Home | Contact | Site Map | Lab Location                                                                                                                                                      
 Meeting Room Bookings  | Lab Members Only 

About Hancock | Research Areas | Methods | Publications | Staff | CMDR | Genome Annotation | OMP Annotation | Links | Career/Jobs


 

 

 

Hancock Laboratory : Book Chapters and Reviews

 

1.     Hancock, R.E.W., R.A. Skurray and P. Reeves. 1975. A mutation in Escherichia coli K-12 affecting conjugation, phage resistance and a major membrane protein. Proc. Aust. Biochem. Soc. 7:80. 

2.         Braun, V., R.E.W. Hancock, K. Hantke and A. Hartman. 1976. Functional organization of the outer membrane of Escherichia coli: Phage and colicin receptors as components of iron uptake systems. In Progress in Clinical and Biological Research 17:11-32 (Revel, J.P., U. Henning and C.F. Fox, eds.) Alan R. Liss Inc., New York.

3.         Hancock, R.E.W. 1981. Aminoglycoside uptake and mode of action - with special reference to streptomycin and gentamicin. I. Antagonists and mutants. J. Antimicrob. Chemother. 8:249-276.

4.         Hancock, R.E.W. 1981. Aminoglycoside uptake and mode of action - with special reference to streptomycin and gentamicin. II. Effects of aminoglycosides on cells. J. Antimicrob. Chemother. 8:429-445.

5.         Benz, R., R.E.W. Hancock and T. Nakae. 1982. Porins from gram-negative bacteria in lipid bilayer membranes. In "Transport in Biomembranes: Model systems and reconstitution" (Antolini et al, eds), pp. 123-134. Raven Press, New York.

6.         Hancock, R.E.W., B. Loh and T.I. Nicas. 1983. Molecular Interactions of aminoglycosides with bacteria - Implications for therapy. Proc. 13th International Congress of Chemotherapy 35:1-3.

7.         Hancock, R.E.W. and T.I. Nicas. 1984. Resistance to antibacterial agents acting on cell membranes. In "Antimicrobial Drug Resistance" (Bryan, L.E., ed). pp.147 - 171. Academic Press, New York.

8.         Benz, R., K. Poole and R.E.W. Hancock. 1984. In Ionic channels in membranes. Biophysical Discussions. (Parsegian, V.A., ed.). pp. 81-82. Rockefeller University Press, New York. 

9.         Mutharia, L.M., J.S.L. Lam and R.E.W. Hancock, 1985. Use of monoclonal antibodies in the study of common antigens in gram negative bacteria. In (A.J.L. Macario and E.C. de Macario, eds.) "Monoclonal antibodies against bacteria", pp. 131-142, Academic Press, New York.

10.     Lam, J.S.L., L.M. Mutharia and R.E.W. Hancock. 1985. Application of monoclonal antibodies to the study of the surface antigens in Pseudomonas aeruginosa. In (A.J.L. Macario and E.C. Macario, eds.) "Monoclonal antibodies against bacteria", Vol. II, pp. 143-157, Academic Press, New York.

11.     Hancock, R.E.W. 1985. The role of the cell surface components of Pseudomonas aeruginosa in virulence. In (G.G. Jackson and J. Thomas, eds.) Bayer Symposium VII: Pathogenesis of Bacterial Infections. pp. 247-256. Springer-Verlag, Berlin.

12.     Hancock, R.E.W. 1985. Monoclonal antibody protection against Pseudomonas aeruginosa.  In (G.G. Jackson and J. Thomas, eds.) pp. 422-424. Bayer Symposium VII: The Pathogenesis of Bacterial Infections. Springer-Verlag, Berlin.

13.     Hancock, R.E.W. 1985. Laboratory characterization of lipopolysaccharides (LPS). In (G.G. Jackson and J. Thomas, eds.) p. 398. Bayer Symposium VII: The Pathogenesis of Bacterial Infections. Springer-Verlag, Berlin.

14.     Hancock, R.E.W. 1985. The Pseudomonas aeruginosa outer membrane permeability barrier and how to overcome it. In (Speert, D.P., and R.E.W. Hancock, Ed.) Antibiotics and Chemotherapy, pp. 95-102, S. Karger, Basel.37.

15.     Hancock, R.E.W. and L.M. Mutharia. 1985. Monoclonal Antibodies against bacterial outer membrane antigens. In Advances in Experimental Medicine and Biology, Vol. 185 (Atassi, M. and H.L. Bachrach, eds.) pp. 215-222. Plenum Press Inc., New York.

16.     Nikaido, H. and R.E.W. Hancock. 1986. Outer membrane permeability of Pseudomonas aeruginosa. In (Sokatch, J.R., ed.) The Bacteria: A treatise on structure and function.  X. pp. 145-193. Academic Press, London.

17.     Hancock, R.E.W., E.C.A. Mouat, S.L. Butters and D.P. Speert. 1986. The outer membrane proteins of Pseudomonas aeruginosa: Immunotherapeutic potential. In (Robbins, J.B., ed.) Seminars in Infectious Diseases.

18.     Moore, R.A. and R.E.W. Hancock. 1985. The penetration of antibiotics into the antibiotic resistant bacterium Pseudomonas aeruginosa: Interaction of polycationic antibiotics at a common site on the lipopolysaccharide. Chemioterapia. 4, Suppl. No. 2: 3-5.

19.     Hancock, R.E.W. 1987. Model membrane studies of porin function. In Bacterial Outer Membranes as Model Systems (Inouye, M., ed.) pp. 187-225. John Wiley and Sons, New York.

20.     Hancock, R.E.W., E.A. Worobec, K. Poole and R. Benz. 1987. Phosphate-binding site of Pseudomonas aeruginosa outer membrane protein P. In (Torriani, A., Silver, S., Rathman, F., Wright, A., and Yagel, E., eds.) "Phosphate metabolism and cellular regulation in microorganisms." pp.176-180, ASM, Washington.

21.     Moore, R.A., W.A. Woodruff and R.E.W. Hancock. 1987. Antibiotic uptake pathways across the outer membrane of Pseudomonas aeruginosa. Antibiotics and Chemotherapy, 39:172-181.

22.     Hancock, R.E.W. and N. Kelly. 1987. Role of outer membrane components in Pseudomonas aeruginosa colonization of the cystic fibrosis lung. Pediatr. Pulmon., Suppl. 1:89-91.

23.     Hancock, R.E.W. and W.A. Woodruff. 1988. Roles of porin and b-lactamase in b-lactam resistance of Pseudomonas aeruginosa. Rev. Infect. Dis. 10:770-775.

24.     Hancock, R.E.W. and A. Bell. 1989. Antibiotic uptake into Gram negative bacteria. In "Perspectives in anti-infective therapy" (G.G. Jackson, H.D. Schlumberger, and H.J. Zeiler, eds.) pp. 21-28. Vieweg and Sohn, Braungshweig.

25.     Martin, N.L. and R.E.W. Hancock. 1990. Function and structure of the major components of the outer membrane of gram-negative bacteria. In Advances in Brucellosis Research (ed. L.G. Adams), pp. 55-75, Texas A & M University Press, College Station.

26.     Siehnel, R.J., N.L. Martin and R.E.W. Hancock. 1990. Function and structure of the porin proteins OprF and OprP of Pseudomonas aeruginosa. In Pseudomonas: Biotransformations pathogenesis and evolving biotechnology. Silver, S., A.M. Chakrabarty, B. Iglewski, and S. Kaplan. pp. 328-342. American Society for Microbiology, Washington.

27.     Hancock, R.E.W. and N. Karunaratne. 1990. LPS integration into outer membrane structures. In Cellular and Molecular Aspects of Endotoxin Reactions. Vol. 1, pp. 191-196. (Nowotny, A., Spitzer, J.J., and Ziegler, E.J., eds.) Elsevier Science Publishers B.V., Amsterdam.

28.     Hancock, R.E.W. 1991. Bacterial outer membranes: Evolving Concepts. ASM News 57:175-182.

29.     Bellido, F., R.L. Finnen, N.L. Martin, R.J. Siehnel and R.E.W. Hancock. 1992. Function and structure of Pseudomonas aeruginosa outer membrane protein OprF. In: Pseudomonas: Molecular Biology and Biotechnology. (Galli, E., S. Silver and B. Witholt, eds.). pp. 170-176. American Society for Microbiology, Washington, D.C.

30.     Hancock, R.E.W. and M.H. Brown. 1992. Bacterial Porins. Today's Life Science 4:24-32.

31.     Bellido,F., and R.E.W.Hancock. 1994. Susceptibility and resistance of Pseudomonas aeruginosa to antimicrobial agents. In Pseudomonas aeruginosa as an opportunistic pathogen. (Campa, M., M. Bendinelli, and H.Friedman, eds) pp.321-348. Plenum Press, NY.

32.     Hancock, R.E.W., C. Egli and N. Karunaratne. 1994. Molecular organization and structural role of outer membrane macromolecules. In Bacterial Cell Envelope (J.M. Ghuysen and Hakenbeck, R., eds). pp. 263-279. pp. 263-279. Elsevier Science Publishers BV, Amsterdam.

33.     Hancock, R.E.W., and K. Piers. 1994. Outer membrane proteins. In Escherichia coli in animals. (Gyles C.L., ed.). pp. 495-532. CAB International, Wallingford, U.K.

34.     Siehnel, R.J., R.S.Y. Wong, H. Huang and R.E.W. Hancock 1994. Cloning of outer membrane protein genes and molecular genetic methods for studying structure function relationships. Meth. Molec. Genet. 3:311-324.

35.     Hancock, R.E.W. and T.E. McCurry. 1993. Canadian Bacterial Diseases Network: a new approach to University-Industry relationships. Clin. Invest. Med. 16:306-313.

36.     Hancock, R.E.W., T. Falla and M.H. Brown, 1995. Cationic Bactericidal peptides. Adv. Microb. Physiol. 37:135-175.

37.     Hancock, R.E.W. 1994. Bacterial transport as an import mechanism and target for antimicrobials. In Georgopapadakou, N. ed., "Drug transport in antimicrobial and anticancer chemotherapy", pp. 289-306. Marcel Dekker, Inc., New York.

38.     Hancock, R.E.W., S. Fidai, M. Gough, M. Wu, and K. Piers. 1994. Small Peptide Antibiotics. Pediatric Pulmonology 10(S):161-162.

39.     Hancock, R.E.W., and T. Falla, 1996. Cationic Peptides. In Biotechnology of Antibiotics, Strohl, W.R., 2nd Edition, Ch. 16: 467-492. Marcell Dekker Inc., N.Y.

40.     Hancock, R.E.W., K. Piers, M. Brown, T. Falla, M. Gough, M. Wu and S. Fidai. 1996. Cationic peptides: a class of antibiotics able to access the self promoted uptake pathway across the outer membrane of Pseudomonas aeruginosa. In: Molecular Biology of Pseudomonads. (Nakazawa, T., Furukawa, K., Haas, D., and Silver, S., eds) ASM Press, Washington.

41.     Hancock, R.E.W., and D.P. Speert. 1996. Antibiotics for Pseudomonas and related infections. In Cystic Fibrosis - current topics (Dodge, J.A., Brock, D.J.H., and Widdicombe, J.H., eds.) Vol. 3, pp. 245-266. John Wiley and Sons Ltd.

42.     Hancock, R.E.W. and M. Exner. 1997. Isolation and characterization of porins from H. pylori. In Clayton, C.L. and H.L.T. Mobley eds. Methods Molec. Med. Helicobacter pylori protocols. pp. 191-204. Humana Press In., Totowa, N.J.

43.     Hancock, R.E.W. and R. Wong. 1997. Potential of protein OprF of Pseudomonas in bivalent vaccines. In Domdey, H., W. Lubitz, F. Schodel and B. von Specht eds. Behring Institute Mitteilungen Vol. 98, 283-290. DMV, Marburg.

44.     Hancock, R.E.W. 1997. The role of fundamental research and biotechnology in finding solutions to the global problem of antibiotic resistance. Clin. Infect. Dis., 24 (Supplement 1): S148-S150.

45.     Hancock, R.E.W., and E.A. Worobec. 1998. Outer membrane proteins, In (Montie T., ed.) Biotechnology Handbooks. 10 Pseudomonas, pp. 139-167. Plenum Press, London.

46.     Hancock, R.E.W. 1998. Resistance mechanisms in Pseudomonas aeruginosa and other nonfermentative Gram-negative bacteria. Clin. Infect. Dis. 27: S93-99.

47.     Hancock, R.E.W. and J.S. Lam. 1998. Pseudomonas aeruginosa: Infection and Immunity. In (P.J.Delves ed.) Encyclopaedia of Immunology, 2nd Edition. 4:2042-2045. Academic Press, London.

48.     Hancock, R.E.W., and D.Knowles. 1998. Are we approaching the end of the antibiotic era? Editorial overview. Curr. Opinion Microbiol. 1:493-494.

49.     Towers, G.H.N., McCutcheon, A., Saxena, G., Matsuura, H., Page, J., Farmers, S., Gibbons, E. Roberts, T.E., Babiuk, L.A., Thorson, I.M., Stokes, R.W., Sokol, P., Klingemann, H., and Hancock, R.E.W.  1999.  Anti-microbial activities of phytochemicals from British Columbian medicinal plants.  In:  Chemistry, Biological, and Pharmacological Properties of Medicinal Plants from the Americas.  Ed.  Hostettmann, K., Gupta, M.P., and Marston, A.  Harwood Academic Publ. Switzerland.  pp. 125-142.

50.     Hancock, R.E.W. 1999. Host defence (cationic) peptides: What is their future clinical potential? Drugs 57: 469-473.

51.     Hancock, R.E.W., and A.Patrzykat. 1999. Cationic peptide antibiotics: a diversified portfolio for the future. Chimica Oggi (Biocides Today supplement) pp. 20-21.

52.     Hancock, R.E.W., M. Scott, C.Friedrich, L.Zhang, H.Yan, P.Nair, A.Patrzykat, and A.Rozek. 1999. Cationic peptide antibiotics for use in treatment of Pseudomonas aeruginosa infections of cystic fibrosis patients. Clin. Microbiol. Infect. 5:S52-S53.

53.     Zhang, L., and R.E.W.Hancock. 2000. Peptide antibiotics. In Hughes, D., and Andersson, D.I., eds. Antibiotic resistance and antibiotic development. pp. 209-232. Harwood Academic Publishers.

54.     Hetru, C., J.A.Hoffmann, and R.E.W.Hancock. 2000. Insect cationic antimicrobial peptides. In Dutton, C., M.Haxell, H.I. McArthur, and R.Wax. Peptide antibiotics: Discovery, modes of action and applications. Marcel Dekker, New York.

55.     Macfarlane, E.L.A., and R.E.W. Hancock. 2000. Antibiotic resistance and survival in the host. In (Brogden, K., J.A. Roth, T.B. Stanton, C.A. Bolin, F.C. Minion, and M.J. Wannemuehler, eds.) Virulence mechanisms of bacterial pathogens, 3rd edition, pp. 93-104, ASM Press, Washington, DC.

56.     Hancock, R.E.W., and P.Nair. 2000. Cationic antimicrobial peptide antibiotics. Curr. Opin. Antiinfective Invest. Drugs. 2:140-148.

57.     Hancock, R.E.W. 2001. Mechanism of action of imipenem and relevance of porin OprD. Infections in Oncology 5:2-3.

58.     Hancock, R.E.W., and A. Patrzykat. 2001. Antimicrobial peptides for fish disease control. In “Recent advances in marine biotechnology” Vol. 7: Seafood Safety and Human Health, Oxford and IBH Publishing Co., New Delhi.

59.     Lewenza, S., and R.E.W. Hancock. 2001. Post-genomic Pseudomonas. Genome Biology 3:4002.1-4002.2.

60.     Hancock, R.E.W. 2002. Cationic anti-microbial peptides. Biochem. Cell Biol. 80:140.

61.     Devine, D.A., and R.E.W.Hancock. 2002. Cationic peptides: Distribution and mechanisms of resistance. Curr. Pharmaceut. Design 8:99-110.

62.     Tamber, S., and R.E.W. Hancock. 2003. Electrophoresis and blotting of DNA. In Nature Encyclopaedia of Life Sciences. London: http://www.els.net/ [http://dx.doi.org/10.1038/npg.els.0003746].

63.     Hassett, D.J., P.A. Limbach, R.F. Hennigan, K.E, Klose, R.E.W. Hancock, M.D.Platt, D.F. Hunt. 2003. Bacterial biofilms of importance to medicine and bioterrorism: proteomic techniques to identify novel vaccine components and drug target. Exp. Opin. Biol. Ther. 3: 1201-1207.

64. Tamber, S., and R.E.W. Hancock. 2004. The Outer Membranes of Pseudomonads. In J.L. Ramos, ed., The Pseudomonads, Vol. I. Pp. 575-601. Kluwer Academic, NY.

65. Hancock, R.E.W., and D.A. Devine, editors. 2004. Mammalian host defence peptides. Advances in Molecular and Cellular Microbiology Series. Cambridge University Press, NY.

66. Hancock, R.E.W., and D.A. Devine. 2004. “Antimicrobial” or “host defence” peptides. In, D.A. Devine and Hancock, R.E.W., eds. Mammalian host defence peptides. pp. 1-4 Cambridge University Press, NY.

67. Hancock, R.E.W. 2004. Bacterial Structure and Physiology: Influence on Susceptibility to Cationic Antimicrobial Peptides. In D.A. Devine and Hancock, R.E.W., eds. Mammalian host defence peptides. pp. 229-244. Cambridge University Press, NY.

68. Hancock, R.E.W., and S. Tamber. 2004. Porins of the outer membrane of Pseudomonas aeruginosa. In Benz, R., ed. Bacterial and Eukaryotic Porins. Ch. 4, pp. 61-77, Wiley VCH Verlag, Weinheim.

69.  Hancock, R.E.W. 2004. Using the Pseudomonas aeruginosa genome to understand pathogenesis. Ped. Pulmon. S27:142-143.

70. Mookerhjee, N., K.L. Brown and R.E.W.Hancock. 2005. Cathelicidins: Cationic Host Defense and Antimicrobial Peptides. Handbook of Biologically Active Peptides, pp. 55-66. (Kastan, A. ed.; Hancock, R.E.W. section ed.).

71.  Bowdish, D.M.E., D.J. Davidson, and R.E.W. Hancock. 2006. Immunomodulatory properties of defensins and cathelicidins. Curr. Top. Microbiol. Immunol. 306:27-66.

72.  Jenssen H., K.Hilpert, and R.E.W. Hancock. 2007. Antibacterial host defence peptides of bovine origin. Chem. Today. 25:17-19.

73.  McPhee, J.B., S. Tamber,  S. Lewenza, M.D. Brazas, and R.E.W. Hancock. 2009. Antibiotic resistance due to reduced uptake. In D.L. Mayers, ed. Antimicrobial drug resistance: Principles and practice for the clinical bench. Pp. 97-110. Humana Press, New Jersey.

74.  Winkler, D.F.H., K. Hilpert, O. Brandt and R.E.W. Hancock. 2009. Synthesis of peptide arrays using

      SPOT-technology and the CelluSpots-method. Peptide Microarrays. Humana Press, New Jersey, in

      press.

75.   Kindrachuk, J., A. Nijnik, and R.E.W. Hancock. 2009. Host defense peptides: Bridging antimicrobial and

       immunomodulatory activities. In Comprehensive Natural Products II Chemistry and Biology; Mander, L.,

       Lui, H.-W., Eds.; Elsevier: Oxford, 2010; volume 5, pp.175–216

76.  Jiang Z., A.I. Vasil, J. Hale, R.E.W. Hancock, M.L. Vasil, and R.S. Hodges. 2009. Effects of net charge

      and the number of positively charged residues on the biological activity of amphipathic alpha-helical

      cationic antimicrobial peptides. Adv. Exp. Med. Biol. 611:561- 562.

77.  Patrzykat, A., and R.E.W. Hancock. 2009. Host Defense Peptides in Fish: From the Peculiar to the Mainstream, in Fish Defenses. In Vol. 2: Pathogens, Parasites and Predators (eds G. Zaccone, C. Perrière, A. Mathis, and B.G. Kapoor), pp.43-63. Science Publishers, New Hampshire.

78.  Lynn D.J., J.L. Gardy, C.D. Fjell, R.E.W. Hancock, and F.S.L.Brinkman 2010. Systems-Level Analyses of the Mammalian Innate Immune Response. In Systems Biology for Signaling Networks, Vol 1, Part 3, pp. 531-560.Springer Publishing, N.Y.

79.  Hancock, R.E.W. 2010. Introduction to the Theme: Seeking Clarity for Membrane-active Peptides. In M. Castanho, ed. Membrane-active peptides: Methods and Results on Structure and Function. pp. 3-9. International University Line, La Jolla.

80.  Mayer M.L., D.M. Easton, and R.E.W. Hancock. 2010. Fine tuning host responses in the face of infection: Emerging roles and clinical applications of host defence peptides. In Wang G. ed., Antimicrobial Peptides: Discovery, Design and Novel Therapeutic Strategies. G. Wang (ed.). Chapter 12, pp. 195-220. CABI: Oxfordshire, UK.

81.  Madera, L., S. Ma, and R.E.W. Hancock. 2010. Host defence (Antimicrobial) Peptides and Proteins. In Kaufmann, S.H.E., B. Rouse, and D. Sacks, eds. The Immune response to infection. Pp. 57-68. ASM Press, Wasshington, DC.

82.  Pena, O.M., J.D.F. Hale, and R.E.W. Hancock. 2011. Host Defense Peptides as Antibacterial Agents. In “Emerging Trends in Antibacterial Discovery”, AA. Miller and P.F. Miller, eds. Horizon Scientific Press, Norwich, UK.

83.  Fernandez, L., E.B.M. Breidenstein, and R.E.W. Hancock. 2011. Importance of adaptive and stepwise changes in the rise and spread of antimicrobial resistance. In: Keen P., Monforts M. (eds.). Antimicrobial resistance in the environment. Wiley-Blackwell Publishing, accepted for publication.ress.

 

 


R.E.W. Hancock Laboratory
Updated
December 2011