Current Members

Project:

Bioinformatics.

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Sepsis Biomarker Signature: Multicenter Research Study

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Bioinformatics and database development for network-based analyses.

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Reverse Vaccinology project. Protein expression and purification.

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Using novel peptides as an adjunctive treatment against multi-drug antibiotic resistant organisms.

• Canada Research Chair
• Professor, Department of Microbiology and Immunology, UBC
• Director, Centre for Microbial Diseases and Immunity Research

More about Dr. Hancock

Project:

Immunomodulatory Peptidomimetics.

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Network-based approaches to integrating patient transcriptome and clinical data.

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Outer membrane proteins in Pseudomonas aeruginosa. Cloning, function and crystallization.

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In vivo immunomodulatory peptide studies and anti-biofilm.

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Exploring antimicrobial peptide and antibiotic susceptibility of drug resistant pathogens in host-mimicking conditions.

Project:

1. Develop and screen novel anti-biofilm peptides with broad-spectrum activity on surfaces.
2. Develop and establish multi-species biofilm models.
3. Investigate the structure-function relationship, the mechanism of action, and biological/therapeutic target(s) of antimicrobial and anti-biofilm peptides.
4. Lipid and liposome biochemistry.

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Infectious diseases and their respective pathogens. Swarming motility and antibiotic resistance in Pseudomonas aeruginosa, a cystic fibrosis and nosocomial pathogen.

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Genes regulating adaptive antibiotic resistance within Pseudomonas aeruginosa biofilms.

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• Microarray experimentation
• siRNA knock-downs

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• Outer membrane permeability and antibiotic uptake in Gram negative bacteria;
• Structure-function of peptide antibiotics;
• Novel antibiotics from plants/natural sources;
• Electron microscopy

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Design and Sequence Optimization of Innate Defence Regulator Peptides.

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Integrative Analysis of Transcriptomic and Metabolomic Data in Sepsis Patients.

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Transcriptomic analysis/Reverse Vaccinology of Johne’s disease

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Inhibition of S.aureus biofilms

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Investigating the mechanism of action of anti-biofilm peptides in vitro and in vivo (using a cutaneous abscess model established for Gram-negative bacteria) in Pseudomonas aeruginosa

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Anti-biofilm peptides

System administrator at Tekworks

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Designing improved anti-infective peptides

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Surfing motility as a complex adaptation.

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Investigating the effect of antimicrobial peptide on bacterial cell division

Administrative assistant

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Inhibition of swarming motility.

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Host defense peptides and toxin-sequestration, liposomal therapy for the use in anti-infective therapy.

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Mechanism of anti-inflammatory peptide IDR-1002 in vitro and in vivo.