Stokes. (2010) PLoS One 5: e11066 PDF

417

Computer-aided design of antimicrobial peptides.

Fjell, C.D., R.E.W. Hancock and H. Jenssen. (2010) Curr. Pharm. Anal. 6: 66-75 PDF

416

Cathelicidins link the endocrine and immune systems.

Mayer, M.L., and R.E.W. Hancock. (2010) Cell Host and Microbe 7: 257-259 PDF

415

Robust TLR4-induced gene expression patterns are not an accurate indicator of human immunity.

Brown, K.L., R. Falsafi, W. Kum, P. Hamill, J.L. Gardy, D.J. Davidson, S. Turvey, B.B. Finlay, D.P. Speert and R.E.W. Hancock. (2010) J. Translational Med. 8: 10.1186/1479-5876-8-6 PDF

414

Synthetic cationic peptide IDR-1002 provides protection against bacterial infections through chemokine induction and enhanced leukocyte recruitment.

Nijnik A., L. Madera, S. Ma, M. Waldbrook, M. Elliott, S.C. Mullaly, J. Kindrachuk, H. Jenssen, R.E.W. Hancock. (2010) J. Immunol. 184: 2539-2550 PDF

413

Strategies for the identification and advancement of novel cationic antimicrobial peptides.

Hadley, E.B., and R.E.W. Hancock (2010) Curr. Topics Medicinal Chem. 8: 1872-1881

412

G-protein-coupled receptor independent, immunomodulatory properties of chemokine CXCL9

Gong, J.-H. E.F. Nicholls, M.R. Elliott, K.L. Brown, K. Hokamp, F.M. Roche, C.Y Cheung, R. Falsafi, F.S. Brinkman, D.M.E. Bowdish, and R.E.W. Hancock. (2010) Cellular Immunol. 261: 105-113

411

Therapeutic Potential of HDPs as Immunomodulatory Agents.

Jenssen, H., and R.E.W. Hancock. (2010) Meth. Molec. Biol. 20: 329-347 PDF

410

Manual annotation and analysis of the defensin gene cluster in the C57BL/6J mouse reference genome.

Amid, C., L.M. Rehaume, K.L. Brown, J.G.R. Gilbert, G. Dougan, R.E.W. Hancock, and J.L. Harrow. (2009) BMC Genomics 10: 10.1186/1471-2164-10-606 PDF

409

Systems-Level Comparison of Host-Responses Elicited by Avian H5N1 and Seasonal H1N1 Influenza Viruses in Primary Human Macrophages.

Lee, S.M.Y., J.L. Gardy, C.Y. Cheung, T.K.W. Cheung, K.P.Y. Hui1, W.W. Gai1, N.Y. Ip, Y. Guan, R.E.W. Hancock, and J.S.M. Peiris (2009) PLoS One 4(12): 10.1371/journal.pone.0008072 PDF

408

Sequestosome-1/p62 is the key intracellular target of innate defense regulator peptide.

Yu, H.B., A. Kielczewska, A. Rozek, S. Takenaka, Y. Li, L. Thorson, R.E.W. Hancock, M.M. Guarna, J.R. North, L.J. Foster, O. Donini and B.B. Finlay. (2009) J. Biol. Chem. 284: 36007-36011 PDF

407

Human cathelicidin peptide LL-37 modulates the effects of IFN-gamma on APCs.

Nijnik, A., J. Pistolic, A. Wyatt, S. Tam, and R.E.W. Hancock. (2009) J. Immunol. 183: 5788-5798 PDF

406

Synthesis of peptide arrays using SPOT-technology and the CelluSpots-method.

Winkler, D.F.H., K. Hilpert, O. Brandt and R.E.W. Hancock. (2009) Meth. Molec. Biol. 570: 157-174 PDF

405

Swarming of Pseudomonas aeruginosa is controlled by a broad spectrum of transcriptional regulators including MetR.

Yeung, A.T.Y., E.C.W. Torfs, F. Jamshidi, M. Bains, I. Wiegand, R.E.W. Hancock, and J. Overhage. (2009) J. Bacteriol. 191: 5591-5602 PDF

404

Involvement of pmrAB and phoPQ in polymyxin B adaptation and inducible resistance in non-cystic fibrosis clinical isolates of Pseudomonas aeruginosa.

Schurek, K.N., J.L.M. Sampaio, C.R.V. Kiffer, S. Sinto, C.M.F. Mendes, and R.E.W. Hancock. (2009) Antimicrob. Agents Chemother. 53: 4345-4351 PDF

403

Intracellular receptor for human host defence peptide LL-37 in monocytes.

Mookherjee, N., D.N.D. Lippert, P. Hamill, R. Falsafi, A. Nijnik, J. Kindrachuk, J. Pistolic, J. Gardy, P. Miri, M. Naseer, L.J. Foster, and R.E.W. Hancock. (2009) J. Immunol. 183: 2688-2696 PDF

402

Potential of immunomodulatory host defense peptides as novel anti-infectives.

Easton, D.M., A. Nijnik, M.L. Mayer, and R.E.W. Hancock. (2009) Trends in Biotechnol. 27: 582-590 PDF

401

A novel vaccine adjuvant comprised of a synthetic innate defence regulator peptide and CpG oligonucleotide links innate and adaptive immunity.

Kindrachuk, J., H. Jenssen, M. Elliott, R. Townsend, A. Nijnik, S.F. Lee, V. Gerdts, L.A. Babiuk, S.A. Halperin and R.E.W. Hancock. (2009) Vaccine 27: 4662-4671 PDF

400

Low concentrations of LL-37 alter IL-8 production by keratinocytes and bronchial epithelial cells in response to pro-inflammatory stimuli.

Filewod, N., J. Pistolic, R.E.W. Hancock. 2009 (2009) FEMS Immunol. Medical Microbiol 53: 223-240 PDF

398

The major outer membrane protein OprG of Pseudomonas aeruginosa contributes to cytotoxicity and forms an anaerobically-regulated, cation-selective channel.

McPhee, J.B., S. Tamber, M. Bains, E. Maier, S. Gellatly, A. Lo, R. Benz, and R.E.W. Hancock. (2009) FEMS Microbiol. Lett. 296: 241-247 PDF

397

An iron-starvation inducible LysR-type regulator regulates the polymyxin resistance pmrF operon and controls virulence in Yersinia pseudotuberculosis.

Arafah, S., M.-L. Rosso, L. Rehaume, R.E.W. Hancock, M. Simonet, and M. Marceau. (2009) Microbiology 155: 2168-2181

396

Enabling a systems biology approach to immunology: focus on innate immunity.

Gardy, J.L., D.J. Lynn, F.S.L. Brinkman, and R.E.W. Hancock. (2009) Trends Immunol. 30: 249-262 PDF

395

The novel adjuvant combination of CpG ODN, indolicidin and polyphosphazene induces potent antibody and cell-mediated immune responses in mice.

Kovacs-Nolan, J., L. Latimer, A. Landi, H. Jenssen, R.E.W. Hancock, L.A. Babiuk, and S. van Drunen Littel-van den Hurk. (2009) Vaccine 27: 2055-2064 PDF

394

Systems biology evaluation of immune responses induced by human host defence peptide LL-37 in mononuclear cells.

Mookherjee, N., P. Hamill, J. Gardy, D. Blimkie, R. Falsafi, A. Chikatamarla, D.J. Arenillas, S. Doria, T.R. Kollmann, R.E.W. Hancock. (2009) Molec. BioSystems 5(5): 483-496 PDF

393

Identification of Novel Antibacterial Peptides by Chemoinformatics and Machine Learning.

Fjell, C.D., H. Jenssen, K. Hilpert, W.A. Cheung, N. Panté, R.E.W. Hancock and A. Cherkasov. (2009) J. Med. Chem. 52: 2006-2015 PDF

392

The human host defense peptide LL-37 induces apoptosis in a calpain- and apoptosis-inducing factor-dependent manner involving Bax activity

Mader J.S., N. Mookherjee, R.E.W. Hancock, and R.C. Bleackley. (2009) Mol Cancer Res. 7: 689-702 PDF

391

Killing of Trypanosomatid parasites by a modified bovine host defense peptide, BMAP-18.

Haines, L.R., J.M. Thomas, A.M. Jackson, B.A. Eyford, M. Razavi, C.N. Watson, B. Gowen, R.E.W. Hancock, and T.W. Pearson. (2009) PLoS Neglected Trop. Dis. 3(2): e373 PDF

390

The sensor kinase PhoQ mediates virulence in Pseudomonas aeruginosa.

Gooderham, W.J., S. Gellatly, F. Sanschagrin, J.B. McPhee, M. Bains, Celine Cosseau, R.C. Levesque, and R.E.W. Hancock. (2009) Microbiology 155: 699-711 PDF

389

Strategies to link innate and adaptive immunity when designing vaccine adjuvants.

Garlapati, S., M. Facci, M. Polewicz, S. Strom, L.A. Babiuk, G. Mutwiri, R.E.W. Hancock, M.R. Elliott, and V. Gerdts. (2009) Vet. Immunol. Immunopathol. 128: 184-191 PDF

388

Regulation of virulence and antibiotic resistance by two-component regulatory systems in Pseudomonas aeruginosa.

Gooderham, W.J., and R.E.W. Hancock. (2009) FEMS Microbiol. Rev. 33: 279-294 PDF

387

Host defense peptide LL-37 induces IL-6 expression in human bronchial epithelial cells by activation of the NF-κB signaling pathway.

Pistolic, J., C. Cosseau, Y. Li, J.Yu, N.Filewod, S. Gellatly, L. Rehaume, D.M. Bowdish, and R.E.W. Hancock. (2009) J. Innate Immun. 1: 254-267 PDF

386

Screening and characterization of surface-tethered cationic peptides for antimicrobial activity.

Hilpert, K., M. Elliott, H. Jenssen, J. Kindrachuk, CD. Fjell, J. Körner, D.F.H. Winkler, L.L. Weaver, P. Henklein, A.S. Ulrich, S.H.Y. Chiang, S.W. Farmer, N. Pante, R. Volkmer, and R.E.W. Hancock. (2009) Chem. Biol. 16: 58-69 PDF

385

Use of artificial intelligence in the design of small peptide antibiotics effective against a broad spectrum of highly antibiotic resistant Superbugs.

Cherkasov, A., K. Hilpert, H. Jenssen, C.D. Fjell, M. Waldbrook, S.C. Mullaly, R. Volkmer and R.E.W. Hancock. (2009) ACS Chemical Biol. 4: 65-74 PDF

384

Pseudomonas Genome Database: Facilitating user-friendly, comprehensive comparisons of microbial genomes.

Winsor, G.L., T. Van Rossum, R. Lo, B. Khaira, MD. Whiteside, R.E.W. Hancock and F.S.L. Brinkman. (2009) Nucl. Acids Res. 378: D483-488 PDF

383

The effect of membrane composition on the antimicrobial peptides Aurein 2.2 and 2.3 from Australian southern bell frogs.

Cheng, J.T.J., J.D. Hale, M. Elliot, R.E.W. Hancock, and S.K. Straus. (2009) Biophys. J. 96: 552-565 PDF

382

Host defence peptides – antimicrobial and immunomodulatory activity and potential applications for tackling antibiotic-resistant infections.

Nijnik, A., and R.E.W. Hancock. (2009) Emerg. Health Threats J. 2: e1. PDF

381

Bovine lactoferrin and lactoferricin interfere with intracellular trafficking of herpes simplex virus-1.

Marr, A. K., H. Jenssen, M. R. Moniri, R.E.W. Hancock and N. Panté. (2009) Biochimie. 91: 160-164 PDF

380

Newly introduced genomic prophage islands are critical determinants of in vivo competitiveness in the Liverpool Epidemic Strain of Pseudomonas aeruginosa.

Winstanley, C., M.G.I. Langille, J.L. Fothergill, I. Kukavica-Ibrulj, C. Paradis-Bleau, F. Sanschagrin, N.R. Thomson, G.L. Winsor, M.A. Quail, N. Lennard, A. Bignell, L. Clarke, K. Seeger, D. Saunders, D. Harris, J. Parkhill, R.E.W. Hancock, F.S.L. Brinkman, and R.C. Levesque. (2009) Genome Research 19: 12-23 PDF

379

Antimicrobial properties of lactoferrin.

Jenssen, H, and R.E.W. Hancock. (2009) Biochimie. 91: 19-29 PDF

378

The roles of cathelicidin LL-37 in immune defences and novel clinical applications.

Nijnik, A., and R.E.W. Hancock. (2009) Curr. Opin. Haematol. 16: 41-47 PDF

377

Novel anti-infectives: is host defence the answer?

Hamill, P., K. Brown, H. Jenssen and R.E.W. Hancock. (2009) Curr. Opin. Biotechnol. 19: 628-636 PDF

376

The global access initiative at the University of British Columbia (UBC): Availability of UBC discoveries and technologies to the developing world (Invited Commentary)

Wasan K.M., S.J. Thornton, Ian Bell, R.E. Goulding, M. Gretes, A.P. Gray, R.E.W. Hancock and B. Campbell. (2009) J. Pharmaceut. Sci. 89: 791-794 PDF

375

Effects of Hydrophobicity on the Antifungal Activity of α-Helical Antimicrobial Peptides.

Jiang Z., B.J. Kullberg, H. van der Lee, A.I. Vasil, J.D. Hale, C.T. Mant, R.E.W. Hancock, M.L. Vasil, M.G. Netea and R.S. Hodges. (2008) Chem. Biology Drug Design 72: 483-495 PDF

374

Novel genetic determinants of low-level aminoglycoside resistance in Pseudomonas aeruginosa.

Schurek, K.N., A.K. Marr, P.K. Taylor, I. Wiegand, L. Semenec, B. K. Khaira, and R.E.W. Hancock. (2008) Antimicrob. Agents Chemother. 52: 4213-4219 PDF

373

A complex ciprofloxacin resistome revealed by screening of a library of Pseudomonas aeruginosa mutants for altered susceptibility.

Breidenstein, E.B.M., B.K. Khaira, I. Wiegand and R.E.W. Hancock. (2008) Antimicrob. Agents Chemother. 52: 4486-4491 PDF

372

Neutrophil elastase is required for innate host defense against Pseudomonas aeruginosa.

Hirche, T.O., R. Benabid, G. Deslee, S. Gangloff, S. Achilefu, M. Guenounou, F. Lebargy, R.E.W. Hancock, and A. Belaaouaj. (2008) J. Immunol. 181: 4945-4954 PDF

371

Mutator genes giving rise to decreased antibiotic susceptibility in Pseudomonas aeruginosa.

Wiegand, I., A.K. Marr, E.B.M. Breidenstein, K.N. Schurek, P. Taylor, and R.E.W. Hancock. (2008) Antimicrob. Agents Chemother. 52: 3810-3813 PDF

370

The human host defence peptide LL-37 prevents bacterial biofilm formation.

Overhage, J., A. Campisano, M. Bains, E.C.W. Torfs, B.H.A. Rehm, and R.E.W. Hancock. (2008) Infect. Immun. 76: 4176-4182 PDF

369

Facilitating systems level analyses of the mammalian innate immune response.

Lynn, D.J., G.L. Winsor, C. Chan, N. Richard, M.R. Laird, A. Barsky, J.L. Gardy, F.M. Roche, T.H.W. Chan, N. Shah, R. Lo, M. Naseer, J. Que, M. Yau, M. Acab, D. Tulpan, M. Whiteside, A. Chikatamarla, B. Mah, T.M. Munzner, K. Hokamp, R.E.W. Hancock, and F.S.L. Brinkman. (2008) Molec. Systems Biol. 4: 218 Epub PDF

368

The commensal Streptococcus salivarius K12 down-regulates the innate immune responses of human epithelial cells and promotes host-microbe homeostasis.

Cosseau, C., D.A. Devine, E. Dullaghan, J.L. Gardy, A. Chikatamarla, S. Gellatly, L.L. Yu, J. Pistolic, R. Falsafi, J. Tagg, and R.E.W. Hancock. (2008) Infect. Immun. 76: 4163-4175 PDF

367

X-ray spectromicroscopy study of competitive adsorption of protein and peptide onto polystyrene-poly (methyl methacrylate).

Leung B.O., A.P. Hitchcock, J.L. Brash, A. Scholl, A. Doran, P. Henklein, J. Overhage, K. Hilpert, J.D. Hale, R.E.W. Hancock. (2008) Biointerphases 3: FB27-FB35 PDF

366

Induction by cationic antimicrobial peptides and involvement in intrinsic polymyxin and antimicrobial peptide resistance, biofilm formation and swarming motility of PsrA in Pseudomonas aeruginosa.

Gooderham W.J., M. Bains, J.B. McPhee, I. Wiegand, R.E.W. Hancock. (2008) J. Bacteriol. 190: 5624-5634 PDF

365

ROS-deficient monocytes have aberrant gene expression that correlate with inflammatory disorders of chronic granulomatous disease.

Brown, K.L., J. Bylund, K.L. MacDonald, G.X. Song-Zhao, M.R. Elliott, R. Falsafi, R.E.W. Hancock and D.P. Speert. (2008) Clin. Immunol. 129: 90-102 PDF

364

Neutrophil-derived defensins as modulators of innate immune function.

Rehaume, L., and R.E.W. Hancock. (2008) Crit. Rev. Immunol. 28: 185-200

363

Lipid-specific binding of the calcium-dependent antibiotic daptomycin leads to changes in lipid polymorphism of model membranes.

Jung, D., J.P. Powers, S.K. Straus, R.E.W. Hancock. (2008) Chem. Biophys. Lipids 154: 120-128 PDF

362

Inhibition of HSV cell-to-cell spread by lactoferrin and lactoferricin.

Jenssen, H., K. Sandvik, J.H. Andersen, R.E.W. Hancock, and T.J. Gutteberg. (2008) Antiviral Res. 79: 192-198 PDF

361

Innate immunity mediated by TLR5 as a novel anti-inflammatory target for cystic fibrosis lung disease.

Blohmke, C.J., A.F. Hirschfeld, I. Elias, R.E. Victor, D.G. Hancock, A.G.F. Davidson, P.G. Wilcox, K.D. Smith, J. Overhage, R.E.W. Hancock, and S.E. Turvey. (2008) J. Immunol. 180: 7764-7773 PDF

360

Identification of novel host defense peptides and the absence of alpha-defensins in the bovine genome.

Fjell, C.D., H. Jennsen, P. Fries, P. Aich, P. Griebel, K. Hilpert, R.E.W. Hancock, and A. Cherkasov. (2008) Proteins 73: 420-430 PDF

359

Metabolic changes associated with adaptive diversification in Escherichia coli.

Le Gac, M., M.D. Brazas, M. Bertrand, J.G. Tyerman, C.C. Spencer, R.E.W. Hancock, and M. Doebeli. (2008) Genetics 178: 1049-1060 PDF

358

Effects of net charge and the number of positively charged residues on the biological activity of amphipathic alpha-helical cationic antimicrobial peptides.

Jiang, Z., A.I. Vasil, J. Hale, R.E.W. Hancock, M.L. Vasil and R.S. Hodges (2008) Biopolymers 90: 369-383 PDF

357

Swarming of Pseudomonas aeruginosa is a complex adaptation leading to increased production of virulence factors and antibiotic resistance.

Overhage, J., M. Bains, M.D. Brazas, and R.E.W. Hancock. (2008) J. Bacteriol. 190: 2671-2679 PDF

356

Pseudomonas.

Goldberg, J.G., R.E.W. Hancock, R.E. Parales, J. Loper, and P. Cornelis. (2008) J. Bacteriol. 190: 2649-2662 PDF

355

Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances.

Wiegand, I., K. Hilpert, and R.E.W. Hancock. (2008) Nature Protocols 3: 163-175 PDF

354

QSAR modeling and computer-aided design of antimicrobial peptides.

Jenssen H., C. Fjell, A. Cherkasov and R.E.W. Hancock. (2008) J. Peptide Sci. 14: 110-114 PDF

353

Expression of a polyphemusin variant in transgenic tobacco confers resistance against plant pathogenic bacteria, fungi and a virus.

Bhargava, A., M. Osusky, B.S. Forward, R.E.W. Hancock, W.M. Kay, and S. Misra. (2007) Plant Cell Tiss. Organ Cult. 88: 301-312 PDF

352

Antiviral indolicidin variant peptides: Evaluation for broad-spectrum disease resistance in transgenic Nicotiana tabacum.

Bhargava, A., M. Osusky, R.E.W. Hancock, B.S. Forward, W.M. Kay, and S. Misra. (2007) Plant Sci. 172: 515-523 PDF

351

NMR structural studies of the antibiotic lipopeptide daptomycin in DHPC micelles.

Scott W.R., S.B. Baek, D. Jung, R.E.W. Hancock and S.K. Straus. (2007) Biochim. Biophys. Acta. 1768: 3116-3126 PDF

350

The alternative mechanisms of action of cationic antimicrobial peptides on bacteria.

Hale, J.D.F. and R.E.W. Hancock. (2007) Expert Rev. Anti Infect. Ther. 5: 951-959 PDF

349

Effect of divalent cations on the structure of the antibiotic daptomycin.

Ho, S.W., D. Jung, J.R. Calhoun, J.D. Lear, M. Okon, W.R.P. Scott, R.E.W. Hancock, and S.K. Straus. (2007) Europ. J. Biophys. 37: 421-433 PDF

348

Host defence peptide LL-37, in synergy with inflammatory mediator IL-1β, augments immune responses by multiple pathways.

Yu, J., N. Mookherjee, K. Wee, D.M.E. Bowdish, J. Pistolic, Y. Li, L. Rehaume, and R.E.W. Hancock. (2007) J. Immunol. 179: 7684-7691 PDF

347

The complexities of antibiotic action.

Hancock, R.E.W. (2007) Molec. Systems Biol. 3: 142 PDF

346

Role of Lon protease in resistance of Pseudomonas aeruginosa to ciprofloxacin.

Brazas, M.D., E.B.M. Breidenstein, J. Overhage and R.E.W.Hancock. (2007) Antimicrob. Agents Chemother. 51: 4276-4283 PDF

345

Evaluating different descriptors for model design of antimicrobial 12-mer peptides with enhanced activity towards Pseudomonas aeruginosa.

Jenssen H., T. Lejon, K. Hilpert, C. Fjell, A.Cherkasov and R.E.W.Hancock. (2007) Chem. Biol. Drug Des. 70: 134-142 PDF

344

Cathelicidins and functional analogues as anti-sepsis molecules.

Mookherjee, N., L. Rehaume and R.E.W. Hancock. (2007) Expert Opin. Therap. Targets 11: 993-1004 PDF

343

Using intrinsic X-ray absorption spectral differences to identify and map peptides and proteins.

Stewart-Ornstein, J., A.P. Hitchcock, D. Hernàndez-Cruz, P. Henklein, J. Overhage, K. Hilpert, J.D. Hale and R.E.W. Hancock. (2007) J. Phys. Chem. 111: 7691-7699 PDF

342

Use of luminescent bacteria for rapid screening and characterization of short catioschurnic antimicrobial peptides synthesized on cellulose using peptide array technology.

Hilpert, K., and R.E.W. Hancock. (2007) Nature Protocols 2: 1652-1660 PDF

341

Cellulose-bound peptide arrays: Preparation and applications.

Hilpert, K., D. Winkler, and R.E.W. Hancock. (2007) Biotechnol. Genet. Engineer. Rev. 24: 31-106 PDF

340

Complexities of targeting innate immunity to treat infection.

Brown, K.L., C. Cosseau, J.L. Gardy and R.E.W. Hancock. (2007) Trends Immunol. 28: 260-266 PDF

339

Secondary acylation of Klebsiella pneumoniae lipopolysaccharide contributes to sensitivity to antibacterial peptides.

Clements, A., D. Tull, A.W. Jenney, J.L. Farn, S.-H Kim, Bishop, R.E., J.B. McPhee, R.E.W Hancock, E.L. Hartland, M.J. Pearse, O.L.C. Wijburg, D.C. Jackson, M.J. McConville and R. A. Strugnell. (2007) J. Biol. Chem. 282: 15569-15577 PDF

338

A database and an automated discovery tool for antimicrobial peptides.

Fjell, C.D., R.E.W. Hancock and A. Cherkasov AMPer. (2007) Bioinformatics 23: 1148-1155 PDF

337

Peptide arrays on cellulose support: a time and cost efficient method for synthesizing large numbers of peptides in a parallel and addressable fashion.

Hilpert, K., D. Winkler, and R.E.W. Hancock. (2007) Nature Protocols 2: 1333-1349 PDF

336

An anti-infective peptide that selectively modulates the innate immune response.

Scott, M.G., E. Dullaghan, N. Mookherjee, N. Glavas, M. Waldbrook, A. Thompson, A. Wang, K. Lee, S. Doria, P. Hamill, J. Yu, Y. Li, O. Donini, M.M. Guarna, B.B. Finlay, J.R. North, and R.E.W. Hancock. (2007) Nature Biotechnology 25: 465-472 PDF

335

Cationic Host Defence Peptides: Innate immune regulatory peptides as a novel approach for treating infections.

Mookherjee, N., and R.E.W. Hancock. (2007) Cell. Molec. Life Sci. 64: 922-933 PDF

334

Cerebral: a Cytoscape plugin for layout of and interaction with biological networks using subcellular localization annotation. Bioinformatics

Barsky, A., J.L. Gardy, R.E.W. Hancock and T. Munzner. (2007) Bioinformatics 23: 1040-1042 PDF

333

Enhanced inflammatory responses of chronic granulomatous disease leukocytes involve reactive oxygen species-independent activation of NF-κB.

Bylund, J., K.L. MacDonald, K.L. Brown, P. Mydel, L.V. Collins, R.E.W. Hancock and D.P. Speert. (2007) J. Immunol. 37: 1087-1096 PDF

332

Characterization of the structure and membrane interaction of the antimicrobial peptides Aurein 2.2 and 2.3 from Australian Southern Bell Frog.

Pan, Y.-L., J.T.J. Cheng, J. Hale, J. Pan, R.E.W. Hancock, and S.K. Straus. (2007) Biophys. J. 92: 2854-2864 PDF

331

Fluorescent probes alter miscibility phase boundaries in ternary vesicles.

Veatch, S.L., S.S.W. Leung, R.E.W. Hancock, J.L. Thewalt. (2007) J. Phys. Chem. 111: 502-504 PDF

330

An arginine ladder mediates phosphate specific transfer across membranes.

Moraes, T.F., M. Bains, R.E.W. Hancock, and N.C. Strynadka. (2007) Nature Struct. Molec. Biol. 14: 85-87 PDF

329

Identification of genes involved in swarming motility using a Pseudomonas aeruginosa PAO1 mini-Tn5-lux mutant library.

Overhage, J., S. Lewenza, A.K. Marr and R.E.W. Hancock. (2007) J. Bacteriol. 189: 2164-2169 PDF

328

Antimicrobial, Host Defence Peptides and Proteins.

Brown, K.L, N. Mookherjee, and R.E.W. Hancock (2007) eLS

327

The Lon protease of Pseudomonas aeruginosa is induced by aminoglycosides and is involved in biofilm formation and motility.

Marr, A.K., J. Overhage, M. Bains and R.E.W. Hancock. (2007) Microbiology 153: 474-482 PDF

326

Characterization of OpdH, a Pseudomonas aeruginosa porin involved in the uptake of tricarboxylates.

Tamber, S., E. Maier, R. Benz, and R.E.W. Hancock. (2007) J. Bacteriol. 189: 929-939 PDF

325

Bovine and human cathelicidin cationic host defence peptides similarly suppress global transcriptional responses to bacterial lipopolysaccharide.

Mookherjee, N., H.L. Wilson, S. Doria, Y. Popowych, R. Falsafi, J. Yu, Y. Li, S. Veatch, F.M. Roche, K.L. Brown, F.S.L. Brinkman, K. Hokamp, A. Potter, L. A. Babiuk, P.J. Griebel and R.E.W. Hancock. (2007) J. Leukocyte Biol. 80: 1563-1574 PDF

324

The end of an era?

Hancock, R.E.W. (2007) Nature Rev. Drug Discov. 6: 28 PDF

323

IRAK-4 mutation (Q293X): rapid detection, and characterisation of defective posttranscriptional TLR/IL-1R responses in human myeloid and non-myeloid cells.

Davidson, D.J., A.J. Currie, DM.E. Bowdish, K.L. Brown, C.M. Rosenberger, RC. Ma, J. Bylund, P.A. Campsall, A. Puel, C. Picard, J.-L. Casanova, S.E. Turvey, R.E.W. Hancock, R.S. Devon, and D.P. Speert. (2006) J. Immunol. 177: 8202-8211 PDF

322

Antimicrobial and host-defence peptides as novel anti-infective therapeutic strategies.

Hancock, R.E.W., and H.G. Sahl. (2006) Nature Biotechnology 24: 1551-1557 PDF

321

Sequence requirements and a novel optimization strategy for short antimicrobial peptides.

Hilpert, K., M.R. Elliott, R. Volkmer-Engert, P. Henklein, O. Donini, Q. Zhou, D.F.H. Winkler and R.E.W. Hancock. (2006) Chem. Biol. 13: 1101-1107 PDF

320

Peptide antimicrobial agents.

Jenssen, H., P. Hamill, and R.E.W. Hancock. (2006) Clin. Microbiol. Rev. 19: 491-511 PDF

319

Antibacterial peptides for therapeutic use: obstacles and realistic outlook.

Marr, A.K., W.J. Gooderham, and R.E.W. Hancock. (2006) Curr. Opin. Pharmacol. 319: 468-472 PDF

318

The human cationic host defense peptide LL-37 mediates contrasting effects on apoptotic pathways in different primary cells of the innate immune system.

Barlow, P.G., Y. Li, T.S.Wilkinson, D.M.E. Bowdish, Y.E. Lau, C. Cosseau, C. Haslett, A.J. Simpson, R.E.W. Hancock, and D.J. Davidson. (2006) J. Leukocyte Biol. 80: 509-520 PDF

317

The antimicrobial peptide polyphemusin localizes to the cytoplasm of Escherichia coli following treatment.

Powers, J.P., M.M. Martin, D.L. Goosney and R.E.W. Hancock. (2005) Antimicrob. Agents Chemother. 50: 1522-1524 PDF

316

Mode of action of the new antibiotic for Gram-positive pathogens daptomycin: comparison with cationic antimicrobial peptides and lipopeptides.

Straus, S.K. and R.E.W. Hancock. (2006) Biochim. Biophys. Acta. 1758: 1215-1223 PDF

315

Contribution of the PhoP-PhoQ and PmrA-PmrB two-component regulatory systems to Mg2+-induced gene regulation in Pseudomonas aeruginosa.

McPhee, J.B., M. Bains, G. Winsor, S. Lewenza, A. Kwasnicka, M.D. Brazas, F.S.L. Brinkman and R.E.W. Hancock. (2006) J. Bacteriol. 188: 3995-4006 PDF

314

Involvement of two related porins, OprD and OpdP, in the uptake of arginine by Pseudomonas aeruginosa.

Tamber, S., and R.E.W. Hancock. (2005) FEMS Microbiol. Lett. 260: 23-29 PDF

313

Apoptosis of airway epithelial cells: human serum sensitive induction by the cathelicidin LL-37.

Lau, Y.E., D.M.E. Bowdish, C. Cosseau, R.E.W. Hancock and D.J. Davidson. (2005) J. Resp. Cell and Molec. Biol. 34: 399-409 PDF

312

Comparison of biophysical and biologic properties of alpha-helical enantiomeric antimicrobial peptides.

Chen Y., A.I. Vasil, L. Rehaume, C.T. Mant, J.L. Burns, M.L. Vasil, R.E.W. Hancock, and R.S. Hodges. (2005) Chem. Biol. Drug Des. 67: 162-173 PDF

311

Modulation of the Toll-like receptor-mediated inflammatory response by the endogenous human host defence peptide LL-37.

Mookherjee, N., K.L. Brown, D.M.E. Bowdish, S. Doria, R. Falsafi, K. Hokamp, F.M. Roche, R. Mu, G.H. Doho, J. Pistolic, J. Powers, J. Bryan, F.S.L. Brinkman and R.E.W. Hancock. (2005) J. Immunol. 176: 2455-2464 PDF

310

Host defence peptides from invertebrates – emerging antimicrobial strategies.

Hancock, R.E.W., K.L. Brown, and N.Mookherjee. (2005) Immunobiol. 211: 315-322 PDF

309

Cationic host defense (antimicrobial) peptides.

Brown, K.L., and R.E.W. Hancock. (2006) Curr. Opp. Immunol. 18: 24-30 PDF

308

The role of the novel OprD family of porins in nutrient uptake in Pseudomonas aeruginosa.

Tamber, S., and R.E.W. Hancock. (2006) J. Bacteriol. 188: 45-54 PDF

307

Solution structure and interaction of the antimicrobial polyphemusins with lipid membranes.

Powers, J.P., A. Tan, A. Ramamoorthy, and R.E.W. Hancock (2005) Biochemistry 44: 15504-15513 PDF

306

Salmonella’s sensor for host defense molecules.

Hancock, R.E.W., and J.B. McPhee. (2005) Cell 122: 320-322 PDF

305

Recognition of host immune activation by Pseudomonas aeruginosa.

Wu, L., O. Estrada, O. Zaborina, M. Bains, L. Shen, J.E. Kohler, N. Patel, M.W. Musch, E.B. Chang, Y. Fu, M.V. Olson, M.A. Jacobs, M.I. Nishimura, R.E.W. Hancock, J.R. Turner, and J.C. Alverdy. (2005) Science 309: 774-777 PDF

304

Use of polymyxin as an endotoxin blocker in the prevention of diffuse lamellar keratitis in an animal model.

Morck, D.W., S.P. Holland, H. Ceri, RE.W.. Hancock, M. Scott-Gough, V. Nguyen, E.J. Keith, and T.L. Lee. (2005) J. Refect. Surg. 21: 152-157 PDF

303

Pathogen-induced expression of a cecropin A-melittin antimicrobial peptide gene confers antifungal resistance in transgenic tobacco

Yevtushenko D.P, R. Romero, B.S. Forward, R.EW. Hancock, W.W. Kay, and S. Misra (2005) J. Exptl. Botany 56: 1685-1695 PDF

302

High-throughput generation of small antibacterial peptides with improved activity.

Hilpert, K., R.Volkmer-Engert, T. Walter, and R.E.W. Hancock. (2005) Nature Biotechnology 23: 1008-1012 PDF

301

Ciprofloxacin induction of a susceptibility determinant in Pseudomonas aeruginosa.

Brazas, M., and R.E.W. Hancock. (2005) Antimicrob. Agents Chemother. 49: 3222-3227 PDF

300

Function and therapeutic potential of host defence peptides.

McPhee, J.B., and R.E.W. Hancock. (2005) J. Peptide Sci. 11: 677-687 PDF

299

Using microarray gene signatures to elucidate mechanisms of antibiotic action and resistance.

Brazas, M., and R.E.W. Hancock. (2005) Drug Discovery Today 10: 1245-1252 PDF

298

Antimicrobial peptide therapeutics for cystic fibrosis.

Zhang, L., J. Parente, S.M. Harris, D.E. Woods, R.E.W. Hancock, and T.J. Falla. (2005) Antimicrob. Agents Chemother. 49: 2921-2927 PDF

297

Rational design of α-helical antimicrobial peptides with enhanced activities and specificity/therapeutic index

Chen Y., C.T. Mant, S.W. Farmer, R.E.W. Hancock, M.L. Vasil, and R.S. Hodges. (2005) J. Biol. Chem. 280: 12316-12329 PDF

296

Anti-endotoxin properties of cationic host defence peptides and proteins.

Bowdish, D.M.E., and R.E.W. Hancock (2005) J. Endotox. Res. 11: 230-236 PDF

295

Construction of a mini-Tn5-luxCDABE mutant library in Pseudomonas aeruginosa PAO1: a tool for identifying differentially regulated genes.

Lewenza S., R.K. Falsafi, G. Winsor, W.J. Gooderham, J.B. McPhee, F.S.L. Brinkman and R.E.W. Hancock. (2005) Genome Research 15: 583-589 PDF

294

Immunomodulatory activities of small host defense peptides.

Bowdish, D.M.E., D.J. Davidson, M.G. Scott, and R.E.W. Hancock. (2005) Antimicrob. Agents Chemother. 49: 1727-1732 PDF

293

Mechanisms of action of newer antibiotics for Gram positive bacteria.

Hancock, R.E.W. (2005) Lancet Infect. Dis. 5: 209-218 PDF

292

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen

Lewenza, S., J.L. Gardy, F.S.L. Brinkman and R.E.W. Hancock (2005) Genome Research 15: 321-329 PDF

291

Impact of LL-37 on anti-infective immunity.

Bowdish, D.M.E., D.J. Davidson, Y.E. Lau, K. Lee, M.G. Scott, and R.E.W. Hancock. (2005) J. Leukocyte Biol. 77: 451-459 PDF

290

Pseudomonas aeruginosa Genome Database and PseudoCAP: Facilitating community-based, continually updated, genome annotation.

Winsor, G., R. Lo, S.J. Ho Sui, K.S.E. Ung, S. Huang, D. Cheng, W.-K. Ho
Ching, R.E.W. Hancock, and F.S.L. Brinkman. (2005) Nucl. Acids Res. 33: D338-343 PDF

289

Interaction and cellular localization of the human host defence peptide, LL-37, with lung epithelial cells

Lau, Y.E., A. Rozek, M.G. Scott, D.L. Goosney, D.J. Davidson and R.E.W. Hancock. (2005) Infect. Immun. 73: 583-591 PDF

288

Design of host defence peptides for antimicrobial and immunity enhancing activities.

McPhee, J.B. M.G. Scott, and R.E.W. Hancock. (2005) Combinat. Chem. High Throughput Screening 8: 257-272 PDF

287

A re-evaluation of the role of host defence peptides in mammalian immunity.

Bowdish, D.M.E., D.J. Davidson, and R.E.W. Hancock (2005) Current Protein Pept. Sci. 6: 35-51 PDF

286

Differential expression of porins OmpP2A and OmpP2B of Haemophilus ducreyi.

Prather, D.T., M.Bains, R.E.W. Hancock, M.J. Filiatrault, and A.A. Campagnari (2004) Infect. Immun. 72: 6271-6278 PDF

285

Transgenic potatoes expressing a novel cationic peptide are resistant to late blight and pink rot.

Osusky, M. L. Osuska, R. E.W Hancock, W. Kay, and S. Misra. (2004) Transgenic Research 13: 181-190 PDF

284

Structural transitions as determinants of the calcium dependent antibiotic daptomycin.

Jung, D., A. Rozek, M. Okon, and R.E.W. Hancock. (2004) Chem. Biol. 11: 949-957 PDF

283

ProbeLynx: A tool for updating the association of microarray probes to genes.

Roche, F.M. K. Hokamp, M. Acab, L.A. Babiuk, R.E.W. Hancock, and F.S.L. Brinkman. (2004) Nucl. Acids Res. 32: W457-459 PDF

282

Structure and association of human lactoferrin peptides with Escherichia coli lipopolysaccharide.

Chapple D.S., R. Hussain, C.L. Joannou, R.E.W. Hancock, E. Odell, R.W. Evans, and G.Siligardi. (2004) Antimicrob. Agents Chemother. 48: 2190-2198 PDF

281

Can innate immunity be enhanced to treat infections?

Finlay, B.B., and R.E.W.Hancock. (2004) Nature Microbiol. Rev. 2: 497-504 PDF

280

Effects of single D-amino acid substitutions on disruption of β-sheet structure and hydrophobicity in cyclic 14-residue antimicrobial peptide analogs related to gramicidin S. J.

Lee, D.L., J.P.S. Powers, K. Pflegerl, M.L. Vasil, R.E.W. Hancock, and R.S. Hodges. (2004) J.Peptide Res. 63: 69-84 PDF

279

The human cationic peptide LL-37 induces activation of the extracellular signal regulated kinase and p38 kinase pathways in primary human monocytes.

Bowdish D.M.E., D.J. Davidson, D.P. Speert, and R.E.W. Hancock. (2004) J. Immunol. 172: 3758-3765 PDF

278

ArrayPipe: a flexible processing pipeline for microarray data.

Hokamp K., F.M. Roche, M. Acab, M.E. Rousseau, B. Kuo, D. Goode, D. Aeschliman, J. Bryan, L. Babiuk, R.E.W. Hancock, and F.S.L. Brinkman. (2004) Nucl. Acids Res. 32: W471-474 PDF

277

Structure-activity relationships for the β-hairpin cationic antimicrobial peptide polyphemusin I.

Powers, J.P., A. Rozek, and R.E.W. Hancock. (2004) Biochim. Biophys. Acta. 1698: 239-250 PDF

276

The cationic antimicrobial peptide LL-37 modulates dendritic cell development and DC-induced T cell polarisation.

Davidson, D.J., A.J. Currie, G. Reid, D.M.E. Bowdish, K. MacDonald, R. Ma, R.E.W. Hancock, and D.P. Speert. (2004) J. Immunol. 172: 1146-1156 PDF

275

Antimicrobial activity and bacterial membrane interaction of ovine-derived cathelicidins.

Anderson, R.C., R.E.W. Hancock and P.-L. Yu. (2004) Antimicrob. Agents Chemother. 48: 673-676 PDF

274

Delivery of liposomes in dry powder form: aerodynamic dispersion properties

Desai, T.R., R.E.W. Hancock, and W.H. Finlay. (2003) Europ. J. Pharamaceut. Sci. 20: 459-467 PDF

273

The relationship between peptide structure and antibacterial activity.

Powers, J.-P.S., and R.E.W. Hancock. (2003) Peptides 24: 1681-1691 PDF

272

Membrane binding and permeation by indolicidin analogs studied by a biomimetic lipid/polydiacetylene vesicle assay.

Halevy, R., A. Rozek, S. Kolusheva, R.E.W. Hancock, and R. Jelinek. (2003) Peptides 24: 1753-1761 PDF

271

Structure-based design of an indolicidin peptide analogue with increased protease stability.

Rozek A., J.P. Powers, C.L. Friedrich, R.E.W.Hancock. (2003) Biochemistry 42: 14130-14138 PDF

270

Concerns regarding resistance to self-proteins (commentary).

Hancock, R.E.W. (2003) Microbiology 149: 3343-3344 PDF

269

Cationic antimicrobial peptide killing of African trypanosomes and Sodalis glossinidius, a bacterial symbiont of the insect vector of sleeping sickness.

Haines, L.R., ,b>R.E.W. Hancock and T.W. Pearson. (2003) Vector Borne and Zoonotic Dis. 3: 175-186

268

Cationic antimicrobial peptides activate a two-component regulatory system, PmrA-PmrB, that regulates resistance to polymyxin B and cationic antimicrobial peptides in Pseudomonas aeruginosa.

McPhee, J.B., S. Lewenza and R.E.W.Hancock (2003) Molec. Microbiol. 50: 205-219 PDF

267

Role of Pseudomonas putida tol-oprL gene products in uptake of solutes through the cytoplasmic membrane.

Llamas, M.A., J.J. Rodriguez-Herva, R.E.W. Hancock, W. Bitter, J. Tommassen, and J.L. Ramos. (2003) J. Bacteriol. 185: 4707-4716 PDF

266

Broad-spectrum peptide inhibitors of aminoglycoside resistance enzymes.

Boehr, D.D., K. Draker, K. Koteva, M. Bains, R.E.W. Hancock, and G.D. Wright (2003) Chem. Biol. 10: 189-196 PDF

265

On the mechanism of solute transport in Pseudomonas.

Tamber, S., and R.E.W. Hancock. (2003) Frontiers in Bioscience 8: S472-S483

264

Aminoglycoside efflux in Pseudomonas aeruginosa: involvement of novel outer membrane proteins.

Jo, J.T.H., F.S.L.Brinkman, and R.E.W.Hancock (2003) Antimicrob. Agents Chemother. 47: 1101-1111 PDF

263

A facile method of delivery of liposomes by nebulization.

Desai, T.R., R.E.W. Hancock, and W.H. Finlay. (2002) J. Controlled Release 84: 69-78 PDF

262

The Vibrio fischeri sapABCDF locus is required for normal growth, both in culture and in symbiosis

Lupp, C., R.E.W. Hancock, and E.G. Ruby. (2002) Arch. Microbiol. 179: 59-65 PDF

261

Pseudomonas aeruginosa anaerobic respiration in biofilms: Relationships to cystic fibrosis pathogenesis.

Yoon, S.S., R.F. Hennigan, G.M. Hilliard, U.A.Ochsner, K.Parvatiyar, M.C.Kamani, H.L.Allen, T.R.DeKievit, P.R. Gardner, U.Schwab, J.J.Rowe, B.H.Iglewski, T.R.McDermott, R.P.Mason, D.J.Wozniak, R.E.W. Hancock, M.R.Parsek, T.L.Noah, R.C.Boucher, and D.J.Hassett. (2002) Developmental Cell. 3: 593-603 PDF

260

The human antimicrobial peptide, LL-37, is a multifunctional modulator of innate immune responses.

Scott, M.G., D.J. Davidson, M.R. Gold, D. Bowdish, and R.E.W. Hancock. (2001) J. Immunol. 169: 3883-3891 PDF

259

Evidence that plant-like genes in Chlamydia species reflect an ancestral relationship between Chlamydiaceae, cyanobacteria and the chloroplast.

Brinkman, F.S.L., J.L. Blanchard, A. Cherkasov, H. Greberg, Y. Av-Gay, R.C. Brunham, R.C. Fernandez, B.B. Finlay, S.P. Otto, B.F.F. Ouellette, P.J. Keeling, A.M. Rose, R.E.W. Hancock and S.J.M. Jones (2002) Genome Research 12: 1159-1167 PDF

258

Exploring relationships between mimic configuration, peptide conformation and biological activity in indolizidin-2-one amino acid analogs of gramicidin S.

Roy, S., H.G. Lombart, W.D. Lubell, R.E.W. Hancock, and S.W. Farmer. (2002) J. Pept. Res. 60: 197-213 PDF

257

Multidrug efflux systems play an important role in the invasiveness of Pseudomonas aeruginosa.

Hirakata, Y., R. Srikumar, K. Poole, N. Gotoh, T. Suematsu, S. Kohno, S. Kamihira, R.E.W. Hancock, and D.P. Speert. (2002) J. Exp. Med. 196: 109-118 PDF

256

Characterization of, and immune responses of mice to, the purified OmpA-equivalent outer membrane protein of Pasteurella multocida serotype A:3 (Omp28),.

Gatto, N.T., S.M. Dabo, R.E.W. Hancock and A.W. Confer. (2002) Vet. Microbiol. 87: 221-235 PDF

255

Pseudomonas aeruginosa outer membrane protein F is an adhesin in bacterial binding to lung epithelial cells in culture.

Azghani, A., S. Idell, M.Bains, and R.E.W.Hancock. (2002) Microb. Pathogenesis 33: 109-114 PDF

254

Function of Pseudomonas porins in uptake and efflux.

Hancock, R.E.W., and F.S.L. Brinkman (2002) Annu. Rev. Microbiol. 56: 17-38 PDF

253

Optimization of microbial specificity in cyclic peptides by modulation of hydrophobicity within a defined structural framework.

Kondejewski, L.H., D.L. Lee, M. Jelokhani-Niaraki, S.W. Farmer, R.E.W. Hancock, and Robert S. Hodges. (2002) J. Biol. Chem. 277: 67-74 PDF

252

Sub-lethal concentrations of pleurocidin-derived antimicrobial peptides inhibit macromolecular synthesis in Escherichia coli.

Patrzykat, A., C.L. Friedrich, L.Zhang, V. Mendoza, and R.E.W.Hancock. (2002) Antimicrob. Agents Chemother. 46: 605-614 PDF

251

Clinical development of cationic antimicrobial peptides: From natural to novel antibiotics.

Hancock, R.E.W., and A. Patrzykat. (2002) Curr. Drug Targets – Infect. Disorders 2: 79-83 PDF

250

Role of membranes in the activities of antimicrobial cationic peptides.

Hancock, R.E.W., and A. Rozek. (2002) FEMS Microbiol. Lett. 206: 143-149 PDF

249

A novel approach to the pulmonary delivery of liposomes in dry powder form to eliminate the deleterious effect of milling.

Desai, T.R., J.P. Wong, R.E.W.Hancock, and W.H. Finlay. (2002) J. Pharmaceut. Sci. 91: 482-491 PDF

248

A brief on bacterial biofilms.

Hancock, R.E.W. (2001) Nature Genetics 29: 360 PDF

247

Antimicrobials in the 21st Century.

Hancock, R.E.W., and W.R. Strohl. (2001) Curr. Opin. Microbiol. 4: 491-492 PDF

246

Adherence of Burkholderia cepacia to respiratory tract epithelial cells and inhibition with dextrans.

Chiu, C.H., S. Wong, R.E.W.Hancock, and D.P. Speert (2001) Microbiology 147: 2651-2658 PDF

245

Morphology of fast-tumbling bicelles: a small angle neutron scattering and NMR study.

Luchette, P.A., T.N. Vetman, R.S. Prosser, R.E.W.Hancock, M.P. Nieh, C.J. Glinka, S. Krueger, and J. Katsaras. (2001) Biochim. Biophys. Acta. 1513: 83-94 PDF

244

Interaction of cationic antimicrobial peptides with model membranes.

Zhang, L., A. Rozek, and R.E.W. Hancock. (2001) J. Biol. Chem. 276: 35714-35722 PDF

243

Evolutionary relationships amongst virulence associated histidine kinases.

Brinkman, F.S.L., E.L.A. MacFarlane, P. Warrener, and R.E.W. Hancock. (2001) Infect. Immun. 69: 5207-5211 PDF

242

Cationic peptides: effectors in innate immunity and novel antimicrobials.

Hancock, R.E.W. (2001) Lancet Infect. Dis. 1: 156-164 PDF

241

In vitro aerosol delivery and regional airway surface liquid concentration of a liposomal cationic peptide.

Lange, C.F., R.E.W. Hancock, J. Samuel, and W.H. Finlay. (2001) J. Pharmaceut. Sci. 90: 1647-1657 PDF

240

Structure and mechanism of action of an indolicidin peptide derivative with improved activity against Gram-positive bacteria.

Friedrich, C.L., A.Rozek, A. Patrzykat, and R.E.W.Hancock. (2001) J. Biol. Chem. 276: 24015-24022 PDF

239

Synergistic interactions between mammalian antimicrobial defense peptides.

Yan, H., and R.E.W.Hancock. (2001) Antimicrob. Agents Chemother. 45: 1558-1560 PDF

238

Synergy of histone-derived peptides of Coho salmon with lysozyme and the flounder peptide pleurocidin.

Patrzykat, A., L. Zhang, V. Mendoza, G.K. Iwama, and R.E.W.Hancock. (2001) Antimicrob. Agents Chemother. 45: 1337-1342 PDF

237

PhyloBLAST: A tool facilitating phylogenetic analysis of BLAST results.

Brinkman, F.S.L., I. Wan, R.E.W. Hancock, A.M. Rose, and S.J. Jones. (2001) Bioinformatics 17: 385-387 PDF

236

. Evaluation of a structural model of Pseudomonas aeruginosa outer membrane protein OprM, an efflux component involved in intrinsic antibiotic resistance.

Wong, K.K.Y., F.S.L. Brinkman, R.S. Benz, and R.E.W.Hancock. (2001) J. Bacteriol. 183: 367-374 PDF

235

Determination of membrane immersion depth with O2: A high pressure 19F NMR study.

Prosser, R.S., P.A. Luchette, P.W. Westermann, A. Rozek, and R.E.W. Hancock. (2000) Biophys. J. 80: 1406-1430 PDF

234

Structure of the bovine antimicrobial peptide indolicidin bound to dodecylphosphocholine and sodium dodecyl sulfate micelles.

Rozek, A., C.L. Friedrich, and R.E.W. Hancock. (2000) Biochemistry 39: 15765-15774 PDF

233

Interaction of polyphemusin I and structural analogs with bacterial membranes, lipopolysaccharide and lipid monolayers.

Zhang, L., M.G. Scott, H. Yan, L.D. Mayer, and R.E.W.Hancock. (2000) Biochemistry 39: 14504-14514 PDF

232

Interactions of bacterial cationic peptide antibiotics with outer and cytoplasmic membranes of Pseudomonas aeruginosa.

Zhang, L., P. Dhillon, H. Yan, S. Farmer, and R.E.W. Hancock. (2000) Antimicrob. Agents Chemother. 44: 3317-3321 PDF

231

Cationic antimicrobial peptides and their multifunctional role in the immune system.

Scott, M.G., and R.E.W. Hancock. (2000) Crit. Rev. Immunol. 20: 407-431

230

Diastereoisomeric analogues of gramicidin S: structure, biological activity and interaction with bilayers.

Jelokhani-Niaraki, M., L.H. Kondajewski, S.W.Farmer, R.E.W.Hancock, C.M.Kay, and R.S.Hodges. (2000) J. Biochem. 349: 747-755 PDF

229

An α-helical cationic antimicrobial peptide selectively modulates macrophage responses to LPS and directly alters macrophage gene expression

Scott, M.G., C.M. Rosenberger, M.R. Gold, B.B. Finlay, and R.E.W. Hancock. (2000) J. Immunol. 165: 3358-3365 PDF

228

Transgenic plants expressing cationic peptide chimeras exhibit broad-spectrum resistance to phytopathogens.

Osusky, M., G. Zhou, L.Osuska, R.E.W. Hancock, W.W. Kay and S. Misra. (2000) Nature Biotechnology 18: 1162-1166 PDF

227

The role of cationic antimicrobial peptides in innate host defences.

Hancock, R.E.W. and G. Diamond. (2000) Trends Microbiol. 8: 402-410 PDF

226

Sequencing solutions: Use of volunteer annotators organized via the Internet.

Brinkman, F.S.L., R.E.W. Hancock and K.C. Stover. (2000) Nature 406: 933 PDF

225

The amino terminus of Pseudomonas aeruginosa outer membrane protein OprF forms channels in lipid bilayer membranes: correlation with a three-dimensional model

Brinkman, F.S.L., M.Bains and R.E.W.Hancock. (2000) J. Bacteriol. 182: 5251-5255 PDF

224

Complete genome sequence of Pseudomonas aeruginosa: an opportunistic pathogen

Stover, K.C., X.Q. Pham, A.L. Erwin, S.D. Mizoguchi, P. Warrener, M.J. Hickey, F.S.L. Brinkman, W. O. Hufnagle, D.J. Kowalik, M. Lagrou, R.L. Garber, L. Goltry, E. Tolentino, S. Westbrock-Wadman, Y. Yuan, L.L. Brody, S.N. Coulter, K.R. Folger, A. Kas, R. Lim, K. Smith, D. Spencer, G.K.-S. Wong, Z. Wu, I. Paulsen, J. Reizer, M.H. Saier, R.E.W. Hancock, S. Lory, and M.V. Olson. (2000) Nature 406: 959-964 PDF

223

Antibiotic resistance in Pseudomonas aeruginosa. Mechanisms and impact on treatment.

Hancock, R.E.W., and D.P. Speert. (2000) Drug Resist. Updates 3: 247-255 PDF

222

Role of Pseudomonas aeruginosa PhoP-PhoQ in resistance to antimicrobial peptides and aminoglycosides

MacFarlane, E.L.A., A. Kwasnicka, and R.E.W.Hancock. (2000) Microbiology 146: 2543-2554 PDF

221

Cationic antimicrobial peptides: towards clinical applications

Hancock, R.E.W (2000) Expert Opinion Invest. Dis. 9: 1723-1729 PDF

220

Comparative genomics of Helicobacter pylori: Analysis of the outer membrane protein families.

Alm, R., J. Bina, B.M. Andrews, P. Doig, R.E.W. Hancock and T.J. Trust. (2000) Infect. Immun. 68: 4155-4168 PDF

219

Role of putative loops 2 and 3 in imipenem passage through the specific porin OprD of Pseudomonas aeruginosa.

Ochs, M.M., M.Bains, and R.E.W. Hancock (2000) Antimicrob. Agents Chemother. 44: 1983-1985 PDF

218

Antibacterial action of structurally diverse cationic peptides on Gram-positive bacteria.

Friedrich, C.L., D. Moyles, T.J.Beveridge, and R.E.W. Hancock. (2000) Antimicrob. Agents Chemother. 44: 2086-2092 PDF

217

Salmonella typhimurium and lipopolysaccharide induce similar changes in macrophage gene expression.

Rosenberger, C.M., M.G. Scott, M.R. Gold, R.E.W. Hancock, and B.B. Finlay (2000) J. Immunol. 164: 5594-5904 PDF

216

In vitro characterization of the anticancer activity of membrane-active cationic peptides. I. Peptide-mediated cytotoxicity and peptide-enhanced cytotoxic activity of doxyrubicin against wild-type and P-glycoprotein over-expressing tumor cell lines.

Johnstone, S.A., K. Gelmon, L.D. Mayer, R.E.W. Hancock, and M.B. Bally (2000) Anti-Cancer Drug Design 15: 151-160

215

The role of antimicrobial peptides in animal defences.

Hancock, R.E.W., and M.G. Scott. (2000) Proc. Natl. Acad. Sci. USA. 97: 8856-8861 PDF

214

Action of lysozyme and nisin mixtures against lactic acid bacteria.

Chung, W., and R.E.W. Hancock. (2000) Intl. J. Food Microbiol. 60: 25-32 PDF

213

Insertion mutagenesis and membrane topology model of the Pseudomonas aeruginosa outer membrane protein OprM.

Wong, K.K.Y., and R.E.W. Hancock. (2000) J. Bacteriol. 182: 2402-2410 PDF

212

Antimicrobial peptides protect Coho salmon from Vibrio anguillarum infections.

Jia, X., A. Patrzykat, R. Devlin, P.A. Ackerman, G.K. Iwama, and R.E.W. Hancock. (2000) Appl. Environ. Microbiol 66: 1928-1932 PDF

211

. Functional expression in Escherichia coli and membrane topology of porin HopE, a member of a large family of conserved proteins in Helicobacter pylori.

Bina, J., M.Bains, and R.E.W. Hancock. (2000) J. Bacteriol. 182: 2370-2375 PDF

210

Cutting Edge: Cationic antimicrobial peptides block the binding of lipopolysaccharide (LPS) to LPS binding protein.

Scott, M.G., A.C.E. Vreugdenhil, W.A. Buurman, R.E.W. Hancock, and M.R. Gold. (2000) J. Immunol. 164: 549-553 PDF

209

Helicobacter pylori uptake and efflux: Basis for intrinsic susceptibility to antibiotics in vitro.

Bina, J., R. A. Alm, M. Uria-Nuickelsen, S.R.Thomas, T.J.Trust, and R.E.W. Hancock. (2000) Antimicrob. Agents Chemother. 44: 248-254 PDF

208

Interaction of cationic peptides with lipoteichoic acid and Gram positive bacteria.

Scott, M.G., M.R.Gold, and R.E.W.Hancock. (1999) Infect. Immun. 67: 6445-6453 PDF

207

PhoP-PhoQ homologues in Pseudomonas aeruginosa regulate expression of the outer-membrane protein OprH and Polymyxin B resistance.

Macfarlane, E.L.A., A.Kwasnicka, M.M.Ochs, and R.E.W.Hancock. (1999) Molec. Microbiol. 34: 305-316 PDF

206

Amino acid-mediated induction of the basic amino acid-specific outer membrane porin OprD from Pseudomonas aeruginosa.

Ochs, M.M., C.-D. Lu, R.E.W.Hancock and A.T. Abdelal. (1999) J. Bacteriol. 181: 5426-5432 PDF

205

Influence of a putative ECF sigma factor on expression of the major outer membrane protein, OprF, in Pseudomonas aeruginosa and Pseudomonas fluorescens.

Brinkman, F.S.L., G. Schoofs, R.E.W.Hancock, and R.DeMot. (1999) J. Bacteriol. 181: 4746-4754 PDF

204

Dissociation of antimicrobial and hemolytic activities in cyclic peptide diastereomers by systematic alterations in amphipathicity.

Kondejewski, L.H., M.Jelokhani-Niaraki, S.W.Farmer, B. Lix, C.M.Kay, B.D.Sykes, R.E.W.Hancock, and R.S.Hodges. (1999) J. Biol. Chem. 274: 13181-13192 PDF

203

Negative regulation of the Pseudomonas aeruginosa outer membrane porin OprD selective for imipenem and basic amino acids

Ochs, M.M., M.P.McCusker, M.Bains and R.E.W.Hancock. (1999) Antimicrob. Agents Chemother. 43: 1085-1090 PDF

202

Influence of proline residues on the antibacterial and synergistic activities of α-helical peptides.

Zhang, L., R.Benz, and R.E.W.Hancock. (1999) Biochemistry 38: 8102-8111 PDF

201

Biological properties of structurally related α-helical cationic antimicrobial peptides

Scott, M.G., H.Yan, and R.E.W.Hancock (1999) Infect. Immun. 67: 2005-2009 PDF

200

Salt-resistant alpha-helical cationic antimicrobial peptides.

Friedrich, C., M.G. Scott, N.Karunaratne, H.Yan, and R.E.W.Hancock. (1999) Antimicrob. Agents Chemother. 43: 1542-1548 PDF

199

Improved derivatives of bactenecin, a cyclic dodecameric antimicrobial cationic peptide.

Wu, M., and R.E.W.Hancock. (1999) Antimicrob. Agents Chemother. 43: 1274-1276 PDF

198

Mechanism of interaction of different classes of cationic antimicrobial peptides with planar bilayers and with the cytoplasmic membrane of Escherichia coli.

Wu, M., E.Maier, R.Benz, and R.E.W.Hancock (1999) Biochemistry 38: 7235-7242 PDF

197

Identification of oprG, a gene encoding a major outer membrane protein of Pseudomonas aeruginosa.

Gensberg, K., A.W.Smith, F.S.L.Brinkman, and R.E.W.Hancock. (1999) J. Antimicrob. Chemother. 43: 607-608 PDF

196

Peptide antibiotics

Hancock, R.E.W., and D.S.Chapple. (1999) Antimicrob. Agents Chemother. 43: 1317-1323 PDF

195

Interaction of the cyclic antimicrobial cationic peptide bactenecin with the outer and cytoplasmic membrane.

Wu, M., and R.E.W.Hancock (1999) J. Biol. Chem. 274: 29-35 PDF

194

Structural variations in nisin associated with different membrane mimicking and pH environments.

Dykes, G.A., R.E.W.Hancock, and J.W.Hastings. (1998) Biochem. Biophys. Res. Commun. 247: 723-727 PDF

193

Determinants of recombinant production of antimicrobial cationic peptides and creation of peptide variants in bacteria

Zhang, L., T.Falla, M.Wu, S.Fidai, J.Burian, W.Kay, and R.E.W.Hancock. (1998) Biochem. Biophys. Res. Commun. 247: 674-680 PDF

192

Role of the carboxy-terminal half of Pseudomonas aeruginosa major outer membrane protein OprF in cell shape, growth in low-osmolarity medium, and peptidoglycan association.

Rawling, E.G., F.S.L. Brinkman, and R.E.W. Hancock. (1998) J. Bacteriol. 180: 3556-3562 PDF

191

Influence of preformed α-helix and α-helix induction on the activity of cationic antimicrobial peptides.

Houston,M.E., L.H.Kondejewski, D.N.Karunaratne, M.Gough, S.Fidai, R.S.Hodges, and R.E.W.Hancock. (1998) J.Peptide Res. 52: 81-88 PDF

190

Helicobacter pylori: A surprisingly conserved bacterium.

Hancock, R.E.W., R.Alm, J.Bina, and T.Trust. (1998) Nature Biotechnology 16: 216-217 PDF

189

The therapeutic potential of cationic peptides.

Hancock, R.E.W. (1998) Expert Opinion Invest. Dis. 7: 167-174 PDF

188

Influence of culture conditions on expression of the 40-kilodalton porin protein of Vibrio anguillarum serotype 02.

Davey, M.L., R.E.W.Hancock, and L.M. Mutharia. (1998) Appl. Environ. Microbiol 64: 138-146 PDF

187

Cationic peptides: a new source of antibiotics.

Hancock, R.E.W., and R. Lehrer. (1998) Trends in Biotechnol. 16: 82-88 (incl. cover photo) PDF

186

Cloning and characterization of the major outer membrane protein gene (OmpH) of Pasteurella multocida X-73.

Luo, Y., J.R. Glisson, M.W. Jackwood, R.E.W. Hancock, M. Bains, I.N. Cheng, and C. Wang. (1997) J. Bacteriol. 179: 7856-7864 PDF

185

Antimycobacterial polyynes of Devil’sClub (Oplopanax horridus), a north american native medicinal plant.

Kobaisy, M., Z.Abramowski, L.Lerner, G.Saxena, R.E.W.Hancock, G.H.N.Towers, D.Doxsee, and R.W.Stokes (1997) J. Natural Prod. 60: 1210-1213

184

Interaction of cationic peptides with bacterial membranes.

Fidai, S., S. W. Farmer, and R.E.W. Hancock. (1997) Meth. Molec. Biol. 184: 187-204 PDF

183

Influence of OprM expression on multiple antibiotic resistance in Pseudomonas aeruginosa.

Wong, K.K.Y., K.Poole, N.Gotoh, and R.E.W.Hancock. (1997) Antimicrob. Agents Chemother. 41: 2009-2012 PDF

182

Sequence analysis and recombinant expression of a 28-kilodalton Treponema pallidum subsp. pallidum rare outer membrane protein (Tromp2).

Champion, C.I., D.R. Blanco, M.M. Exner, H. Erdjument-Bromage, R.E.W. Hancock, P. Tempst, J.N. Miller and M.A. Lovett. (1997) J. Bacteriol. 179: 1230-1238 PDF

181

Identification of a penicillin-binding protein 3 homologue, PBPC, in Pseudomonas aeruginosa: Gene cloning and growth phase dependent expression.

Liao, X. and R.E.W. Hancock. (1997) J. Bacteriol. 179: 1490-1496 PDF

180

Antibacterial Peptides and the outer membranes of Gram negative bacilli.

Hancock, R.E.W. (1997) J. Med. Microbiol. 46: 1-3 PDF

179

Improved activity of a synthetic indolicidin analog

Falla, T.J. and R.E.W. Hancock. (1997) Antimicrob. Agents Chemother. 41: 771-775 PDF

178

Susceptibility to ß-lactam antibiotics of Pseudomonas aeruginosa overproducing penicillin-binding protein 3.

Liao, J. and R.E.W. Hancock. (1997) Antimicrob. Agents Chemother. 41: 1158-1161 PDF

177

Peptide antibiotics.

Hancock, R.E.W. (1997) The Lancet 349: 418-422 PDF

176

Utilization of alkaline phosphatase fusions to identify secreted proteins, including potential efflux proteins and virulence factors from Helicobacter pylori.

Bina, J.E., F. Nano and R.E.W. Hancock. (1997) FEMS Microbiol. Lett. 148: 63-68 PDF

175

Anti-mycobacterial screening of British Columbian Medicinal Plants.

McCutcheon, A.R., R.W. Stokes, L.M. Thorson, S.M. Ellis, R.E.W. Hancock, and G.H.N. Towers. (1997) Intl. Journ. Pharmacog. 35: 77-83 PDF

174

The bacterial outer membrane as a drug barrier.

Hancock, R.E.W. (1997) Trends Microbiol. 5: 37-42 PDF

173

Purification and partial characterization of the OmpA family of proteins of Pasteurella haemolytica.

Mahasreshti, P.J., G.L. Murphy, J.H. Wyckoff, S. Farmer, R.E.W. Hancock and A.W. Confer. (1997) Infect. Immun. 65: 211-218 PDF

172

Recombinant Treponema pallidum rare outer membrane protein 1 (Tromp1) expressed in Escherichia coli has porin activity and surface antigenic exposure.

Blanco, D.R., C.I. Champion, M.M. Exner, E.S. Shang, J.T. Skare, R.E.W. Hancock, J.N. Miller and M.A. Lovett. (1996) J. Bacteriol. 178: 6685-6692 PDF

171

Effect of ring size of gramicidin S analogs on structure, antibacterial and hemolytic activity.

Kondejewski, L.H., S.W. Farmer, D.S. Wishart, C.M. Kay, R.E.W. Hancock, and R.S. Hodges. (1996) J. Biol. Chem. 271: 25261-25268 PDF

170

Anti-endotoxin potential of cationic peptide antimicrobials.

Gough, M., R.E.W. Hancock and N.M. Kelly. (1996) Infect. Immun. 64: 4922-4927 PDF

169

Role of gyrA mutation and loss of OprF in the multiple antibiotic resistance (MAR) phenotype of Pseudomonas aeruginosa G49.

Pumbwe, L., M.J. Everett, R.E.W. Hancock, and L.J.V. Piddock. (1996) FEMS Microbiol. Lett. 143: 25-28 PDF

168

The role of specific lysine residues in the passage of anions through the Pseudomonas aeruginosa porin OprP.

Sukhan A. and R.E.W. Hancock. (1996) J. Biol. Chem. 271: 21239-21242 PDF

167

Mode of action of the antimicrobial peptide indolicidin.

Falla, T.J., D.N. Karunaratne, and R.E.W. Hancock. (1996) J. Biol. Chem. 271: 19298-19303 PDF

166

Membrane topology of the outer membrane protein OprH from Pseudomonas aeruginosa: PCR-mediated site-directed insertion and deletion mutagenesis.

Rehm, B.H.A. and R.E.W. Hancock. (1996) J. Bacteriol. 178: 3346-3349 PDF

165

The effect of the length of a malarial epitope on its antigenicity and immunogenicity in an epitope presentation system using the Pseudomonas aeruginosa outer membrane protein OprF as the carrier.

Wong, R.S.Y. and R.E.W. Hancock. (1996) FEMS Microbiol. Lett. 140: 209-214 PDF

164

Antimicrobial peptides: Broad-spectrum antibiotics from nature.

Hancock, R.E.W. and T.J. Falla. (1996) Clin. Microbiol. Infect. 1: 226-229 PDF

163

Antibacterial and antifungal polyine compounds from Glehnia littoralis ssp Leiocarpa.

Matsuura, H., G. Saxena, S.W. Farmer, R.E.W. Hancock, and G.H.N. Towers. (1996) Planta Medica 62: 256-259 PDF

162

The role of specific surface loop regions in determining the function of the imipenem-specific pore protein OprD of Pseudomonas aeruginosa.

Huang, H. and R.E.W. Hancock. (1996) J. Bacteriol. 178: 3085-3090 PDF

161

Gramicidin S is active against both gram-positive and gram-negative bacteria.

Kondejewski, L.H., S.W. Farmer, D.S. Wishart, R.E.W. Hancock and R.S. Hodges. (1996) Int. J. Pept. Prot. Res. 47: 460-466 PDF

160

Antibacterial in vitro activity of fourth generation cephalosporins.

Hancock, R.E.W. and F. Bellido. (1996) J. Chemotherapy 8 Supp 2: 31-36

159

Chlorochimaphilin: A new antibiotic from Moneses uniflora.

Saxena, G., S.W. Farmer, R.E.W. Hancock and G.H.N. Towers. (1996) J. Natural Prod. 59: 62-65 PDF

158

Physical mapping of 32 genetic markers on the Pseudomonas aeruginosa PAO1 chromosome.

Liao, X., I. Charlebois, C. Ouellet, M.-J. Morency, K. Dewar, J. Lightfoot, J. Foster, R. Siehnel, H. Schweizer, J. Lam, R.E.W. Hancock and R.C. Levesque. (1996) Microbiology 142: 79-86 PDF

157

An antibacterial thiophene from Balsamorhiza sagittata.

Matsuura, H., G. Saxena, S.W. Farmer, R.E.W. Hancock and G.H.N. Towers. (1996) Planta Medica 62: 65-66 PDF

156

A conserved Aeromonas salmonicida porin provides protective immunity to rainbow trout.

Lutwyche, P., M.M. Exner, R.E.W. Hancock and T.J. Trust (1995) Infect. Immun. 63: 3137-3142 PDF

155

Insertion mutagenesis of the Pseudomonas aeruginosa phosphate-specific porin OprP.

Sukhan, A. and R.E.W. Hancock. (1995) J. Bacteriol. 177: 4914-4920 PDF

154

Functional and regulatory analysis of the OmpF-like porin, OpnP, of the symbiotic bacterium Xenorhabdus nematophilus.

Forst, S., J. Waukau, G. Leisman, M. Exner and R.E.W. Hancock. (1995) Molec. Microbiol. 18: 779-789 PDF

153

Isolation and characterization of a conserved porin protein from Helicobacter pylori.

Doig, P., M.M. Exner, R.E.W. Hancock, and T.J. Trust (1995) J. Bacteriol. 177: 5447-5452 PDF

152

Antibacterial and antifungal compounds from Empetrum nigrum.

Matsuura, H., G. Saxena, S.W. Farmer, R.E.W. Hancock and G.H.N. Towers. (1995) Planta Medica 61: 580 PDF

151

Cloning and characterization of the Pseudomonas aeruginosa pbpB gene encoding penicillin-binding protein 3.

Liao, X., and R.E.W. Hancock. (1995) Antimicrob. Agents Chemother. 39: 1871-1874 PDF

150

Pseudomonas aeruginosa outer membrane protein OprF as an expression vector for foreign epitopes: the effects of positioning and length on the antigenicity of the epitope.

Wong, R.S.Y., R.A. Wirtz, and R.E.W. Hancock. (1995) Gene 158: 55-60 PDF

149

Antiviral screening of British Columbian medicinal plants.

McCutcheon, A.R., T.E. Roberts, E. Gibbons, S.M. Ellis, L.A. Babiuk, R.E.W. Hancock, and G.H.N. Towers. (1995) J. Ethnopharmacol. 49: 101-110 PDF

148

Porin activity and sequence analysis of a 31-kilodalton Treponema pallidum subsp. pallidum rare outer membrane protein (Tromp1).

Blanco, D.R., C.I. Champion, M.E. Exner, H. Erdjument-Bromage, R.E.W. Hancock, P. Tempst, J.N. Miller, and M.A. Lovett. (1995) J. Bacteriol. 177: 3556-3562 PDF

147

The rare outer membrane protein, OmpL1, of pathogenic Leptospira species is a heat-modifiable porin.

Shang, E.S., M.M. Exner, T.A. Summers, C. Martinich, C.I. Champion, R.E.W. Hancock, and D.A. Haake. (1995) Infect. Immun. 63: 3174-3181 PDF

146

Membrane topology and site-specific mutagenesis of Pseudomonas aeruginosa porin OprD.

Huang, H., D. Jeanteur, F. Pattus, and R.E.W. Hancock (1995) Molec. Microbiol. 16: 931-941 PDF

145

Isolation and characterization of a family of porin proteins from Helicobacter pylori.

Exner, M.M., P. Doig, T.J. Trust and R.E.W. Hancock (1995) Infect. Immun. 63: 1567-1572 PDF

144

Development of multiple-antibiotic-resistant (MAR) mutants of Pseudomonas aeruginosa after serial exposure to fluoroquinolones.

Zhanel, G.G., J.A. Karlowsky, M.H. Saunders, R.J. Davidson, D.J. Hoban, R.E.W. Hancock, I. McLean, and L.E. Nicolle. (1995) Antimicrob. Agents Chemother. 39: 489-495 PDF

143

Epitope mapping of the Pseudomonas aeruginosa major outer membrane porin protein OprF.

Rawling, E.G., N.L. Martin, and R.E.W. Hancock (1995) Infect. Immun. 63: 38-42 PDF

142

Use of specific dyes in the detection of antimicrobial compounds from crude plant extracts using a thin layer chromatography agar overlay technique.

Saxena, G., S. Farmer, G.H.N. Towers, and R.E.W. Hancock (1995) Phytochem. Anal 6: 125-129

141

Antimicrobial compounds from Alnus rubra

Saxena, G., S. Farmer, R.E.W. Hancock, and G.H.N. Towers (1995) Intl. J. Pharmacognosy 33: 33-36 PDF

140

Antimicrobial constituents of Rhus glabra.

Saxena, G., A.R. McCutcheon, S. Farmer, G.H.N. Towers and R.E.W. Hancock. (1994) J. Ethnopharmacol. 42: 95-99

140

Cationic bactericidal peptides.

Hancock, R.E.W., T. Falla and M.H. Brown, (1995) Adv. Microb. Physiol 37: 135-175

139

Isolation of the outer membranes from Treponema pallidum and Treponema vincentii.

Blanco, D.R., K. Reimann, J. Skare, C.I. Champion, D. Foley, M.M. Exner, R.E.W. Hancock, J.N. Miller, and M.A. Lovett. (1994) J. Bacteriol. 176: 6088-6099 PDF

138

Antifungal screening of medicinal plants of British Columbian native peoples

McCutcheon, A.R., S.M. Ellis, R.E.W. Hancock and G.H.N. Towers. (1994) J. Ethnopharmacol. 44: 157-169

137

Improvement of outer membrane-permeabilizing and lipopolysaccharide-binding activities of an antimicrobial cationic peptide by C-terminal modification.

Piers, K.L., M.H. Brown and R.E.W. Hancock (1994) Antimicrob. Agents Chemother. 38: 2311-2316 PDF

136

The interaction of a recombinant cecropin/melittin hybrid peptide with the outer membrane of Pseudomonas aeruginosa.

Piers, K., and R.E.W. Hancock. (1994) Molec. Microbiol. 12: 951-958 PDF

135

Genetic definition of the substrate selectivity of outer membrane porin protein OprD of Pseudomonas aeruginosa

Huang, H., and R.E.W. Hancock (1993) J. Bacteriol. 175: 7793-7800 PDF

134

Synthesis of bulky β-lactams for inhibition of cell surface β-lactamase activity.

Karunaratne, D.N., S. Farmer and R.E.W. Hancock (1993) Bioconjugate Chemistry 4: 434-439 PDF

133

Conservation of surface epitopes in Pseudomonas aeruginosa outer membrane porin protein OprF.

Martin, N.M. E. G. Rawling, R. Wong, M. Rosok, and R.E.W. Hancock (1993) FEMS Microbiol. Lett. 113: 261-266 PDF

132

Linker-insertion mutagenesis of Pseudomonas aeruginosa outer membrane protein OprF.

Wong, R.S.Y., H. Jost, and R.E.W. Hancock (1993) Molec. Microbiol. 10: 283-292 PDF

131

Recombinant DNA procedures for producing small antimicrobial cationic peptides in bacteria.

Piers, K.L., M.H. Brown, and R.E.W. Hancock. (1993) Gene 134: 7-13 PDF

130

Mechanisms of nonopsonic phagocytosis of Pseudomonas aeruginosa.

Mork, T., and R.E.W. Hancock (1993) Infect. Immun. 61: 3287-3293 PDF

129

Pore-forming properties of the major 53-kilodalton surface antigen from the outer sheath of Treponema denticola.

Egli, C., W.K. Leung, K.H. Müller, R.E.W. Hancock, and B.C. McBride (1993) Infect. Immun. 61: 1694-1699 PDF

128

Anion transport through the phosphate-specific OprP-channel of the Pseudomonas aeruginosa outer membrane: Effects of phosphate, di- and tri-basic anions and of negatively-charged lipids.

Benz, R., C. Egli, and R.E.W. Hancock (1993) Biochim. Biophys. Acta. 1149: 224-230 PDF

127

Mechanism of uptake of deglucoteicoplanin amide derivatives across outer membranes of Escherichia coli and Pseudomonas aeruginosa.

Hancock, R.E.W., and S.W. Farmer (1993) Antimicrob. Agents Chemother. 37: 453-456 PDF

126

Analysis of two gene regions involved in the expression of the imipenem-specific, outer membrane porin protein OprD of Pseudomonas aeruginosa.

Huang, H., R.J. Siehnel, F. Bellido, E. Rawling, and R.E.W. Hancock (1992) FEMS Microbiol. Lett. 97: 267-274 PDF

125

Role of Pseudomonas aeruginosa outer membrane protein OprH in polymyxin and gentamicin resistance: Isolation of an OprH-deficient mutant by gene replacement techniques.

Young, M.L., M. Bains, A. Bell and R.E.W. Hancock. (1992) Antimicrob. Agents Chemother. 36: 2566-2568 PDF

124

Fluoroquinolone supersusceptibility mediated by outer membrane protein OprH overexpression in Pseudomonas aeruginosa: Evidence for involvement of a non-porin pathway.

Young, M., and R.E.W. Hancock. (1992) Antimicrob. Agents Chemother. 36: 2365-2369 PDF

123

Pore-forming ability of major outer membrane proteins from Wolinella recta ATCC 33238.

Kennel, W.L., C. Egli, R.E.W. Hancock, and S.C. Holt. (1992) Infect. Immun. 60: 380-384 PDF

122

Antibiotic screening of medicinal plants of the British Columbian native peoples.

McCutcheon, A.R., S.M. Ellis, R.E.W. Hancock and G.H.N. Towers. (1992) J. Ethnopharmacol. 37: 213-223

121

Analysis of the Pseudomonas aeruginosa major outer membrane protein OprF by use of truncated OprF derivatives and monoclonal antibodies.

Finnen, R.L., N.L. Martin, R.J. Siehnel, W.A. Woodruff, M. Rosok, and R.E.W. Hancock. (1992) J. Bacteriol. 174: 4977-4985. PDF

120

Reevaluation, using intact cells, of the exclusion limit and role of porin OprF in Pseudomonas aeruginosa outer membrane permeability.

Bellido, F., N.L. Martin, R.J. Siehnel, and R.E.W. Hancock. (1992) J. Bacteriol. 174: 5196-5203. PDF

119

Characterization of lipid A from Pseudomonas aeruginosa O-antigenic B-band lipopolysaccharide by 1D and 2D NMR and mass spectral analysis.

Karunaratne, D.N., J.C. Richards and R.E.W. Hancock. (1992) Arch. Biochem. Biophys. 299: 368-376. PDF

118

Extracellular lipase from Pseudomonas aeruginosa is an amphiphilic protein.

Jaeger, K.E., F.-J. Adrian, H.E. Meyer, R.E.W. Hancock, and U.K. Winkler. (1992) Biochim. Biophys. Acta. 1120: 315-321. PDF

117

Polyphosphate-selective porin OprO of Pseudomonas aeruginosa: Expression, purification and sequence.

Siehnel, R.J., C. Egli, and R.E.W. Hancock. (1992) Molec. Microbiol. 6: 2319-2326. PDF

116

Overexpression in Escherichia coli and functional analysis of a novel PPi selective porin, OprO, from Pseudomonas aeruginosa.

Hancock, R.E.W., C. Egli, R. Benz, and R.J. Siehnel. (1992) J. Bacteriol. 174: 471-476. PDF

115

A pleiotropic, post-therapy, enoxacin-resistant mutant of Pseudomonas aeruginosa.

Piddock, L.J.V., M.C. Hall, F. Bellido, M. Bains, and R.E.W. Hancock (1992) Antimicrob. Agents Chemother. 36: 1057-1061. PDF

114

Influence of outer membrane mutations on susceptibility of Escherichia coli to the dibasic macrolide azithromycin.

Farmer, S., Z. Li, and R.E.W. Hancock. (1992) J. Antimicrob. Chemother. 29: 27-33. PDF

113

Antibiotic uptake: unusual results for unusual molecules.

Hancock, R.E.W., and F. Bellido. (1992) J. Antimicrob. Chemother. 29: 235-243. PDF

112

Factors involved in the enhanced efficacy against Gram-negative bacteria of fourth generation cephalosporins.

Hancock, R.E.W., and F. Bellido. (1992) J. Antimicrob. Chemother. 29: Suppl. A:1-6. PDF

111

Pseudomonas aeruginosa outer membrane protein OprH: Expression from the cloned gene and function in EDTA and gentamicin resistance.

Bell, A., M. Bains, and R.E.W. Hancock. (1991) J. Bacteriol. 173: 6657-6664. PDF

110

Purification of glucose-inducible outer membrane protein OprB of Pseudomonas putida and reconstitution of glucose-specific pores.

Saravolac, E.G., N.F. Taylor, R. Benz, and R.E.W. Hancock. (1991) J. Bacteriol. 173: 4970-4976. PDF

109

Reevaluation of the factors involved in the efficacy of new β-lactams against Enterobacter cloacae.

Bellido, F., J.-C. Pechere, and R.E.W. Hancock. (1991) Antimicrob. Agents Chemother. 35: 73-78. PDF

108

Novel method for measurement of outer membrane permeability to new β-lactams in intact Enterobacter cloacae cells.

Bellido, F., J.-C. Pechere, and R.E.W. Hancock. (1991) Antimicrob. Agents Chemother. 35: 68-72. PDF

107

Expression in Caulobacter cresentus of the phosphate-starvation-inducible porin OprP of Pseudomonas aeruginosa.

Walker, S.G., R.E.W. Hancock, and J. Smit. (1991) FEMS Microbiol. Lett. 77: 217-222. PDF

106

Interaction of aminoglycosides with the outer membranes and purified lipopolysaccharide and OmpF porin of Escherichia coli.

Hancock, R.E.W., S.W. Farmer, Z. Li, and K. Poole. (1991) Antimicrob. Agents Chemother. 35: 1309-1314. PDF

105

Conservation of the gene for outer membrane protein OprF in the family Pseudomonadaceae: Sequence of the Pseudomonas syringae OprF gene.

Ullstrom, C.A., R. Siehnel, W. Woodruff, S. Steinbach, and R.E.W. Hancock. (1991) J. Bacteriol. 173: 768-775. PDF

104

Outer membrane proteins of Pseudomonas.

Hancock, R.E.W., R. Siehnel and N. Martin. (1990) Molec. Microbiol. 4: 1069-1075. PDF

103

Sequence and relatedness in other bacteria of the Pseudomonas aeruginosa oprP gene coding for the phosphate-specific porin P.

Siehnel, R.J., N.L. Martin, and R.E.W. Hancock. (1990) Molec. Microbiol. 4: 831-838. PDF

102

Comparison of the outer membrane protein and lipopolysaccharide profiles of mucoid and nonmucoid Pseudomonas aeruginosa.

Kelly, N.M., M.H. MacDonald, N. Martin, T.I. Nicas, and R.E.W. Hancock. (1990) J. Clin. Microbiol. 28: 2017-2021. PDF

101

Pseudomonas aeruginosa pili as ligands for nonopsonic phagocytosis by fibronectin-stimulated macrophages.

Kelly, N.M., J.L. Kluftinger, B.L. Pasloske, W. Paranchych, and R.E.W. Hancock. (1989) Infect. Immun. 57: 3841-3845. PDF

100

Fibronectin as an enhancer of nonopsonic phagocytosis of Pseudomonas aeruginosa by macrophages.

Kluftinger, J.L., N.M. Kelly, B.H. Jost and R.E.W. Hancock. (1989) Infect. Immun. 57: 2782-2785. PDF

Determinants of the efficacy of tobramycin therapy against isogenic nonmucoid and mucoid derivatives of Pseudomonas aeruginosa PA01 growing in peritoneal chambers in mice.

Kelly, N.M., E.G. Rawling and R.E.W. Hancock. (1989) Antimicrob. Agents Chemother. 33: 1207-1211. PDF

Properties of a Pseudomonas stutzeri outer membrane channel-forming protein (NosA) required for production of copper-containing N₂0 reductase.

Lee, H.S., R.E.W. Hancock, and J.L. Ingraham. (1989) J. Bacteriol. 171: 2096-2100. PDF

Pseudomonas aeruginosa outer membrane protein F: Structural role and relationship to the Escherichia coli OmpA protein.

Woodruff, W.A., and R.E.W. Hancock. (1989) J. Bacteriol. 171: 3304-3309. PDF

Outer membrane protein H1 of Pseudomonas aeruginosa: Purification of the protein and cloning and nucleotide sequence of the gene.

Bell, A., and R.E.W. Hancock. (1989) J. Bacteriol. 171: 3211-3217. PDF

Stimulation by fibronectin of macrophage-mediated phagocytosis of Pseudomonas aeruginosa.

Kluftinger, J.L., N.M. Kelly and R.E.W. Hancock. (1989) Infect. Immun. 57: 817-822. PDF

Pseudomonas aeruginosa cytotoxin: Periplasmic localization and inhibition of macrophages.

Kluftinger, J., F. Lutz and R.E.W. Hancock. (1989) Infect. Immun. 57: 882-886. PDF

Surface characteristics of Pseudomonas aeruginosa grown in a chamber implant model in mice and rats.

Kelly, N.M., A. Bell and R.E.W. Hancock. (1989) Infect. Immun. 57: 344-350. PDF

Antibiotic uptake into Gram-negative bacteria.

Hancock, R.E.W. and A. Bell. (1988) J. Clin. Microbiol. 7: 713-720. PDF

Outer membranes of environmental isolates of Pseudomonas aeruginosa.

Hancock, R.E.W. and L. Chan. (1988) Molec. Microbiol. 26: 2423-2424. PDF

Regulation of components of the Pseudomonas aeruginosa phosphate-starvation-inducible regulon in Escherichia coli.

Siehnel, R.J., E. Worobec, and R.E.W. Hancock. (1988) Molec. Microbiol. 2: 347-352. PDF

Monoclonal antibodies provide protection against ocular Pseudomonas aeruginosa infection.

Moon, M.M., L.D. Hazlett, R.E.W. Hancock, R.S. Berk and R. Barrett. (1988) Invest. Opthamol. Vis. Sci. 29: 1277-1284. PDF

Enhanced binding of polycationic antibiotics to lipopolysaccharide from an aminoglycoside-supersusceptible, tolA mutant strain of Pseudomonas aeruginosa.

Rivera, M., R.E.W. Hancock, J.G. Sawyer, A. Haug and E.J. McGroarty. (1988) Antimicrob. Agents Chemother. 32: 649-655. PDF

Heterogeneity of lipopolysaccharides from Pseudomonas aeruginosa. Analysis of lipopolysaccharide chain length.

Rivera, M., L.E. Bryan, R.E.W. Hancock and E.J. McGroarty. (1988) J. Bacteriol. 170: 512-521. PDF

Cloning of the Pseudomonas aeruginosa outer membrane porin protein P gene: Evidence for a linked region of DNA homology.

Siehnel, R., E.A. Worobec, and R.E.W. Hancock. (1988) J. Bacteriol. 170: 2312-2318. PDF

Construction and characterization of Pseudomonas aeruginosa protein F-deficient mutants after in vitro and in vivo insertion mutagenesis of the cloned gene.

Woodruff, W.A. and R.E.W. Hancock. (1988) J. Bacteriol. 170: 2592-2598. PDF

Large-scale purification and biochemical characterization of crystallization-grade porin protein P from Pseudomonas aeruginosa.

Worobec, B., N.L. Martin, W. McCubbin, C. Kay, G. Brayer and R.E.W. Hancock. (1988) Biochim. Biophys. Acta. 939: 366-374. PDF

Gene cloning and expression of the Pseudomonas aeruginosa periplasmic phosphate-binding protein.

Worobec, B., R. Siehnel, P. Gladman and R.E.W. Hancock. (1988) FEMS Microbiol. Lett. 52: 235-238. PDF

Interaction of macrophage cationic proteins with the outer membrane of Pseudomonas aeruginosa.

Sawyer, J.G., N.L. Martin and R.E.W. Hancock. (1988) Infect. Immun. 56: 693-698. PDF

Visualization of Pseudomonas aeruginosa 0 antigens by using a protein A-dextran-colloidal gold conjugate with both immunoglobulin G and immunoglobulin M in monoclonal antibodies.

Lam, J.S., M.Y.C. Lam, L.A. MacDonald and R.E.W. Hancock. (1987) J. Bacteriol. 169: 3531-3538. PDF

Mapping and characterization of two mutations to antibiotic supersusceptibility in Pseudomonas aeruginosa.

Angus, B.L., J. Fyfe and R.E.W. Hancock. (1987) J. Gen. Microbiol. 133: 2905-2914. PDF

The hydrophobic uptake pathway across the outer membrane of the antibiotic supersusceptible Pseudomonas aeruginosa mutant Z61.

Angus, B.L., J. Fyfe and R.E.W. Hancock. (1987) FEMS Microbiol. Lett. 48: 153-57. PDF

Colonial dissociation and susceptibility to phagocytosis of Pseudomonas aeruginosa grown in a chamber implant model in mice.

Kelly, N.M., J.P. Arbuthnott, J. Battershill, S. Kuo, and R.E.W. Hancock. (1987) Infect. Immun. 55: 2841-2843. PDF

Use of monoclonal antibodies to protein F of Pseudomonas aeruginosa as opsonins for phagocytosis by macrophages.

Battershill, J., D.P. Speert, and R.E.W. Hancock. (1987) Infect. Immun. 55: 2531-2533. PDF

An immunohistological evaluation of Pseudomonas aeruginosa pulmonary infection in two patients with cystic fibrosis.

Speert, D.P., J.E. Dimmick, G.B. Pier, J.M. Saunders, R.E.W. Hancock and N.M. Kelly. (1987) Pediatr. Res. 22: 743-747. PDF

Role of porins in outer membrane permeability.

Hancock, R.E.W. (1987) J. Bacteriol. 169: 929-933. PDF

Role of β-lactamase in in vivo development of ceftazidime resistance in experimental Pseudomonas aeruginosa endocarditis.

Bayer, A.S., J. Peters, T.R. Parr, L. Chan and R.E.W. Hancock. (1987) Antimicrob. Agents Chemother. 31: 253-258. PDF

Role of porins in intrinsic antibiotic resistance of Pseudomonas cepacia.

Parr, T.R., R.A. Moore, L.V. Moore and R.E.W. Hancock. (1987) Antimicrob. Agents Chemother. 31: 121-123. PDF

Phosphate-selective porins from the outer membranes of fluorescent Pseudomonas sp.

Poole, K., T.R. Parr and R.E.W. Hancock. (1987) Can. J. Microbiol. 33: 63-69. PDF

Mechanism of ion transport through the anion-selective channel of the Pseudomonas aeruginosa outer membrane.

Benz, R., and R.E.W. Hancock. (1987) J. Gen. Physiol. 89: 275-295. PDF

Isolation of the outer membrane and characterization of the major outer membrane protein of Spirocheata aurantia.

Kropinski, A.M., T.R. Parr, B. Angus, R.E.W. Hancock, W.C. Ghiorse, and E.P. Greenberg. (1987) J. Bacteriol. 169: 172-179 PDF

Involvement of outer membrane of Pseudomonas cepacia in aminoglycoside and polymyxin resistance.

Moore, R.A., and R.E.W. Hancock. (1986) Antimicrob. Agents Chemother. 30: 923-926. PDF

Intrinsic antibiotic resistance of Pseudomonas aeruginosa.

Hancock, R.E.W. (1986) J. Antimicrob. Chemother. 18: 653-659. PDF

Outer membrane porin protein of Campylobacter jejuni.

Huyer, M., T.R. Parr, R.E.W. Hancock and W.J. Page. (1986) FEMS Microbiol. Lett. 37: 247-250. PDF

Role of lysines in ion selectivity of bacterial outer membrane porins.

Hancock, R.E.W., A. Schmidt, K. Bauer, and R. Benz. (1986) Biochim. Biophys. Acta. 860: 263-267. PDF

Expression in Escherichia coli and function of Pseudomonas aeruginosa outer membrane porin protein F.

Woodruff, W.A., T.R. Parr, R.E.W. Hancock, L. Hanne, T.I. Nicas, and B. Iglewski. (1986) J. Bacteriol. 167: 473-479. PDF

Bordetella pertussis major outer membrane porin protein forms small, anion-selective channels in lipid bilayer membranes.

Armstrong, S.K., T.R. Parr, C.D. Parker, and R.E.W. Hancock. (1986) J. Bacteriol. 166: 212-216. PDF

Phosphate-starvation-induced outer membrane proteins of the families Enterobacteriaceae and Pseudomonadaceae: demonstration of immunological cross-reactivity with an antiserum specific for porin protein P of Pseudomonas aeruginosa.

Poole, K., and R.E.W. Hancock. (1986) J. Bacteriol. 165: 987-993. PDF

Isolation of a Tn501 insertion mutant lacking porin protein P of Pseudomonas aeruginosa.

Poole, K., and R.E.W. Hancock. (1986) Mol. Gen. Genet. 202: 403-409. PDF

Demonstration and chemical modification of a specific phosphate binding site in the phosphate-starvation-inducible outer membrane porin protein P of Pseudomonas aeruginosa.

Hancock, R.E.W., and R. Benz. (1986) Biochim. Biophys. Acta. 860: 699-707. PDF

Lipopolysaccharide-free Escherichia coli Omp F and Pseudomonas aeruginosa protein P porins are functionally active in lipid bilayer membranes.

Parr, T.R., K. Poole, G.W.K. Crockford, and R.E.W. Hancock. (1986) J. Bacteriol. 165: 523-526. PDF

Interaction of polycationic antibiotics with Pseudomonas aeruginosa lipopolysaccharide and lipid A studied by using dansyl-polymyxin.

Moore, R.A., N.C. Bates and R.E.W. Hancock. (1986) Antimicrob. Agents Chemother. 29: 496-500. PDF

Biochemical model for enhanced biological phosphorous removal.

Comeau, Y., J.J. Hall, R.E.W. Hancock, and W.K. Oldham. (1986) Water Res. 20: 1511-1521. PDF

Binding of polycationic antibiotics and polyamines to lipopolysaccharides of Pseudomonas aeruginosa.

Peterson, A.A., R.E.W. Hancock, and E.J. McGroarty. (1985) J. Bacteriol. 164: 1256-1261. PDF

Monoclonal antibody for an outer membrane lipoprotein of the Pseudomonas fluorescens group of the family Pseudomonadaceae.

Mutharia, L.M., and R.E.W. Hancock. (1985) J. Bacteriol. 35: 530-532. PDF

Immunotherapeutic potential of monoclonal antibodies against Pseudomonas aeruginosa protein F.

Hancock, R.E.W., L.M. Mutharia and E.C.A. Mouat. (1985) Eur. J. Clin. Microbiol. 4: 224-227. PDF

Ion selectivity of gram-negative bacterial porins.

Benz, R., A. Schmidt, and R.E.W. Hancock. (1985) J. Bacteriol. 162: 722-727. PDF

Characterization of two surface-localized antigenic sites on porin protein F of Pseudomonas aeruginosa.

Mutharia, L.M., and R.E.W. Hancock. (1985) Can. J. Microbiol. 31: 381-386. PDF

Outer membrane protein NmpC of Escherichia coli: Pore-forming properties in black lipid bilayers.

Hindahl, M.S., G.W.K. Crockford, and R.E.W. Hancock. (1984) J. Bacteriol. 159: 1053-1055. PDF

Evidence for two distinct mechanisms of resistance to polymyxin B in Pseudomonas aeruginosa.

Moore, R.A., L. Chan, and R.E.W. Hancock. (1984) Antimicrob. Agents Chemother. 26: 539-545. PDF

Phosphate transport in Pseudomonas aeruginosa: Involvement of a periplasmic phosphate-binding protein.

Poole, K. and R.E.W. Hancock. (1984) Eur. J. Biochem. 144: 607-612. PDF

Compounds which increase the permeability of the Pseudomonas aeruginosa outer membrane.

Hancock, R.E.W., and P.G.W. Wong. (1984) Antimicrob. Agents Chemother. 26: 48-52. PDF

Use of the fluorescent probe 1-N-phenylnapthylamine to study the interactions of aminoglycoside antibiotics with the outer membrane of Pseudomonas aeruginosa.

Loh, B., C. Grant and R.E.W. Hancock. (1984) Antimicrob. Agents Chemother. 26: 546-551. PDF

Monoclonal antibodies specific for Escherichia coli J-5 lipopolysaccharide: Cross-reaction with other gram-negative bacterial species.

Mutharia, L.M., G. Crockford, W.C. Bogard, and R.E.W. Hancock. (1984) Infect. Immun. 45: 631-636. PDF

Chemical modification of the anion selectivity of the PhoE porin from the Escherichia coli outer membrane.

Darveau, R.P., R.E.W. Hancock and R. Benz. (1984) Biochim. Biophys. Acta. 774: 69-74. PDF

Outer-membrane protein PhoE from Escherichia coli forms anion-selective pores in lipid-bilayer membranes.

Benz, R., R.P. Darveau, and R.E.W. Hancock. (1984) Eur. J. Biochem. 140: 319-324. PDF

Quantitation and identification of antibodies to the outer-membrane proteins of Pseudomonas aeruginosa in sera of patients with cystic fibrosis.

Hancock, R.E.W., E. Mouat, and D.P. Speert. (1984) J. Infect. Dis. 149: 220-226. PDF

Characterization and chemical modification of small anion specific channels formed in lipid bilayer membranes by outer membrane protein P of Pseudomonas aeruginosa.

Benz, R., K. Poole, and R.E.W. Hancock. (1984) Biophys. J. 45: 81-82. PDF

Alterations in outer membrane permeability.

Hancock, R.E.W. (1984) Annu. Rev. Microbiol. 38: 237-264. PDF

Photodynamic action on Escherichia coli of natural acetylenic thiophenes, particularly 5-(buten-l-ynyl)-2,2'-bithienyl.

Downum, K.R., R.E.W. Hancock and G.H.N. Towers. (1983) Photochem. Photobiol. 6: 145-152. PDF

Immunogenicity of Pseudomonas aeruginosa outer membrane antigens examined by crossed immunoelectrophoresis.

Lam, J.S., L.M. Mutharia, R.E.W. Hancock, N. Hoiby, K. Lam, L. Baek, and J.W. Costerton. (1983) Infect. Immun. 42: 88-98. PDF

Effects of growth temperature, 47-megadalton plasmid, and calcium deficiency on the outer membrane protein porin and lipopolysaccharide composition of Yersina pestis EV76.

Darveau, R.P., W.T. Charnetzky, R.E. Hurlbert, and R.E.W. Hancock. (1983) Infect. Immun. 42: 1092-1101. PDF

Purification and reconstitution in lipid bilayer membranes of an outer membrane pore-forming protein of Aeromonas salmonicida.

Darveau, R.P., S. MacIntyre, J.T. Buckley, and R.E.W. Hancock. (1983) J. Bacteriol. 156: 1006-1011. PDF

Outer membrane protein K of Escherichia coli: Purification and pore-forming properties in lipid bilayer membranes.

Whitfield, C., R.E.W. Hancock, and J.W. Costerton. (1983) J. Bacteriol. 156: 873-879. PDF

Modification of the conductance, selectivity and concentration-dependent saturation of Pseudomonas aeruginosa protein P channels by chemical acetylation.

Hancock, R.E.W., K. Poole, M. Gimple and R. Benz. (1983) Biochim. Biophys. Acta. 735: 137-144. PDF

Pseudomonas aeruginosa isolates from patients with cystic fibrosis: a class of serum-sensitive, nontypable strains deficient in lipopolysaccharide 0 side-chains.

Hancock, R.E.W., L.M. Mutharia, L. Chan, R.P. Darveau, D.P. Speert, and G.B. Pier (1983) Infect. Immun. 42: 170-177. PDF

Surface localization of Pseudomonas aeruginosa outer membrane porin protein F by using monoclonal antibodies.

Mutharia, L.M., and R.E.W. Hancock. (1983) Infect. Immun. 42: 1027-1033. PDF

Outer membrane porin proteins F, P and D1 of Pseudomonas aeruginosa and Pho E of Escherichia coli : Chemical crosslinking to reveal native oligomers.

Angus, B.L., and R.E.W. Hancock. (1983) J. Bacteriol. 155: 1042-1051. PDF

An anion-selective channel from the Pseudomonas aeruginosa outer membrane.

Benz, R., M. Gimple, K. Poole and R.E.W. Hancock. (1983) Biochim. Biophys. Acta. 730: 387-390. PDF

Procedure for isolation of bacterial lipopolysaccharides from both smooth and rough Pseudomonas aeruginosa and Salmonella typhimurium strains.

Darveau, R.P., and R.E.W. Hancock. (1983) J. Bacteriol. 155: 831-838. PDF

Pseudomonas aeruginosa outer membrane permeability: Isolation of a porin protein F-deficient mutant.

Nicas, T.I., and R.E.W. Hancock. (1983) J. Bacteriol. 153: 281-285. PDF

Secretion of alkaline phosphatase and phospholipase C in Pseudomonas aeruginosa is specific and does not involve an increase in outer membrane permeability.

Poole, K., and R.E.W. Hancock. (1983) FEMS Microbiol. Lett. 16: 25-29. PDF

Alteration of susceptibility to EDTA, polymyxin B and gentamicin in Pseudomonas aeruginosa by divalent cation regulation of outer membrane protein H1.

Nicas, T.I., and R.E.W. Hancock. (1983) J. Gen. Microbiol. 129: 509-517. PDF

Comparison of fatty acid, protein and serological properties distinguishing outer membranes of Pseudomonas anguilliseptica strains from those of fish pathogens and other Pseudomonads.

Nakajima, K., K. Muroga, and R.E.W. Hancock. (1983) Int. J. Systemat. Bacteriol. 33: 1-8. PDF

Mode of action of alpha-terthienyl on Escherichia coli. Evidence for a photodynamic effect on membranes.

Downum, K.R., R.E.W. Hancock, and G.H.N. Towers. (1982) Photochem. Photobiol. 36: 517-523. PDF

Outer membrane proteins of Pseudomonas aeruginosa serotype strains.

Mutharia, L.M., T. I. Nicas, and R.E.W. Hancock. (1982) J. Infect. Dis. 146: 770-779. PDF

Monoclonal antibodies against Pseudomonas aeruginosa outer membrane antigens: Isolation and characterization.

Hancock, R.E.W., A.A. Wieczorek, L.M. Mutharia, and K. Poole. (1982) Infect. Immun. 37: 166-171. PDF

Outer membrane protein P of Pseudomonas aeruginosa: Regulation by phosphate deficiency and formation of small anion-specific channels in lipid bilayer membranes.

Hancock, R.E.W., K. Poole, and R. Benz. (1982) J. Bacteriol. 150: 730-738. PDF

Chemical and chromatographic analysis of lipopolysaccharide from an antibiotic-supersusceptible mutant of Pseudomonas aeruginosa.

Kropinski, A.M.B., J. Kuzio, B.L. Angus, and R.E.W. Hancock. (1982) Antimicrob. Agents Chemother. 21: 310-319. PDF

Outer membrane permeability in Pseudomonas aeruginosa: Comparison of a wild-type with an antibiotic-supersusceptible mutant.

Angus, B.L., A.M. Carey, D.A. Caron, A.M.B. Kropinski, and R.E.W. Hancock. (1982) Antimicrob. Agents Chemother. 21: 299-309. PDF

Properties of the large ion-permeable pores formed from protein F of Pseudomonas aeruginosa in lipid bilayer membranes.

Benz, R., and R.E.W. Hancock. (1981) Biochim. Biophys. Acta. 646: 298-308. PDF

Aminoglycoside uptake and mode of action - with special reference to streptomycin and gentamicin. II. Effects of aminoglycosides on cells.

Hancock, R.E.W. (1981) J. Antimicrob. Chemother. 8: 429-445. PDF

Aminoglycoside uptake and mode of action - with special reference to streptomycin and gentamicin. I. Antagonists and mutants.

Hancock, R.E.W. (1981) J. Antimicrob. Chemother. 8: 249-276. PDF

Involvement of the outer membrane in gentamicin and streptomycin uptake and killing in Pseudomonas aeruginosa.

Hancock, R.E.W., V.J. Raffle, and T.I. Nicas. (1981) Antimicrob. Agents Chemother. 19: 777-785. PDF

Pseudomonas aeruginosa outer membrane: peptidoglycan associated proteins.

Hancock, R.E.W., R.T. Irvin, J.W. Costerton, and A.M. Carey. (1981) J. Bacteriol. 145: 628-631. PDF

Outer membrane protein H1 of Pseudomonas aeruginosa: Involvement in adaptive and mutational resistance to ethylenediamine tetraacetate, polymyxin B and gentamicin.

Nicas, T.I., and R.E.W. Hancock. (1980) J. Bacteriol. 143: 872-878. PDF

Identification of the protein producing transmembrane diffusion pores in the outer membrane of Pseudomonas aeruginosa PA01.

Hancock, R.E.W., and G.M. Decad and H. Nikaido. (1979) Biochim. Biophys. Acta. 554: 323-331. PDF

Outer membrane of Gram negative bacteria. XIX Isolation from Pseudomonas aeruginosa PAO1 and use in reconstitution and definition of the permeability barrier.

Hancock, R.E.W., and H. Nikaido. (1978) J. Bacteriol. 136: 381-390. PDF

Iron transport in Escherichia coli K-12: 2,3-dihydroxybenzoate-promoted iron uptake.

Hancock, R.E.W., K. Hantke, and V. Braun. (1977) Arch. Microbiol. 114: 231-239. PDF

Iron transport in Escherichia coli K-12: Involvement of the colicin B receptor and of a citrate-inducible protein.

Hancock, R.E.W., K. Hantke, and V. Braun. (1976) J. Bacteriol. 127: 1370-1375. PDF

Functional organization of the outer membrane of Escherichia coli. Phage and colicin receptors as components of iron uptake systems.

Braun, V., R.E.W. Hancock, K. Hantke, and A. Hartmann. (1976) J. Supramol. Struct. 5: 37-58 PDF

Con^- mutants: class of mutants in Escherichia coli K-12 lacking a major cell wall protein and defective in conjugation and adsorption of a bacteriophage.

Skurray, R.A., R.E.W. Hancock, and P. Reeves. (1974) J. Bacteriol. 119: 726-735 PDF