Selected Publications

A P4-ATPase subunit of the Cdc50 family plays a role in iron acquisition and virulence in Cryptococcus neoformans.

Hu G, Caza M, Bakkeren E, Kretschmer M, Bairwa G, Reiner E, Kronstad J. (2017) Cell Microbiol. 19(6): doi: 10.1111/cmi.12718 PDF

Comprehensive Identification of mRNA-Binding Proteins of Leishmania donovani by Interactome Capture.

Nandan D, Thomas SA, Nguyen A, Moon KM, Foster LJ, Reiner NE. (2017) PLoS One 12(1): doi: 10.1371/journal.pone.0170068 PDF

Genomic Infectious Disease Epidemiology in Partially Sampled and Ongoing Outbreaks.

Didelot X, Fraser C, Gardy J, Colijn C. (2017) Mol Biol Evol 34(4): 997-1007

Iron acquisition in fungal pathogens of humans.

Bairwa G, Hee Jung W, Kronstad JW. (2017) Metallomics 9(3): 215-227

IslandViewer 4: expanded prediction of genomic islands for larger-scale datasets.

Bertelli C, Laird MR, Williams KP; Simon Fraser University Research Computing Group., Lau BY, Hoad G, Winsor GL, Brinkman FS (2017) Nucleic Acids Research doi: 10.1093/nar/gkx343

JAK1 gain-of-function causes an autosomal dominant immune dysregulatory and hypereosinophilic syndrome

Del Bel KL, Ragotte RJ^, Saferali A, Lee S, Vercauteren SM, Mostafavi SA, Schreiber RA, Prendiville JS, Phang MS, Halparin J, Au N, Dean JM, Priatel JJ, Jewels E, Junker AK, Rogers PC, Seear M, McKinnon ML*, Turvey SE* ^These authors contributed equally to this paper. *Co-corresponding authors. (2017) J. Allergy Clin Immunol 139: 2016-2020 PDF

Kisameet Glacial Clay: an Unexpected Source of Bacterial Diversity

Sarah L. Svensson, Shekooh Behroozian, Wanjing Xu, Michael G. Surette, Loretta Li, Julian Davies. (2017) MBio 8(3): e00590-17 PDF

Leishmania donovani chaperonin 10 regulates parasite internalization and intracellular survival in human macrophages.

Colineau L, Clos J, Moon KM, Foster LJ, Reiner NE. (2017) Med Microbiol Immunol 206(3): 235-257 PDF

Maternal immunisation: collaborating with mother nature.

Marchant A, Sadarangani M, Garand M, Dauby N, Verhasselt V, Pereira L, Bjornson G, Jones CE, Halperin SA, Edwards KM, Heath P, Openshaw PJ, Scheifele DW, Kollmann TR (2017) Lancet Infect Dis epub: ahead of print PDF

Protecting the Newborn and Young Infant from Infectious Diseases: Lessons from Immune Ontogeny.

Kollmann TR, Kampmann B, Mazmanian SK, Marchant A, Levy O. (2017) Immunity 46(3): 350-363 PDF

The Rap1-cofilin-1 pathway coordinates actin reorganization and MTOC polarization at the B-cell immune synapse

Wang, J.C., J.Y.-J. Lee, S. Christian, M. Dang-Lawson, C. Pritchard, S.A. Freeman, and M.R. Gold (2017) J Cell Sci 130: 1094-1109 PDF

Transient Oral Human Cytomegalovirus Infections Indicate Inefficient Viral Spread from Very Few Initially Infected Cells.

Mayer BT, Krantz EM, Swan D, Ferrenberg J, Simmons K, Selke S, Huang ML,
Casper C, Corey L, Wald A, Schiffer JT, Gantt S. (2017) J Virol 91(12): E00380-17 PDF

Treatment-induced viral cure of hepatitis C virus-infected patients involves a dynamic interplay among three important molecular players in lipid homeostasis: Circulating microRNA (miR)-24, miR-223, and proprotein convertase subtilisin/kexin type 9.

Hyrina, A., Olmstead, A.O., Steven, P., Krajden, M. , Tam, E. , Jean, F (2017) eBiomedicine 10.1016/j.ebiom.2017.08.020 PDF

Activity of SHIP, Which Prevents Expression of Interleukin 1β, Is Reduced in Patients With Crohn's Disease.

Ngoh EN, Weisser SB, Lo Y, Kozicky LK, Jen R, Brugger HK, Menzies SC, McLarren KW, Nackiewicz D, van Rooijen N, Jacobson K, Ehses JA, Turvey SE, Sly LM. (2016) Gastroenterology 150(2): 465-476 PDF

Analysis of the Protein Kinase A-Regulated Proteome of Cryptococcus neoformans Identifies a Role for the Ubiquitin-Proteasome Pathway in Capsule Formation.

Geddes JM, Caza M, Croll D, Stoynov N, Foster LJ, Kronstad JW. (2016) MBio 7(1): e01862-15. PDF

Antibiotic prescribing by dentists has increased: Why?

Marra F, George D, Chong M, Sutherland S, Patrick DM. (2016) J Am Dent Assoc 147(5): 320-7

CD45 regulates GM-CSF, retinoic acid and T cell homing in intestinal inflammation.

Samarakoon A, Shim Ya, Dosanjh M, Crickmer M, Labonte-Raymond C, Arif A, Johnson P. (2016) Mucosal Immunol. 9(6): 1514-1527 PDF

Cleavage of DAP5 by coxsackievirus B3 2A protease facilitates viral replication and enhances apoptosis by altering translation of IRES containing genes.

Hanson PJ, Ye X, Qiu Y, Zhang HM, Hemida MG, Wang F, Lim T, Gu A, Cho B, Kim H, Fung G, Granville D, Yang DC. (2016) Cell Death Differ. 25(5): 828-840 PDF

Construction of a Multiplex Promoter Reporter Platform to Monitor Staphylococcus aureus Virulence Gene Expression and the Identification of Usnic Acid as a Potent Suppressor of psm Gene Expression

Peng GAO, Yanli Wang, Iván Villanueva, Pak Leung Ho, Julian Davies and Richard Yi Tsun KAO, (2016) Front. Microbiol. 7: 1344 PDF

Cost-effectiveness of Universal and Targeted Newborn Screening for
Congenital Cytomegalovirus Infection.

Gantt S, Dionne F, Kozak FK, Goshen O, Goldfarb DM, Park AH, Boppana SB,
Fowler K. (2016) JAMA Pediatr 170(12): 1173-1180 PDF

Declaring a tuberculosis outbreak over with genomic epidemiology.

Hatherell HA, Didelot X, Pollock SL, Tang P, Crisan A, Johnston JC, Colijn C, Gardy JL. (2016) Mirob Genom 2(5): e000060 PDF

Dynamics of Persistent Oral Cytomegalovirus Shedding During Primary Infection
in Ugandan Infants.

Mayer BT, Matrajt L, Casper C, Krantz EM, Corey L, Wald A, Gantt S, Schiffer
JT. (2016) J Infect Dis 214(11): 1735-1743

Endosomal pH modulation by peptide-gold nanoparticle hybrids enables potent anti-inflammatory activity in phagocytic immune cells.

Yang H, Kozicky L, Saferali A, Fung SY, Afacan N, Cai B, Falsafi R, Gill E, Liu M, Kollmann TR, Hancock RE, Sly LM, Turvey SE (2016) Biomaterials 111: 90-102 PDF

Enhanced annotations and features for comparing thousands of Pseudomonas genomes in the Pseudomonas genome database

Winsor GL, Griffiths EJ, Lo R, Dhillon BK, Shay JA, Brinkman FSL (2016) Nucleic Acids Research 44: 646-653 PDF

Frozen vs Fresh Fecal Microbiota Transplantation and Clinical
Resolution of Diarrhea in Patients With Recurrent Clostridium difficile
Infection: A Randomized Clinical Trial.

Lee CH, Steiner T, Petrof EO, Smieja M, Roscoe D, Nematallah A, Weese JS,
Collins S, Moayyedi P, Crowther M, Ropeleski MJ, Jayaratne P, Higgins D, Li Y, Rau NV, Kim PT. (2016) JAMA 315-(2): 142-9

Hsp70-1: upregulation via selective phosphorylation of heat shock factor 1 during coxsackieviral infection and promotion of viral replication via the AU-rich element.

Qiu Y, Ye X, Hanson PJ, Zhang HM, Zong J, Cho B, Yang DC. (2016) Cell Mol Life Sci. 73(5): 1067-1084 PDF

Interconnection of post-transcriptional regulation: The RNA-binding protein Hfq is a novel target of the Lon protease in Pseudomonas aeruginosa.

Fernández, L., E.B.M. Breidenstein, P.K. Taylor, M. Bains, C. de la Fuente-Núñez, Y. Fang, L.J. Foster, and R.E.W. Hancock. (2016) Scientific Reports 6: 26811 PDF

Kisameet clay exhibits potent antibacterial activity against the ESKAPE pathogens

Behroozian S, Svensson SL, Davies J. (2016) MBio 7(1): e01842-15 PDF

Systematic Review of Factors Associated with Antibiotic Prescribing for Respiratory Tract Infections.

McKay R, Mah A, Law MR, McGrail K, Patrick DM (2016) Antimcrob Agents Chemother 60(7): 4106-18 PDF

Diet and specific microbial exposure trigger features of environmental enteropathy in a novel murine model.

Brown EM, Finlay BB, et al. (2015) Nat. Commun 6: 7806 PDF

Early infancy microbial and metabolic alterations affect risk of childhood asthma.

Arrieta MC, Stiemsma LT, Dimitriu PA,; CHILD Study Investigators, Mohn WW, Turvey SE, Finlay BB, et al. (2015) Sci Transl Med 7(307): 10.1126/scitranslmed.aab2271. PDF

Human microRNA-24 modulates highly pathogenic avian-origin H5N1 influenza A virus infection in A549 cells by targeting secretory pathway furin.

Loveday E.K., Diederich, S., Pasick, J., and Jean, F. (2015) Journal of General Virology doi: 10.1099/vir.0.068585-0. PDF

Hyaluronan binding identifies a functionally distinct alveolar macrophage-like population in bone marrow-derived dendritic cell cultures

Poon Gf, Dong Y, Marshall Kc, Arif A, Deeg Cm, Dosanjh M, Johnson P. (2015) J Immunol. 195(2): 632-642 PDF

Intravenous immunoglobulin skews macrophages to an anti-inflammatory, IL-10-producing activation state.

Kozicky LK, Zhao ZY, Menzies SC, Fidanza M, Reid GS, Wilhelmsen K, Hellman J, Hotte N, Madsen KL, Sly LM.
(2015) J Leukoc Biol. 98(6): 983-994 PDF

NetworkAnalyst for statistical, visual and network-based meta-analysis of gene expression data.

Xia J, E Gill and REW Hancock. (2015) Nature Protocols 10: 823-844 PDF

Small RNAs derived from tRNAs and rRNAs are highly enriched in exosomes from both old and new world Leishmania providing evidence for conserved exosomal RNA Packaging.

Lambertz U, Oviedo Ovando ME, Vasconcelos EJ, Unrau PJ, Myler PJ, Reiner NE (2015) BMC Genomics 16: 151 PDF

Surveillance of Borrelia burgdorferi in Ixodes ticks and small rodents in British Columbia.

Morshed MG, MK Lee, S Man, K Fernando, Q Wong, A Hojgaard, P Tang, S Mak, B Henry, DM Patrick. (2015) Vector Borne Zoonotic Dis. 15(11): 701-5 PDF

The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquitination by LUBAC to dampen lymphocyte NF-κB signalling

Klein T^, Fung SY^, Renner F, Blank MA, Dufour A, Kang S, Bolger-Munro M, Scurll JM, Priatel JJ, Schweigler P, Melkko S, Gold MR, Viner RI, Régnier CH, Turvey SE*, Overall CM*. ^These authors contributed equally to this paper. *Co-senior and co-corresponding authors (2015) Nat. Commun 6: 87777 PDF

The where, when, how, and why of hyaluronan binding by immune cells

Lee-Sayer SS, Dong Y, Arif AA, Olsson M, Brown Kl, Johnson P. (2015) Front Immunol. 14:6: 150 PDF

Toll-like receptor ligands sensitize B-cell receptor signalling by reducing actin-dependent spatial confinement of the receptor

Freeman, S.A., V. Jaumouillé, K. Choi, B.E. Hsu, H.S. Wong, L. Abraham, M.L. Graves, D. Coombs, C.D. Roskelley, R. Das, S. Grinstein, and M.R. Gold (2015) Nat. Commun 6: 6168 PDF

Tr1 Cells, but Not Foxp3+ Regulatory T Cells, Suppress NLRP3 Inflammasome Activation via an IL-10-Dependent Mechanism.

Yao Y, Vent-Schmidt J, McGeough MD, Wong M, Hoffman HM, Steiner TS, Levings MK. (2015) J Immunol. 195 (2): 488-97

Whole-Genome Sequencing of Measles Virus Genotypes H1 and D8 During Outbreaks of Infection Following the 2010 Olympic Winter Games Reveals Viral Transmission Routes.

Gardy JL, Naus M, Amlani A, Chung W, Kim H, Tan M, Severini A, Krajden M, Puddicombe D, Sahni V, Hayden AS, Gustafson R, Henry B, Tang P. (2015) J Infect Dis 212(10): 1574-1578

Year-Long Metagenomic Study of River Microbiomes Across Land Use and Water Quality.

Van Rossum T, Peabody MA, Uyaguari-Diaz MI, Cronin KI, Chan M, Slobodan JR, Nesbitt MJ, Suttle CA, Hsiao WW, Tang PK, Prystajecky NA, Brinkman FSL (2015) Front. Microbiol. 6: 1405 PDF

An endotoxin tolerance signature predicts sepsis and organ dysfunction at initial clinical presentation.

Pena, O.M., D.G. Hancock, N.H. Lyle, A. Linder, J.A. Russell, J. Xia, C.D. Fjell, J.H. Boyd, and R.E.W. Hancock. (2014) eBiomedicine 1: 64-71 PDF

Broad-spectrum anti-biofilm peptide that targets a cellular stress response.

Fuente-Núñez, C., F. Reffuveille, E.F. Haney, S.K. Straus and R.E.W. Hancock (2014) PLos Pathogens 10(5): e1004152 PDF

Coxsackievirus-induced miR-21 disrupts cardiomyocyte interactions via the downregulation of intercalated disk components.

Ye X, Zhang HM, Qiu Y, Hanson P, Hemida MG, Wei W, Hoodless PA, Chu F,Yang DC (2014) PLos Pathogens 10(4): e1004070 PDF

Does variation among provincial drug formulary antimicrobial listings in Canada influence prescribing rates?

Glass-Kaastra SK, Finley R, Hutchinson J, Patrick DM, Weiss K, Conly J. (2014) PLoS One 9(9): doi: 10.1371/journal.pone.0107515. PDF

Mutations of Cx43 that affect B cell spreading in response to BCR signaling.

Falk, L., Dang-Lawson, M., Vega Pizarro, José Luis, Pournia, F., Choi, K., Jang, C., Naus, C.C., and Matsuuchi, L. (2014) Biol Open 3: 185-194 PDF

Gap junction proteins on the move: Connexins, the cytoskeleton and migration. Biomembranes: The Communicating Junctions Part II

Matsuuchi, L. and Naus, C.G. (2013) BBA 1828: 94-108 PDF

ATP conditions intestinal epithelial cells to
an inflammatory state that promotes components of DC maturation.

Yao Y, Levings MK, Steiner TS. (2012) Eur J Immunol. 42(12): 3310-21 PDF

Effective adjunctive therapy by an innate defense regulatory peptide in a pre-clinical model of severe malaria.

Achtman, A.H., S. Pilat, C.W. Law, D.J. Lynn, L. Janot, M. Mayer, S. Ma, J. Kindrachuk, B.B. Finlay, F.S.L. Brinkman, G.K. Smyth, R.E.W. Hancock and L. Schofield. (2012) Science Transl. Med 4: 135ra64 PDF

Human subtilase SKI-1/S1P is a master regulator of the HCV life cycle and a potential host cell target for developing indirect-acting antiviral agents.

Olmstead, A.D., Knecht, W., Lazarov, I., Dixit, S.G., and Jean, F. (2012) PLos Pathogens 8(1): e1002468 PDF

Temporal and strain-specific host microRNA molecular signatures associated with swine-orgin H1N1 and avian-origin H7N7 influenza A virus infection

Loveday, E.K., Svinti, V., Diederich, S., Pasick, J., and Jean, F. (2012) Journal of Virology 86: 6109-6122 PDF

The gap junction protein Connexin43 (Cx43) regulates B-lymphocyte spreading and adhesion.

Machtaler, S., Dang-Lawson, M., Choi, K., Jang, C., Naus, C.C. and Matsuuchi, L (2011) J Cell Sci 124: 2611-2621 PDF

Neurosyphilitic gumma in a homosexual man with HIV infection confirmed by polymerase chain reaction.

Morshed MG, Lee MK, Maguire J, Zwimpfer T, Willoughby B, Clement J, Crawford RI, Barberie J, Gul S, Jones H. (2008) Int J STD AIDS 19(8): 568-9 PDF

Migratory songbirds disperse ticks across Canada, and first isolation of the Lyme disease spirochete, Borrelia burgdorferi, from the avian tick, Ixodes auritulus.

Morshed MG, Scott JD, Fernando K, Beati L, Mazerolle DF, Geddes G, Durden LA. (2005) J Parasitol 91(4): 780-90 PDF

Common themes in microbial pathogenicity revisited.

BB Finlay, S Falkow. (1997) Microbiol Mol Biol Rev. 61(2): 136-69 PDF

Transfer of antibody against Borrelia duttonii from mother to young in ddY mice.

Morshed MG, Yokota M, Nakazawa T, Konishi H. (1993) Infect Immun 61(10): 4147-52 PDF